{"id":"https://openalex.org/W7140856534","doi":"https://doi.org/10.64898/2026.03.23.713115","title":"\u03b2II and \u03b2III spectrin paralogues define robustness and specialization of the neuronal membrane periodic skeleton","display_name":"\u03b2II and \u03b2III spectrin paralogues define robustness and specialization of the neuronal membrane periodic skeleton","publication_year":2026,"publication_date":"2026-03-25","ids":{"openalex":"https://openalex.org/W7140856534","doi":"https://doi.org/10.64898/2026.03.23.713115"},"language":"en","primary_location":{"id":"doi:10.64898/2026.03.23.713115","doi":"https://doi.org/10.64898/2026.03.23.713115","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.03.23.713115","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/03/25/2026.03.23.713115.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/03/25/2026.03.23.713115.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080431707","display_name":"Marie\u2010Lise Jobin","orcid":"https://orcid.org/0000-0002-7112-4217","observed_orcids":["https://orcid.org/0000-0002-7112-4217"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210133144","display_name":"Institut Interdisciplinaire de Neuroscience","ror":"https://ror.org/032j53342","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210096427","https://openalex.org/I4210133144"]},{"id":"https://openalex.org/I4210137504","display_name":"Chimie et Biologie des Membranes et des Nanoobjects","ror":"https://ror.org/03jtzcc30","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210091158","https://openalex.org/I4210128300","https://openalex.org/I4210137504","https://openalex.org/I4210160189"]},{"id":"https://openalex.org/I4210160189","display_name":"Institut Polytechnique de Bordeaux","ror":"https://ror.org/054qv7y42","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210160189"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie-Lise Jobin","raw_affiliation_strings":["Interdisciplinary Institute for Neuroscience, Universit\u00e9 Bordeaux, CNRS, UMR 5297, 33000 Bordeaux, France","Univ. Bordeaux, CNRS, Bordeaux INP, CBMN, UMR 5248, F-33600 Pessac, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Institute for Neuroscience, Universit\u00e9 Bordeaux, CNRS, UMR 5297, 33000 Bordeaux, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210133144"]},{"raw_affiliation_string":"Univ. Bordeaux, CNRS, Bordeaux INP, CBMN, UMR 5248, F-33600 Pessac, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210137504","https://openalex.org/I4210160189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130672777","display_name":"L\u00e9a Sarzynski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210133144","display_name":"Institut Interdisciplinaire de Neuroscience","ror":"https://ror.org/032j53342","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210096427","https://openalex.org/I4210133144"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"L\u00e9a Sarzynski","raw_affiliation_strings":["Interdisciplinary Institute for Neuroscience, Universit\u00e9 Bordeaux, CNRS, UMR 5297, 33000 Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Institute for Neuroscience, Universit\u00e9 Bordeaux, CNRS, UMR 5297, 33000 Bordeaux, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210133144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081900461","display_name":"Magali Mondin","orcid":"https://orcid.org/0000-0001-5802-007X","observed_orcids":["https://orcid.org/0000-0001-5802-007X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387155075","display_name":"Bordeaux Imaging Center","ror":"https://ror.org/04dyeh227","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4387155075"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Magali Mondin","raw_affiliation_strings":["Univ. Bordeaux, CNRS, INSERM, BIC, UAR 3420, F-33600 Pessac, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Bordeaux, CNRS, INSERM, BIC, UAR 3420, F-33600 Pessac, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4387155075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130659095","display_name":"Tatiana Charbonnier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210133144","display_name":"Institut Interdisciplinaire de Neuroscience","ror":"https://ror.org/032j53342","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210096427","https://openalex.org/I4210133144"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Tatiana Charbonnier","raw_affiliation_strings":["Interdisciplinary Institute for Neuroscience, Universit\u00e9 Bordeaux, CNRS, UMR 5297, 33000 Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Institute for Neuroscience, Universit\u00e9 Bordeaux, CNRS, UMR 5297, 33000 Bordeaux, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210133144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006164228","display_name":"Sophie Daburon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210133144","display_name":"Institut Interdisciplinaire de Neuroscience","ror":"https://ror.org/032j53342","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210096427","https://openalex.org/I4210133144"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sophie Daburon","raw_affiliation_strings":["Interdisciplinary Institute for Neuroscience, Universit\u00e9 Bordeaux, CNRS, UMR 5297, 33000 Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Institute for Neuroscience, Universit\u00e9 Bordeaux, CNRS, UMR 5297, 33000 Bordeaux, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210133144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054446581","display_name":"Nicolas Chevrier","orcid":"https://orcid.org/0000-0002-9667-4506","observed_orcids":["https://orcid.org/0000-0002-9667-4506"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210133144","display_name":"Institut Interdisciplinaire de Neuroscience","ror":"https://ror.org/032j53342","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210096427","https://openalex.org/I4210133144"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicolas Chevrier","raw_affiliation_strings":["Interdisciplinary Institute for Neuroscience, Universit\u00e9 Bordeaux, CNRS, UMR 5297, 33000 Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Institute for Neuroscience, Universit\u00e9 Bordeaux, CNRS, UMR 5297, 33000 Bordeaux, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210133144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027016566","display_name":"Pauline Belzanne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210133144","display_name":"Institut Interdisciplinaire de Neuroscience","ror":"https://ror.org/032j53342","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210096427","https://openalex.org/I4210133144"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pauline Belzanne","raw_affiliation_strings":["Interdisciplinary Institute for Neuroscience, Universit\u00e9 Bordeaux, CNRS, UMR 5297, 33000 Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Institute for Neuroscience, Universit\u00e9 Bordeaux, CNRS, UMR 5297, 33000 Bordeaux, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210133144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089409021","display_name":"Isabelle Jansen","orcid":"https://orcid.org/0000-0002-4333-1868","observed_orcids":["https://orcid.org/0000-0002-4333-1868"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isabelle Jansen","raw_affiliation_strings":["Abberior Instruments GmbH, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abberior Instruments GmbH, G\u00f6ttingen, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042191140","display_name":"Evelyn Garlick","orcid":"https://orcid.org/0000-0002-9292-1354","observed_orcids":["https://orcid.org/0000-0002-9292-1354"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Evelyn Garlick","raw_affiliation_strings":["Abberior Instruments GmbH, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abberior Instruments GmbH, G\u00f6ttingen, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087579323","display_name":"Matthieu Sainlos","orcid":"https://orcid.org/0000-0001-5465-5641","observed_orcids":["https://orcid.org/0000-0001-5465-5641"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210133144","display_name":"Institut Interdisciplinaire de Neuroscience","ror":"https://ror.org/032j53342","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210096427","https://openalex.org/I4210133144"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Matthieu Sainlos","raw_affiliation_strings":["Interdisciplinary Institute for Neuroscience, Universit\u00e9 Bordeaux, CNRS, UMR 5297, 33000 Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Institute for Neuroscience, Universit\u00e9 Bordeaux, CNRS, UMR 5297, 33000 Bordeaux, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210133144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081422974","display_name":"Daniel Choquet","orcid":"https://orcid.org/0000-0003-4726-9763","observed_orcids":["https://orcid.org/0000-0003-4726-9763"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210133144","display_name":"Institut Interdisciplinaire de Neuroscience","ror":"https://ror.org/032j53342","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210096427","https://openalex.org/I4210133144"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Daniel Choquet","raw_affiliation_strings":["Interdisciplinary Institute for Neuroscience, Universit\u00e9 Bordeaux, CNRS, UMR 5297, 33000 Bordeaux, France"],"raw_orcid":"https://orcid.org/0000-0003-4726-9763","affiliations":[{"raw_affiliation_string":"Interdisciplinary Institute for Neuroscience, Universit\u00e9 Bordeaux, CNRS, UMR 5297, 33000 Bordeaux, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210133144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018374686","display_name":"Anna Brachet","orcid":"https://orcid.org/0000-0001-5672-4153","observed_orcids":["https://orcid.org/0000-0001-5672-4153"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210133144","display_name":"Institut Interdisciplinaire de Neuroscience","ror":"https://ror.org/032j53342","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210096427","https://openalex.org/I4210133144"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Anna Brachet","raw_affiliation_strings":["Interdisciplinary Institute for Neuroscience, Universit\u00e9 Bordeaux, CNRS, UMR 5297, 33000 Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Institute for Neuroscience, Universit\u00e9 Bordeaux, CNRS, UMR 5297, 33000 Bordeaux, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210133144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5018374686"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210133144"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.6104000210762024,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.6104000210762024,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.3188000023365021,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/betaii-spectrin","display_name":"\u03b2II-spectrin","score":0.8379999995231628},{"id":"https://openalex.org/keywords/dendritic-cytoskeleton","display_name":"dendritic cytoskeleton","score":0.7860000133514404},{"id":"https://openalex.org/keywords/actin-binding","display_name":"actin binding","score":0.8899999856948853},{"id":"https://openalex.org/keywords/dendritic-spines","display_name":"dendritic spines","score":0.9110000133514404},{"id":"https://openalex.org/keywords/synaptic-function","display_name":"synaptic function","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C50244902","wikidata":"https://www.wikidata.org/wiki/Q420870","display_name":"Spectrin","level":4,"score":0.5985999703407288},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.5776000022888184},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4341000020503998},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41850000619888306},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.4074999988079071},{"id":"https://openalex.org/C152124472","wikidata":"https://www.wikidata.org/wiki/Q1204361","display_name":"Redundancy (engineering)","level":2,"score":0.3885999917984009},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.3691999912261963},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3529999852180481},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3287000060081482},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.32839998602867126},{"id":"https://openalex.org/C183786373","wikidata":"https://www.wikidata.org/wiki/Q5964993","display_name":"Signal transducing adaptor protein","level":3,"score":0.32089999318122864},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.31619998812675476},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.31150001287460327},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2955000102519989},{"id":"https://openalex.org/C53645450","wikidata":"https://www.wikidata.org/wiki/Q907093","display_name":"Scaffold protein","level":3,"score":0.29019999504089355},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.2840999960899353},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.27079999446868896},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.26980000734329224},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.26750001311302185},{"id":"https://openalex.org/C174884520","wikidata":"https://www.wikidata.org/wiki/Q902079","display_name":"Dendritic spine","level":3,"score":0.2565999925136566},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.2547999918460846}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.64898/2026.03.23.713115","doi":"https://doi.org/10.64898/2026.03.23.713115","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.03.23.713115","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/03/25/2026.03.23.713115.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:HAL:hal-05782489v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-05782489","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2026","raw_type":"info:eu-repo/semantics/preprint"}],"best_oa_location":{"id":"doi:10.64898/2026.03.23.713115","doi":"https://doi.org/10.64898/2026.03.23.713115","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.03.23.713115","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/03/25/2026.03.23.713115.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2659019386","display_name":null,"funder_award_id":"ANR-17-EURE-","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G3444564074","display_name":null,"funder_award_id":"ANR-10-INBS-04","funder_id":"https://openalex.org/F4320321589","funder_display_name":"Fondation pour la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G381665449","display_name":null,"funder_award_id":"ANR\u201010_INBS\u201004","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G5795861575","display_name":null,"funder_award_id":"ARF201809006996","funder_id":"https://openalex.org/F4320321589","funder_display_name":"Fondation pour la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G6069939831","display_name":null,"funder_award_id":"BRAIN_2030","funder_id":"https://openalex.org/F4320323712","funder_display_name":"Universit\u00e9 de Bordeaux"},{"id":"https://openalex.org/G6803667113","display_name":null,"funder_award_id":"ANR-17","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G6842278841","display_name":"University of Bordeaux Neurocampus Graduate School","funder_award_id":"ANR-17-EURE-0028","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G7240651115","display_name":null,"funder_award_id":"ANR-10","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G8963978083","display_name":"\u00df spectrin implication in dendritic spine shape and physiology","funder_award_id":"ANR-21-CE16-0001","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G996255883","display_name":null,"funder_award_id":"GPR BRAIN_2030","funder_id":"https://openalex.org/F4320323712","funder_display_name":"Universit\u00e9 de Bordeaux"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320321589","display_name":"Fondation pour la Recherche M\u00e9dicale","ror":"https://ror.org/04w6kn183"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"},{"id":"https://openalex.org/F4320323712","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7140856534.pdf","grobid_xml":"https://content.openalex.org/works/W7140856534.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W567403462","https://openalex.org/W1857738277","https://openalex.org/W1913751214","https://openalex.org/W1967407513","https://openalex.org/W1967589676","https://openalex.org/W1969302126","https://openalex.org/W1972338658","https://openalex.org/W1978553600","https://openalex.org/W1986287316","https://openalex.org/W1989834685","https://openalex.org/W1995949213","https://openalex.org/W2004427197","https://openalex.org/W2012034410","https://openalex.org/W2037632846","https://openalex.org/W2039469316","https://openalex.org/W2043470805","https://openalex.org/W2046096403","https://openalex.org/W2051501508","https://openalex.org/W2054264185","https://openalex.org/W2054455698","https://openalex.org/W2055127006","https://openalex.org/W2065490663","https://openalex.org/W2072979040","https://openalex.org/W2077746083","https://openalex.org/W2080550406","https://openalex.org/W2085015211","https://openalex.org/W2085967893","https://openalex.org/W2091626637","https://openalex.org/W2093040545","https://openalex.org/W2103705255","https://openalex.org/W2114129553","https://openalex.org/W2135576636","https://openalex.org/W2150814613","https://openalex.org/W2161496609","https://openalex.org/W2164565944","https://openalex.org/W2165073216","https://openalex.org/W2167612537","https://openalex.org/W2198355387","https://openalex.org/W2250512933","https://openalex.org/W2349604136","https://openalex.org/W2415591668","https://openalex.org/W2415595698","https://openalex.org/W2633993541","https://openalex.org/W2735674872","https://openalex.org/W2765127679","https://openalex.org/W2765993789","https://openalex.org/W2766341732","https://openalex.org/W2884023735","https://openalex.org/W2887350925","https://openalex.org/W2951096450","https://openalex.org/W2970332547","https://openalex.org/W3005432512","https://openalex.org/W3011519685","https://openalex.org/W3011853439","https://openalex.org/W3043538473","https://openalex.org/W3047687114","https://openalex.org/W4210270532","https://openalex.org/W4232960931","https://openalex.org/W4281725317","https://openalex.org/W4317936730","https://openalex.org/W4386369144","https://openalex.org/W4387609042","https://openalex.org/W4390538095","https://openalex.org/W4391102271","https://openalex.org/W4396708180","https://openalex.org/W4401752448","https://openalex.org/W4413045852","https://openalex.org/W7097258137","https://openalex.org/W7118413673"],"related_works":["https://openalex.org/W2737711489","https://openalex.org/W2804776485","https://openalex.org/W2349604136","https://openalex.org/W4408235486","https://openalex.org/W7130991703","https://openalex.org/W4281725317","https://openalex.org/W4410283225","https://openalex.org/W2995059938","https://openalex.org/W4407931724","https://openalex.org/W2621216408"],"abstract_inverted_index":{"Abstract":[0],"Neuron":[1],"connectivity":[2],"and":[3,49,53,60,76],"signal":[4],"processing":[5],"rely":[6],"on":[7,123],"a":[8,21,27,42,138],"complex,":[9],"dynamic":[10],"morphology":[11],"regulated":[12],"by":[13],"the":[14,36,56,117,131,134],"cytoskeleton.":[15],"The":[16],"membrane-associated":[17],"periodic":[18,23],"skeleton":[19],"(MPS),":[20],"190-nm":[22],"actin-spectrin":[24],"lattice,":[25],"is":[26,39,89,110,137],"conserved":[28],"feature":[29],"of":[30],"neurons.":[31],"Here,":[32],"we":[33,105],"show":[34,106],"that":[35,67,107],"dendritic":[37,135],"MPS":[38,100,136],"built":[40],"from":[41],"dual":[43],"\u03b2-spectrin":[44],"system":[45],"in":[46,58,141],"which":[47,142],"\u03b2II-":[48],"\u03b2III-spectrins":[50],"are":[51],"co-expressed":[52],"interleaved":[54],"at":[55],"nanoscale":[57],"shafts":[59],"spine":[61],"necks.":[62],"3D":[63],"MINFLUX":[64],"nanoscopy":[65],"suggests":[66],"these":[68],"paralogues":[69,115],"form":[70],"both":[71,114],"homotypic":[72],"(\u03b2II-":[73],"or":[74],"\u03b2III-only)":[75],"heterotypic":[77],"(\u03b2II/\u03b2III)":[78],"tetramers":[79],"with":[80,146,150],"an":[81],"approximately":[82],"100-nm":[83],"radial":[84],"periodicity.":[85],"Either":[86],"paralogue":[87],"alone":[88],"sufficient":[90],"to":[91,112],"maintain":[92],"lattice":[93],"architecture,":[94],"whereas":[95,119],"their":[96],"combined":[97],"loss":[98],"disrupts":[99],"integrity.":[101],"Using":[102],"targeted":[103],"mutagenesis,":[104],"actin":[108],"binding":[109],"required":[111],"stabilize":[113],"within":[116],"MPS,":[118,133],"\u03b2III-spectrin":[120],"additionally":[121],"depends":[122],"phosphoinositide":[124],"interactions.":[125],"Our":[126],"findings":[127],"reveal":[128],"that,":[129],"unlike":[130],"axonal":[132],"composite":[139],"scaffold":[140],"structural":[143],"redundancy":[144],"coexists":[145],"paralogue-specific":[147],"regulatory":[148],"mechanisms,":[149],"potential":[151],"consequences":[152],"for":[153],"synaptic":[154],"function.":[155]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-03-27T00:00:00"}