{"id":"https://openalex.org/W7140700036","doi":"https://doi.org/10.1227/neu.0000000000003964_440","title":"440 Insights into Radiotherapy Response and Meningioma Biology Through Molecular Characterization of RTOG-0539 Clinical Trial","display_name":"440 Insights into Radiotherapy Response and Meningioma Biology Through Molecular Characterization of RTOG-0539 Clinical Trial","publication_year":2026,"publication_date":"2026-03-26","ids":{"openalex":"https://openalex.org/W7140700036","doi":"https://doi.org/10.1227/neu.0000000000003964_440"},"language":"en","primary_location":{"id":"doi:10.1227/neu.0000000000003964_440","doi":"https://doi.org/10.1227/neu.0000000000003964_440","is_oa":false,"landing_page_url":"https://doi.org/10.1227/neu.0000000000003964_440","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046433972","display_name":"Leeor S. Yefet","orcid":"https://orcid.org/0000-0003-1504-1772","observed_orcids":["https://orcid.org/0000-0003-1504-1772"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leeor S. Yefet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103009737","display_name":"Alexander Landry","orcid":"https://orcid.org/0000-0002-7250-8466","observed_orcids":["https://orcid.org/0000-0002-7250-8466"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alex Landry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130673459","display_name":"Justin Z. Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Justin Z. Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113840334","display_name":"Chloe Gui","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chloe Gui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053538256","display_name":"Andrew A. Ajisebutu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew A. Ajisebutu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066462262","display_name":"Yosef Ellenbogen","orcid":"https://orcid.org/0000-0003-1390-1361","observed_orcids":["https://orcid.org/0000-0003-1390-1361"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yosef Ellenbogen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006813610","display_name":"Jeff Liu","orcid":"https://orcid.org/0000-0001-8977-6590","observed_orcids":["https://orcid.org/0000-0001-8977-6590","https://orcid.org/0000-0002-9928-7552"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeff Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007013927","display_name":"Farshad Nassiri","orcid":"https://orcid.org/0000-0002-0797-3425","observed_orcids":["https://orcid.org/0000-0002-0797-3425"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Farshad Nassiri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5072584423","display_name":"Gelareh Mohammed Zadeh","orcid":"https://orcid.org/0000-0002-6637-4502","observed_orcids":["https://orcid.org/0000-0002-6637-4502","https://orcid.org/0009-0009-2002-5313"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gelareh Zadeh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"Supplement_1","first_page":"127","last_page":"127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11251","display_name":"Meningioma and schwannoma management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11251","display_name":"Meningioma and schwannoma management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/meningioma","display_name":"meningioma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/radiotherapy-response","display_name":"radiotherapy response","score":0.9150000214576721},{"id":"https://openalex.org/keywords/radiotherapy-resistance","display_name":"radiotherapy resistance","score":0.7910000085830688},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.7799999713897705},{"id":"https://openalex.org/keywords/molecular-reclassification","display_name":"molecular reclassification","score":0.5099999904632568},{"id":"https://openalex.org/keywords/cell-cycle-dysregulation","display_name":"cell cycle dysregulation","score":0.9309999942779541},{"id":"https://openalex.org/keywords/vorinostat","display_name":"vorinostat","score":0.9940000176429749},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.7850000262260437},{"id":"https://openalex.org/keywords/multi-omics-profiling","display_name":"multi-omics profiling","score":0.7570000290870667},{"id":"https://openalex.org/keywords/risk-adapted-radiotherapy","display_name":"risk-adapted radiotherapy","score":0.7059999704360962},{"id":"https://openalex.org/keywords/precision-neuro-oncology","display_name":"precision neuro-oncology","score":0.800000011920929}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9142000079154968},{"id":"https://openalex.org/C2779160599","wikidata":"https://www.wikidata.org/wiki/Q369157","display_name":"Meningioma","level":2,"score":0.8256999850273132},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.7623999714851379},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.7555999755859375},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.42739999294281006},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.424699991941452},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.38839998841285706},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3294999897480011},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.3160000145435333},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3084999918937683},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.2791000008583069},{"id":"https://openalex.org/C2992477034","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Clinical neurology","level":2,"score":0.27570000290870667},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.27149999141693115}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1227/neu.0000000000003964_440","doi":"https://doi.org/10.1227/neu.0000000000003964_440","is_oa":false,"landing_page_url":"https://doi.org/10.1227/neu.0000000000003964_440","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4416141092","https://openalex.org/W4412166776","https://openalex.org/W7161485222","https://openalex.org/W4413856506","https://openalex.org/W4408448441","https://openalex.org/W4401760017","https://openalex.org/W4388588586","https://openalex.org/W4398781282","https://openalex.org/W4309017246","https://openalex.org/W4392871315"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Meningiomas":[1],"are":[2],"the":[3,46,149,182,222],"most":[4],"common":[5],"primary":[6],"brain":[7],"tumors,":[8],"with":[9],"variable":[10],"outcomes":[11],"despite":[12],"standard":[13],"treatment.":[14],"Radiotherapy":[15],"(RT)":[16],"is":[17],"commonly":[18],"used":[19,107],"after":[20],"surgery,":[21],"but":[22],"predictive":[23],"biomarkers":[24],"of":[25,51,128,151,157,185,200,224],"response":[26],"remain":[27],"undefined.":[28],"The":[29],"RTOG-0539":[30,63],"phase":[31],"2":[32],"trial":[33,55,191],"established":[34],"a":[35,52,172,189,206],"risk-adapted":[36],"framework":[37],"for":[38,209],"RT":[39,54,158],"in":[40,56,99,176,188,228],"meningioma":[41,218],"patients.":[42],"This":[43,179],"study":[44,180],"represents":[45],"first":[47],"comprehensive":[48],"molecular":[49,183,215],"characterization":[50],"prospective":[53,190,225],"meningioma.":[57],"METHODS:":[58],"Tumor":[59],"samples":[60],"from":[61],"100":[62],"patients":[64],"were":[65,88,130],"analyzed":[66],"using":[67,90],"DNA":[68],"methylation":[69],"profiling,":[70],"RNA":[71],"sequencing,":[72],"and":[73,84,92,120,123,202,220],"whole-exome":[74],"sequencing.":[75],"We":[76],"examined":[77],"copy":[78],"number":[79],"changes,":[80],"mutations,":[81],"gene":[82],"expression,":[83],"pathway":[85,163],"enrichment.":[86],"Tumors":[87],"reclassified":[89,131],"2016":[91],"2021":[93],"WHO":[94,135],"criteria":[95],"to":[96,108],"evaluate":[97],"changes":[98],"histologic":[100,146],"grading":[101,136,143],"over":[102],"time.":[103],"Integrative":[104],"analysis":[105],"was":[106,169],"nominate":[109],"potential":[110],"therapeutic":[111,174],"agents.":[112],"RESULTS:":[113],"High-risk":[114],"tumors":[115,129],"demonstrated":[116],"cell":[117],"cycle":[118],"dysregulation":[119],"frequent":[121],"1p":[122],"14q":[124],"loss.":[125],"Ten":[126],"percent":[127],"when":[132],"applying":[133],"updated":[134],"systems,":[137],"reflecting":[138],"improved":[139],"molecular-histologic":[140],"alignment.":[141],"Molecular":[142],"revealed":[144],"misclassified":[145],"grades,":[147],"highlighting":[148],"limitations":[150],"traditional":[152],"pathology.":[153],"Crucially,":[154],"transcriptional":[155],"signatures":[156],"resistance":[159],"converged":[160],"on":[161],"HDAC":[162,167],"activation.":[164],"Vorinostat,":[165],"an":[166],"inhibitor,":[168],"identified":[170,198],"as":[171,205],"rational":[173],"candidate":[175],"non-responders.":[177],"CONCLUSIONS:":[178],"defines":[181],"architecture":[184],"RT-treated":[186],"meningiomas":[187],"setting.":[192],"Multi-omic":[193],"profiling":[194],"enhanced":[195],"risk":[196],"classification,":[197],"mechanisms":[199],"resistance,":[201],"highlighted":[203],"vorinostat":[204],"targeted":[207],"opportunity":[208],"future":[210],"trials.":[211],"These":[212],"findings":[213],"support":[214],"integration":[216],"into":[217],"care":[219],"reinforce":[221],"importance":[223],"tumor":[226],"banking":[227],"advancing":[229],"precision":[230],"neuro-oncology.":[231]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-03-27T00:00:00"}