{"id":"https://openalex.org/W7141502002","doi":"https://doi.org/10.33808/clinexphealthsci.1803243","title":"Investigation of TRPM8 Gene Variations in A Turkish Population with Migraine","display_name":"Investigation of TRPM8 Gene Variations in A Turkish Population with Migraine","publication_year":2026,"publication_date":"2026-03-27","ids":{"openalex":"https://openalex.org/W7141502002","doi":"https://doi.org/10.33808/clinexphealthsci.1803243"},"language":"en","primary_location":{"id":"doi:10.33808/clinexphealthsci.1803243","doi":"https://doi.org/10.33808/clinexphealthsci.1803243","is_oa":true,"landing_page_url":"https://doi.org/10.33808/clinexphealthsci.1803243","pdf_url":"https://dergipark.org.tr/en/download/article-file/5328443","source":{"id":"https://openalex.org/S2764997520","display_name":"Clinical and Experimental Health Sciences","issn_l":"2146-3654","issn":["2146-3654","2459-1459"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4","tr-dizin","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Health Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://dergipark.org.tr/en/download/article-file/5328443","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5130761176","display_name":"Beg\u00fcm Gen\u00e7","orcid":"https://orcid.org/0000-0002-3849-1891","observed_orcids":["https://orcid.org/0000-0002-3849-1891"]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Beg\u00fcm Gen\u00e7","raw_affiliation_strings":["Marmara University School of Medicine"],"raw_orcid":"https://orcid.org/0000-0002-3849-1891","affiliations":[{"raw_affiliation_string":"Marmara University School of Medicine","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021036531","display_name":"\u0130lknur Ayd\u0131n Cant\u00fcrk","orcid":"https://orcid.org/0000-0003-1855-1153","observed_orcids":["https://orcid.org/0000-0003-1855-1153"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u0130lknur Ayd\u0131n Cant\u00fcrk","raw_affiliation_strings":["Istanbul G\u00f6ztepe Prof. Dr. S\u00fcleyman Yalcin City Hospital, Department of Neurology"],"raw_orcid":"https://orcid.org/0000-0003-1855-1153","affiliations":[{"raw_affiliation_string":"Istanbul G\u00f6ztepe Prof. Dr. S\u00fcleyman Yalcin City Hospital, Department of Neurology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054384134","display_name":"Banu Ayd\u0131n","orcid":"https://orcid.org/0000-0002-3267-8620","observed_orcids":["https://orcid.org/0000-0002-3267-8620"]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Banu Aydin","raw_affiliation_strings":["Marmara University School of Medicine"],"raw_orcid":"https://orcid.org/0000-0002-3267-8620","affiliations":[{"raw_affiliation_string":"Marmara University School of Medicine","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009722624","display_name":"Fatma Candan","orcid":"https://orcid.org/0000-0001-8936-5134","observed_orcids":["https://orcid.org/0000-0001-8936-5134"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fatma Candan","raw_affiliation_strings":["Istanbul G\u00f6ztepe Prof. Dr. S\u00fcleyman Yalcin City Hospital, Department of Neurology"],"raw_orcid":"https://orcid.org/0000-0001-8936-5134","affiliations":[{"raw_affiliation_string":"Istanbul G\u00f6ztepe Prof. Dr. S\u00fcleyman Yalcin City Hospital, Department of Neurology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071357905","display_name":"H\u00fclya Cabadak","orcid":"https://orcid.org/0000-0001-5757-2198","observed_orcids":["https://orcid.org/0000-0001-5757-2198"]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Hulya Cabadak","raw_affiliation_strings":["Marmara University School of Medicine"],"raw_orcid":"https://orcid.org/0000-0001-5757-2198","affiliations":[{"raw_affiliation_string":"Marmara University School of Medicine","institution_ids":["https://openalex.org/I74897591"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19357325,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"1","first_page":"72","last_page":"79"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/migraine","display_name":"migraine","score":0.8989999890327454},{"id":"https://openalex.org/keywords/trpm8","display_name":"TRPM8","score":0.9860000014305115},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9929999709129333},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.7020000219345093},{"id":"https://openalex.org/keywords/turkish-population","display_name":"Turkish population","score":0.8610000014305115},{"id":"https://openalex.org/keywords/genotype-distribution","display_name":"genotype distribution","score":0.5580000281333923},{"id":"https://openalex.org/keywords/allele-frequency","display_name":"allele frequency","score":0.6949999928474426},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.8870000243186951},{"id":"https://openalex.org/C163146387","wikidata":"https://www.wikidata.org/wiki/Q15324395","display_name":"TRPM8","level":5,"score":0.7641000151634216},{"id":"https://openalex.org/C2778817970","wikidata":"https://www.wikidata.org/wiki/Q7855390","display_name":"Turkish population","level":4,"score":0.7638000249862671},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6934999823570251},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5587000250816345},{"id":"https://openalex.org/C50929876","wikidata":"https://www.wikidata.org/wiki/Q164280","display_name":"Subfamily","level":3,"score":0.555899977684021},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.5231999754905701},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5199999809265137},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.5009999871253967},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4715999960899353},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.4681999981403351},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.46470001339912415},{"id":"https://openalex.org/C175239580","wikidata":"https://www.wikidata.org/wiki/Q656595","display_name":"Genotype frequency","level":5,"score":0.4383000135421753},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4228000044822693},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.421999990940094},{"id":"https://openalex.org/C2777350023","wikidata":"https://www.wikidata.org/wiki/Q1154226","display_name":"Aura","level":3,"score":0.36550000309944153},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.361299991607666},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3450999855995178},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.33169999718666077},{"id":"https://openalex.org/C2993230221","wikidata":"https://www.wikidata.org/wiki/Q431095","display_name":"Turkish economy","level":3,"score":0.32089999318122864},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.3154999911785126},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.30390000343322754},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.29330000281333923},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2865000069141388},{"id":"https://openalex.org/C61470247","wikidata":"https://www.wikidata.org/wiki/Q7229825","display_name":"Population study","level":3,"score":0.2847999930381775},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2825999855995178},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.2818000018596649},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.27709999680519104},{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.2687000036239624},{"id":"https://openalex.org/C2777989426","wikidata":"https://www.wikidata.org/wiki/Q2936142","display_name":"Channelopathy","level":2,"score":0.2685999870300293},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.26460000872612},{"id":"https://openalex.org/C2776497919","wikidata":"https://www.wikidata.org/wiki/Q739481","display_name":"Migraine with aura","level":4,"score":0.2563000023365021},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.25060001015663147},{"id":"https://openalex.org/C76252995","wikidata":"https://www.wikidata.org/wiki/Q3395645","display_name":"Gene polymorphism","level":4,"score":0.2500999867916107}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.33808/clinexphealthsci.1803243","doi":"https://doi.org/10.33808/clinexphealthsci.1803243","is_oa":true,"landing_page_url":"https://doi.org/10.33808/clinexphealthsci.1803243","pdf_url":"https://dergipark.org.tr/en/download/article-file/5328443","source":{"id":"https://openalex.org/S2764997520","display_name":"Clinical and Experimental Health Sciences","issn_l":"2146-3654","issn":["2146-3654","2459-1459"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4","tr-dizin","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Health Sciences","raw_type":"journal-article"},{"id":"pmh:oai:dergipark.org.tr:article/1803243","doi":null,"is_oa":false,"landing_page_url":"https://dergipark.org.tr/en/pub/clinexphealthsci/article/1803243","pdf_url":null,"source":{"id":"https://openalex.org/S4306401840","display_name":"DergiPark (Istanbul University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67581229","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/I67581229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical and Experimental Health Sciences, Vol. 16 No. 1","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.33808/clinexphealthsci.1803243","doi":"https://doi.org/10.33808/clinexphealthsci.1803243","is_oa":true,"landing_page_url":"https://doi.org/10.33808/clinexphealthsci.1803243","pdf_url":"https://dergipark.org.tr/en/download/article-file/5328443","source":{"id":"https://openalex.org/S2764997520","display_name":"Clinical and Experimental Health Sciences","issn_l":"2146-3654","issn":["2146-3654","2459-1459"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4","tr-dizin","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Health Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5174883604049683}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320325078","display_name":"Marmara \u00dcniversitesi","ror":"https://ror.org/02kswqa67"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7141502002.pdf","grobid_xml":"https://content.openalex.org/works/W7141502002.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W152075184","https://openalex.org/W1969509610","https://openalex.org/W1993227624","https://openalex.org/W1994800580","https://openalex.org/W1995330222","https://openalex.org/W1997788790","https://openalex.org/W1998398057","https://openalex.org/W2008022422","https://openalex.org/W2012825395","https://openalex.org/W2013288107","https://openalex.org/W2020513332","https://openalex.org/W2025006950","https://openalex.org/W2026697515","https://openalex.org/W2028436965","https://openalex.org/W2028643581","https://openalex.org/W2028927099","https://openalex.org/W2034559642","https://openalex.org/W2053095154","https://openalex.org/W2064974052","https://openalex.org/W2066080151","https://openalex.org/W2066875663","https://openalex.org/W2085607345","https://openalex.org/W2087196799","https://openalex.org/W2087665027","https://openalex.org/W2099722952","https://openalex.org/W2112239428","https://openalex.org/W2113737911","https://openalex.org/W2116004796","https://openalex.org/W2120229762","https://openalex.org/W2125566127","https://openalex.org/W2144693103","https://openalex.org/W2162104155","https://openalex.org/W2163946681","https://openalex.org/W2494086305","https://openalex.org/W2588315103","https://openalex.org/W2617500217","https://openalex.org/W2793434832","https://openalex.org/W2801085490","https://openalex.org/W2909518617","https://openalex.org/W2912667201","https://openalex.org/W2995869997","https://openalex.org/W2996955061","https://openalex.org/W3174665810","https://openalex.org/W4220745579","https://openalex.org/W4230768398","https://openalex.org/W4247292047","https://openalex.org/W4404071200","https://openalex.org/W4411527348"],"related_works":[],"abstract_inverted_index":{"Objective:":[0],"A":[1,127],"migraine":[2,89,99,138,170,202],"is":[3,42],"a":[4,46,66,91],"type":[5],"of":[6,21,25,51,82,175],"headache":[7],"that":[8],"occurs":[9],"in":[10,17,48,73,90,130,148,203,206],"attacks.":[11],"The":[12,94,109,142,191],"rs10166942":[13,111,133,193],"single-nucleotide":[14],"polymorphism":[15,113,195],"(SNP)":[16],"the":[18,22,26,49,80,106,117,131,149,167,173,176,207],"eighth":[19],"member":[20,38],"subfamily":[23,36],"melastin":[24],"potential":[27,33,67],"transition":[28],"receptor":[29,32],"channel":[30],"(transient":[31],"cation":[34],"channel,":[35],"M,":[37],"8)":[39],"(TRPM8)":[40],"genes":[41],"thought":[43],"to":[44,78,198],"play":[45],"role":[47],"etiology":[50],"migraine.":[52],"Migraine":[53],"shares":[54],"certain":[55],"characteristics":[56],"with":[57,88,201],"neuropathic":[58,71],"pain,":[59],"and":[60,85,101,140,157,169,178,183,186,188],"TRPM8":[61,83,110,132,143,192],"has":[62],"been":[63],"identified":[64,115],"as":[65,105],"target":[68],"for":[69],"treating":[70],"pain":[72],"animal":[74],"models.This":[75],"study":[76,95],"aimed":[77],"determine":[79],"frequency":[81],"polymorphisms":[84],"their":[86],"association":[87],"Turkish":[92,208],"population.Methods:":[93],"included":[96],"68":[97],"unrelated":[98],"patients":[100,139,205],"59":[102],"healthy":[103],"individuals":[104],"control":[107,158,168],"group.":[108],"gene":[112,194],"was":[114,135,196],"using":[116],"Real":[118],"Time":[119],"Polymerase":[120],"Chain":[121],"Reaction":[122],"Melting":[123],"Curve":[124],"Analysis":[125],"system.Results:":[126],"significant":[128],"difference":[129],"variant":[134],"observed":[136],"between":[137],"controls.":[141],"genotype":[144],"distribution":[145],"differed":[146],"significantly":[147],"patient":[150,171],"group":[151,159],"(TT=72":[152],"%;":[153,161,163],"TC=26.4%;":[154],"CC=1.5":[155],"%)":[156],"(TT=64.4":[160],"TC=25.4":[162],"CC=10.2":[164],"%).":[165],"In":[166],"groups,":[172],"frequencies":[174],"C":[177],"T":[179],"alleles":[180],"were":[181],"22.8%":[182],"77.1%,":[184],"respectively,":[185],"14.7%":[187],"85.3%,":[189],"respectively.Conclusion:":[190],"found":[197],"be":[199],"associated":[200],"female":[204],"population.":[209]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-03-28T00:00:00"}
