{"id":"https://openalex.org/W7140107032","doi":"https://doi.org/10.1016/j.labinv.2025.105138","title":"850 The \u201cFemale\u201d Pattern of X-Chromosome Inactivation Evidenced by H3K27me3 Dotlike Nuclear Staining Is Observed in Testicular Germ Cell Tumors","display_name":"850 The \u201cFemale\u201d Pattern of X-Chromosome Inactivation Evidenced by H3K27me3 Dotlike Nuclear Staining Is Observed in Testicular Germ Cell Tumors","publication_year":2026,"publication_date":"2026-03-01","ids":{"openalex":"https://openalex.org/W7140107032","doi":"https://doi.org/10.1016/j.labinv.2025.105138"},"language":"en","primary_location":{"id":"doi:10.1016/j.labinv.2025.105138","doi":"https://doi.org/10.1016/j.labinv.2025.105138","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.labinv.2025.105138","pdf_url":"https://www.laboratoryinvestigation.org/article/S0023-6837(25)01049-9/pdf","source":{"id":"https://openalex.org/S137146891","display_name":"Laboratory Investigation","issn_l":"0023-6837","issn":["0023-6837","1530-0307"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.laboratoryinvestigation.org/article/S0023-6837(25)01049-9/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035582011","display_name":"Agnese Orsatti","orcid":"https://orcid.org/0009-0005-8560-1925","observed_orcids":["https://orcid.org/0009-0005-8560-1925"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Agnese Orsatti","raw_affiliation_strings":["S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117776308","display_name":"Fernanda Fernandes\u2010Pontes","orcid":"https://orcid.org/0009-0007-3931-0443","observed_orcids":["https://orcid.org/0009-0007-3931-0443"]},"institutions":[{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Fernanda Fernandes-Pontes","raw_affiliation_strings":["IPO Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IPO Porto, Porto, Portugal","institution_ids":["https://openalex.org/I4210111164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068191549","display_name":"Nuno Tiago Tavares","orcid":"https://orcid.org/0000-0001-8426-1838","observed_orcids":["https://orcid.org/0000-0001-8426-1838"]},"institutions":[{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Nuno Tavares","raw_affiliation_strings":["IPO Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IPO Porto, Porto, Portugal","institution_ids":["https://openalex.org/I4210111164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119502227","display_name":"Bruno Oliveira\u2010Lopes","orcid":"https://orcid.org/0000-0001-5972-8096","observed_orcids":["https://orcid.org/0000-0001-5972-8096"]},"institutions":[{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Bruno Oliveira-Lopes","raw_affiliation_strings":["IPO Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IPO Porto, Porto, Portugal","institution_ids":["https://openalex.org/I4210111164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114184906","display_name":"Rita Guimar\u00e3es","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Rita Guimar\u00e3es","raw_affiliation_strings":["IPO Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IPO Porto, Porto, Portugal","institution_ids":["https://openalex.org/I4210111164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042199157","display_name":"C\u00e1rmen Jer\u00f3nimo","orcid":"https://orcid.org/0000-0003-4186-5345","observed_orcids":["https://orcid.org/0000-0003-4186-5345"]},"institutions":[{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Carmen Jeronimo","raw_affiliation_strings":["Instituto Portugu\u00eas de Oncologia do Porto FG, EPE, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Portugu\u00eas de Oncologia do Porto FG, EPE, Porto, Portugal","institution_ids":["https://openalex.org/I4210111164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057879270","display_name":"Rui Henrique","orcid":"https://orcid.org/0000-0003-3171-4666","observed_orcids":["https://orcid.org/0000-0003-3171-4666"]},"institutions":[{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Rui Henrique","raw_affiliation_strings":["Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil, Porto, Portugal","institution_ids":["https://openalex.org/I4210111164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085931728","display_name":"Giovanni Tallini","orcid":"https://orcid.org/0000-0003-0113-6682","observed_orcids":["https://orcid.org/0000-0003-0113-6682"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Tallini","raw_affiliation_strings":["University of Bologna Medical Center, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bologna Medical Center, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011935671","display_name":"Michelangelo Fiorentino","orcid":"https://orcid.org/0000-0002-1749-150X","observed_orcids":["https://orcid.org/0000-0002-1749-150X"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michelangelo Fiorentino","raw_affiliation_strings":["Alma Mater Studiorum-University of Bologna, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alma Mater Studiorum-University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026150237","display_name":"Costantino Ricci","orcid":"https://orcid.org/0000-0001-7254-4195","observed_orcids":["https://orcid.org/0000-0001-7254-4195"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Costantino Ricci","raw_affiliation_strings":["S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087200653","display_name":"Jo\u00e3o Lobo","orcid":"https://orcid.org/0000-0001-6829-1391","observed_orcids":["https://orcid.org/0000-0001-6829-1391"]},"institutions":[{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o Lobo","raw_affiliation_strings":["Portuguese Oncology Institute - Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Portuguese Oncology Institute - Porto, Porto, Portugal","institution_ids":["https://openalex.org/I4210111164"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"106","issue":"3","first_page":"105138","last_page":"105138"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.3474000096321106,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.3474000096321106,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.26339998841285706,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11069","display_name":"Testicular diseases and treatments","score":0.1632000058889389,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/x-chromosome-inactivation","display_name":"X chromosome inactivation","score":0.9829999804496765},{"id":"https://openalex.org/keywords/h3k27me3","display_name":"H3K27me3","score":0.9789999723434448},{"id":"https://openalex.org/keywords/testicular-germ-cell-tumors","display_name":"testicular germ cell tumors","score":0.9150000214576721},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.7170000076293945},{"id":"https://openalex.org/keywords/sex-chromosome-inactivation","display_name":"sex chromosome inactivation","score":0.36899998784065247}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7656999826431274},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.5049999952316284},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4918999969959259},{"id":"https://openalex.org/C2780258238","wikidata":"https://www.wikidata.org/wiki/Q2520842","display_name":"Germ","level":2,"score":0.4855000078678131},{"id":"https://openalex.org/C2776938808","wikidata":"https://www.wikidata.org/wiki/Q1737977","display_name":"Germ cell tumors","level":3,"score":0.4627000093460083},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.40939998626708984},{"id":"https://openalex.org/C2779122487","wikidata":"https://www.wikidata.org/wiki/Q281579","display_name":"Germ cell","level":3,"score":0.36390000581741333},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3400000035762787},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.33559998869895935},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3160000145435333},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.28600001335144043},{"id":"https://openalex.org/C2776057878","wikidata":"https://www.wikidata.org/wiki/Q200741","display_name":"Teratoma","level":2,"score":0.25690001249313354}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.labinv.2025.105138","doi":"https://doi.org/10.1016/j.labinv.2025.105138","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.labinv.2025.105138","pdf_url":"https://www.laboratoryinvestigation.org/article/S0023-6837(25)01049-9/pdf","source":{"id":"https://openalex.org/S137146891","display_name":"Laboratory Investigation","issn_l":"0023-6837","issn":["0023-6837","1530-0307"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory Investigation","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.labinv.2025.105138","doi":"https://doi.org/10.1016/j.labinv.2025.105138","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.labinv.2025.105138","pdf_url":"https://www.laboratoryinvestigation.org/article/S0023-6837(25)01049-9/pdf","source":{"id":"https://openalex.org/S137146891","display_name":"Laboratory Investigation","issn_l":"0023-6837","issn":["0023-6837","1530-0307"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7140107032.pdf","grobid_xml":"https://content.openalex.org/works/W7140107032.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4401824908","https://openalex.org/W192655000","https://openalex.org/W2307754398","https://openalex.org/W2419228593","https://openalex.org/W2406367141","https://openalex.org/W2074101479","https://openalex.org/W2411732004","https://openalex.org/W2407974783","https://openalex.org/W2974334552","https://openalex.org/W4244231522"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2026-03-24T00:00:00"}
