{"id":"https://openalex.org/W7135411241","doi":"https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.642","title":"Once again about HPV and cervical neoplasia: biology and pathogenesis","display_name":"Once again about HPV and cervical neoplasia: biology and pathogenesis","publication_year":2026,"publication_date":"2026-03-12","ids":{"openalex":"https://openalex.org/W7135411241","doi":"https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.642"},"language":"en","primary_location":{"id":"doi:10.17749/2313-7347/ob.gyn.rep.2026.642","doi":"https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.642","is_oa":true,"landing_page_url":"https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.642","pdf_url":"https://www.gynecology.su/jour/article/download/2717/1443","source":{"id":"https://openalex.org/S2764951701","display_name":"Obstetrics Gynecology and Reproduction","issn_l":"2313-7347","issn":["2313-7347","2500-3194"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/I4210126206","host_organization_name":"Irbis (Czechia)","host_organization_lineage":["https://openalex.org/I4210126206"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obstetrics, Gynecology and Reproduction","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.gynecology.su/jour/article/download/2717/1443","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5129312226","display_name":"V. Yu. Shchukin","orcid":"https://orcid.org/0009-0004-3139-7765","observed_orcids":["https://orcid.org/0009-0004-3139-7765"]},"institutions":[{"id":"https://openalex.org/I4210162998","display_name":"Samara Regional Clinical Oncology Center","ror":"https://ror.org/05y09dk26","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210162998"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"V. Yu. Shchukin","raw_affiliation_strings":["Samara Regional Clinical Oncology Dispensary"],"raw_orcid":"https://orcid.org/0009-0004-3139-7765","affiliations":[{"raw_affiliation_string":"Samara Regional Clinical Oncology Dispensary","institution_ids":["https://openalex.org/I4210162998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044919901","display_name":"\u0413\u0435\u0440\u0444\u0430\u043d\u043e\u0432\u0430 \u0415\u0432\u0433\u0435\u043d\u0438\u044f \u0412\u0438\u043a\u0442\u043e\u0440\u043e\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0001-9092-7149","observed_orcids":["https://orcid.org/0000-0001-9092-7149"]},"institutions":[{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210129564","display_name":"National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation","ror":"https://ror.org/03yfnyw34","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210117042","https://openalex.org/I4210129564"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E. V. Gerfanova","raw_affiliation_strings":["Academician Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation"],"raw_orcid":"https://orcid.org/0000-0001-9092-7149","affiliations":[{"raw_affiliation_string":"Academician Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation","institution_ids":["https://openalex.org/I4210117042","https://openalex.org/I4210129564"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074170826","display_name":"\u041d \u0410 \u0411\u0430\u0431\u0430\u0435\u0432\u0430","orcid":"https://orcid.org/0000-0002-4654-9512","observed_orcids":["https://orcid.org/0000-0002-4654-9512"]},"institutions":[{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210129564","display_name":"National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation","ror":"https://ror.org/03yfnyw34","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210117042","https://openalex.org/I4210129564"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"N. A. Babaeva","raw_affiliation_strings":["Academician Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation"],"raw_orcid":"https://orcid.org/0000-0002-4654-9512","affiliations":[{"raw_affiliation_string":"Academician Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation","institution_ids":["https://openalex.org/I4210117042","https://openalex.org/I4210129564"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110646585","display_name":"\u041e. \u0418. \u0410\u043b\u0435\u0448\u0438\u043a\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0002-2957-3940","observed_orcids":["https://orcid.org/0000-0002-2957-3940"]},"institutions":[{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210129564","display_name":"National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation","ror":"https://ror.org/03yfnyw34","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210117042","https://openalex.org/I4210129564"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"O. I. Aleshikova","raw_affiliation_strings":["Academician Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation"],"raw_orcid":"https://orcid.org/0000-0002-2957-3940","affiliations":[{"raw_affiliation_string":"Academician Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation","institution_ids":["https://openalex.org/I4210117042","https://openalex.org/I4210129564"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007022894","display_name":"N. A. Abdugaffarova","orcid":"https://orcid.org/0000-0002-8285-9091","observed_orcids":["https://orcid.org/0000-0002-8285-9091"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. A. Mukhsinzoda","raw_affiliation_strings":["Republican Oncology Research Center"],"raw_orcid":"https://orcid.org/0000-0002-8285-9091","affiliations":[{"raw_affiliation_string":"Republican Oncology Research Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030804438","display_name":"V. P. Kiselev","orcid":"https://orcid.org/0000-0002-4721-3420","observed_orcids":["https://orcid.org/0000-0002-4721-3420"]},"institutions":[{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210129564","display_name":"National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation","ror":"https://ror.org/03yfnyw34","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210117042","https://openalex.org/I4210129564"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"V. I. Kiselev","raw_affiliation_strings":["Academician Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation"],"raw_orcid":"https://orcid.org/0000-0002-4721-3420","affiliations":[{"raw_affiliation_string":"Academician Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation","institution_ids":["https://openalex.org/I4210117042","https://openalex.org/I4210129564"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069276613","display_name":"L. \u0410. Ashrafyan","orcid":"https://orcid.org/0000-0001-6396-4948","observed_orcids":["https://orcid.org/0000-0001-6396-4948"]},"institutions":[{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210129564","display_name":"National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation","ror":"https://ror.org/03yfnyw34","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210117042","https://openalex.org/I4210129564"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"L. A. Ashrafyan","raw_affiliation_strings":["Academician Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation"],"raw_orcid":"https://orcid.org/0000-0001-6396-4948","affiliations":[{"raw_affiliation_string":"Academician Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation","institution_ids":["https://openalex.org/I4210117042","https://openalex.org/I4210129564"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":15000,"currency":"RUB","value_usd":142},"apc_paid":{"value":15000,"currency":"RUB","value_usd":142},"fwci":6.7275,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.94223934,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"20","issue":"1","first_page":"192","last_page":"203"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13544","display_name":"Women's cancer prevention and management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.8809999823570251},{"id":"https://openalex.org/keywords/uterine-cervical-neoplasms","display_name":"cervical neoplasia","score":0.8740000128746033},{"id":"https://openalex.org/keywords/hpv-genotypes","display_name":"HPV genotypes","score":0.7429999709129333},{"id":"https://openalex.org/keywords/squamous-intraepithelial-lesions","display_name":"squamous intraepithelial lesions","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cervical-intraepithelial-neoplasia","display_name":"cervical intraepithelial neoplasia","score":0.9340000152587891},{"id":"https://openalex.org/keywords/p16ink4a","display_name":"p16INK4a","score":0.9700000286102295},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.9779999852180481},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.800000011920929},{"id":"https://openalex.org/keywords/cervical-cytology","display_name":"cervical cytology","score":0.843999981880188},{"id":"https://openalex.org/keywords/ascus","display_name":"ASCUS","score":0.8560000061988831},{"id":"https://openalex.org/keywords/cervical-biopsy","display_name":"cervical biopsy","score":0.5950000286102295},{"id":"https://openalex.org/keywords/diagnostic-variability","display_name":"diagnostic variability","score":0.45500001311302185},{"id":"https://openalex.org/keywords/hpv-pathogenesis","display_name":"HPV pathogenesis","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9101999998092651},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.6725000143051147},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.6010000109672546},{"id":"https://openalex.org/C2777343196","wikidata":"https://www.wikidata.org/wiki/Q196788","display_name":"Cervical intraepithelial neoplasia","level":4,"score":0.597100019454956},{"id":"https://openalex.org/C2778580637","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"HPV infection","level":4,"score":0.564300000667572},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4973999857902527},{"id":"https://openalex.org/C138055712","wikidata":"https://www.wikidata.org/wiki/Q924466","display_name":"Koilocyte","level":5,"score":0.49219998717308044},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4810999929904938},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.46299999952316284},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.45719999074935913},{"id":"https://openalex.org/C2775924586","wikidata":"https://www.wikidata.org/wiki/Q7581955","display_name":"Squamous intraepithelial lesion","level":5,"score":0.4221999943256378},{"id":"https://openalex.org/C2994532551","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"Human papillomavirus","level":2,"score":0.4162999987602234},{"id":"https://openalex.org/C18823058","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cytology","level":2,"score":0.4120999872684479},{"id":"https://openalex.org/C2776270601","wikidata":"https://www.wikidata.org/wiki/Q9055203","display_name":"Papillomaviridae","level":4,"score":0.4074000120162964},{"id":"https://openalex.org/C2780647465","wikidata":"https://www.wikidata.org/wiki/Q5065348","display_name":"Cervical screening","level":4,"score":0.40290001034736633},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3668000102043152},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35190001130104065},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3264999985694885},{"id":"https://openalex.org/C140779682","wikidata":"https://www.wikidata.org/wiki/Q210868","display_name":"Sampling (signal processing)","level":3,"score":0.32120001316070557},{"id":"https://openalex.org/C2779534503","wikidata":"https://www.wikidata.org/wiki/Q6058399","display_name":"Intraepithelial neoplasia","level":4,"score":0.275299996137619},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2628999948501587},{"id":"https://openalex.org/C3019814559","wikidata":"https://www.wikidata.org/wiki/Q681817","display_name":"Squamous cell cancer","level":3,"score":0.2623000144958496},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.2535000145435333},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.2533999979496002}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.17749/2313-7347/ob.gyn.rep.2026.642","doi":"https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.642","is_oa":true,"landing_page_url":"https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.642","pdf_url":"https://www.gynecology.su/jour/article/download/2717/1443","source":{"id":"https://openalex.org/S2764951701","display_name":"Obstetrics Gynecology and Reproduction","issn_l":"2313-7347","issn":["2313-7347","2500-3194"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/I4210126206","host_organization_name":"Irbis (Czechia)","host_organization_lineage":["https://openalex.org/I4210126206"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obstetrics, Gynecology and Reproduction","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:ff3cc178c76c4ceba2ed76efb2fe09aa","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ff3cc178c76c4ceba2ed76efb2fe09aa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0410\u043a\u0443\u0448\u0435\u0440\u0441\u0442\u0432\u043e, \u0433\u0438\u043d\u0435\u043a\u043e\u043b\u043e\u0433\u0438\u044f \u0438 \u0440\u0435\u043f\u0440\u043e\u0434\u0443\u043a\u0446\u0438\u044f, Vol 20, Iss 1, Pp 192-203 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.17749/2313-7347/ob.gyn.rep.2026.642","doi":"https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.642","is_oa":true,"landing_page_url":"https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.642","pdf_url":"https://www.gynecology.su/jour/article/download/2717/1443","source":{"id":"https://openalex.org/S2764951701","display_name":"Obstetrics Gynecology and Reproduction","issn_l":"2313-7347","issn":["2313-7347","2500-3194"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/I4210126206","host_organization_name":"Irbis (Czechia)","host_organization_lineage":["https://openalex.org/I4210126206"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obstetrics, Gynecology and Reproduction","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7135411241.pdf","grobid_xml":"https://content.openalex.org/works/W7135411241.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W145363270","https://openalex.org/W600225349","https://openalex.org/W1800166103","https://openalex.org/W1895984058","https://openalex.org/W1967229727","https://openalex.org/W1972338386","https://openalex.org/W1975891631","https://openalex.org/W1980026827","https://openalex.org/W1981634843","https://openalex.org/W1987350137","https://openalex.org/W1988558796","https://openalex.org/W1988805004","https://openalex.org/W1998567451","https://openalex.org/W2004785738","https://openalex.org/W2006692128","https://openalex.org/W2007742789","https://openalex.org/W2008958654","https://openalex.org/W2014012970","https://openalex.org/W2021622568","https://openalex.org/W2027107462","https://openalex.org/W2035204091","https://openalex.org/W2045772332","https://openalex.org/W2048253216","https://openalex.org/W2051827489","https://openalex.org/W2052699028","https://openalex.org/W2053726024","https://openalex.org/W2060613671","https://openalex.org/W2064292292","https://openalex.org/W2065211440","https://openalex.org/W2068965703","https://openalex.org/W2072013516","https://openalex.org/W2088578285","https://openalex.org/W2089130754","https://openalex.org/W2090810083","https://openalex.org/W2100273422","https://openalex.org/W2105407815","https://openalex.org/W2114418380","https://openalex.org/W2115240529","https://openalex.org/W2121189112","https://openalex.org/W2129701815","https://openalex.org/W2131255017","https://openalex.org/W2132640627","https://openalex.org/W2139736159","https://openalex.org/W2141258884","https://openalex.org/W2149824494","https://openalex.org/W2151317851","https://openalex.org/W2155548195","https://openalex.org/W2162482957","https://openalex.org/W2166632132","https://openalex.org/W2168904810","https://openalex.org/W2174023915","https://openalex.org/W2281050940","https://openalex.org/W2303326370","https://openalex.org/W2318506814","https://openalex.org/W2342313348","https://openalex.org/W2409974242","https://openalex.org/W2464695171","https://openalex.org/W2573152477","https://openalex.org/W2593799506","https://openalex.org/W2600185569","https://openalex.org/W2604545585","https://openalex.org/W2605034809","https://openalex.org/W2605381176","https://openalex.org/W2617112634","https://openalex.org/W2620739723","https://openalex.org/W2626576440","https://openalex.org/W2742931966","https://openalex.org/W4211002643","https://openalex.org/W4246047707"],"related_works":["https://openalex.org/W2332317220","https://openalex.org/W2091154163","https://openalex.org/W2084273630","https://openalex.org/W2083911787","https://openalex.org/W2094097297","https://openalex.org/W2004785738","https://openalex.org/W2022358833","https://openalex.org/W1520483630","https://openalex.org/W2503924540","https://openalex.org/W2411816155"],"abstract_inverted_index":{"Human":[0],"papillomavirus":[1],"(HPV)":[2],"is":[3,105,124,180],"the":[4,106,131,144,158,163,183,196,213],"main":[5],"risk":[6],"factor":[7],"for":[8,52,71,85],"developing":[9],"cervical":[10,76,122,137,186],"cancer":[11],"(CC).":[12],"About":[13],"70\u201375":[14],"%":[15,31],"of":[16,68,83,90,119,150,165,177,185,198,208,216],"all":[17],"invasive":[18,75],"CC":[19],"cases":[20,32],"worldwide":[21],"are":[22,47],"associated":[23],"with":[24,157],"HPV":[25,36,53],"16":[26],"and":[27,42,65,74,78,169,188,195],"18":[28],"genotypes,":[29],"20\u201325":[30],"being":[33],"related":[34],"to":[35,57,63,191],"31,":[37],"33,":[38],"35,":[39],"45,":[40],"52,":[41],"58":[43],"genotypes.":[44],"Currently,":[45],"there":[46],"more":[48,87],"than":[49],"100":[50],"tests":[51],"diagnostics,":[54],"but":[55],"up":[56],"now,":[58],"it":[59],"has":[60],"been":[61],"difficult":[62],"establish":[64],"evaluate":[66],"sensitivity":[67],"cytological":[69],"examination":[70],"detecting":[72],"pre-invasive":[73],"squamous":[77,91,206],"glandular":[79],"lesions.":[80],"The":[81,100,117,134,148],"use":[82,149],"biomarkers":[84],"a":[86,174],"objective":[88],"diagnostics":[89],"intraepithelial":[92,138],"lesions":[93],"(SIL)":[94],"was":[95],"investigated":[96],"in":[97,155,202],"numerous":[98],"studies.":[99],"most":[101],"widely":[102],"used":[103],"biomarker":[104],"p16INK4a":[107],"(p16)":[108],"antibody":[109],"that":[110],"flags":[111],"E7-induced":[112],"high-risk":[113],"HPV-caused":[114],"cell":[115],"proliferation.":[116],"diagnosis":[118],"SIL":[120,168],"upon":[121],"biopsy":[123,189],"also":[125],"highly":[126],"variable":[127],"convincingly":[128],"supported":[129],"by":[130],"documented":[132],"evidence.":[133],"intermediate":[135],"category,":[136],"neoplasia":[139],"grade":[140],"2":[141],"(CIN2),":[142],"provides":[143],"least":[145],"reproducible":[146],"results.":[147],"immunohistochemistry":[151],"p16,":[152],"alone":[153],"or":[154],"combination":[156],"proliferation":[159],"marker":[160],"Ki-67,":[161],"increases":[162],"effectiveness":[164],"differentiation":[166],"between":[167,182],"its":[170],"benign":[171],"imitators.":[172],"Thus,":[173],"high":[175],"degree":[176],"variability":[178],"still":[179],"observed":[181],"data":[184,203],"cytology":[187],"due":[190],"both":[192],"sampling":[193],"errors":[194],"expertise":[197],"medical":[199],"works":[200],"involved":[201],"interpretation.":[204],"Atypical":[205],"cells":[207],"undetermined":[209],"significance":[210],"(ASC-US)":[211],"represent":[212],"primary":[214],"source":[215],"such":[217],"variability.":[218]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-03-15T00:00:00"}