{"id":"https://openalex.org/W7136406174","doi":"https://doi.org/10.1177/14703203261434412","title":"Association between seizure, epilepsy and the angiotensin receptor blocker therapy in patients after acute stroke","display_name":"Association between seizure, epilepsy and the angiotensin receptor blocker therapy in patients after acute stroke","publication_year":2026,"publication_date":"2026-03-01","ids":{"openalex":"https://openalex.org/W7136406174","doi":"https://doi.org/10.1177/14703203261434412"},"language":"en","primary_location":{"id":"doi:10.1177/14703203261434412","doi":"https://doi.org/10.1177/14703203261434412","is_oa":false,"landing_page_url":"https://doi.org/10.1177/14703203261434412","pdf_url":null,"source":{"id":"https://openalex.org/S107472416","display_name":"Journal of the Renin-Angiotensin-Aldosterone System","issn_l":"1470-3203","issn":["1470-3203","1752-8976"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Renin-Angiotensin-Aldosterone System","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Zoltan Kiss","orcid":"https://orcid.org/0009-0000-5336-6135","observed_orcids":["https://orcid.org/0009-0000-5336-6135"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Zoltan Kiss","raw_affiliation_strings":["South-buda Central Hospital, Szent Imre Teaching Hospital, Department of Neurology and Stroke, Budapest, Hungary"],"raw_orcid":"https://orcid.org/0009-0000-5336-6135","affiliations":[{"raw_affiliation_string":"South-buda Central Hospital, Szent Imre Teaching Hospital, Department of Neurology and Stroke, Budapest, Hungary","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129435257","display_name":"Bence Fulop","orcid":"https://orcid.org/0009-0009-7409-5931","observed_orcids":["https://orcid.org/0009-0009-7409-5931"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bence Fulop","raw_affiliation_strings":["South-buda Central Hospital, Szent Imre Teaching Hospital, Department of Neurology and Stroke, Budapest, Hungary"],"raw_orcid":"https://orcid.org/0009-0009-7409-5931","affiliations":[{"raw_affiliation_string":"South-buda Central Hospital, Szent Imre Teaching Hospital, Department of Neurology and Stroke, Budapest, Hungary","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116162776","display_name":"Zsuzsa Hermann","orcid":"https://orcid.org/0009-0007-2510-8180","observed_orcids":["https://orcid.org/0009-0007-2510-8180"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zsuzsa Hermann","raw_affiliation_strings":["South-buda Central Hospital, Szent Imre Teaching Hospital, Department of Neurology and Stroke, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"South-buda Central Hospital, Szent Imre Teaching Hospital, Department of Neurology and Stroke, Budapest, Hungary","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059601687","display_name":"Benjamin Jassoy","orcid":"https://orcid.org/0009-0002-2153-3159","observed_orcids":["https://orcid.org/0009-0002-2153-3159"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benjamin Jassoy","raw_affiliation_strings":["South-buda Central Hospital, Szent Imre Teaching Hospital, Department of Neurology and Stroke, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"South-buda Central Hospital, Szent Imre Teaching Hospital, Department of Neurology and Stroke, Budapest, Hungary","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093523688","display_name":"Alexandra Koszta","orcid":"https://orcid.org/0009-0006-5789-932X","observed_orcids":["https://orcid.org/0009-0006-5789-932X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandra Koszta","raw_affiliation_strings":["South-buda Central Hospital, Szent Imre Teaching Hospital, Department of Neurology and Stroke, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"South-buda Central Hospital, Szent Imre Teaching Hospital, Department of Neurology and Stroke, Budapest, Hungary","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116162777","display_name":"Katalin Kov\u00e1cs-Kusza","orcid":"https://orcid.org/0009-0007-1787-4168","observed_orcids":["https://orcid.org/0009-0007-1787-4168"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katalin Kovacs-Kusza","raw_affiliation_strings":["South-buda Central Hospital, Szent Imre Teaching Hospital, Department of Neurology and Stroke, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"South-buda Central Hospital, Szent Imre Teaching Hospital, Department of Neurology and Stroke, Budapest, Hungary","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129607472","display_name":"Kamilla Magyari-Zuberecz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kamilla Magyari-Zuberecz","raw_affiliation_strings":["South-buda Central Hospital, Szent Imre Teaching Hospital, Department of Neurology and Stroke, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"South-buda Central Hospital, Szent Imre Teaching Hospital, Department of Neurology and Stroke, Budapest, Hungary","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092018289","display_name":"Edit Pord\u00e1ny-Bagoly","orcid":"https://orcid.org/0009-0008-1417-098X","observed_orcids":["https://orcid.org/0009-0008-1417-098X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edit Pordany-Bagoly","raw_affiliation_strings":["South-buda Central Hospital, Szent Imre Teaching Hospital, Department of Neurology and Stroke, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"South-buda Central Hospital, Szent Imre Teaching Hospital, Department of Neurology and Stroke, Budapest, Hungary","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129573461","display_name":"Krisztina Rado","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krisztina Rado","raw_affiliation_strings":["South-buda Central Hospital, Szent Imre Teaching Hospital, Department of Neurology and Stroke, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"South-buda Central Hospital, Szent Imre Teaching Hospital, Department of Neurology and Stroke, Budapest, Hungary","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092018288","display_name":"G\u00e1bor Szegleti","orcid":"https://orcid.org/0009-0009-4337-7127","observed_orcids":["https://orcid.org/0009-0009-4337-7127"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabor Szegleti","raw_affiliation_strings":["South-buda Central Hospital, Szent Imre Teaching Hospital, Department of Neurology and Stroke, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"South-buda Central Hospital, Szent Imre Teaching Hospital, Department of Neurology and Stroke, Budapest, Hungary","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113526488","display_name":"Vince Varga","orcid":"https://orcid.org/0009-0003-3222-4674","observed_orcids":["https://orcid.org/0009-0003-3222-4674"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vince Varga","raw_affiliation_strings":["South-buda Central Hospital, Szent Imre Teaching Hospital, Department of Neurology and Stroke, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"South-buda Central Hospital, Szent Imre Teaching Hospital, Department of Neurology and Stroke, Budapest, Hungary","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065448827","display_name":"Zolt\u00e1n Szupera","orcid":"https://orcid.org/0009-0001-4697-2871","observed_orcids":["https://orcid.org/0009-0001-4697-2871"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zoltan Szupera","raw_affiliation_strings":["South-buda Central Hospital, Szent Imre Teaching Hospital, Department of Neurology and Stroke, Budapest, Hungary"],"raw_orcid":"https://orcid.org/0009-0001-4697-2871","affiliations":[{"raw_affiliation_string":"South-buda Central Hospital, Szent Imre Teaching Hospital, Department of Neurology and Stroke, Budapest, Hungary","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":3.0444,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.84363713,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"27","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13966","display_name":"Neurological and metabolic disorders","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.9869999885559082},{"id":"https://openalex.org/keywords/acute-stroke","display_name":"acute stroke","score":0.7910000085830688},{"id":"https://openalex.org/keywords/post-stroke-seizures","display_name":"post-stroke seizures","score":0.921999990940094},{"id":"https://openalex.org/keywords/post-stroke-epilepsy","display_name":"post-stroke epilepsy","score":0.9779999852180481},{"id":"https://openalex.org/keywords/acute-symptomatic-seizures","display_name":"acute symptomatic seizures","score":0.8769999742507935},{"id":"https://openalex.org/keywords/seizure-incidence","display_name":"seizure incidence","score":0.6790000200271606},{"id":"https://openalex.org/keywords/antihypertensive-therapy","display_name":"antihypertensive therapy","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.896399974822998},{"id":"https://openalex.org/C104849204","wikidata":"https://www.wikidata.org/wiki/Q24778533","display_name":"Angiotensin receptor","level":4,"score":0.7160000205039978},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.6902999877929688},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.6003000140190125},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5939000248908997},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5813999772071838},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5157999992370605},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.46480000019073486},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.4390000104904175},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.43320000171661377},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.40779998898506165},{"id":"https://openalex.org/C3020166492","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Acute stroke","level":3,"score":0.3772999942302704},{"id":"https://openalex.org/C2910553456","wikidata":"https://www.wikidata.org/wiki/Q285044","display_name":"Angiotensin Receptor Blockers","level":4,"score":0.364300012588501},{"id":"https://openalex.org/C2778742482","wikidata":"https://www.wikidata.org/wiki/Q816759","display_name":"Beta blocker","level":3,"score":0.3619999885559082},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.3167000114917755},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.3084000051021576},{"id":"https://openalex.org/C2780356492","wikidata":"https://www.wikidata.org/wiki/Q421700","display_name":"Calcium channel blocker","level":3,"score":0.2897999882698059},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.257099986076355}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1177/14703203261434412","doi":"https://doi.org/10.1177/14703203261434412","is_oa":false,"landing_page_url":"https://doi.org/10.1177/14703203261434412","pdf_url":null,"source":{"id":"https://openalex.org/S107472416","display_name":"Journal of the Renin-Angiotensin-Aldosterone System","issn_l":"1470-3203","issn":["1470-3203","1752-8976"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Renin-Angiotensin-Aldosterone System","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320330809","display_name":"Hungarian Society of Hypertension","ror":"https://ror.org/00b4mms22"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1746603715","https://openalex.org/W1866907517","https://openalex.org/W1899888746","https://openalex.org/W1902557062","https://openalex.org/W1967675399","https://openalex.org/W2002415449","https://openalex.org/W2016020917","https://openalex.org/W2063665693","https://openalex.org/W2074583516","https://openalex.org/W2083900220","https://openalex.org/W2096254843","https://openalex.org/W2109069036","https://openalex.org/W2124077349","https://openalex.org/W2144588257","https://openalex.org/W2803132200","https://openalex.org/W2911890416","https://openalex.org/W2921160324","https://openalex.org/W2943369412","https://openalex.org/W2968002412","https://openalex.org/W2984823486","https://openalex.org/W2987321562","https://openalex.org/W3037073111","https://openalex.org/W3213677880","https://openalex.org/W4214577212","https://openalex.org/W4284708928","https://openalex.org/W4303649523","https://openalex.org/W4306663567","https://openalex.org/W4306964319","https://openalex.org/W4307338781","https://openalex.org/W4307560921","https://openalex.org/W4385609187","https://openalex.org/W4389547268","https://openalex.org/W4392705696","https://openalex.org/W4393507463","https://openalex.org/W4397042209","https://openalex.org/W4399029900","https://openalex.org/W4399732268","https://openalex.org/W4399981643","https://openalex.org/W4400061531","https://openalex.org/W4401269267","https://openalex.org/W4401915816","https://openalex.org/W4405078499","https://openalex.org/W4407175337","https://openalex.org/W4413947900"],"related_works":["https://openalex.org/W4407175337","https://openalex.org/W4410587714","https://openalex.org/W7163074028","https://openalex.org/W2739982209","https://openalex.org/W4413947900","https://openalex.org/W7133127699","https://openalex.org/W4401915816","https://openalex.org/W4362505719","https://openalex.org/W7100950896","https://openalex.org/W1968326423"],"abstract_inverted_index":{"Introduction":[0],"To":[1],"further":[2],"clarify":[3],"the":[4,65,71,95,104,174],"association":[5],"between":[6,38],"angiotensin":[7,57,165,188],"receptor":[8,58,166,189],"blocker":[9,59,167,190],"therapy":[10,168,191],"and":[11,42,82,103,164,204],"post-stroke":[12,139,205],"seizures,":[13],"we":[14],"analysed":[15],"a":[16,170,196],"database":[17],"of":[18,67,75,90,123,199],"patients":[19,30,92,125],"with":[20,31,195],"acute":[21,32,132,201],"stroke.":[22],"Methods":[23],"This":[24],"single-centre,":[25],"retrospective":[26],"observational":[27],"study":[28],"included":[29],"stroke":[33],"admitted":[34],"to":[35],"our":[36,186],"hospital":[37],"1":[39],"January":[40],"2019":[41],"31":[43],"December":[44],"2023.":[45],"Patients":[46],"were":[47,78,93,106,154],"allocated":[48],"into":[49],"two":[50,72],"groups":[51,159],"based":[52],"on":[53,185],"whether":[54],"they":[55],"received":[56],"therapy.":[60],"The":[61,112,149],"primary":[62],"outcome":[63],"was":[64,98,116],"incidence":[66,153,198],"any":[68],"seizure":[69,76,152],"in":[70,80,151,173],"groups.":[73],"Predictors":[74],"occurrence":[77],"assessed":[79],"univariable":[81],"multivariable":[83,175],"logistic":[84,176],"regression":[85,177],"models.":[86],"Results":[87],"A":[88,121],"total":[89,122],"2589":[91],"enrolled;":[94],"mean":[96],"age":[97],"72":[99],"years":[100],"(SD":[101],"13.2),":[102],"majority":[105],"female":[107],"(n":[108,136,141,146],"=":[109,137,142,147],"1306,":[110],"50.4%).":[111],"median":[113],"follow-up":[114],"duration":[115],"18":[117],"months":[118],"(IQR":[119],"3\u201331).":[120],"243":[124],"experienced":[126],"at":[127],"least":[128],"one":[129],"seizure,":[130],"including":[131],"symptomatic":[133,202],"seizures":[134,203],"only":[135],"101),":[138],"epilepsy":[140],"92),":[143],"or":[144],"both":[145,200],"50).":[148],"differences":[150],"significant":[155,171],"across":[156],"all":[157],"three":[158],"(":[160,179],"P":[161,180],"<":[162,181],"0.05),":[163],"remained":[169],"factor":[172],"model":[178],"0.001).":[182],"Conclusions":[183],"Based":[184],"results,":[187],"is":[192],"independently":[193],"associated":[194],"lower":[197],"epilepsy.":[206]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-03-17T00:00:00"}
