{"id":"https://openalex.org/W7140201167","doi":"https://doi.org/10.64898/2026.03.21.713243","title":"Polycystin-1 C-Terminus Regulates Protein Synthesis-Related Pathways in Cardiomyocytes","display_name":"Polycystin-1 C-Terminus Regulates Protein Synthesis-Related Pathways in Cardiomyocytes","publication_year":2026,"publication_date":"2026-03-24","ids":{"openalex":"https://openalex.org/W7140201167","doi":"https://doi.org/10.64898/2026.03.21.713243","pmid":"https://pubmed.ncbi.nlm.nih.gov/41929131","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13041827"},"language":"en","primary_location":{"id":"doi:10.64898/2026.03.21.713243","doi":"https://doi.org/10.64898/2026.03.21.713243","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.03.21.713243","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/03/24/2026.03.21.713243.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/03/24/2026.03.21.713243.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053092460","display_name":"Matthew J. Fiedler","orcid":"https://orcid.org/0000-0003-0628-000X","observed_orcids":["https://orcid.org/0000-0003-0628-000X"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Fiedler","raw_affiliation_strings":["Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA","Program in Physiology, Biophysics & Systems Biology, Weill Cornell Medicine, NY, NY, USA"],"raw_orcid":"https://orcid.org/0000-0003-0628-000X","affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]},{"raw_affiliation_string":"Program in Physiology, Biophysics & Systems Biology, Weill Cornell Medicine, NY, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060416040","display_name":"Alejandra V\u00e1squez\u2010Limeta","orcid":"https://orcid.org/0000-0002-2504-6270","observed_orcids":["https://orcid.org/0000-0002-2504-6270"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alejandra Vasquez Limeta","raw_affiliation_strings":["Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA"],"raw_orcid":"https://orcid.org/0000-0002-2504-6270","affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104423808","display_name":"Ernesto Reyes-Sanchez","orcid":"https://orcid.org/0009-0001-6906-8922","observed_orcids":["https://orcid.org/0009-0001-6906-8922"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ernesto Reyes-Sanchez","raw_affiliation_strings":["Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA"],"raw_orcid":"https://orcid.org/0009-0001-6906-8922","affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104423809","display_name":"Monserrat Reyes-Lozano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monserrat Reyes-Lozano","raw_affiliation_strings":["Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000937717","display_name":"William M. Perez","orcid":"https://orcid.org/0000-0003-0344-4160","observed_orcids":["https://orcid.org/0000-0003-0344-4160"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Perez","raw_affiliation_strings":["Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA"],"raw_orcid":"https://orcid.org/0000-0003-0344-4160","affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004508807","display_name":"Leah Carter","orcid":"https://orcid.org/0009-0004-5869-6132","observed_orcids":["https://orcid.org/0009-0004-5869-6132"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leah Carter","raw_affiliation_strings":["Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA"],"raw_orcid":"https://orcid.org/0009-0004-5869-6132","affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101970592","display_name":"Christopher J. Ward","orcid":"https://orcid.org/0000-0002-2507-9398","observed_orcids":["https://orcid.org/0000-0002-2507-9398"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher J. Ward","raw_affiliation_strings":["The Jared Grantham Kidney Institute at the University of Kansas Medical Center, Department of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, KS, USA"],"raw_orcid":"https://orcid.org/0000-0002-2507-9398","affiliations":[{"raw_affiliation_string":"The Jared Grantham Kidney Institute at the University of Kansas Medical Center, Department of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, KS, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062067826","display_name":"Francisco J Altamirano","orcid":"https://orcid.org/0000-0002-1612-2729","observed_orcids":["https://orcid.org/0000-0002-1612-2729"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Francisco Altamirano","raw_affiliation_strings":["Department of Cardiothoracic Surgery, Weill Cornell Medicine, NY, NY, USA","Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA","Program in Physiology, Biophysics & Systems Biology, Weill Cornell Medicine, NY, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-1612-2729","affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Weill Cornell Medicine, NY, NY, USA","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]},{"raw_affiliation_string":"Program in Physiology, Biophysics & Systems Biology, Weill Cornell Medicine, NY, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5062067826"],"corresponding_institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4387153466","https://openalex.org/I4405286254"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.3292999863624573,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.3292999863624573,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.18080000579357147,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0731000006198883,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycystin-1","display_name":"polycystin-1","score":0.9150000214576721},{"id":"https://openalex.org/keywords/pkd1","display_name":"PKD1","score":0.7900000214576721},{"id":"https://openalex.org/keywords/c-terminal-tail","display_name":"C-terminal tail","score":0.7860000133514404},{"id":"https://openalex.org/keywords/cardiomyocyte-hypertrophy","display_name":"cardiomyocyte hypertrophy","score":0.8790000081062317},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.9200000166893005},{"id":"https://openalex.org/keywords/ribosome-biogenesis","display_name":"ribosome biogenesis","score":0.8989999890327454},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.847000002861023},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cell-derived-cardiomyocytes","display_name":"iPSC-derived cardiomyocytes","score":0.8100000023841858},{"id":"https://openalex.org/keywords/human-cardiomyocytes","display_name":"human cardiomyocytes","score":0.5440000295639038},{"id":"https://openalex.org/keywords/translational-control","display_name":"translational regulation","score":0.5960000157356262},{"id":"https://openalex.org/keywords/cardiomyocyte-maturation","display_name":"cardiomyocyte maturation","score":0.6710000038146973},{"id":"https://openalex.org/keywords/alpha-actinin","display_name":"alpha-actinin","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C2780926556","wikidata":"https://www.wikidata.org/wiki/Q7322419","display_name":"Ribosomal protein s6","level":5,"score":0.7103999853134155},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6513000130653381},{"id":"https://openalex.org/C2776879804","wikidata":"https://www.wikidata.org/wiki/Q7630919","display_name":"Subcellular localization","level":3,"score":0.5593000054359436},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5367000102996826},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5360000133514404},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4921000003814697},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.47999998927116394},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.41350001096725464},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.3562999963760376},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35499998927116394},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.3425000011920929},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32100000977516174},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.3149999976158142},{"id":"https://openalex.org/C49773422","wikidata":"https://www.wikidata.org/wiki/Q4859345","display_name":"Pertussis toxin","level":4,"score":0.311599999666214},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.3052000105381012},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29980000853538513},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.29910001158714294},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.29510000348091125},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.29420000314712524},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2930000126361847},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.2897000014781952},{"id":"https://openalex.org/C2778236600","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Immunofluorescence","level":3,"score":0.28870001435279846},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.28700000047683716},{"id":"https://openalex.org/C140051345","wikidata":"https://www.wikidata.org/wiki/Q7251501","display_name":"Protein subcellular localization prediction","level":3,"score":0.2800000011920929},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.2759999930858612},{"id":"https://openalex.org/C2780044377","wikidata":"https://www.wikidata.org/wiki/Q24778284","display_name":"Ribosomal s6 kinase","level":5,"score":0.27559998631477356},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.2678000032901764},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.2671000063419342},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.2605000138282776},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.2515000104904175}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.03.21.713243","doi":"https://doi.org/10.64898/2026.03.21.713243","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.03.21.713243","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/03/24/2026.03.21.713243.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:41929131","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41929131","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13041827","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13041827/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.03.21.713243","doi":"https://doi.org/10.64898/2026.03.21.713243","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.03.21.713243","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/03/24/2026.03.21.713243.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5496731519","display_name":"Polycystin-1-dependent governance of cardiomyocyte hypertrophy via potassium channel control","funder_award_id":"19CDA34680003","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G5989231357","display_name":"Human-specific Abnormal Alternative Splicing of the Wild-type PKD1 Gene Induces Premature Termination of Polycystin-1","funder_award_id":"R01DK122205","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000871585","display_name":"Mechanisms driving cardiac dysfunction in Autosomal Dominant Polycystic Kidney Disease","funder_award_id":"R01HL158703","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320310169","display_name":"University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690"},{"id":"https://openalex.org/F4320333841","display_name":"Houston Methodist Research Institute","ror":null},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7140201167.pdf","grobid_xml":"https://content.openalex.org/works/W7140201167.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1797700808","https://openalex.org/W1876131152","https://openalex.org/W1996847747","https://openalex.org/W2010148876","https://openalex.org/W2014604277","https://openalex.org/W2017991176","https://openalex.org/W2022926357","https://openalex.org/W2058889865","https://openalex.org/W2079546843","https://openalex.org/W2100483988","https://openalex.org/W2115147488","https://openalex.org/W2141316016","https://openalex.org/W2141331673","https://openalex.org/W2166754647","https://openalex.org/W2767510266","https://openalex.org/W2952879102","https://openalex.org/W2988469020","https://openalex.org/W3003354741","https://openalex.org/W3015354305","https://openalex.org/W3127229298","https://openalex.org/W3193363978","https://openalex.org/W4214876469","https://openalex.org/W4232767515","https://openalex.org/W4361255683","https://openalex.org/W4386255144","https://openalex.org/W4405941268"],"related_works":["https://openalex.org/W4415792714","https://openalex.org/W2079546843","https://openalex.org/W7155072545","https://openalex.org/W3125514536","https://openalex.org/W2201778716","https://openalex.org/W4414167690","https://openalex.org/W1978109583","https://openalex.org/W2981300784","https://openalex.org/W2157772749","https://openalex.org/W2336773233"],"abstract_inverted_index":{"ABSTRACT":[0],"Pathologic":[1],"cardiac":[2,32],"hypertrophy":[3,40],"requires":[4],"increased":[5,181,186],"protein":[6,121,170,194,265],"synthesis,":[7,171,266],"but":[8],"the":[9,66,100,106,111,119,204],"mechanosensors":[10],"that":[11,128,210,252],"link":[12,279],"membrane":[13],"stretch":[14],"to":[15,139,150,164,256,261],"translational":[16],"control":[17],"remain":[18,51],"poorly":[19],"understood.":[20],"Polycystin-1":[21],"(PC1),":[22],"encoded":[23],"by":[24],"PKD1":[25],",":[26],"has":[27],"been":[28],"proposed":[29],"as":[30],"a":[31,85,96,234,247,269,277],"mechanosensor,":[33],"with":[34,95,123],"its":[35,45],"C-terminal":[36],"tail":[37],"(PC1-CT)":[38],"promoting":[39],"in":[41,55,72,116,147],"rodent":[42],"cardiomyocytes.":[43,57],"However,":[44],"subcellular":[46],"localization":[47,64],"and":[48,65,78,99,125,169,192,225,264,282],"downstream":[49,143],"signaling":[50,239,255],"incompletely":[52],"defined,":[53],"especially":[54],"human":[56,73],"Here,":[58],"we":[59],"examined":[60],"endogenous":[61,91],"PC1":[62,92,107],"C-terminus":[63,93,108],"effects":[67],"of":[68,144,160,188,203,250],"adenoviral":[69],"PC1-CT":[70,97,102,129,145,184,251,281],"overexpression":[71,146,185],"iPSC-derived":[74],"ventricular":[75,81],"cardiomyocytes":[76],"(hiPSC-CMs)":[77],"adult":[79,117],"mouse":[80],"myocytes.":[82],"Immunofluorescence":[83],"revealed":[84,158],"striking":[86],"striated":[87],"pattern":[88],"for":[89],"both":[90],"(detected":[94],"antibody)":[98],"overexpressed":[101,120],"fragment.":[103],"In":[104,114],"hiPSC-CMs,":[105],"localized":[109],"between":[110,280],"\u03b1-actinin":[112,124],"bands.":[113],"contrast,":[115],"cardiomyocytes,":[118],"colocalized":[122],"desmin,":[126],"suggesting":[127,200,233],"sarcomeric":[130],"distribution":[131],"depends":[132],"on":[133],"cardiomyocyte":[134,283],"maturation.":[135],"We":[136],"performed":[137],"RNA-seq":[138],"assess":[140],"transcriptional":[141,258],"responses":[142],"hiPSC-CMs":[148],"relative":[149],"LacZ":[151],"controls.":[152],"Gene":[153],"Set":[154],"Enrichment":[155],"Analysis":[156],"(GSEA)":[157],"enrichment":[159],"gene":[161,272],"sets":[162],"related":[163,260],"ribosome":[165,262],"biogenesis,":[166],"RNA":[167],"processing,":[168],"while":[172],"classical":[173],"hypertrophic":[174,271],"markers":[175],"remained":[176],"unchanged.":[177],"Pathway":[178],"analysis":[179],"suggested":[180],"PI3K":[182],"activity.":[183],"phosphorylation":[187],"Akt,":[189],"ERK,":[190],"S6K1,":[191],"ribosomal":[193],"S6":[195,214],"without":[196,267],"altering":[197],"4EBP1":[198],"phosphorylation,":[199,215],"preferential":[201],"activation":[202],"mTOR-S6K1-S6":[205,241],"branch.":[206],"Pharmacological":[207],"studies":[208],"showed":[209],"pan-PI3K":[211],"inhibition":[212],"abolished":[213],"whereas":[216],"MEK":[217],"blockade":[218],"did":[219,229],"not":[220,230],"affect":[221,231],"it;":[222],"pertussis":[223],"toxin":[224],"PI3K\u03b3-selective":[226],"inhibitors":[227],"also":[228],"S6,":[232],"G":[235],"i/o":[236],"-independent":[237],"PI3K/Akt":[238],"driving":[240],"activation.":[242],"Collectively,":[243],"these":[244],"data":[245],"identify":[246],"sarcomere-associated":[248],"pool":[249],"engages":[253],"PI3K-Akt-mTOR-S6K1-S6":[254],"enhance":[257],"programs":[259],"biogenesis":[263],"activating":[268],"canonical":[270],"program.":[273],"These":[274],"findings":[275],"reveal":[276],"mechanistic":[278],"growth.":[284]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-03-25T00:00:00"}
