{"id":"https://openalex.org/W7136124545","doi":"https://doi.org/10.1158/2767-9764.31761838","title":"Figure S1 from Oncogenic Mutant p53 Sensitizes Non\u2013Small Cell Lung Cancer Cells to Proteasome Inhibition via Oxidative Stress\u2013Dependent Induction of Mitochondrial Apoptosis","display_name":"Figure S1 from Oncogenic Mutant p53 Sensitizes Non\u2013Small Cell Lung Cancer Cells to Proteasome Inhibition via Oxidative Stress\u2013Dependent Induction of Mitochondrial Apoptosis","publication_year":2026,"publication_date":"2026-03-16","ids":{"openalex":"https://openalex.org/W7136124545","doi":"https://doi.org/10.1158/2767-9764.31761838"},"language":"en","primary_location":{"id":"doi:10.1158/2767-9764.31761838","doi":"https://doi.org/10.1158/2767-9764.31761838","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.31761838","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2767-9764.31761838","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007401608","display_name":"Kranthi Kumar Chougoni","orcid":"https://orcid.org/0000-0003-4102-8723","observed_orcids":["https://orcid.org/0000-0003-4102-8723"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kranthi Kumar Chougoni","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4102-8723","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027336976","display_name":"Victoria L. Neely","orcid":"https://orcid.org/0009-0004-8409-1823","observed_orcids":["https://orcid.org/0009-0004-8409-1823"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Victoria Neely","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-8409-1823","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109978292","display_name":"Boxiao Ding","orcid":"https://orcid.org/0009-0008-0050-9217","observed_orcids":["https://orcid.org/0009-0008-0050-9217"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Boxiao Ding","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-0050-9217","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035466597","display_name":"Eziafa Oduah","orcid":"https://orcid.org/0000-0001-8517-6360","observed_orcids":["https://orcid.org/0000-0001-8517-6360"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eziafa Oduah","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8517-6360","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111334251","display_name":"Vianna T. Lam","orcid":"https://orcid.org/0009-0002-9640-2321","observed_orcids":["https://orcid.org/0009-0002-9640-2321"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vianna T. Lam","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-9640-2321","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129590581","display_name":"Bin Hu","orcid":"https://orcid.org/0009-0001-1345-9764","observed_orcids":["https://orcid.org/0009-0001-1345-9764"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bin Hu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-1345-9764","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071844087","display_name":"Jennifer E. Koblinski","orcid":"https://orcid.org/0000-0002-7156-2030","observed_orcids":["https://orcid.org/0000-0002-7156-2030"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer E. Koblinski","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7156-2030","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112556304","display_name":"Bradford E. Windle","orcid":"https://orcid.org/0000-0001-9613-7084","observed_orcids":["https://orcid.org/0000-0001-9613-7084"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bradford E. Windle","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9613-7084","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103489441","display_name":"Swati Palit Deb","orcid":"https://orcid.org/0009-0001-4642-6424","observed_orcids":["https://orcid.org/0009-0001-4642-6424"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Swati Palit Deb","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-4642-6424","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006892532","display_name":"Sumitra Deb","orcid":"https://orcid.org/0009-0000-1008-3100","observed_orcids":["https://orcid.org/0009-0000-1008-3100"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sumitra Deb","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-1008-3100","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071469591","display_name":"Jorge J. Nieva","orcid":"https://orcid.org/0000-0003-1605-4719","observed_orcids":["https://orcid.org/0000-0003-1605-4719"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jorge J. Nieva","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1605-4719","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058228140","display_name":"Senthil K. Radhakrishnan","orcid":"https://orcid.org/0000-0002-5211-9498","observed_orcids":["https://orcid.org/0000-0002-5211-9498"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Senthil K. Radhakrishnan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5211-9498","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056911226","display_name":"Hisashi Harada","orcid":"https://orcid.org/0000-0001-5993-1289","observed_orcids":["https://orcid.org/0000-0001-5993-1289"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hisashi Harada","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5993-1289","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5011412916","display_name":"Steven R. Grossman","orcid":"https://orcid.org/0009-0003-4692-6925","observed_orcids":["https://orcid.org/0009-0003-4692-6925"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven R. Grossman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-4692-6925","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.8866999745368958,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.8866999745368958,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.06019999831914902,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.03759999945759773,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.6909999847412109},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9129999876022339},{"id":"https://openalex.org/keywords/proteasome-inhibition","display_name":"proteasome inhibition","score":0.9750000238418579},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mitochondrial-apoptosis","display_name":"mitochondrial apoptosis","score":0.8709999918937683},{"id":"https://openalex.org/keywords/drug-sensitivity","display_name":"drug sensitivity","score":0.35499998927116394}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7009999752044678},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6172000169754028},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5665000081062317},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4900999963283539},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4821999967098236},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.47099998593330383},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.4706000089645386},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41370001435279846},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3840999901294708},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.3619999885559082},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.3546999990940094},{"id":"https://openalex.org/C2778367456","wikidata":"https://www.wikidata.org/wiki/Q7251235","display_name":"Proteasome inhibitor","level":3,"score":0.34950000047683716},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.34540000557899475},{"id":"https://openalex.org/C3020296196","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative damage","level":3,"score":0.34540000557899475},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.33629998564720154},{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.335999995470047},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.30730000138282776},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.30239999294281006},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3003000020980835},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2996000051498413},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.29170000553131104},{"id":"https://openalex.org/C2776148510","wikidata":"https://www.wikidata.org/wiki/Q6468907","display_name":"Lactacystin","level":4,"score":0.273499995470047},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2727999985218048},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.2709999978542328}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2767-9764.31761838","doi":"https://doi.org/10.1158/2767-9764.31761838","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.31761838","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2767-9764.31761838","doi":"https://doi.org/10.1158/2767-9764.31761838","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.31761838","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4403432883","https://openalex.org/W4409127693","https://openalex.org/W7136632794","https://openalex.org/W4403433780","https://openalex.org/W4403433779","https://openalex.org/W4409127554","https://openalex.org/W4403433604","https://openalex.org/W4403433802","https://openalex.org/W4403433633","https://openalex.org/W4403432966"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-03-17T00:00:00"}