{"id":"https://openalex.org/W7140132983","doi":"https://doi.org/10.1016/j.labinv.2025.105234","title":"944 Increased Combined Density of CD8+ T cells and CD68+ Macrophages Co-Localizing LAG3 or PD-L1 is Associated with Recurrence in Ovarian Clear Cell Carcinoma: A Multiplex Immunofluorescence (mIF) and AI Based Digital Image Analysis Study","display_name":"944 Increased Combined Density of CD8+ T cells and CD68+ Macrophages Co-Localizing LAG3 or PD-L1 is Associated with Recurrence in Ovarian Clear Cell Carcinoma: A Multiplex Immunofluorescence (mIF) and AI Based Digital Image Analysis Study","publication_year":2026,"publication_date":"2026-03-01","ids":{"openalex":"https://openalex.org/W7140132983","doi":"https://doi.org/10.1016/j.labinv.2025.105234"},"language":"en","primary_location":{"id":"doi:10.1016/j.labinv.2025.105234","doi":"https://doi.org/10.1016/j.labinv.2025.105234","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.labinv.2025.105234","pdf_url":null,"source":{"id":"https://openalex.org/S137146891","display_name":"Laboratory Investigation","issn_l":"0023-6837","issn":["0023-6837","1530-0307"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5138822502","display_name":"Sai Tun Hein Aung","orcid":"https://orcid.org/0009-0002-3178-1877","observed_orcids":["https://orcid.org/0009-0002-3178-1877"]},"institutions":[{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sai Tun Hein Aung","raw_affiliation_strings":["Rutgers New Jersey Medical School, Newark, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rutgers New Jersey Medical School, Newark, NJ","institution_ids":["https://openalex.org/I4402554120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068456606","display_name":"Valeria Mezzano","orcid":"https://orcid.org/0000-0003-4675-9146","observed_orcids":["https://orcid.org/0000-0003-4675-9146"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valeria Mezzano","raw_affiliation_strings":["NYU School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NYU School of Medicine, New York, NY","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043455810","display_name":"Cynthia A. Loomis","orcid":"https://orcid.org/0000-0001-8668-1270","observed_orcids":["https://orcid.org/0000-0001-8668-1270"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cynthia Loomis","raw_affiliation_strings":["NYU School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NYU School of Medicine, New York, NY","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017906707","display_name":"Pratibha Sharma Shukla","orcid":"https://orcid.org/0000-0001-5605-5885","observed_orcids":["https://orcid.org/0000-0001-5605-5885"]},"institutions":[{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pratibha Shukla","raw_affiliation_strings":["Rutgers New Jersey Medical School, Newark, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rutgers New Jersey Medical School, Newark, NJ","institution_ids":["https://openalex.org/I4402554120"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15556745,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"106","issue":"3","first_page":"105234","last_page":"105234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.09860000014305115,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-clear-cell-carcinoma","display_name":"ovarian clear cell carcinoma","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cd68-macrophages","display_name":"CD68+ macrophages","score":0.9710000157356262},{"id":"https://openalex.org/keywords/lag-3","display_name":"LAG-3","score":0.9800000190734863},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.6930000185966492},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.8529999852180481},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.8429999947547913},{"id":"https://openalex.org/keywords/colocalization","display_name":"colocalization","score":0.6790000200271606},{"id":"https://openalex.org/keywords/multiplex-immunofluorescence","display_name":"multiplex immunofluorescence","score":0.9039999842643738},{"id":"https://openalex.org/keywords/ai-based-image-analysis","display_name":"artificial intelligence image analysis","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.7547000050544739},{"id":"https://openalex.org/C2778236600","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Immunofluorescence","level":3,"score":0.5332000255584717},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48159998655319214},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.42480000853538513},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4101000130176544},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3619999885559082},{"id":"https://openalex.org/C2984894117","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Indirect immunofluorescence","level":3,"score":0.33379998803138733},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32600000500679016},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32019999623298645},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2883000075817108},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25609999895095825}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.labinv.2025.105234","doi":"https://doi.org/10.1016/j.labinv.2025.105234","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.labinv.2025.105234","pdf_url":null,"source":{"id":"https://openalex.org/S137146891","display_name":"Laboratory Investigation","issn_l":"0023-6837","issn":["0023-6837","1530-0307"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory Investigation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2997388224","https://openalex.org/W7046095424","https://openalex.org/W4224230572","https://openalex.org/W2776372829","https://openalex.org/W3164890381","https://openalex.org/W4407263698","https://openalex.org/W2061227063","https://openalex.org/W4388042253","https://openalex.org/W3177942607","https://openalex.org/W4392376481"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2026-03-24T00:00:00"}
