{"id":"https://openalex.org/W7140388554","doi":"https://doi.org/10.1200/go-25-00066","title":"Systematic Review and Meta-Analysis of Lung Cancer Diagnostic Methods by the Brazilian Thoracic Oncology Group (GBOT)","display_name":"Systematic Review and Meta-Analysis of Lung Cancer Diagnostic Methods by the Brazilian Thoracic Oncology Group (GBOT)","publication_year":2026,"publication_date":"2026-03-01","ids":{"openalex":"https://openalex.org/W7140388554","doi":"https://doi.org/10.1200/go-25-00066","pmid":"https://pubmed.ncbi.nlm.nih.gov/41886721"},"language":"en","primary_location":{"id":"doi:10.1200/go-25-00066","doi":"https://doi.org/10.1200/go-25-00066","is_oa":true,"landing_page_url":"https://doi.org/10.1200/go-25-00066","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/GO-25-00066","source":{"id":"https://openalex.org/S4210209558","display_name":"JCO Global Oncology","issn_l":"2687-8941","issn":["2687-8941"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO Global Oncology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ascopubs.org/doi/pdfdirect/10.1200/GO-25-00066","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005241227","display_name":"Vladmir Cl\u00e1udio Cordeiro de Lima","orcid":"https://orcid.org/0000-0003-3955-1101","observed_orcids":["https://orcid.org/0000-0003-3955-1101"]},"institutions":[{"id":"https://openalex.org/I3019035496","display_name":"AC Camargo Hospital","ror":"https://ror.org/03025ga79","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I3019035496"]},{"id":"https://openalex.org/I4210148096","display_name":"Fleury S.A. (Brazil)","ror":"https://ror.org/04q9me654","country_code":"BR","type":"company","lineage":["https://openalex.org/I4210148096"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Vladmir C. Cordeiro de Lima","raw_affiliation_strings":["Brazilian Group of Clinical Oncology, S\u00e3o Paulo, Brazil","Department of Medical Oncology, A. C. Camargo Cancer Center, S\u00e3o Paulo, Brazil","Fleury Group Precision Oncology, S\u00e3o Paulo, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-3955-1101","affiliations":[{"raw_affiliation_string":"Brazilian Group of Clinical Oncology, S\u00e3o Paulo, Brazil","institution_ids":[]},{"raw_affiliation_string":"Department of Medical Oncology, A. C. Camargo Cancer Center, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I3019035496"]},{"raw_affiliation_string":"Fleury Group Precision Oncology, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I4210148096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051135380","display_name":"Clarissa Serodio da Rocha Baldotto","orcid":"https://orcid.org/0000-0001-9539-3094","observed_orcids":["https://orcid.org/0000-0001-9539-3094"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Clarissa Baldotto","raw_affiliation_strings":["COI Research and Teaching Institute, Rio de Janeiro, Brazil","Jos\u00e9 Alencar Gomes da Silva Cancer Institute (INCA), S\u00e3o Paulo, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-9539-3094","affiliations":[{"raw_affiliation_string":"COI Research and Teaching Institute, Rio de Janeiro, Brazil","institution_ids":[]},{"raw_affiliation_string":"Jos\u00e9 Alencar Gomes da Silva Cancer Institute (INCA), S\u00e3o Paulo, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025549987","display_name":"Eldsamira Mascarenhas","orcid":"https://orcid.org/0000-0001-6107-5098","observed_orcids":["https://orcid.org/0000-0001-6107-5098"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eldsamira Mascarenhas","raw_affiliation_strings":["D'or Research and Teaching Institute, S\u00e3o Paulo, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-6107-5098","affiliations":[{"raw_affiliation_string":"D'or Research and Teaching Institute, S\u00e3o Paulo, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019904063","display_name":"Ana Caroline Zimmer Gelatti","orcid":"https://orcid.org/0000-0002-5939-8071","observed_orcids":["https://orcid.org/0000-0002-5939-8071"]},"institutions":[{"id":"https://openalex.org/I4210137261","display_name":"Hospital S\u00e3o Lucas da PUCRS","ror":"https://ror.org/0353n6963","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210137261"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana Caroline Z. Gelatti","raw_affiliation_strings":["Hospital S\u00e3o Lucas, Porto Alegre, Brazil","Oncocl\u00ednicas Institute, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital S\u00e3o Lucas, Porto Alegre, Brazil","institution_ids":["https://openalex.org/I4210137261"]},{"raw_affiliation_string":"Oncocl\u00ednicas Institute, S\u00e3o Paulo, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015995148","display_name":"C Mathias","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Clarissa Mathias","raw_affiliation_strings":["N\u00facleo de Oncologia da Bahia, Salvador, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N\u00facleo de Oncologia da Bahia, Salvador, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103882829","display_name":"Luiz Henrique Lima de Ara\u00fajo","orcid":"https://orcid.org/0000-0001-9486-7139","observed_orcids":["https://orcid.org/0000-0001-9486-7139"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luiz Henrique de Lima Araujo","raw_affiliation_strings":["COI Research and Teaching Institute, Rio de Janeiro, Brazil","Jos\u00e9 Alencar Gomes da Silva Cancer Institute (INCA), S\u00e3o Paulo, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-9486-7139","affiliations":[{"raw_affiliation_string":"COI Research and Teaching Institute, Rio de Janeiro, Brazil","institution_ids":[]},{"raw_affiliation_string":"Jos\u00e9 Alencar Gomes da Silva Cancer Institute (INCA), S\u00e3o Paulo, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005937823","display_name":"Mauro Zukin","orcid":"https://orcid.org/0000-0002-6439-3136","observed_orcids":["https://orcid.org/0000-0002-6439-3136"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mauro Zukin","raw_affiliation_strings":["COI Research and Teaching Institute, Rio de Janeiro, Brazil","Jos\u00e9 Alencar Gomes da Silva Cancer Institute (INCA), S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"COI Research and Teaching Institute, Rio de Janeiro, Brazil","institution_ids":[]},{"raw_affiliation_string":"Jos\u00e9 Alencar Gomes da Silva Cancer Institute (INCA), S\u00e3o Paulo, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053765773","display_name":"Gustavo Faibischew Prado","orcid":"https://orcid.org/0000-0001-8023-4904","observed_orcids":["https://orcid.org/0000-0001-8023-4904"]},"institutions":[{"id":"https://openalex.org/I4210088998","display_name":"Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo","ror":"https://ror.org/005vqqr19","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210088998"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gustavo Faibischew Prado","raw_affiliation_strings":["Cancer Institute of the State of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-8023-4904","affiliations":[{"raw_affiliation_string":"Cancer Institute of the State of S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I4210088998"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046957099","display_name":"G. Castro","orcid":"https://orcid.org/0000-0001-8765-3044","observed_orcids":["https://orcid.org/0000-0001-8765-3044"]},"institutions":[{"id":"https://openalex.org/I4210088998","display_name":"Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo","ror":"https://ror.org/005vqqr19","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210088998"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gilberto Castro","raw_affiliation_strings":["Cancer Institute of the State of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-8765-3044","affiliations":[{"raw_affiliation_string":"Cancer Institute of the State of S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I4210088998"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2472,"currency":"USD","value_usd":2472},"apc_paid":{"value":2472,"currency":"USD","value_usd":2472},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14758937,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"3","first_page":"e2500066","last_page":"e2500066"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12379","display_name":"Cancer Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer-diagnosis","display_name":"lung cancer diagnosis","score":0.9639999866485596},{"id":"https://openalex.org/keywords/bronchoscopy","display_name":"bronchoscopy","score":0.843999981880188},{"id":"https://openalex.org/keywords/percutaneous-transthoracic-needle-biopsy","display_name":"transthoracic needle biopsy","score":0.996999979019165},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.9940000176429749},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.9629999995231628},{"id":"https://openalex.org/keywords/likelihood-ratios","display_name":"likelihood ratios","score":0.7739999890327454},{"id":"https://openalex.org/keywords/peripheral-pulmonary-lesions","display_name":"peripheral lung lesions","score":0.8889999985694885},{"id":"https://openalex.org/keywords/mediastinal-lesions","display_name":"mediastinal lesions","score":0.7559999823570251},{"id":"https://openalex.org/keywords/biopsy-complications","display_name":"biopsy complications","score":0.5669999718666077},{"id":"https://openalex.org/keywords/surgical-biopsy-comparison","display_name":"surgical biopsy comparison","score":0.75}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9253000020980835},{"id":"https://openalex.org/C2778996910","wikidata":"https://www.wikidata.org/wiki/Q237232","display_name":"Bronchoscopy","level":2,"score":0.723800003528595},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7213000059127808},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.5656999945640564},{"id":"https://openalex.org/C3020132585","wikidata":"https://www.wikidata.org/wiki/Q2671652","display_name":"Diagnostic accuracy","level":2,"score":0.4819999933242798},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.4805999994277954},{"id":"https://openalex.org/C40993552","wikidata":"https://www.wikidata.org/wiki/Q514654","display_name":"Gold standard (test)","level":2,"score":0.3944000005722046},{"id":"https://openalex.org/C2779563453","wikidata":"https://www.wikidata.org/wiki/Q6040221","display_name":"Lung biopsy","level":3,"score":0.37279999256134033},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.37130001187324524},{"id":"https://openalex.org/C534262118","wikidata":"https://www.wikidata.org/wiki/Q177719","display_name":"Medical diagnosis","level":2,"score":0.3644999861717224},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.35679998993873596},{"id":"https://openalex.org/C160022790","wikidata":"https://www.wikidata.org/wiki/Q2964004","display_name":"Cardiothoracic surgery","level":2,"score":0.32739999890327454},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.32670000195503235},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.32589998841285706},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.31139999628067017},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2996000051498413},{"id":"https://openalex.org/C3017697588","wikidata":"https://www.wikidata.org/wiki/Q237232","display_name":"Flexible bronchoscopy","level":3,"score":0.2985999882221222},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.29429998993873596},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.28859999775886536},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.2824000120162964},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.27379998564720154},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.2678000032901764},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.2667999863624573},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.2549000084400177}],"mesh":[{"descriptor_ui":"D001707","descriptor_name":"Biopsy, Needle","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001707","descriptor_name":"Biopsy, Needle","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001707","descriptor_name":"Biopsy, Needle","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001707","descriptor_name":"Biopsy, Needle","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001938","descriptor_name":"Brazil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001938","descriptor_name":"Brazil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001938","descriptor_name":"Brazil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001938","descriptor_name":"Brazil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001999","descriptor_name":"Bronchoscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D001999","descriptor_name":"Bronchoscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001999","descriptor_name":"Bronchoscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D001999","descriptor_name":"Bronchoscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1200/go-25-00066","doi":"https://doi.org/10.1200/go-25-00066","is_oa":true,"landing_page_url":"https://doi.org/10.1200/go-25-00066","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/GO-25-00066","source":{"id":"https://openalex.org/S4210209558","display_name":"JCO Global Oncology","issn_l":"2687-8941","issn":["2687-8941"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO Global Oncology","raw_type":"journal-article"},{"id":"pmid:41886721","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41886721","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO global oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b0f666733f774d99a91c1fa5b93859ec","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b0f666733f774d99a91c1fa5b93859ec","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JCO Global Oncology, Vol 12, Iss 3 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1200/go-25-00066","doi":"https://doi.org/10.1200/go-25-00066","is_oa":true,"landing_page_url":"https://doi.org/10.1200/go-25-00066","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/GO-25-00066","source":{"id":"https://openalex.org/S4210209558","display_name":"JCO Global Oncology","issn_l":"2687-8941","issn":["2687-8941"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO Global Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9943000078201294}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7140388554.pdf","grobid_xml":"https://content.openalex.org/works/W7140388554.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W264132560","https://openalex.org/W1601442485","https://openalex.org/W1902990752","https://openalex.org/W1940266261","https://openalex.org/W1987104679","https://openalex.org/W1991971975","https://openalex.org/W2019285214","https://openalex.org/W2026247750","https://openalex.org/W2051799951","https://openalex.org/W2060270482","https://openalex.org/W2081709636","https://openalex.org/W2088630864","https://openalex.org/W2091858371","https://openalex.org/W2097367687","https://openalex.org/W2107638293","https://openalex.org/W2118147646","https://openalex.org/W2119859819","https://openalex.org/W2144912367","https://openalex.org/W2146683706","https://openalex.org/W2154076372","https://openalex.org/W2154857631","https://openalex.org/W2155945189","https://openalex.org/W2160028806","https://openalex.org/W2324508732","https://openalex.org/W2418904248","https://openalex.org/W2553587720","https://openalex.org/W2570984524","https://openalex.org/W2586972330","https://openalex.org/W2680126013","https://openalex.org/W2784730671","https://openalex.org/W2803442565","https://openalex.org/W2889877184","https://openalex.org/W2911005357","https://openalex.org/W2944310279","https://openalex.org/W2953600484","https://openalex.org/W2987702876","https://openalex.org/W3027088329","https://openalex.org/W3029659209","https://openalex.org/W3107064869","https://openalex.org/W4206218075","https://openalex.org/W4221011855","https://openalex.org/W4224283329","https://openalex.org/W4285058703","https://openalex.org/W4303986228","https://openalex.org/W4309849218","https://openalex.org/W4415163478"],"related_works":[],"abstract_inverted_index":{"PURPOSE:":[0],"Although":[1],"various":[2],"techniques":[3],"are":[4],"available":[5],"for":[6,14,58,186,201,212],"diagnosing":[7],"lung":[8,188],"cancer":[9],"(LC),":[10],"comprehensive":[11],"literature":[12],"synthesis":[13],"selecting":[15],"the":[16,30,51,108,210,218],"most":[17],"appropriate":[18],"diagnostic":[19,31,52,80,103,184,215],"method":[20],"remains":[21,199],"lacking.":[22],"This":[23],"study":[24],"aims":[25],"to":[26,49,73,91,158,165],"synthesize":[27],"and":[28,35,56,68,107,151,160,204,223],"meta-analyze":[29],"accuracy":[32,53,81,104,185],"of":[33,54,64,110,123,132,145,153,174,220],"bronchoscopy":[34,55,88,121],"transthoracic":[36],"needle":[37],"biopsy":[38,93],"(TTNB)":[39],"in":[40],"LC":[41,59],"diagnosis.":[42,60],"METHODS:":[43],"A":[44],"systematic":[45],"review":[46],"was":[47,112],"conducted":[48],"evaluate":[50],"TTNB":[57,90,146,181],"MEDLINE/PubMed,":[61],"EMBASE,":[62],"Web":[63],"Science,":[65],"Cochrane":[66],"Library,":[67],"LILACS":[69],"were":[70,98,139],"systematically":[71],"searched":[72],"identify":[74],"relevant":[75],"studies.":[76],"We":[77],"included":[78],"original":[79],"studies":[82,138,147],"with":[83,141],"over":[84],"50":[85],"participants":[86],"comparing":[87],"or":[89,94],"surgical":[92],"clinical":[95,178],"follow-up.":[96],"Data":[97],"synthesized":[99],"using":[100,114],"a":[101,213],"bivariate":[102],"random-effects":[105],"model,":[106],"quality":[109],"evidence":[111],"assessed":[113],"QUADAS-2.":[115],"RESULTS:":[116],"The":[117],"search":[118],"identified":[119],"3,707":[120],"studies,":[122],"which":[124],"two":[125],"met":[126],"inclusion":[127],"criteria,":[128],"precluding":[129],"meta-analysis":[130],"because":[131],"high":[133,171],"heterogeneity.":[134],"For":[135],"TTNB,":[136],"1,136":[137],"screened,":[140],"20":[142],"included.":[143],"Meta-analysis":[144],"revealed":[148],"pooled":[149],"sensitivity":[150],"specificity":[152],"0.91":[154],"(95%":[155,162],"CI,":[156,163],"0.90":[157],"0.93)":[159],"0.99":[161],"0.98":[164],"1.00),":[166],"respectively.":[167],"Likelihood":[168],"ratios":[169],"indicated":[170],"post-test":[172],"probability":[173],"accurate":[175],"diagnosis":[176],"across":[177],"scenarios.":[179],"CONCLUSION:":[180],"demonstrates":[182],"good":[183],"peripheral":[187],"lesions,":[189],"but":[190],"carries":[191],"notable":[192],"complication":[193],"risks.":[194],"Bronchoscopy,":[195],"while":[196],"less":[197],"sensitive,":[198],"valuable":[200],"central":[202],"lesions":[203],"mediastinal":[205],"evaluation.":[206],"These":[207],"findings":[208],"underscore":[209],"need":[211],"tailored":[214],"approach":[216],"on":[217],"basis":[219],"lesion":[221],"characteristics":[222],"patient":[224],"profiles,":[225],"complemented":[226],"by":[227],"multidisciplinary":[228],"expertise.":[229]},"counts_by_year":[],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2026-03-27T00:00:00"}