{"id":"https://openalex.org/W7140274175","doi":"https://doi.org/10.24433/co.0466697.v1","title":"Pinhole Engineering based Enhanced Resolution (PEER) for Fluorescence Lifetime Imaging Microscopy","display_name":"Pinhole Engineering based Enhanced Resolution (PEER) for Fluorescence Lifetime Imaging Microscopy","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7140274175","doi":"https://doi.org/10.24433/co.0466697.v1"},"language":"en","primary_location":{"id":"doi:10.24433/co.0466697.v1","doi":"https://doi.org/10.24433/co.0466697.v1","is_oa":true,"landing_page_url":"https://doi.org/10.24433/co.0466697.v1","pdf_url":null,"source":{"id":"https://openalex.org/S7407052302","display_name":"Code Ocean","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Software"},"volume":null,"type":"software","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.24433/co.0466697.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022275789","display_name":"Wonsang Hwang","orcid":"https://orcid.org/0000-0002-6156-9554","observed_orcids":["https://orcid.org/0000-0002-6156-9554"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wonsang Hwang","raw_affiliation_strings":["Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073936872","display_name":"Conor L. Evans","orcid":"https://orcid.org/0000-0003-2185-6505","observed_orcids":["https://orcid.org/0000-0003-2185-6505"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evans, Conor","raw_affiliation_strings":["Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010188860","display_name":"Iv\u00e1n Coto Hern\u00e1ndez","orcid":"https://orcid.org/0000-0003-3611-7959","observed_orcids":["https://orcid.org/0000-0003-3611-7959"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hernandez, Ivan Coto","raw_affiliation_strings":["Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101902583","display_name":"Sinyoung Jeong","orcid":"https://orcid.org/0000-0001-9407-7006","observed_orcids":["https://orcid.org/0000-0001-9407-7006"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sinyoung Jeong","raw_affiliation_strings":["Intek Scientific"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intek Scientific","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048670286","display_name":"John Matthew Dubach","orcid":"https://orcid.org/0000-0002-7469-8910","observed_orcids":["https://orcid.org/0000-0002-7469-8910"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Matthew Dubach","raw_affiliation_strings":["Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11129","display_name":"Photochemistry and Electron Transfer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluorescence-lifetime-imaging-microscopy","display_name":"fluorescence lifetime imaging","score":0.9739999771118164},{"id":"https://openalex.org/keywords/phasor-analysis","display_name":"phasor analysis","score":0.8579999804496765},{"id":"https://openalex.org/keywords/confocal-microscopy","display_name":"confocal microscopy","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C2776700484","wikidata":"https://www.wikidata.org/wiki/Q15832623","display_name":"Pinhole (optics)","level":2,"score":0.6722999811172485},{"id":"https://openalex.org/C136009344","wikidata":"https://www.wikidata.org/wiki/Q336201","display_name":"Confocal","level":2,"score":0.6028000116348267},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.539900004863739},{"id":"https://openalex.org/C60439489","wikidata":"https://www.wikidata.org/wiki/Q634407","display_name":"Streamlines, streaklines, and pathlines","level":2,"score":0.5335000157356262},{"id":"https://openalex.org/C176605952","wikidata":"https://www.wikidata.org/wiki/Q827674","display_name":"Phasor","level":4,"score":0.4943000078201294},{"id":"https://openalex.org/C67649825","wikidata":"https://www.wikidata.org/wiki/Q196538","display_name":"Microscope","level":2,"score":0.48410001397132874},{"id":"https://openalex.org/C2779178360","wikidata":"https://www.wikidata.org/wiki/Q902045","display_name":"Confocal microscopy","level":2,"score":0.46070000529289246},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.45419999957084656},{"id":"https://openalex.org/C57477423","wikidata":"https://www.wikidata.org/wiki/Q1434196","display_name":"Fluorescence-lifetime imaging microscopy","level":3,"score":0.43630000948905945},{"id":"https://openalex.org/C113976765","wikidata":"https://www.wikidata.org/wiki/Q1823502","display_name":"Light sheet fluorescence microscopy","level":4,"score":0.4212999939918518},{"id":"https://openalex.org/C519991488","wikidata":"https://www.wikidata.org/wiki/Q28865","display_name":"Python (programming language)","level":2,"score":0.40380001068115234},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.39899998903274536},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.3935000002384186},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3716999888420105},{"id":"https://openalex.org/C88412794","wikidata":"https://www.wikidata.org/wiki/Q902045","display_name":"Confocal laser scanning microscopy","level":2,"score":0.35989999771118164},{"id":"https://openalex.org/C3020199158","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"High resolution","level":2,"score":0.35989999771118164},{"id":"https://openalex.org/C169274487","wikidata":"https://www.wikidata.org/wiki/Q840211","display_name":"Fluorescence microscope","level":3,"score":0.3522999882698059},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3456999957561493},{"id":"https://openalex.org/C121684516","wikidata":"https://www.wikidata.org/wiki/Q7600677","display_name":"Computer graphics (images)","level":1,"score":0.3447999954223633},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.3352000117301941},{"id":"https://openalex.org/C205372480","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"Image resolution","level":2,"score":0.3314000070095062},{"id":"https://openalex.org/C147075424","wikidata":"https://www.wikidata.org/wiki/Q1604780","display_name":"Hemidesmosome","level":3,"score":0.33009999990463257},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.32739999890327454},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.29280000925064087},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2703000009059906}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.24433/co.0466697.v1","doi":"https://doi.org/10.24433/co.0466697.v1","is_oa":true,"landing_page_url":"https://doi.org/10.24433/co.0466697.v1","pdf_url":null,"source":{"id":"https://openalex.org/S7407052302","display_name":"Code Ocean","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Software"}],"best_oa_location":{"id":"doi:10.24433/co.0466697.v1","doi":"https://doi.org/10.24433/co.0466697.v1","is_oa":true,"landing_page_url":"https://doi.org/10.24433/co.0466697.v1","pdf_url":null,"source":{"id":"https://openalex.org/S7407052302","display_name":"Code Ocean","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Software"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4393836315","https://openalex.org/W7135661509","https://openalex.org/W6950679391","https://openalex.org/W7165175845","https://openalex.org/W4392680939","https://openalex.org/W2889971728","https://openalex.org/W2104928963","https://openalex.org/W4324319759","https://openalex.org/W3135036503","https://openalex.org/W6991163301"],"abstract_inverted_index":{"This":[0],"Python":[1],"script":[2],"streamlines":[3],"the":[4,22,43,62],"PEER":[5,46],"workflow:":[6],"it":[7],"ingests":[8],"six":[9],"TIFF":[10],"images\u2014intensity":[11],"(I)":[12],"and":[13,17,24,38,45,56],"phasor":[14],"coordinates":[15],"(G":[16],"S)":[18],"captured":[19],"with":[20],"both":[21],"small\u2011pinhole":[23],"large\u2011pinhole":[25],"settings":[26],"of":[27],"a":[28],"confocal":[29,44],"FLIM":[30],"system\u2014and":[31],"automatically":[32],"generates":[33],"four":[34],"figures:":[35],"phasor\u2011density":[36],"plots":[37],"intensity\u2011weighted":[39],"lifetime":[40],"maps":[41],"for":[42],"channels.":[47],"The":[48],"resulting":[49],"PNG":[50],"files":[51],"\u2014":[52,58],"\u201cphasor_confocal.png,\u201d":[53],"\u201cphasor_peer.png,\u201d":[54],"\u201cflim_confocal.png,\u201d":[55],"\u201cflim_peer.png\u201d":[57],"are":[59],"saved":[60],"in":[61],"specified":[63],"results":[64],"folder.":[65]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2026-03-26T00:00:00"}
