{"id":"https://openalex.org/W7140230972","doi":"https://doi.org/10.1007/s12247-026-10598-8","title":"Development of Film Formulations of Acyclovir as Safe and Effective Antiviral Agent: Optimization, In Vitro Characterization and Antialphaherpesviral Efficacy","display_name":"Development of Film Formulations of Acyclovir as Safe and Effective Antiviral Agent: Optimization, In Vitro Characterization and Antialphaherpesviral Efficacy","publication_year":2026,"publication_date":"2026-03-24","ids":{"openalex":"https://openalex.org/W7140230972","doi":"https://doi.org/10.1007/s12247-026-10598-8"},"language":"en","primary_location":{"id":"doi:10.1007/s12247-026-10598-8","doi":"https://doi.org/10.1007/s12247-026-10598-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12247-026-10598-8","pdf_url":null,"source":{"id":"https://openalex.org/S168111969","display_name":"Journal of Pharmaceutical Innovation","issn_l":"1872-5120","issn":["1872-5120","1939-8042"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Innovation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089614808","display_name":"Berat Urguplu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Berat \u00dcrg\u00fcpl\u00fc","raw_affiliation_strings":["Faculty of Pharmacy, Department of Pharmaceutical Technology, Hacettepe University, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Department of Pharmaceutical Technology, Hacettepe University, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002877734","display_name":"Dilara \u00d6rg\u00fcl","orcid":"https://orcid.org/0000-0002-8947-4995","observed_orcids":["https://orcid.org/0000-0002-8947-4995"]},"institutions":[{"id":"https://openalex.org/I137996928","display_name":"Sel\u00e7uk University","ror":"https://ror.org/045hgzm75","country_code":"TR","type":"education","lineage":["https://openalex.org/I137996928"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Dilara \u00d6rg\u00fcl","raw_affiliation_strings":["Faculty of Pharmacy, Department of Pharmaceutical Technology, Sel\u00e7uk University, Konya, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Department of Pharmaceutical Technology, Sel\u00e7uk University, Konya, Turkey","institution_ids":["https://openalex.org/I137996928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072057607","display_name":"Gamze Varan","orcid":"https://orcid.org/0000-0002-1291-9503","observed_orcids":["https://orcid.org/0000-0002-1291-9503"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Gamze Varan","raw_affiliation_strings":["Department of Vaccine Technology, Hacettepe University Vaccine Institute, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vaccine Technology, Hacettepe University Vaccine Institute, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118975669","display_name":"Tar\u0131k Fedai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Tar\u0131k Fedai","raw_affiliation_strings":["Faculty of Veterinary Medicine, Department of Virology, Ankara University, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Veterinary Medicine, Department of Virology, Ankara University, Ankara, Turkey","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010046096","display_name":"S\u0131d\u0131ka \u00d6ztop","orcid":"https://orcid.org/0000-0001-5653-6080","observed_orcids":["https://orcid.org/0000-0001-5653-6080"]},"institutions":[{"id":"https://openalex.org/I4387152971","display_name":"Ankara Medipol \u00dcniversitesi","ror":"https://ror.org/01c9cnw16","country_code":"TR","type":"education","lineage":["https://openalex.org/I4387152971"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"S\u0131d\u0131ka \u00d6ztop","raw_affiliation_strings":["Faculty of Medicine, Department of Medical Biology, Ankara Medipol University, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Medical Biology, Ankara Medipol University, Ankara, Turkey","institution_ids":["https://openalex.org/I4387152971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055287651","display_name":"Aykut \u00d6zkul","orcid":"https://orcid.org/0000-0001-5008-9443","observed_orcids":["https://orcid.org/0000-0001-5008-9443"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Aykut \u00d6zkul","raw_affiliation_strings":["Faculty of Veterinary Medicine, Department of Virology, Ankara University, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Veterinary Medicine, Department of Virology, Ankara University, Ankara, Turkey","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049075240","display_name":"Nazl\u0131 Erdo\u011far","orcid":"https://orcid.org/0000-0003-2527-5484","observed_orcids":["https://orcid.org/0000-0003-2527-5484"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Nazl\u0131 Erdo\u011far","raw_affiliation_strings":["Faculty of Pharmacy, Department of Pharmaceutical Technology, Hacettepe University, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Department of Pharmaceutical Technology, Hacettepe University, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5049075240"],"corresponding_institution_ids":["https://openalex.org/I66514158"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10488","display_name":"Nanocomposite Films for Food Packaging","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acyclovir","display_name":"acyclovir","score":0.9990000128746033},{"id":"https://openalex.org/keywords/buccal-films","display_name":"buccal films","score":0.9610000252723694},{"id":"https://openalex.org/keywords/mucoadhesion","display_name":"mucoadhesion","score":0.7670000195503235},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.8220000267028809},{"id":"https://openalex.org/keywords/controlled-release","display_name":"controlled release","score":0.4819999933242798},{"id":"https://openalex.org/keywords/herpes-simplex-virus","display_name":"herpes simplex virus","score":0.8510000109672546},{"id":"https://openalex.org/keywords/alphaherpesvirus","display_name":"alphaherpesvirus","score":0.8420000076293945},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.8519999980926514},{"id":"https://openalex.org/keywords/swelling-index","display_name":"swelling index","score":0.765999972820282},{"id":"https://openalex.org/keywords/elastic-modulus","display_name":"elastic modulus","score":0.828000009059906},{"id":"https://openalex.org/keywords/drug-polymer-compatibility","display_name":"drug-polymer compatibility","score":0.5609999895095825},{"id":"https://openalex.org/keywords/oral-drug-delivery","display_name":"oral drug delivery","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C2780020223","wikidata":"https://www.wikidata.org/wiki/Q25323681","display_name":"Mucoadhesion","level":4,"score":0.8551999926567078},{"id":"https://openalex.org/C195735259","wikidata":"https://www.wikidata.org/wiki/Q16963239","display_name":"Buccal administration","level":2,"score":0.8098999857902527},{"id":"https://openalex.org/C2778540859","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Swelling","level":2,"score":0.7354999780654907},{"id":"https://openalex.org/C169222746","wikidata":"https://www.wikidata.org/wiki/Q4116558","display_name":"Factorial experiment","level":2,"score":0.6912000179290771},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5242000222206116},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4683000147342682},{"id":"https://openalex.org/C112950240","wikidata":"https://www.wikidata.org/wiki/Q76005","display_name":"Ultimate tensile strength","level":2,"score":0.41990000009536743},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41600000858306885},{"id":"https://openalex.org/C68928338","wikidata":"https://www.wikidata.org/wiki/Q131790","display_name":"Adhesive","level":3,"score":0.41449999809265137},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4000000059604645},{"id":"https://openalex.org/C2780449318","wikidata":"https://www.wikidata.org/wiki/Q18344773","display_name":"Critical quality attributes","level":3,"score":0.3707999885082245},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.3644999861717224},{"id":"https://openalex.org/C204320433","wikidata":"https://www.wikidata.org/wiki/Q7268772","display_name":"Quality by Design","level":3,"score":0.3569999933242798},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.33079999685287476},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.321399986743927},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.29789999127388},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.288100004196167},{"id":"https://openalex.org/C16469947","wikidata":"https://www.wikidata.org/wiki/Q2400745","display_name":"Fractional factorial design","level":3,"score":0.2639000117778778},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.25999999046325684},{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.2574999928474426},{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.2547999918460846}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s12247-026-10598-8","doi":"https://doi.org/10.1007/s12247-026-10598-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12247-026-10598-8","pdf_url":null,"source":{"id":"https://openalex.org/S168111969","display_name":"Journal of Pharmaceutical Innovation","issn_l":"1872-5120","issn":["1872-5120","1939-8042"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Innovation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323272","display_name":"Hacettepe \u00dcniversitesi","ror":"https://ror.org/04kwvgz42"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1525975143","https://openalex.org/W1970835872","https://openalex.org/W1984335257","https://openalex.org/W1989069389","https://openalex.org/W2001013492","https://openalex.org/W2006336378","https://openalex.org/W2016304386","https://openalex.org/W2037194041","https://openalex.org/W2045559197","https://openalex.org/W2047667390","https://openalex.org/W2083591990","https://openalex.org/W2100837670","https://openalex.org/W2101269168","https://openalex.org/W2104591205","https://openalex.org/W2134673353","https://openalex.org/W2140077340","https://openalex.org/W2144175913","https://openalex.org/W2161656515","https://openalex.org/W2164263515","https://openalex.org/W2400966255","https://openalex.org/W2551342424","https://openalex.org/W2767677562","https://openalex.org/W2796866823","https://openalex.org/W2808488080","https://openalex.org/W2907983490","https://openalex.org/W2944014142","https://openalex.org/W2945699153","https://openalex.org/W2951944722","https://openalex.org/W2956183950","https://openalex.org/W3008251468","https://openalex.org/W3010224452","https://openalex.org/W3022275668","https://openalex.org/W3159971818","https://openalex.org/W3174751601","https://openalex.org/W3193106770","https://openalex.org/W3202944404","https://openalex.org/W4214653080","https://openalex.org/W4230386810","https://openalex.org/W4281709382","https://openalex.org/W4293281196","https://openalex.org/W4297372642"],"related_works":["https://openalex.org/W2140077340","https://openalex.org/W2515425750","https://openalex.org/W4399578594","https://openalex.org/W2167495741","https://openalex.org/W2083591990","https://openalex.org/W1948079628","https://openalex.org/W1608055533","https://openalex.org/W4409242038","https://openalex.org/W7214981960","https://openalex.org/W4297372642"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2026-03-25T00:00:00"}