{"id":"https://openalex.org/W7141136879","doi":"https://doi.org/10.1134/s1990519x26030053","title":"Changes in Noradrenaline- and Serotonin-Dependent Intracellular Signaling in Senescent Multipotent Mesenchymal Stromal Cells","display_name":"Changes in Noradrenaline- and Serotonin-Dependent Intracellular Signaling in Senescent Multipotent Mesenchymal Stromal Cells","publication_year":2026,"publication_date":"2026-03-27","ids":{"openalex":"https://openalex.org/W7141136879","doi":"https://doi.org/10.1134/s1990519x26030053"},"language":"en","primary_location":{"id":"doi:10.1134/s1990519x26030053","doi":"https://doi.org/10.1134/s1990519x26030053","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s1990519x26030053","pdf_url":null,"source":{"id":"https://openalex.org/S168634447","display_name":"Cell and Tissue Biology","issn_l":"1990-519X","issn":["1990-519X","1990-5203"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell and Tissue Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092689407","display_name":"\u0427\u0435\u0447\u0435\u0445\u0438\u043d\u0430 \u0415\u043b\u0438\u0437\u0430\u0432\u0435\u0442\u0430 \u0421\u0435\u0440\u0433\u0435\u0435\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0002-5377-2712","observed_orcids":["https://orcid.org/0000-0002-5377-2712"]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E. S. Chechekhina","raw_affiliation_strings":["Medical Research and Educational Institute, Lomonosov Moscow State University, 119192, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research and Educational Institute, Lomonosov Moscow State University, 119192, Moscow, Russia","institution_ids":["https://openalex.org/I19880235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130787744","display_name":"K. Yu. Kulebyakin","orcid":"https://orcid.org/0000-0001-6954-5787","observed_orcids":["https://orcid.org/0000-0001-6954-5787"]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"K. Yu. Kulebyakin","raw_affiliation_strings":["Medical Research and Educational Institute, Lomonosov Moscow State University, 119192, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research and Educational Institute, Lomonosov Moscow State University, 119192, Moscow, Russia","institution_ids":["https://openalex.org/I19880235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034675608","display_name":"Olga Grigorieva","orcid":"https://orcid.org/0000-0003-2954-2420","observed_orcids":["https://orcid.org/0000-0003-2954-2420"]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"O. A. Grigorieva","raw_affiliation_strings":["Medical Research and Educational Institute, Lomonosov Moscow State University, 119192, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research and Educational Institute, Lomonosov Moscow State University, 119192, Moscow, Russia","institution_ids":["https://openalex.org/I19880235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130806432","display_name":"Anastasiya Yu. Efimenko","orcid":"https://orcid.org/0000-0002-0696-1369","observed_orcids":["https://orcid.org/0000-0002-0696-1369"]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. Yu. Efimenko","raw_affiliation_strings":["Medical Research and Educational Institute, Lomonosov Moscow State University, 119192, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research and Educational Institute, Lomonosov Moscow State University, 119192, Moscow, Russia","institution_ids":["https://openalex.org/I19880235"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058056357","display_name":"Pyotr A. Tyurin\u2010Kuzmin","orcid":"https://orcid.org/0000-0002-1901-1637","observed_orcids":["https://orcid.org/0000-0002-1901-1637"]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"P. A. Tyurin-Kuzmin","raw_affiliation_strings":["Medical Research and Educational Institute, Lomonosov Moscow State University, 119192, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research and Educational Institute, Lomonosov Moscow State University, 119192, Moscow, Russia","institution_ids":["https://openalex.org/I19880235"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5058056357"],"corresponding_institution_ids":["https://openalex.org/I19880235"],"apc_list":null,"apc_paid":null,"fwci":3.9675,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.91386872,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"20","issue":"3","first_page":"200","last_page":"211"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.8429999947547913},{"id":"https://openalex.org/keywords/adipose-derived-stem-cells","display_name":"adipose-derived stem cells","score":0.9490000009536743},{"id":"https://openalex.org/keywords/replicative-senescence","display_name":"replicative senescence","score":0.9589999914169312},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.968999981880188},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.8840000033378601},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":1.0},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.9200000166893005},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.8169999718666077},{"id":"https://openalex.org/keywords/phosphoinositide-signaling","display_name":"phosphoinositide signaling","score":0.9330000281333923},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.9430000185966492},{"id":"https://openalex.org/keywords/intracellular-signaling","display_name":"intracellular signaling","score":0.7369999885559082},{"id":"https://openalex.org/keywords/hormone-regulation","display_name":"hormonal regulation","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C122927707","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Adipogenesis","level":3,"score":0.8901000022888184},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.8384000062942505},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7541000247001648},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.7455999851226807},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7386999726295471},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6521000266075134},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.635699987411499},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.553600013256073},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4952999949455261},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.41690000891685486},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.3846000134944916},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.382999986410141},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.367900013923645},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35370001196861267},{"id":"https://openalex.org/C2910776680","wikidata":"https://www.wikidata.org/wiki/Q862600","display_name":"Multipotent Stem Cell","level":4,"score":0.3450999855995178},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.33399999141693115},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.3303999900817871},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.3287000060081482},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2994000017642975},{"id":"https://openalex.org/C201571599","wikidata":"https://www.wikidata.org/wiki/Q5018840","display_name":"Calcium signaling","level":3,"score":0.2833999991416931},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.27059999108314514},{"id":"https://openalex.org/C2776175234","wikidata":"https://www.wikidata.org/wiki/Q357519","display_name":"Adipocyte","level":3,"score":0.2529999911785126}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1134/s1990519x26030053","doi":"https://doi.org/10.1134/s1990519x26030053","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s1990519x26030053","pdf_url":null,"source":{"id":"https://openalex.org/S168634447","display_name":"Cell and Tissue Biology","issn_l":"1990-519X","issn":["1990-519X","1990-5203"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell and Tissue Biology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.49995487928390503,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1945109846","https://openalex.org/W1968628080","https://openalex.org/W1979861058","https://openalex.org/W1996234987","https://openalex.org/W2004314923","https://openalex.org/W2012549032","https://openalex.org/W2014259643","https://openalex.org/W2018930439","https://openalex.org/W2025371271","https://openalex.org/W2027753197","https://openalex.org/W2059851474","https://openalex.org/W2060134459","https://openalex.org/W2082645451","https://openalex.org/W2083156208","https://openalex.org/W2110330424","https://openalex.org/W2115919687","https://openalex.org/W2128170119","https://openalex.org/W2156079592","https://openalex.org/W2156278540","https://openalex.org/W2225363832","https://openalex.org/W2494515430","https://openalex.org/W2507978151","https://openalex.org/W2518778566","https://openalex.org/W2766971919","https://openalex.org/W2782081342","https://openalex.org/W2895061301","https://openalex.org/W2900485409","https://openalex.org/W3035832355","https://openalex.org/W3188405770","https://openalex.org/W4309269237","https://openalex.org/W4327733952","https://openalex.org/W4389570622","https://openalex.org/W4391290286"],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"In":[1],"this":[2],"work,":[3],"we":[4],"studied":[5],"how":[6,19],"hormonal":[7,22,48],"regulation":[8,23,76],"of":[9,29,75,77,86,101,114,137,143],"human":[10,144],"adipose":[11,33],"tissue":[12,34],"stem":[13,35],"cells":[14,39,71],"changes":[15,20],"during":[16,95],"aging":[17],"and":[18,59,82,104],"in":[21,119,121,133],"are":[24],"associated":[25],"with":[26,55,123],"adipogenic":[27,68,78,141],"differentiation":[28,79,142],"these":[30,115],"cells.":[31],"Postnatal":[32],"cells\u2014multipotent":[36],"mesenchymal":[37],"stromal":[38],"(MSCs),":[40],"were":[41,117],"used":[42],"as":[43],"an":[44],"object":[45],"for":[46],"studying":[47],"regulation.":[49],"We":[50],"showed":[51],"that":[52,94],"both":[53,102],"MSCs":[54,60,97,122],"induced":[56,124],"replicative":[57,125],"senescence":[58,128],"obtained":[61],"from":[62],"elderly":[63],"donors":[64],"have":[65,72],"a":[66,131],"reduced":[67,99],"potential.":[69],"These":[70],"impaired":[73],"mechanisms":[74],"under":[80],"noradrenaline":[81],"serotonin.":[83],"The":[84],"study":[85],"intracellular":[87],"signaling":[88,106],"cascades":[89],"allowed":[90],"us":[91],"to":[92,111,130],"establish":[93],"senescence,":[96],"exhibit":[98],"activation":[100],"cAMP-dependent":[103],"phosphoinositide/calcium-dependent":[105],"cascades.":[107],"Moreover,":[108],"calcium":[109],"responses":[110],"the":[112,134,140],"addition":[113],"hormones":[116,138],"delayed":[118],"time":[120],"aging.":[126],"Thus,":[127],"leads":[129],"decrease":[132],"regulatory":[135],"effect":[136],"on":[139],"MSCs.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-03-28T00:00:00"}