{"id":"https://openalex.org/W7141237277","doi":"https://doi.org/10.3390/jcm15072559","title":"Comparative Proteomic Analysis of Lipoprotein(a): Method-Dependent Profiles and Disease Pathways","display_name":"Comparative Proteomic Analysis of Lipoprotein(a): Method-Dependent Profiles and Disease Pathways","publication_year":2026,"publication_date":"2026-03-27","ids":{"openalex":"https://openalex.org/W7141237277","doi":"https://doi.org/10.3390/jcm15072559","pmid":"https://pubmed.ncbi.nlm.nih.gov/41976861"},"language":"en","primary_location":{"id":"doi:10.3390/jcm15072559","doi":"https://doi.org/10.3390/jcm15072559","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm15072559","pdf_url":"https://www.mdpi.com/2077-0383/15/7/2559/pdf?version=1774606756","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2077-0383/15/7/2559/pdf?version=1774606756","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066455990","display_name":"Nelsa Matienzo","orcid":"https://orcid.org/0000-0002-8826-0311","observed_orcids":["https://orcid.org/0000-0002-8826-0311"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nelsa Matienzo","raw_affiliation_strings":["Division of Preventive Medicine and Nutrition, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons (P&S), 630 West 168th Street, New York, NY 10032, USA"],"raw_orcid":"https://orcid.org/0000-0002-8826-0311","affiliations":[{"raw_affiliation_string":"Division of Preventive Medicine and Nutrition, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons (P&S), 630 West 168th Street, New York, NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130783068","display_name":"Zoe Kress","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zoe Kress","raw_affiliation_strings":["Division of Preventive Medicine and Nutrition, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons (P&S), 630 West 168th Street, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Preventive Medicine and Nutrition, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons (P&S), 630 West 168th Street, New York, NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015707475","display_name":"Sasha A. Singh","orcid":"https://orcid.org/0000-0003-0929-3164","observed_orcids":["https://orcid.org/0000-0003-0929-3164"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sasha A. Singh","raw_affiliation_strings":["Center for Interdisciplinary Cardiovascular Sciences, Division of Cardiovascular Medicine, Department of Medicine, Brigham Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Interdisciplinary Cardiovascular Sciences, Division of Cardiovascular Medicine, Department of Medicine, Brigham Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104683906","display_name":"Masanori Aikawa","orcid":"https://orcid.org/0000-0002-9275-2079","observed_orcids":["https://orcid.org/0000-0002-9275-2079"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masanori Aikawa","raw_affiliation_strings":["Center for Excellence in Vascular Biology, Division of Cardiovascular Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA","Center for Interdisciplinary Cardiovascular Sciences, Division of Cardiovascular Medicine, Department of Medicine, Brigham Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA","Channing Division of Network Medicine, Department of Medicine, Brigham Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Excellence in Vascular Biology, Division of Cardiovascular Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Center for Interdisciplinary Cardiovascular Sciences, Division of Cardiovascular Medicine, Department of Medicine, Brigham Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Channing Division of Network Medicine, Department of Medicine, Brigham Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079956746","display_name":"Rajesh Kumar Soni","orcid":"https://orcid.org/0000-0002-4556-4358","observed_orcids":["https://orcid.org/0000-0002-4556-4358"]},"institutions":[{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4390039230"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajesh K. Soni","raw_affiliation_strings":["Proteomics and Macromolecular Crystallography Shared Resource, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA"],"raw_orcid":"https://orcid.org/0000-0002-4556-4358","affiliations":[{"raw_affiliation_string":"Proteomics and Macromolecular Crystallography Shared Resource, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA","institution_ids":["https://openalex.org/I4390039230","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045162395","display_name":"Yihao Li","orcid":"https://orcid.org/0009-0009-8722-3437","observed_orcids":["https://orcid.org/0009-0009-8722-3437"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yihao Li","raw_affiliation_strings":["Division of Preventive Medicine and Nutrition, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons (P&S), 630 West 168th Street, New York, NY 10032, USA"],"raw_orcid":"https://orcid.org/0009-0009-8722-3437","affiliations":[{"raw_affiliation_string":"Division of Preventive Medicine and Nutrition, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons (P&S), 630 West 168th Street, New York, NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012063139","display_name":"Gissette Reyes\u2010Soffer","orcid":"https://orcid.org/0000-0002-6746-4569","observed_orcids":["https://orcid.org/0000-0002-6746-4569"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gissette Reyes-Soffer","raw_affiliation_strings":["Division of Preventive Medicine and Nutrition, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons (P&S), 630 West 168th Street, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Preventive Medicine and Nutrition, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons (P&S), 630 West 168th Street, New York, NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5012063139"],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15317685,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"7","first_page":"2559","last_page":"2559"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.6577000021934509,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.6577000021934509,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.23579999804496765,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.03290000185370445,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipoprotein-a","display_name":"lipoprotein(a)","score":0.9980000257492065},{"id":"https://openalex.org/keywords/in-gel-digestion","display_name":"in-gel digestion","score":0.9919999837875366},{"id":"https://openalex.org/keywords/core-proteome","display_name":"core proteome","score":0.7429999709129333},{"id":"https://openalex.org/keywords/atherosclerotic-cardiovascular-disease","display_name":"atherosclerotic cardiovascular disease","score":0.906000018119812},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.7699999809265137},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7379999756813049},{"id":"https://openalex.org/keywords/vascular-calcification","display_name":"vascular calcification","score":0.9959999918937683},{"id":"https://openalex.org/keywords/blood-coagulation-regulation","display_name":"coagulation regulation","score":0.8209999799728394},{"id":"https://openalex.org/keywords/vesicular-trafficking","display_name":"vesicle trafficking","score":0.8169999718666077},{"id":"https://openalex.org/keywords/lipid-binding","display_name":"lipid binding","score":0.7570000290870667},{"id":"https://openalex.org/keywords/extracellular-matrix-organization","display_name":"extracellular matrix organization","score":0.8410000205039978},{"id":"https://openalex.org/keywords/lipoprotein-remodeling","display_name":"lipoprotein remodeling","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.8295000195503235},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.6269000172615051},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.5309000015258789},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4819999933242798},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.4595000147819519},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.41830000281333923},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41690000891685486},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3472000062465668},{"id":"https://openalex.org/C80311884","wikidata":"https://www.wikidata.org/wiki/Q7268939","display_name":"Quantitative proteomics","level":4,"score":0.33820000290870667},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.33410000801086426},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33250001072883606},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.329800009727478},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3230000138282776},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.30799999833106995},{"id":"https://openalex.org/C146543888","wikidata":"https://www.wikidata.org/wiki/Q425056","display_name":"Blood proteins","level":2,"score":0.30169999599456787},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.299699991941452},{"id":"https://openalex.org/C156399914","wikidata":"https://www.wikidata.org/wiki/Q7444454","display_name":"Secretory protein","level":3,"score":0.28999999165534973},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2863999903202057},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.28349998593330383},{"id":"https://openalex.org/C2910703447","wikidata":"https://www.wikidata.org/wiki/Q494918","display_name":"Protein Array Analysis","level":5,"score":0.27059999108314514},{"id":"https://openalex.org/C2909478654","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Atherosclerotic cardiovascular disease","level":3,"score":0.2689000070095062},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.26019999384880066},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.2547999918460846},{"id":"https://openalex.org/C71829478","wikidata":"https://www.wikidata.org/wiki/Q901305","display_name":"Immunoprecipitation","level":3,"score":0.25290000438690186}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3390/jcm15072559","doi":"https://doi.org/10.3390/jcm15072559","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm15072559","pdf_url":"https://www.mdpi.com/2077-0383/15/7/2559/pdf?version=1774606756","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},{"id":"pmid:41976861","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41976861","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13073900","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13073900/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13073900/pdf/jcm-15-02559.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Clin Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/jcm15072559","doi":"https://doi.org/10.3390/jcm15072559","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm15072559","pdf_url":"https://www.mdpi.com/2077-0383/15/7/2559/pdf?version=1774606756","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6679793000221252,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1133076894","display_name":null,"funder_award_id":"UL1 TR001873","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G8095401071","display_name":null,"funder_award_id":"HL139759","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320316438","display_name":"Georgia Clinical and Translational Science Alliance","ror":"https://ror.org/034hw7m59"},{"id":"https://openalex.org/F4320333627","display_name":"Irving Medical Center, Columbia University","ror":"https://ror.org/01esghr10"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7141237277.pdf","grobid_xml":"https://content.openalex.org/works/W7141237277.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1876370444","https://openalex.org/W1991366673","https://openalex.org/W2032106401","https://openalex.org/W2046152785","https://openalex.org/W2094744791","https://openalex.org/W2099581978","https://openalex.org/W2111144965","https://openalex.org/W2133772687","https://openalex.org/W2155737525","https://openalex.org/W2160182135","https://openalex.org/W2887280175","https://openalex.org/W2900529369","https://openalex.org/W3107302989","https://openalex.org/W3107527779","https://openalex.org/W3184993555","https://openalex.org/W4210474510","https://openalex.org/W4281663248","https://openalex.org/W4288475273","https://openalex.org/W4317932487","https://openalex.org/W4385777848","https://openalex.org/W4388539829","https://openalex.org/W4388704440","https://openalex.org/W4389002814","https://openalex.org/W4391229570","https://openalex.org/W4399902461","https://openalex.org/W4406702923"],"related_works":[],"abstract_inverted_index":{"Background:":[0],"Lipoprotein(a)":[1],"[Lp(a)]":[2],"is":[3,142],"a":[4,145],"genetically":[5],"determined":[6],"risk":[7],"factor":[8],"for":[9,109],"atherosclerotic":[10],"cardiovascular":[11],"disease":[12],"(ASCVD).":[13],"Proteomic":[14],"studies":[15],"suggest":[16],"that":[17,163],"Lp(a)-associated":[18],"proteins":[19,91,100,106,152],"mediate":[20],"inflammation,":[21,133],"thrombosis,":[22,134],"and":[23,45,64,79,92,121,135],"vascular":[24],"calcification,":[25],"but":[26],"methodological":[27],"variability":[28],"may":[29,164],"influence":[30],"proteome":[31,149],"definition.":[32],"Methods:":[33],"Lp(a)":[34,131,141],"was":[35,153],"immunoprecipitated":[36],"from":[37],"human":[38],"plasma":[39],"using":[40,84],"an":[41],"apo(a)-specific":[42],"monoclonal":[43],"antibody":[44],"analyzed":[46],"by":[47,60,70],"mass":[48],"spectrometry":[49],"following":[50],"either":[51],"in-gel":[52,93],"digestion":[53,94],"or":[54],"automated":[55],"in-solution":[56],"proteolysis.":[57],"Proteins":[58],"identified":[59,89,95,155],"\u22653":[61],"unique":[62],"peptides":[63],"consistently":[65,154],"detected":[66],"across":[67,156],"all":[68],"samples":[69],"both":[71],"methods":[72],"were":[73,82,107],"considered":[74],"high":[75],"confidence.":[76],"Functional":[77],"enrichment":[78],"interaction":[80],"networks":[81],"assessed":[83],"STRING.":[85],"Results:":[86],"In-solution":[87],"proteolysis":[88],"92":[90],"55":[96],"proteins,":[97],"with":[98],"34":[99,151],"shared":[101],"between":[102],"methods.":[103],"These":[104],"high-confidence":[105],"enriched":[108],"pathways":[110,162],"involved":[111],"in":[112],"lipoprotein":[113],"remodeling,":[114],"coagulation":[115],"regulation,":[116],"vesicle-mediated":[117],"transport,":[118],"lipid":[119],"binding,":[120],"extracellular":[122],"matrix":[123],"organization,":[124],"providing":[125],"biological":[126],"insight":[127],"into":[128],"mechanisms":[129],"linking":[130],"to":[132],"calcification.":[136],"Conclusions:":[137],"Proteome":[138],"composition":[139],"of":[140,150],"method-dependent;":[143],"however,":[144],"rigorously":[146],"defined":[147],"core":[148],"analytical":[157],"approaches,":[158],"highlighting":[159],"biologically":[160],"relevant":[161],"underlie":[165],"Lp(a)-mediated":[166],"ASCVD":[167],"risk.":[168]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2026-03-28T00:00:00"}