{"id":"https://openalex.org/W7135644142","doi":null,"title":"Mutual interaction between glucocorticoids and the circadian clock","display_name":"Mutual interaction between glucocorticoids and the circadian clock","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W7135644142"},"language":"cs","primary_location":{"id":"pmh:oai:invenio.nusl.cz:685377","doi":null,"is_oa":false,"landing_page_url":"http://www.nusl.cz/ntk/nusl-685377","pdf_url":null,"source":{"id":"https://openalex.org/S4306402266","display_name":"Digital Repository (National Repository of Grey Literature)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79620101","host_organization_name":"University of Arkansas for Medical Sciences","host_organization_lineage":["https://openalex.org/I79620101"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/bachelorThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5129299546","display_name":"Aneta Astrov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Astrov\u00e1, Aneta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5129299546"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":1.0},{"id":"https://openalex.org/keywords/circadian-clock","display_name":"circadian clock","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.9160000085830688},{"id":"https://openalex.org/keywords/diurnal-cycle","display_name":"diurnal cycle","score":0.6570000052452087},{"id":"https://openalex.org/keywords/glucocorticoid-secretion","display_name":"glucocorticoid secretion","score":0.7870000004768372},{"id":"https://openalex.org/keywords/peripheral-clocks","display_name":"peripheral clocks","score":0.5590000152587891},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.8629999756813049},{"id":"https://openalex.org/keywords/circadian-rhythm-disorders","display_name":"circadian rhythm disorders","score":0.7229999899864197},{"id":"https://openalex.org/keywords/metabolic-disorders","display_name":"metabolic disorders","score":0.9309999942779541},{"id":"https://openalex.org/keywords/neuropsychiatric-disorders","display_name":"neuropsychiatric disorders","score":0.9340000152587891}],"concepts":[{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.8485999703407288},{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.7314000129699707},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.656000018119812},{"id":"https://openalex.org/C130679736","wikidata":"https://www.wikidata.org/wiki/Q3454009","display_name":"Bacterial circadian rhythms","level":4,"score":0.6306999921798706},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6122999787330627},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5493999719619751},{"id":"https://openalex.org/C139992725","wikidata":"https://www.wikidata.org/wiki/Q5380656","display_name":"Entrainment (biomusicology)","level":3,"score":0.5080999732017517},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.445499986410141},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4397999942302704},{"id":"https://openalex.org/C201176492","wikidata":"https://www.wikidata.org/wiki/Q6546168","display_name":"Light effects on circadian rhythm","level":4,"score":0.3783000111579895},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3774000108242035},{"id":"https://openalex.org/C2780352252","wikidata":"https://www.wikidata.org/wiki/Q422543","display_name":"Corticosterone","level":3,"score":0.3619999885559082},{"id":"https://openalex.org/C93586867","wikidata":"https://www.wikidata.org/wiki/Q62527","display_name":"Negative feedback","level":3,"score":0.3393999934196472},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.3084999918937683},{"id":"https://openalex.org/C2776888042","wikidata":"https://www.wikidata.org/wiki/Q422137","display_name":"Steroid hormone","level":3,"score":0.30730000138282776},{"id":"https://openalex.org/C135343436","wikidata":"https://www.wikidata.org/wiki/Q170406","display_name":"Rhythm","level":2,"score":0.30550000071525574},{"id":"https://openalex.org/C2781291010","wikidata":"https://www.wikidata.org/wiki/Q178580","display_name":"Period (music)","level":2,"score":0.2976999878883362},{"id":"https://openalex.org/C2778562939","wikidata":"https://www.wikidata.org/wiki/Q1298791","display_name":"Synchronization (alternating current)","level":3,"score":0.29510000348091125},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.29269999265670776},{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.28220000863075256},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.27160000801086426},{"id":"https://openalex.org/C187765855","wikidata":"https://www.wikidata.org/wiki/Q506874","display_name":"Chronobiology","level":3,"score":0.25760000944137573}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:invenio.nusl.cz:685377","doi":null,"is_oa":false,"landing_page_url":"http://www.nusl.cz/ntk/nusl-685377","pdf_url":null,"source":{"id":"https://openalex.org/S4306402266","display_name":"Digital Repository (National Repository of Grey Literature)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79620101","host_organization_name":"University of Arkansas for Medical Sciences","host_organization_lineage":["https://openalex.org/I79620101"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/bachelorThesis"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2918302743","https://openalex.org/W2092647381","https://openalex.org/W2776289667","https://openalex.org/W1988701246","https://openalex.org/W2117286783","https://openalex.org/W2005229523","https://openalex.org/W2027635336","https://openalex.org/W1968014809","https://openalex.org/W2092138635","https://openalex.org/W3006107828"],"abstract_inverted_index":{"Glucocorticoids,":[0],"steroid":[1],"hormones":[2,17],"produced":[3],"in":[4,80,155],"the":[5,19,31,46,50,55,73,82,113,118,122,126,138,159],"adrenal":[6],"cortex,":[7],"are":[8,77],"essential":[9],"regulators":[10],"of":[11,18,45,49,72,107,125,146,158],"many":[12],"physiological":[13],"processes":[14],"and":[15,63,76,129,132,163],"key":[16,43],"hypothalamus-pituitary-adrenal":[20],"(HPA)":[21],"axis,":[22],"activated,":[23],"among":[24],"others,":[25],"by":[26,116],"stress.":[27],"In":[28],"addition":[29],"to":[30],"stress":[32],"response,":[33],"glucocorticoid":[34,130],"secretion":[35],"exhibits":[36],"a":[37,105],"marked":[38],"diurnal":[39],"rhythmicity,":[40],"which":[41,117,156],"is":[42,61,97,102],"evidence":[44],"controlling":[47],"influence":[48],"internal":[51],"circadian":[52,119,164,172],"system":[53,120],"on":[54,69],"HPA":[56,127],"axis.":[57],"However,":[58],"this":[59,94],"relationship":[60],"complex":[62],"bidirectional,":[64],"as":[65,87,99,149],"glucocorticoids":[66,135,162],"themselves":[67],"act":[68],"some":[70],"components":[71],"biological":[74],"clock":[75,139],"primarily":[78],"involved":[79],"adjusting":[81],"body's":[83],"peripheral":[84],"clock,":[85],"functioning":[86],"an":[88,167],"important":[89,168],"humoral":[90],"synchronization":[91],"signal.":[92],"Understanding":[93],"reciprocal":[95],"regulation":[96],"crucial,":[98],"its":[100],"disruption":[101],"associated":[103],"with":[104],"number":[106],"pathophysiological":[108],"conditions.":[109],"This":[110],"thesis":[111],"summarizes":[112],"basic":[114],"mechanisms":[115],"controls":[121],"rhythmic":[123],"activity":[124],"axis":[128],"production,":[131],"describes":[133],"how":[134],"retroactively":[136],"modulate":[137],"system.":[140],"Finally,":[141],"it":[142],"briefly":[143],"outlines":[144],"examples":[145],"diseases,":[147],"such":[148],"metabolic,":[150],"endocrine,":[151],"or":[152],"neuropsychiatric":[153],"disorders,":[154],"deregulation":[157],"interplay":[160],"between":[161],"rhythms":[165],"plays":[166],"role.":[169],"Keywords:":[170],"glucocorticoids,":[171],"clock,...":[173]},"counts_by_year":[],"updated_date":"2026-03-15T07:19:55.029819","created_date":"2026-03-15T00:00:00"}