{"id":"https://openalex.org/W7135609702","doi":null,"title":"Validation of Piroxicam-Accelerated Colitis in the Interleukin-10 Knock out Mouse - a Preclinical Model Mimicking Human Inflammatory Bowel Disease","display_name":"Validation of Piroxicam-Accelerated Colitis in the Interleukin-10 Knock out Mouse - a Preclinical Model Mimicking Human Inflammatory Bowel Disease","publication_year":2014,"publication_date":"2014-05-01","ids":{"openalex":"https://openalex.org/W7135609702"},"language":"en","primary_location":{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/e02987d7-5609-479a-8689-21c041c41ff2","doi":null,"is_oa":true,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/e02987d7-5609-479a-8689-21c041c41ff2","pdf_url":"https://curis.ku.dk/ws/files/117780006/Kristine_Holgersen_DDW_14.pdf","source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Holgersen , K , Kvist , P H , Hansen , A J K & Holm , T L 2014 , ' Validation of Piroxicam-Accelerated Colitis in the Interleukin-10 Knock out Mouse - a Preclinical Model Mimicking Human Inflammatory Bowel Disease ' , Digestive Disease Week 2014 , Chicago , United States , 03/05/2014 - 06/05/2014 .","raw_type":"conferenceObject"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://curis.ku.dk/ws/files/117780006/Kristine_Holgersen_DDW_14.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064215377","display_name":"Kristine Holgersen","orcid":"https://orcid.org/0000-0002-3141-5685","observed_orcids":["https://orcid.org/0000-0002-3141-5685"]},"institutions":[{"id":"https://openalex.org/I4210163740","display_name":"Lifepharms (United States)","ror":"https://ror.org/02xvj0167","country_code":"US","type":"company","lineage":["https://openalex.org/I4210163740"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Holgersen, Kristine","raw_affiliation_strings":["Lifepharm","Sektion, Preclinical Disease Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lifepharm","institution_ids":["https://openalex.org/I4210163740"]},{"raw_affiliation_string":"Sektion, Preclinical Disease Biology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064111567","display_name":"Peter Helding Kvist","orcid":"https://orcid.org/0000-0003-0189-992X","observed_orcids":["https://orcid.org/0000-0003-0189-992X"]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Kvist, Peter Helding","raw_affiliation_strings":["Novo Nordisk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048781267","display_name":"Axel Kornerup Hansen","orcid":"https://orcid.org/0000-0003-1575-2507","observed_orcids":["https://orcid.org/0000-0003-1575-2507"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hansen, Axel Jacob Kornerup","raw_affiliation_strings":["Sektion, Preclinical Disease Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sektion, Preclinical Disease Biology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064604287","display_name":"Thomas Lindebo Holm","orcid":"https://orcid.org/0000-0002-8837-7130","observed_orcids":["https://orcid.org/0000-0002-8837-7130"]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Holm, Thomas Lindebo","raw_affiliation_strings":["Novo Nordisk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk","institution_ids":["https://openalex.org/I189090001"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.6101176,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-10-knockout-mice","display_name":"IL-10 knockout mice","score":0.972000002861023},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.953000009059906},{"id":"https://openalex.org/keywords/preclinical-disease-models","display_name":"preclinical disease models","score":0.7110000252723694},{"id":"https://openalex.org/keywords/predictive-validity","display_name":"predictive validity","score":0.847000002861023},{"id":"https://openalex.org/keywords/colitis-pathogenesis","display_name":"colitis pathogenesis","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.7817999720573425},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7484999895095825},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7172999978065491},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.5878000259399414},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5437999963760376},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.478300005197525},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.4580000042915344},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41929998993873596},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.36329999566078186},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.3465999960899353},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.30809998512268066},{"id":"https://openalex.org/C2777572184","wikidata":"https://www.wikidata.org/wiki/Q15749161","display_name":"Inflammatory Bowel Diseases","level":4,"score":0.3061999976634979},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.28870001435279846},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.2838999927043915},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.26739999651908875},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2635999917984009},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.2621000111103058},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2535000145435333}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/e02987d7-5609-479a-8689-21c041c41ff2","doi":null,"is_oa":true,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/e02987d7-5609-479a-8689-21c041c41ff2","pdf_url":"https://curis.ku.dk/ws/files/117780006/Kristine_Holgersen_DDW_14.pdf","source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Holgersen , K , Kvist , P H , Hansen , A J K & Holm , T L 2014 , ' Validation of Piroxicam-Accelerated Colitis in the Interleukin-10 Knock out Mouse - a Preclinical Model Mimicking Human Inflammatory Bowel Disease ' , Digestive Disease Week 2014 , Chicago , United States , 03/05/2014 - 06/05/2014 .","raw_type":"conferenceObject"}],"best_oa_location":{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/e02987d7-5609-479a-8689-21c041c41ff2","doi":null,"is_oa":true,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/e02987d7-5609-479a-8689-21c041c41ff2","pdf_url":"https://curis.ku.dk/ws/files/117780006/Kristine_Holgersen_DDW_14.pdf","source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Holgersen , K , Kvist , P H , Hansen , A J K & Holm , T L 2014 , ' Validation of Piroxicam-Accelerated Colitis in the Interleukin-10 Knock out Mouse - a Preclinical Model Mimicking Human Inflammatory Bowel Disease ' , Digestive Disease Week 2014 , Chicago , United States , 03/05/2014 - 06/05/2014 .","raw_type":"conferenceObject"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7135609702.pdf","grobid_xml":"https://content.openalex.org/works/W7135609702.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2333792526","https://openalex.org/W4412275731","https://openalex.org/W1973823396","https://openalex.org/W7135909860","https://openalex.org/W1965660328","https://openalex.org/W2118678473","https://openalex.org/W7095697056","https://openalex.org/W2090645490","https://openalex.org/W2050513293","https://openalex.org/W7202166872"],"abstract_inverted_index":{"Predictive":[0],"validity":[1],"and":[2],"immune":[3],"cell":[4],"involvement":[5],"in":[6,12],"the":[7],"pathogenesis":[8],"of":[9],"piroxicam-accelerated":[10],"colitis":[11],"interleukin-10":[13],"knock":[14],"out":[15],"mice.":[16]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-03-15T00:00:00"}
