{"id":"https://openalex.org/W7140735800","doi":"https://doi.org/10.1227/neu.0000000000003964_429","title":"429 Microelectrophysiologic Mapping of the Visual System in Preparation for Whole Eye Transplant: Circumferential Recordings of the Optic Nerve and High-Density Surface Recordings of Early Visual Cortex","display_name":"429 Microelectrophysiologic Mapping of the Visual System in Preparation for Whole Eye Transplant: Circumferential Recordings of the Optic Nerve and High-Density Surface Recordings of Early Visual Cortex","publication_year":2026,"publication_date":"2026-03-26","ids":{"openalex":"https://openalex.org/W7140735800","doi":"https://doi.org/10.1227/neu.0000000000003964_429"},"language":"en","primary_location":{"id":"doi:10.1227/neu.0000000000003964_429","doi":"https://doi.org/10.1227/neu.0000000000003964_429","is_oa":false,"landing_page_url":"https://doi.org/10.1227/neu.0000000000003964_429","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053575011","display_name":"Kiefer James Forseth","orcid":"https://orcid.org/0000-0003-1624-8329","observed_orcids":["https://orcid.org/0000-0003-1624-8329"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kiefer J. Forseth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034716528","display_name":"Mickey Ellis Abraham","orcid":"https://orcid.org/0000-0002-6223-9610","observed_orcids":["https://orcid.org/0000-0002-6223-9610"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mickey E. Abraham","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015642507","display_name":"Jungho Yi","orcid":"https://orcid.org/0000-0001-8057-6285","observed_orcids":["https://orcid.org/0000-0001-8057-6285"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jungho Yi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042473166","display_name":"Kaushik Shukla","orcid":"https://orcid.org/0000-0002-5042-9265","observed_orcids":["https://orcid.org/0000-0002-5042-9265"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kaushik Shukla","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042715530","display_name":"Jihwan Lee","orcid":"https://orcid.org/0000-0003-1971-0152","observed_orcids":["https://orcid.org/0000-0003-1971-0152"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jihwan Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022215889","display_name":"Anne M. Hanneken","orcid":"https://orcid.org/0000-0002-7390-2596","observed_orcids":["https://orcid.org/0000-0002-7390-2596"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anne Hanneken","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026684787","display_name":"Alexander Arash Khalessi","orcid":"https://orcid.org/0000-0002-5559-9175","observed_orcids":["https://orcid.org/0000-0002-5559-9175"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander A. Khalessi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5045100404","display_name":"Shadi A. Dayeh","orcid":"https://orcid.org/0000-0002-1756-1774","observed_orcids":["https://orcid.org/0000-0002-1756-1774"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shadi Dayeh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"Supplement_1","first_page":"123","last_page":"123"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10427","display_name":"Visual perception and processing mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/optic-nerve","display_name":"optic nerve","score":0.6549999713897705},{"id":"https://openalex.org/keywords/visual-cortex","display_name":"visual cortex","score":0.9010000228881836},{"id":"https://openalex.org/keywords/retinal-stimulation","display_name":"retinal stimulation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/flexible-electrode-arrays","display_name":"flexible electrode arrays","score":0.6809999942779541},{"id":"https://openalex.org/keywords/calcarine-cortex","display_name":"calcarine cortex","score":0.7049999833106995},{"id":"https://openalex.org/keywords/lateral-occipital-cortex","display_name":"lateral occipital cortex","score":0.9290000200271606},{"id":"https://openalex.org/keywords/accommodation-response","display_name":"accommodation response","score":0.656000018119812},{"id":"https://openalex.org/keywords/evoked-potentials","display_name":"evoked potentials","score":0.4690000116825104},{"id":"https://openalex.org/keywords/pig-model","display_name":"porcine model","score":0.5730000138282776},{"id":"https://openalex.org/keywords/neurorrhaphy","display_name":"neurorrhaphy","score":0.9139999747276306}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8919000029563904},{"id":"https://openalex.org/C2780837183","wikidata":"https://www.wikidata.org/wiki/Q186029","display_name":"Optic nerve","level":2,"score":0.6391000151634216},{"id":"https://openalex.org/C2779345533","wikidata":"https://www.wikidata.org/wiki/Q75785","display_name":"Visual cortex","level":2,"score":0.6353999972343445},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.48809999227523804},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.4426000118255615},{"id":"https://openalex.org/C119088629","wikidata":"https://www.wikidata.org/wiki/Q558363","display_name":"Visual system","level":3,"score":0.42489999532699585},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.415800005197525},{"id":"https://openalex.org/C2776058522","wikidata":"https://www.wikidata.org/wiki/Q2364768","display_name":"Visual field","level":2,"score":0.32359999418258667},{"id":"https://openalex.org/C3018323323","wikidata":"https://www.wikidata.org/wiki/Q618678","display_name":"Visual evoked potentials","level":2,"score":0.3190999925136566},{"id":"https://openalex.org/C2776799497","wikidata":"https://www.wikidata.org/wiki/Q484298","display_name":"Surface (topology)","level":2,"score":0.30140000581741333},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.29330000281333923},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.28519999980926514},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.2703000009059906},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.25459998846054077},{"id":"https://openalex.org/C523008124","wikidata":"https://www.wikidata.org/wiki/Q5357996","display_name":"Electrodiagnosis","level":2,"score":0.2526000142097473},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.251800000667572}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1227/neu.0000000000003964_429","doi":"https://doi.org/10.1227/neu.0000000000003964_429","is_oa":false,"landing_page_url":"https://doi.org/10.1227/neu.0000000000003964_429","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1979289573","https://openalex.org/W2055959676","https://openalex.org/W2013089574","https://openalex.org/W4320907274","https://openalex.org/W1973701820","https://openalex.org/W2012493816","https://openalex.org/W1991783980","https://openalex.org/W2319301243","https://openalex.org/W1981928210","https://openalex.org/W4320907264"],"abstract_inverted_index":{"INTRODUCTION:":[0],"ARPA-H":[1],"has":[2],"initiated":[3],"a":[4,23,56,122,148,245,274,281],"concerted":[5],"effort":[6],"to":[7,28,31,62,75,104,133,169,201,220,295],"achieve":[8],"human":[9],"whole":[10],"eye":[11],"transplant.":[12],"A":[13],"critical":[14],"milestone":[15],"in":[16,73,86,273],"this":[17],"endeavor":[18],"is":[19],"the":[20,46,53,64,87,105,113,130,158,211,226,230,265,270,284],"creation":[21],"of":[22,45,55,83,112,210,229,269,287],"micro-electrophysiologic":[24],"map":[25],"from":[26,290],"retina":[27,291],"optic":[29,47,90,114,222,231,293],"nerve":[30,48,143,223,294],"visual":[32,140,258,271],"cortex.":[33,296],"This":[34],"will":[35],"inform":[36],"surgical":[37],"approaches":[38],"for":[39,80,283],"donor":[40],"harvest":[41],"and":[42,58,89,109,138,173,180,244,256,279],"primary":[43,255],"neurorrhaphy":[44],"as":[49,51,175,177],"well":[50,176],"constrain":[52],"design":[54],"drug":[57],"stimulation":[59,162,204],"delivery":[60],"device":[61],"support":[63],"graft.":[65],"METHODS:":[66],"We":[67],"use":[68],"platinum":[69],"nanorod":[70],"contacts":[71],"embedded":[72],"polyimide":[74],"create":[76],"flexible":[77],"electrode":[78],"arrays":[79],"microscale":[81],"recordings":[82,118,144,263],"electrical":[84],"activity":[85],"brain":[88],"nerve.":[91,115,159,232],"In":[92],"an":[93,97,237],"acute":[94,262,277],"pig":[95],"model,":[96],"extended":[98],"orbitozygomatic":[99],"craniectomy":[100],"provided":[101],"simultaneous":[102],"access":[103],"posterior":[106],"interhemispheric":[107],"corridor":[108],"intraorbital":[110,227],"segment":[111,228],"Visual":[116],"cortex":[117,137,243,252],"were":[119,145],"obtained":[120,146],"with":[121,147,254],"16":[123],"\u00d7":[124,150],"32":[125],"mm":[126,152],"array":[127,153],"placed":[128],"over":[129,241,249],"occipital":[131,251],"pole":[132],"cover":[134],"both":[135],"calcarine":[136,242],"secondary":[139,257],"cortices.":[141],"Optic":[142],"1.1":[149],"17":[151],"that":[154],"was":[155,163,184,198],"wrapped":[156],"around":[157],"RESULTS:":[160],"Retinal":[161],"delivered":[164],"by":[165,186,193],"collimated":[166],"light":[167,288],"source":[168],"selectively":[170],"adjust":[171],"luminance":[172,187],"wavelength":[174],"pulse":[178],"frequency":[179],"duration.":[181],"Response":[182],"amplitude":[183],"modulated":[185],"(p":[188,205],"<":[189,206],"0.05)":[190],"but":[191],"not":[192],"wavelength.":[194],"An":[195],"accommodation":[196],"response":[197,213,235],"observed":[199],"up":[200],"30":[202],"Hz":[203],"0.05).":[207],"Phase":[208],"reversal":[209],"evoked":[212],"between":[214],"adjacent":[215],"channels":[216],"suggests":[217],"sufficient":[218],"resolution":[219],"distinguish":[221],"fascicles":[224],"within":[225],"The":[233],"cortical":[234],"demonstrated":[236],"early":[238],"phase":[239,247],"reorganization":[240,248],"late":[246],"lateral":[250],"consistent":[253],"processing.":[259],"CONCLUSIONS:":[260],"These":[261],"are":[264],"first":[266],"global":[267],"microelectrophysiology":[268],"system":[272],"large":[275],"animal":[276],"model":[278],"form":[280],"foundation":[282],"direct":[285],"registration":[286],"processing":[289],"through":[292]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2026-03-27T00:00:00"}