{"id":"https://openalex.org/W7140190367","doi":"https://doi.org/10.21203/rs.3.rs-8097564/v1","title":"Delivering cytokine mRNA to secondary lymphoid organs for robust cancer immunotherapy","display_name":"Delivering cytokine mRNA to secondary lymphoid organs for robust cancer immunotherapy","publication_year":2026,"publication_date":"2026-03-25","ids":{"openalex":"https://openalex.org/W7140190367","doi":"https://doi.org/10.21203/rs.3.rs-8097564/v1","pmid":"https://pubmed.ncbi.nlm.nih.gov/41928788","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13042184"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-8097564/v1","doi":"https://doi.org/10.21203/rs.3.rs-8097564/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-8097564/v1","pdf_url":"https://www.researchsquare.com/article/rs-8097564/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-8097564/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053775273","display_name":"Willem J. M. Mulder","orcid":"https://orcid.org/0000-0001-8665-3878","observed_orcids":["https://orcid.org/0000-0001-8665-3878"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Willem Mulder","raw_affiliation_strings":["Radboud University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radboud University Medical Center","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065137320","display_name":"Tom Anbergen","orcid":"https://orcid.org/0000-0002-7155-7709","observed_orcids":["https://orcid.org/0000-0002-7155-7709"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Tom Anbergen","raw_affiliation_strings":["Radboud University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radboud University Medical Center","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067445802","display_name":"Yuri van Elsas","orcid":"https://orcid.org/0009-0002-2985-3368","observed_orcids":["https://orcid.org/0009-0002-2985-3368"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Yuri van Elsas","raw_affiliation_strings":["Radboud University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radboud University Medical Center","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077174032","display_name":"Stijn R. J. Hofstraat","orcid":"https://orcid.org/0000-0003-2120-5171","observed_orcids":["https://orcid.org/0000-0003-2120-5171"]},"institutions":[{"id":"https://openalex.org/I83019370","display_name":"Eindhoven University of Technology","ror":"https://ror.org/02c2kyt77","country_code":"NL","type":"education","lineage":["https://openalex.org/I83019370"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Stijn Hofstraat","raw_affiliation_strings":["Eindhoven University of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eindhoven University of Technology","institution_ids":["https://openalex.org/I83019370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102747095","display_name":"M. Hendrikx","orcid":"https://orcid.org/0009-0000-3553-5927","observed_orcids":["https://orcid.org/0009-0000-3553-5927"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Merel Hendrikx","raw_affiliation_strings":["BioTrip B.V"],"raw_orcid":"https://orcid.org/0009-0000-3553-5927","affiliations":[{"raw_affiliation_string":"BioTrip B.V","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000520065","display_name":"Jeroen Deckers","orcid":"https://orcid.org/0000-0003-2723-8660","observed_orcids":["https://orcid.org/0000-0003-2723-8660"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jeroen Deckers","raw_affiliation_strings":["Radboud University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radboud University Medical Center","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113031894","display_name":"Iris Versteeg","orcid":"https://orcid.org/0009-0005-7700-0775","observed_orcids":["https://orcid.org/0009-0005-7700-0775"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Iris Versteeg","raw_affiliation_strings":["Radboud University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radboud University Medical Center","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146615926","display_name":"Gijs Ros","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Gijs Ros","raw_affiliation_strings":["Radboud University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radboud University Medical Center","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146838857","display_name":"Myrthe Kapteijns","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83019370","display_name":"Eindhoven University of Technology","ror":"https://ror.org/02c2kyt77","country_code":"NL","type":"education","lineage":["https://openalex.org/I83019370"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Myrthe Kapteijns","raw_affiliation_strings":["Eindhoven University of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eindhoven University of Technology","institution_ids":["https://openalex.org/I83019370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116135504","display_name":"Branca M. Bartelet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Branca Bartelet","raw_affiliation_strings":["Radboud University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radboud University Medical Center","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088409466","display_name":"Robby C. Zwolsman","orcid":"https://orcid.org/0000-0001-6059-2982","observed_orcids":["https://orcid.org/0000-0001-6059-2982"]},"institutions":[{"id":"https://openalex.org/I83019370","display_name":"Eindhoven University of Technology","ror":"https://ror.org/02c2kyt77","country_code":"NL","type":"education","lineage":["https://openalex.org/I83019370"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Robby Zwolsman","raw_affiliation_strings":["Eindhoven University of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eindhoven University of Technology","institution_ids":["https://openalex.org/I83019370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030960660","display_name":"Mirre M. Trines","orcid":"https://orcid.org/0009-0003-6474-1959","observed_orcids":["https://orcid.org/0009-0003-6474-1959"]},"institutions":[{"id":"https://openalex.org/I83019370","display_name":"Eindhoven University of Technology","ror":"https://ror.org/02c2kyt77","country_code":"NL","type":"education","lineage":["https://openalex.org/I83019370"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Mirre Trines","raw_affiliation_strings":["Eindhoven University of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eindhoven University of Technology","institution_ids":["https://openalex.org/I83019370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093703140","display_name":"Daniek Hoorn","orcid":"https://orcid.org/0009-0006-5274-883X","observed_orcids":["https://orcid.org/0009-0006-5274-883X"]},"institutions":[{"id":"https://openalex.org/I83019370","display_name":"Eindhoven University of Technology","ror":"https://ror.org/02c2kyt77","country_code":"NL","type":"education","lineage":["https://openalex.org/I83019370"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Daniek Hoorn","raw_affiliation_strings":["Eindhoven University of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eindhoven University of Technology","institution_ids":["https://openalex.org/I83019370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146920731","display_name":"Scott Bex","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Scott Bex","raw_affiliation_strings":["Radboud University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radboud University Medical Center","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050504219","display_name":"Pepijn van Houten","orcid":"https://orcid.org/0000-0002-8503-4140","observed_orcids":["https://orcid.org/0000-0002-8503-4140"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Pepijn van Houten","raw_affiliation_strings":["Radboud University Medical Center"],"raw_orcid":"https://orcid.org/0000-0002-8503-4140","affiliations":[{"raw_affiliation_string":"Radboud University Medical Center","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110662335","display_name":"Athanasios Ziogas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Athanasios Ziogas","raw_affiliation_strings":["Radboud University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radboud University Medical Center","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118955444","display_name":"Cristina Grao-Rold\u00e1n","orcid":"https://orcid.org/0009-0000-4174-8531","observed_orcids":["https://orcid.org/0009-0000-4174-8531"]},"institutions":[{"id":"https://openalex.org/I2809107791","display_name":"Spanish National Centre for Cardiovascular Research","ror":"https://ror.org/02qs1a797","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I2809107791","https://openalex.org/I4387152914"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cristina Grao-Rold\u00e1n","raw_affiliation_strings":["Centro Nacional de Investigaciones Cardiovasculares (CNIC)"],"raw_orcid":"https://orcid.org/0009-0000-4174-8531","affiliations":[{"raw_affiliation_string":"Centro Nacional de Investigaciones Cardiovasculares (CNIC)","institution_ids":["https://openalex.org/I2809107791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146683372","display_name":"Giulia Davighi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giulia Davighi","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146616393","display_name":"William Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Wang","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025782931","display_name":"Georgios M. Soultanidis","orcid":"https://orcid.org/0000-0001-9620-1728","observed_orcids":["https://orcid.org/0000-0001-9620-1728"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Georgios Soultanidis","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047403830","display_name":"Ali Salehi Farid","orcid":"https://orcid.org/0000-0003-3135-1076","observed_orcids":["https://orcid.org/0000-0003-3135-1076"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ali Salehi Farid","raw_affiliation_strings":["Dana-Farber Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5145369401","display_name":"Yoon Ho Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoon Ho Lee","raw_affiliation_strings":["Dana-Farber Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092135809","display_name":"N. Voeten","orcid":"https://orcid.org/0000-0003-0771-966X","observed_orcids":["https://orcid.org/0000-0003-0771-966X"]},"institutions":[{"id":"https://openalex.org/I83019370","display_name":"Eindhoven University of Technology","ror":"https://ror.org/02c2kyt77","country_code":"NL","type":"education","lineage":["https://openalex.org/I83019370"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Noortje Voeten","raw_affiliation_strings":["Eindhoven University of Technology"],"raw_orcid":"https://orcid.org/0000-0003-0771-966X","affiliations":[{"raw_affiliation_string":"Eindhoven University of Technology","institution_ids":["https://openalex.org/I83019370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038438236","display_name":"Jurgen M.J. Piek","orcid":"https://orcid.org/0000-0002-0487-0631","observed_orcids":["https://orcid.org/0000-0002-0487-0631"]},"institutions":[{"id":"https://openalex.org/I2801238018","display_name":"Catharina Ziekenhuis","ror":"https://ror.org/01qavk531","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801238018"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jurgen Piek","raw_affiliation_strings":["Catharina Hospital"],"raw_orcid":"https://orcid.org/0000-0002-0487-0631","affiliations":[{"raw_affiliation_string":"Catharina Hospital","institution_ids":["https://openalex.org/I2801238018"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036420006","display_name":"Gerben FRANSSEN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Gerben Franssen","raw_affiliation_strings":["Radboud University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radboud University Medical Center","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049757541","display_name":"Sandra Heskamp","orcid":"https://orcid.org/0000-0001-7250-0846","observed_orcids":["https://orcid.org/0000-0001-7250-0846"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sandra Heskamp","raw_affiliation_strings":["Radboud University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radboud University Medical Center","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080214970","display_name":"Henk M. Janssen","orcid":"https://orcid.org/0000-0002-2588-846X","observed_orcids":["https://orcid.org/0000-0002-2588-846X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Henk Janssen","raw_affiliation_strings":["SyMO-Chem B.V"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SyMO-Chem B.V","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058069287","display_name":"Michel Fransen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michel Fransen","raw_affiliation_strings":["SyMO-Chem B.V"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SyMO-Chem B.V","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037995049","display_name":"Mireille Langouo Fontsa","orcid":"https://orcid.org/0000-0002-0504-7671","observed_orcids":["https://orcid.org/0000-0002-0504-7671"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Mireille Langouo-Fontsa","raw_affiliation_strings":["Universit\u00e9 Libre de Bruxelles"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Libre de Bruxelles","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085258466","display_name":"Andrea Garavello","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Andrea Garavello","raw_affiliation_strings":["Universit\u00e9 Libre de Bruxelles"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Libre de Bruxelles","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061315439","display_name":"Panagiotis Karras","orcid":"https://orcid.org/0000-0002-7642-0875","observed_orcids":["https://orcid.org/0000-0002-7642-0875"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Panagiotis Karras","raw_affiliation_strings":["Universite Libre de Bruxelles (ULB)"],"raw_orcid":"https://orcid.org/0000-0002-7642-0875","affiliations":[{"raw_affiliation_string":"Universite Libre de Bruxelles (ULB)","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133254891","display_name":"Romana Netea-Maier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Romana Netea-Maier","raw_affiliation_strings":["Radboud University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radboud University Medical Center","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017795588","display_name":"Carlos P\u00e9rez\u2010Medina","orcid":"https://orcid.org/0000-0002-6011-0629","observed_orcids":["https://orcid.org/0000-0002-6011-0629"]},"institutions":[{"id":"https://openalex.org/I2809107791","display_name":"Spanish National Centre for Cardiovascular Research","ror":"https://ror.org/02qs1a797","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I2809107791","https://openalex.org/I4387152914"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carlos P\u00e9rez-Medina","raw_affiliation_strings":["Centro Nacional de Investigaciones Cardiovasculares (CNIC)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Nacional de Investigaciones Cardiovasculares (CNIC)","institution_ids":["https://openalex.org/I2809107791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089434484","display_name":"Zahi Adel Fayad","orcid":"https://orcid.org/0000-0002-3439-7347","observed_orcids":["https://orcid.org/0000-0002-3439-7347"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zahi Fayad","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai"],"raw_orcid":"https://orcid.org/0000-0002-3439-7347","affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035597774","display_name":"Mandy M. T. van Leent","orcid":"https://orcid.org/0000-0002-9747-1022","observed_orcids":["https://orcid.org/0000-0002-9747-1022"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mandy van Leent","raw_affiliation_strings":["Icahn School of Medicine"],"raw_orcid":"https://orcid.org/0000-0002-9747-1022","affiliations":[{"raw_affiliation_string":"Icahn School of Medicine","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143865894","display_name":"Abraham Teunissen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abraham Teunissen","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077522096","display_name":"Mohammad Rashidian","orcid":"https://orcid.org/0000-0002-3708-0038","observed_orcids":["https://orcid.org/0000-0002-3708-0038"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammad Rashidian","raw_affiliation_strings":["Dana-Farber Cancer Institute"],"raw_orcid":"https://orcid.org/0000-0002-3708-0038","affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056661367","display_name":"Ewelina Kluza","orcid":"https://orcid.org/0000-0002-7040-0427","observed_orcids":["https://orcid.org/0000-0002-7040-0427"]},"institutions":[{"id":"https://openalex.org/I83019370","display_name":"Eindhoven University of Technology","ror":"https://ror.org/02c2kyt77","country_code":"NL","type":"education","lineage":["https://openalex.org/I83019370"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ewelina Kluza","raw_affiliation_strings":["Eindhoven University of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eindhoven University of Technology","institution_ids":["https://openalex.org/I83019370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110943405","display_name":"Yohana C. Toner","orcid":"https://orcid.org/0000-0001-5309-6366","observed_orcids":["https://orcid.org/0000-0001-5309-6366"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Yohana C. Toner","raw_affiliation_strings":["Radboud University Medical Center"],"raw_orcid":"https://orcid.org/0000-0001-5309-6366","affiliations":[{"raw_affiliation_string":"Radboud University Medical Center","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081033744","display_name":"Bram Priem","orcid":"https://orcid.org/0009-0002-6793-816X","observed_orcids":["https://orcid.org/0009-0002-6793-816X"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Bram Priem","raw_affiliation_strings":["Radboud University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radboud University Medical Center","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108491072","display_name":"Joost H. C. M. Kreijtz","orcid":"https://orcid.org/0000-0003-4180-7567","observed_orcids":["https://orcid.org/0000-0003-4180-7567"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joost Kreijtz","raw_affiliation_strings":["BioTrip B.V"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioTrip B.V","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000735204","display_name":"Thijs J. Beldman","orcid":"https://orcid.org/0000-0003-4742-636X","observed_orcids":["https://orcid.org/0000-0003-4742-636X"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Thijs Beldman","raw_affiliation_strings":["Radboud University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radboud University Medical Center","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027955775","display_name":"Mihai Gheorghe Netea","orcid":"https://orcid.org/0000-0003-2421-6052","observed_orcids":["https://orcid.org/0000-0003-2421-6052"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Mihai Netea","raw_affiliation_strings":["Radboud University Nijmegen Medical Centre"],"raw_orcid":"https://orcid.org/0000-0003-2421-6052","affiliations":[{"raw_affiliation_string":"Radboud University Nijmegen Medical Centre","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061977961","display_name":"Roy van der Meel","orcid":"https://orcid.org/0000-0002-2200-7946","observed_orcids":["https://orcid.org/0000-0002-2200-7946"]},"institutions":[{"id":"https://openalex.org/I83019370","display_name":"Eindhoven University of Technology","ror":"https://ror.org/02c2kyt77","country_code":"NL","type":"education","lineage":["https://openalex.org/I83019370"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Roy van der Meel","raw_affiliation_strings":["Eindhoven University of Technology"],"raw_orcid":"https://orcid.org/0000-0002-2200-7946","affiliations":[{"raw_affiliation_string":"Eindhoven University of Technology","institution_ids":["https://openalex.org/I83019370"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5053775273","https://openalex.org/A5061977961"],"corresponding_institution_ids":["https://openalex.org/I2802934949","https://openalex.org/I83019370"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.050200000405311584,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.012600000016391277,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mrna-delivery","display_name":"mRNA delivery","score":0.46700000762939453},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cytokine-therapy","display_name":"cytokine therapy","score":0.7979999780654907},{"id":"https://openalex.org/keywords/secondary-lymphoid-organs","display_name":"secondary lymphoid organs","score":0.9259999990463257},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.7820000052452087},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.7269999980926514},{"id":"https://openalex.org/keywords/b16f10-melanoma","display_name":"B16F10 melanoma","score":0.9179999828338623},{"id":"https://openalex.org/keywords/mc38-colon-cancer","display_name":"MC38 colon cancer","score":0.9559999704360962},{"id":"https://openalex.org/keywords/positron-emission-tomography","display_name":"positron emission tomography","score":0.7929999828338623},{"id":"https://openalex.org/keywords/nonhuman-primates","display_name":"non-human primates","score":0.8450000286102295},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.625},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.640999972820282},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.8076000213623047},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6754999756813049},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6492999792098999},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6412000060081482},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.5658000111579895},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5468000173568726},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5030999779701233},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.4643000066280365},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4336000084877014},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.4323999881744385},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.4041000008583069},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.35199999809265137},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3305000066757202},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.2994000017642975},{"id":"https://openalex.org/C29331040","wikidata":"https://www.wikidata.org/wiki/Q7239554","display_name":"Preclinical imaging","level":3,"score":0.27570000290870667},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2646999955177307},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.25429999828338623},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.2533999979496002}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.21203/rs.3.rs-8097564/v1","doi":"https://doi.org/10.21203/rs.3.rs-8097564/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-8097564/v1","pdf_url":"https://www.researchsquare.com/article/rs-8097564/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13042184","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13042184/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13042184/pdf/nihpp-rs8097564v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Res Sq","raw_type":"Text"},{"id":"pmid:41928788","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41928788","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research square","raw_type":"Journal Article"},{"id":"pmh:oai:pure.tue.nl:openaire/a80bfa84-010e-42df-a18b-0070728e6d13","doi":null,"is_oa":true,"landing_page_url":"https://research.tue.nl/en/publications/a80bfa84-010e-42df-a18b-0070728e6d13","pdf_url":null,"source":{"id":"https://openalex.org/S4406922641","display_name":"TU/e Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"+25 authors, Hofstraat, S R J, Kapteijns, M H A P, Zwolsman, R, Trines, M M, Hoorn, D, Voeten, N, Kluza, E & van der Meel, R 2026 'Delivering cytokine mRNA to secondary lymphoid organs for robust cancer immunotherapy' Research Square. https://doi.org/10.21203/rs.3.rs-8097564/v1","raw_type":"info:eu-repo/semantics/preprint"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-8097564/v1","doi":"https://doi.org/10.21203/rs.3.rs-8097564/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-8097564/v1","pdf_url":"https://www.researchsquare.com/article/rs-8097564/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.44719770550727844,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000868449","display_name":"Stress-induced immune reprogramming in cardiovascular disease","funder_award_id":"P01HL131478","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7140190367.pdf","grobid_xml":"https://content.openalex.org/works/W7140190367.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4220663685","https://openalex.org/W4402200278","https://openalex.org/W7125636934","https://openalex.org/W4405040084","https://openalex.org/W4388076817","https://openalex.org/W4386241904","https://openalex.org/W3198902724","https://openalex.org/W7123343755","https://openalex.org/W4392902102","https://openalex.org/W2988214546"],"abstract_inverted_index":{"Abstract":[0],"Recombinant":[1],"cytokine":[2,29,123,141,152],"therapeutics,":[3],"among":[4],"the":[5,93],"earliest":[6],"clinical":[7,115],"immunotherapies,":[8],"have":[9],"yet":[10],"to":[11,37,48,57,88,143,150],"reach":[12],"their":[13],"full":[14],"potential":[15,113],"despite":[16],"bioengineering":[17],"advances.":[18],"Here,":[19],"we":[20,66],"propose":[21],"a":[22,68,147],"novel":[23],"approach":[24],"focusing":[25],"on":[26,132],"in":[27,34,59,85,92,102,125],"vivo":[28],"production":[30,91,124],"by":[31],"immune":[32,134],"cells":[33,135],"lymphoid":[35,61,144],"organs":[36,145],"mimic":[38],"these":[39],"proteins\u2019":[40],"physiological":[41],"function.":[42],"We":[43,110],"developed":[44],"apolipoprotein":[45],"nanoparticles":[46],"(aNPs)":[47],"deliver":[49],"mRNA":[50,76],"encoding":[51],"cytokines,":[52],"such":[53],"as":[54],"interleukin-2":[55],"(IL-2),":[56],"monocytes":[58],"secondary":[60],"tissues.":[62],"To":[63],"this":[64],"end,":[65],"engineered":[67],"scalable":[69],"manufacturing":[70],"process":[71],"that":[72],"yields":[73],"stable":[74],"aNP-":[75],"formulations":[77],"suitable":[78],"for":[79,154],"long-term":[80],"storage.":[81],"Intravenous":[82],"aNP-mRNA-IL-2":[83],"administration":[84],"mice":[86],"led":[87],"sustained":[89],"IL-2":[90],"spleen":[94],"and":[95,105,121,128,156,165],"lymph":[96],"nodes,":[97],"significantly":[98],"inhibiting":[99],"tumor":[100],"growth":[101],"B16F10":[103],"melanoma":[104],"MC38":[106],"colon":[107],"cancer":[108,137,155],"models.":[109],"confirmed":[111],"translational":[112],"through":[114],"positron":[116],"emission":[117],"tomography":[118],"(PET)":[119],"imaging":[120],"functional":[122],"non-human":[126],"primates,":[127],"validated":[129],"aNP-mRNA":[130],"efficacy":[131],"primary":[133],"from":[136],"patients.":[138],"This":[139],"mRNA-based":[140],"delivery":[142],"offers":[146],"promising":[148],"strategy":[149],"enhance":[151],"immunotherapy":[153],"potentially":[157],"other":[158],"immune-mediated":[159],"diseases,":[160],"including":[161],"autoimmunity,":[162],"cardiovascular":[163],"disease,":[164],"neurodegenerative":[166],"conditions.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-03-25T00:00:00"}