{"id":"https://openalex.org/W7141127922","doi":"https://doi.org/10.1038/s41598-026-41751-5","title":"Elimusertib enhances cytotoxic effects of conventional chemotherapy and sensitizes to radiation in preclinical Ewing sarcoma models","display_name":"Elimusertib enhances cytotoxic effects of conventional chemotherapy and sensitizes to radiation in preclinical Ewing sarcoma models","publication_year":2026,"publication_date":"2026-03-27","ids":{"openalex":"https://openalex.org/W7141127922","doi":"https://doi.org/10.1038/s41598-026-41751-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/41896265","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13039535"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-41751-5","doi":"https://doi.org/10.1038/s41598-026-41751-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-41751-5","pdf_url":"https://www.nature.com/articles/s41598-026-41751-5_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-41751-5_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060840950","display_name":"Leonhard Koch","orcid":"https://orcid.org/0009-0007-9017-8329","observed_orcids":["https://orcid.org/0009-0007-9017-8329"]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Leonhard Koch","raw_affiliation_strings":["Department of Pediatrics III, University Hospital Essen, Essen, Germany. leonhard.koch@uk-essen.de","German Cancer Consortium (DKTK), National Center for Tumordiseases (NCT) West, Partner Site Essen, Essen, Germany. leonhard.koch@uk-essen.de","West German Cancer Center Essen, University Hospital Essen, Essen, Germany. leonhard.koch@uk-essen.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics III, University Hospital Essen, Essen, Germany. leonhard.koch@uk-essen.de","institution_ids":["https://openalex.org/I4210119759"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK), National Center for Tumordiseases (NCT) West, Partner Site Essen, Essen, Germany. leonhard.koch@uk-essen.de","institution_ids":[]},{"raw_affiliation_string":"West German Cancer Center Essen, University Hospital Essen, Essen, Germany. leonhard.koch@uk-essen.de","institution_ids":["https://openalex.org/I4210119759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055773673","display_name":"Maximilian Kerkhoff","orcid":"https://orcid.org/0009-0004-4458-1609","observed_orcids":["https://orcid.org/0009-0004-4458-1609"]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maximilian Kerkhoff","raw_affiliation_strings":["Department of Pediatrics III, University Hospital Essen, Essen, Germany","German Cancer Consortium (DKTK), National Center for Tumordiseases (NCT) West, Partner Site Essen, Essen, Germany","West German Cancer Center Essen, University Hospital Essen, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics III, University Hospital Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK), National Center for Tumordiseases (NCT) West, Partner Site Essen, Essen, Germany","institution_ids":[]},{"raw_affiliation_string":"West German Cancer Center Essen, University Hospital Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030671050","display_name":"Maximilian Bretschneider","orcid":"https://orcid.org/0000-0002-2270-6501","observed_orcids":["https://orcid.org/0000-0002-2270-6501"]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maximilian Bretschneider","raw_affiliation_strings":["Department of Pediatrics III, University Hospital Essen, Essen, Germany","German Cancer Consortium (DKTK), National Center for Tumordiseases (NCT) West, Partner Site Essen, Essen, Germany","West German Cancer Center Essen, University Hospital Essen, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics III, University Hospital Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK), National Center for Tumordiseases (NCT) West, Partner Site Essen, Essen, Germany","institution_ids":[]},{"raw_affiliation_string":"West German Cancer Center Essen, University Hospital Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019140685","display_name":"Samet Dayi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Samet Dayi","raw_affiliation_strings":["Department of Pediatrics III, University Hospital Essen, Essen, Germany","German Cancer Consortium (DKTK), National Center for Tumordiseases (NCT) West, Partner Site Essen, Essen, Germany","West German Cancer Center Essen, University Hospital Essen, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics III, University Hospital Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK), National Center for Tumordiseases (NCT) West, Partner Site Essen, Essen, Germany","institution_ids":[]},{"raw_affiliation_string":"West German Cancer Center Essen, University Hospital Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027245372","display_name":"Pauline Plaumann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Pauline Plaumann","raw_affiliation_strings":["Department of Pediatrics III, University Hospital Essen, Essen, Germany","German Cancer Consortium (DKTK), National Center for Tumordiseases (NCT) West, Partner Site Essen, Essen, Germany","West German Cancer Center Essen, University Hospital Essen, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics III, University Hospital Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK), National Center for Tumordiseases (NCT) West, Partner Site Essen, Essen, Germany","institution_ids":[]},{"raw_affiliation_string":"West German Cancer Center Essen, University Hospital Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130814342","display_name":"Bahareh Sadeghi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bahareh Sadeghi","raw_affiliation_strings":["Department of Pediatrics III, University Hospital Essen, Essen, Germany","German Cancer Consortium (DKTK), National Center for Tumordiseases (NCT) West, Partner Site Essen, Essen, Germany","West German Cancer Center Essen, University Hospital Essen, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics III, University Hospital Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK), National Center for Tumordiseases (NCT) West, Partner Site Essen, Essen, Germany","institution_ids":[]},{"raw_affiliation_string":"West German Cancer Center Essen, University Hospital Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130763247","display_name":"Emma Maa\u00dfen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Emma Maa\u00dfen","raw_affiliation_strings":["Department of Pediatrics III, University Hospital Essen, Essen, Germany","German Cancer Consortium (DKTK), National Center for Tumordiseases (NCT) West, Partner Site Essen, Essen, Germany","West German Cancer Center Essen, University Hospital Essen, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics III, University Hospital Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK), National Center for Tumordiseases (NCT) West, Partner Site Essen, Essen, Germany","institution_ids":[]},{"raw_affiliation_string":"West German Cancer Center Essen, University Hospital Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120338016","display_name":"Emilia Hillesheim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Emilia Hillesheim","raw_affiliation_strings":["Department of Pediatrics III, University Hospital Essen, Essen, Germany","German Cancer Consortium (DKTK), National Center for Tumordiseases (NCT) West, Partner Site Essen, Essen, Germany","West German Cancer Center Essen, University Hospital Essen, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics III, University Hospital Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK), National Center for Tumordiseases (NCT) West, Partner Site Essen, Essen, Germany","institution_ids":[]},{"raw_affiliation_string":"West German Cancer Center Essen, University Hospital Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004927057","display_name":"Marc Kuballa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marc Kuballa","raw_affiliation_strings":["Department of Pediatrics III, University Hospital Essen, Essen, Germany","German Cancer Consortium (DKTK), National Center for Tumordiseases (NCT) West, Partner Site Essen, Essen, Germany","West German Cancer Center Essen, University Hospital Essen, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics III, University Hospital Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK), National Center for Tumordiseases (NCT) West, Partner Site Essen, Essen, Germany","institution_ids":[]},{"raw_affiliation_string":"West German Cancer Center Essen, University Hospital Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134152391","display_name":"Christiane Schaefer","orcid":"https://orcid.org/0000-0001-5495-975X","observed_orcids":["https://orcid.org/0000-0001-5495-975X"]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christiane Schaefer","raw_affiliation_strings":["Department of Pediatrics III, University Hospital Essen, Essen, Germany","German Cancer Consortium (DKTK), National Center for Tumordiseases (NCT) West, Partner Site Essen, Essen, Germany","West German Cancer Center Essen, University Hospital Essen, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics III, University Hospital Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK), National Center for Tumordiseases (NCT) West, Partner Site Essen, Essen, Germany","institution_ids":[]},{"raw_affiliation_string":"West German Cancer Center Essen, University Hospital Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071830380","display_name":"Daniel Rauh","orcid":"https://orcid.org/0000-0002-1970-7642","observed_orcids":["https://orcid.org/0000-0002-1970-7642"]},"institutions":[{"id":"https://openalex.org/I200332995","display_name":"TU Dortmund University","ror":"https://ror.org/01k97gp34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200332995"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniel Rauh","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, TU Dortmund, Dortmund, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, TU Dortmund, Dortmund, Germany","institution_ids":["https://openalex.org/I200332995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113583584","display_name":"Susanne Gr\u00fcnewald","orcid":"https://orcid.org/0009-0004-7901-6028","observed_orcids":["https://orcid.org/0009-0004-7901-6028"]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Susanne Grunewald","raw_affiliation_strings":["German Cancer Consortium (DKTK), National Center for Tumordiseases (NCT) West, Partner Site Essen, Essen, Germany","West German Cancer Center Essen, University Hospital Essen, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Cancer Consortium (DKTK), National Center for Tumordiseases (NCT) West, Partner Site Essen, Essen, Germany","institution_ids":[]},{"raw_affiliation_string":"West German Cancer Center Essen, University Hospital Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031540987","display_name":"Sebastian Bauer","orcid":"https://orcid.org/0000-0001-5949-8120","observed_orcids":["https://orcid.org/0000-0001-5949-8120"]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sebastian Bauer","raw_affiliation_strings":["German Cancer Consortium (DKTK), National Center for Tumordiseases (NCT) West, Partner Site Essen, Essen, Germany","West German Cancer Center Essen, University Hospital Essen, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Cancer Consortium (DKTK), National Center for Tumordiseases (NCT) West, Partner Site Essen, Essen, Germany","institution_ids":[]},{"raw_affiliation_string":"West German Cancer Center Essen, University Hospital Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079383491","display_name":"Cl\u00e4re von Neubeck","orcid":"https://orcid.org/0000-0003-2955-1626","observed_orcids":["https://orcid.org/0000-0003-2955-1626"]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]},{"id":"https://openalex.org/I4210134834","display_name":"Krankenhaus Nordwest","ror":"https://ror.org/02rppq041","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134834"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Cl\u00e4re von Neubeck","raw_affiliation_strings":["Department of Particle Therapy, University Hospital Essen, Essen, Germany","Nordwest Krankenhaus Frankfurt, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Particle Therapy, University Hospital Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]},{"raw_affiliation_string":"Nordwest Krankenhaus Frankfurt, Frankfurt, Germany","institution_ids":["https://openalex.org/I4210134834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045183692","display_name":"Uta Dirksen","orcid":"https://orcid.org/0000-0002-5435-7860","observed_orcids":["https://orcid.org/0000-0002-5435-7860"]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Uta Dirksen","raw_affiliation_strings":["Department of Pediatrics III, University Hospital Essen, Essen, Germany. uta.dirksen@uk-essen.de","German Cancer Consortium (DKTK), National Center for Tumordiseases (NCT) West, Partner Site Essen, Essen, Germany. uta.dirksen@uk-essen.de","West German Cancer Center Essen, University Hospital Essen, Essen, Germany. uta.dirksen@uk-essen.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics III, University Hospital Essen, Essen, Germany. uta.dirksen@uk-essen.de","institution_ids":["https://openalex.org/I4210119759"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK), National Center for Tumordiseases (NCT) West, Partner Site Essen, Essen, Germany. uta.dirksen@uk-essen.de","institution_ids":[]},{"raw_affiliation_string":"West German Cancer Center Essen, University Hospital Essen, Essen, Germany. uta.dirksen@uk-essen.de","institution_ids":["https://openalex.org/I4210119759"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5045183692","https://openalex.org/A5060840950"],"corresponding_institution_ids":["https://openalex.org/I4210119759"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16006011,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.015300000086426735,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ewing-sarcoma","display_name":"Ewing sarcoma","score":0.9100000262260437},{"id":"https://openalex.org/keywords/elimusertib","display_name":"elimusertib","score":0.996999979019165},{"id":"https://openalex.org/keywords/atr-inhibition","display_name":"ATR inhibition","score":0.972000002861023},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.7739999890327454},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.5649999976158142},{"id":"https://openalex.org/keywords/chorioallantoic-membrane-model","display_name":"chorioallantoic membrane model","score":0.7950000166893005},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.6769999861717224},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/dose-reduction","display_name":"dose reduction","score":0.48500001430511475},{"id":"https://openalex.org/keywords/small-molecule-kinase-inhibitors","display_name":"small-molecule kinase inhibitors","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.7599999904632568},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7293999791145325},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6360999941825867},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.5184000134468079},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.4634999930858612},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.42500001192092896},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4235000014305115},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.3871999979019165},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.3637999892234802},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.358599990606308},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3409000039100647},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.32580000162124634},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.325300008058548},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3027999997138977},{"id":"https://openalex.org/C2778629024","wikidata":"https://www.wikidata.org/wiki/Q720020","display_name":"Soft tissue sarcoma","level":3,"score":0.29750001430511475},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2897000014781952},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2815999984741211},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.2809999883174896},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.259799987077713},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.25200000405311584}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012512","descriptor_name":"Sarcoma, Ewing","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012512","descriptor_name":"Sarcoma, Ewing","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012512","descriptor_name":"Sarcoma, Ewing","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049033","descriptor_name":"Chorioallantoic Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064007","descriptor_name":"Ataxia Telangiectasia Mutated Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D064007","descriptor_name":"Ataxia Telangiectasia Mutated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41598-026-41751-5","doi":"https://doi.org/10.1038/s41598-026-41751-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-41751-5","pdf_url":"https://www.nature.com/articles/s41598-026-41751-5_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-7879443/v1","doi":"https://doi.org/10.21203/rs.3.rs-7879443/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-7879443/v1","pdf_url":"https://www.researchsquare.com/article/rs-7879443/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13039535","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13039535/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13039535/pdf/41598_2026_Article_41751.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:41896265","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41896265","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:bibliographie.ub.uni-due.de:ubo_mods_00241371","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pubmed/41896265","pdf_url":null,"source":{"id":"https://openalex.org/S7407055102","display_name":"Universit\u00e4tsbibliographie, Universit\u00e4t Duisburg-Essen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:032aa41af9b44714843a236e9b154053","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/032aa41af9b44714843a236e9b154053","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 16, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-41751-5","doi":"https://doi.org/10.1038/s41598-026-41751-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-41751-5","pdf_url":"https://www.nature.com/articles/s41598-026-41751-5_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4463545759","display_name":null,"funder_award_id":"70113419","funder_id":"https://openalex.org/F4320323556","funder_display_name":"Deutsche Krebshilfe"}],"funders":[{"id":"https://openalex.org/F4320317492","display_name":"Universit\u00e4tsklinikum Essen","ror":"https://ror.org/02na8dn90"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320323556","display_name":"Deutsche Krebshilfe","ror":"https://ror.org/01wxdd722"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7141127922.pdf","grobid_xml":"https://content.openalex.org/works/W7141127922.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1484740038","https://openalex.org/W1488341083","https://openalex.org/W1603285299","https://openalex.org/W1967630574","https://openalex.org/W1969885393","https://openalex.org/W2013895149","https://openalex.org/W2021469530","https://openalex.org/W2031700343","https://openalex.org/W2040860750","https://openalex.org/W2046131550","https://openalex.org/W2061197983","https://openalex.org/W2086333179","https://openalex.org/W2107054629","https://openalex.org/W2125789330","https://openalex.org/W2134647795","https://openalex.org/W2144847112","https://openalex.org/W2151620853","https://openalex.org/W2201979800","https://openalex.org/W2219054050","https://openalex.org/W2317055602","https://openalex.org/W2346506773","https://openalex.org/W2502508548","https://openalex.org/W2513016538","https://openalex.org/W2549803280","https://openalex.org/W2559890484","https://openalex.org/W2606331566","https://openalex.org/W2625452721","https://openalex.org/W2680204723","https://openalex.org/W2766300480","https://openalex.org/W2775990711","https://openalex.org/W2807942883","https://openalex.org/W2889136929","https://openalex.org/W2972107575","https://openalex.org/W2995953807","https://openalex.org/W3027186100","https://openalex.org/W3041985146","https://openalex.org/W3089375288","https://openalex.org/W3103977213","https://openalex.org/W3152750978","https://openalex.org/W3164816973","https://openalex.org/W3183394989","https://openalex.org/W3185515039","https://openalex.org/W3210866519","https://openalex.org/W4200360917","https://openalex.org/W4200421690","https://openalex.org/W4205248358","https://openalex.org/W4211227438","https://openalex.org/W4225910596","https://openalex.org/W4282983004","https://openalex.org/W4302424483","https://openalex.org/W4307290131","https://openalex.org/W4310383137","https://openalex.org/W4316466731","https://openalex.org/W4365136675","https://openalex.org/W4366983764","https://openalex.org/W4379332922","https://openalex.org/W4387638611","https://openalex.org/W4390444794","https://openalex.org/W4399529221","https://openalex.org/W7095159806"],"related_works":["https://openalex.org/W4366990191","https://openalex.org/W4309046366","https://openalex.org/W4390444794","https://openalex.org/W6888831175","https://openalex.org/W4307907526","https://openalex.org/W4362596803","https://openalex.org/W4399529221","https://openalex.org/W4379984881","https://openalex.org/W4409914027","https://openalex.org/W2886397600"],"abstract_inverted_index":{"Ewing":[0],"Sarcoma":[1],"(EwS)":[2],"is":[3,115],"a":[4,42,65],"highly":[5],"aggressive":[6],"malignancy":[7],"predominantly":[8],"affecting":[9],"young":[10],"individuals,":[11],"with":[12,47,83],"poor":[13],"prognosis":[14],"in":[15,45,60,126],"metastatic":[16],"or":[17,50],"relapsed":[18],"cases.":[19],"This":[20],"study":[21],"investigates":[22],"the":[23,35],"therapeutic":[24],"potential":[25,125],"of":[26,109],"ataxia":[27],"telangiectasia":[28],"and":[29,44,57,74,86,105,121],"Rad3-related":[30],"protein":[31],"(ATR)":[32],"inhibition":[33,97],"using":[34],"selective":[36],"small-molecule":[37],"inhibitor":[38],"elimusertib,":[39],"both":[40],"as":[41],"monotherapy":[43],"combination":[46],"cytotoxic":[48,110],"drugs":[49],"radiotherapy.":[51],"Elimusertib":[52],"significantly":[53],"inhibited":[54],"cell":[55,62],"proliferation":[56],"induced":[58],"apoptosis":[59],"EwS":[61,103,127],"lines.":[63],"In":[64],"chorioallantoic":[66],"membrane":[67],"(CAM)":[68],"model,":[69],"elimusertib":[70,79,99],"suppressed":[71],"tumor":[72,76],"initiation":[73],"reduced":[75],"volume.":[77],"Notably,":[78],"exhibited":[80],"synergistic":[81],"effects":[82],"standard":[84],"chemotherapeutics":[85],"radiation,":[87],"enhancing":[88],"antitumor":[89],"efficacy.":[90],"These":[91],"preclinical":[92],"findings":[93,120],"suggest":[94],"that":[95],"ATR":[96],"by":[98],"may":[100],"enhance":[101],"current":[102],"therapies":[104],"enable":[106],"dose":[107],"reduction":[108],"drugs.":[111],"Further":[112],"clinical":[113],"evaluation":[114],"warranted":[116],"to":[117],"validate":[118],"these":[119],"explore":[122],"elimusertib\u2019s":[123],"translational":[124],"treatment.":[128]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-03-28T00:00:00"}
