{"id":"https://openalex.org/W7135306311","doi":null,"title":"AGING REPROGRAMS CIRCADIAN METABOLIC AND TRANSCRIPTIONAL RHYTHMS","display_name":"AGING REPROGRAMS CIRCADIAN METABOLIC AND TRANSCRIPTIONAL RHYTHMS","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W7135306311"},"language":"en","primary_location":{"id":"pmh:oai:repository.upenn.edu:20.500.14332/59744","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/handle/20.500.14332/59744","pdf_url":null,"source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation/Thesis"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003491338","display_name":"Jessica E. Schwarz","orcid":"https://orcid.org/0000-0003-4831-225X","observed_orcids":["https://orcid.org/0000-0003-4831-225X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Schwarz, Jessica , E.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5003491338"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8489999771118164},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.9649999737739563},{"id":"https://openalex.org/keywords/circadian-clock","display_name":"circadian clock","score":0.777999997138977},{"id":"https://openalex.org/keywords/circadian-transcriptome","display_name":"circadian transcriptome","score":0.9279999732971191},{"id":"https://openalex.org/keywords/sleep-wake-cycle","display_name":"sleep-wake cycle","score":0.718999981880188},{"id":"https://openalex.org/keywords/pentose-phosphate-pathway","display_name":"pentose phosphate pathway","score":0.8600000143051147},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.6980000138282776},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.7699999809265137},{"id":"https://openalex.org/keywords/anti-aging-treatment","display_name":"anti-aging therapy","score":0.8379999995231628},{"id":"https://openalex.org/keywords/circadian-rhythm-disruption","display_name":"circadian rhythm disruption","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.8483999967575073},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7809000015258789},{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.7005000114440918},{"id":"https://openalex.org/C130679736","wikidata":"https://www.wikidata.org/wiki/Q3454009","display_name":"Bacterial circadian rhythms","level":4,"score":0.6148999929428101},{"id":"https://openalex.org/C2781291010","wikidata":"https://www.wikidata.org/wiki/Q178580","display_name":"Period (music)","level":2,"score":0.6140000224113464},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5907999873161316},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5788999795913696},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45660001039505005},{"id":"https://openalex.org/C2779317972","wikidata":"https://www.wikidata.org/wiki/Q1156516","display_name":"Suprachiasmatic nucleus","level":3,"score":0.4278999865055084},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.4090000092983246},{"id":"https://openalex.org/C184738001","wikidata":"https://www.wikidata.org/wiki/Q14908739","display_name":"CLOCK","level":4,"score":0.4025000035762787},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.3779999911785126},{"id":"https://openalex.org/C201176492","wikidata":"https://www.wikidata.org/wiki/Q6546168","display_name":"Light effects on circadian rhythm","level":4,"score":0.3668999969959259},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.3488999903202057},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.3407000005245209},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.33869999647140503},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.33180001378059387},{"id":"https://openalex.org/C196662502","wikidata":"https://www.wikidata.org/wiki/Q827541","display_name":"Molecular clock","level":4,"score":0.3239000141620636},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.3086000084877014},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.2994000017642975},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2985000014305115},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.2924000024795532},{"id":"https://openalex.org/C3409486","wikidata":"https://www.wikidata.org/wiki/Q827489","display_name":"Pentose phosphate pathway","level":4,"score":0.2881999909877777},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.28200000524520874},{"id":"https://openalex.org/C176777502","wikidata":"https://www.wikidata.org/wiki/Q4774623","display_name":"Anticipation (artificial intelligence)","level":2,"score":0.2621999979019165},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25769999623298645},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2556000053882599},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.2524000108242035},{"id":"https://openalex.org/C125168821","wikidata":"https://www.wikidata.org/wiki/Q7106408","display_name":"Oscillating gene","level":5,"score":0.25200000405311584}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:repository.upenn.edu:20.500.14332/59744","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/handle/20.500.14332/59744","pdf_url":null,"source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation/Thesis"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4311867703","https://openalex.org/W2033795673","https://openalex.org/W4384666600","https://openalex.org/W4399035757","https://openalex.org/W4327519698","https://openalex.org/W2943169140","https://openalex.org/W2776526212","https://openalex.org/W2037252802","https://openalex.org/W2112237181","https://openalex.org/W4200394024"],"abstract_inverted_index":{"As":[0,25],"human":[1,227],"lifespan":[2],"increasingly":[3],"exceeds":[4],"the":[5,14,22,53,56,68,72,76,84,103,118,140,158,164,187,206,219,241,246,249,291,299,302],"period":[6],"of":[7,21,55,71,120,208,221,248,256,270,313],"good":[8],"health":[9],"in":[10,75,91,98,157,170,200,214,233,298],"one\u2019s":[11],"life,":[12],"ameliorating":[13],"detriments":[15],"associated":[16,43,197],"with":[17,44,125,149,179,193,198,265,296],"age-related":[18,64,155,212,278,314],"decline":[19],"is":[20,88,112,196],"upmost":[23],"importance.":[24],"individuals":[26],"age,":[27,67,126,194],"sleep:wake":[28,201],"patterns":[29],"degrade,":[30],"hormonal":[31],"release":[32],"dysregulates,":[33],"and":[34,37,131,137,166,195,225,301,304],"metabolic":[35],"dysfunction":[36],"neurodegenerative":[38],"disease":[39],"become":[40,258],"prevalent.":[41],"Pathways":[42],"all":[45],"these":[46,271],"are":[47,94,105,173],"subject":[48],"to":[49,58,63,153,211,229],"circadian":[50,60,121,159,242,273,292,315],"regulation,":[51],"raising":[52],"question":[54],"extent":[57],"which":[59],"disruption":[61],"contributes":[62],"pathology.":[65],"With":[66],"molecular":[69,133],"mechanism":[70],"central":[73,85],"clock":[74,86],"brain":[77],"remains":[78],"largely":[79],"intact,":[80],"but":[81,101],"signaling":[82],"from":[83,127,175,223],"neurons":[87],"disrupted.":[89],"Clocks":[90],"peripheral":[92,215,231],"tissues":[93,216],"affected":[95],"by":[96,109,217],"age":[97,247,297],"different":[99,174],"ways,":[100],"whether":[102],"changes":[104,156,199,213],"tissue-autonomous":[106],"or":[107,260],"driven":[108],"extrinsic":[110],"cues":[111],"not":[113],"known.":[114],"This":[115],"thesis":[116],"reviews":[117],"breakdown":[119],"rhythms":[122],"across":[123],"species":[124],"both":[128],"a":[129,132,150,253],"behavioral":[130],"perspective":[134],"(Chapter":[135],"1),":[136],"then":[138],"addresses":[139],"questions":[141],"raised":[142],"above.":[143],"Chapter":[144,203,288],"2":[145],"describes":[146],"our":[147],"research":[148],"Drosophila":[151],"model":[152],"investigate":[154],"metabolome.":[160],"We":[161],"found":[162,185],"that":[163,168,177,186,240,252,294],"metabolites":[165],"lipids":[167],"cycle":[169,178,261],"young":[171,224],"flies":[172],"those":[176],"advanced":[180],"age.":[181],"In":[182],"particular,":[183],"we":[184],"Pentose":[188],"Phosphate":[189],"Pathway":[190,268],"loses":[191],"rhythmicity":[192],"cycles.":[202],"3":[204],"investigates":[205],"contribution":[207],"systemic":[209],"signals":[210],"comparing":[218],"ability":[220],"serum":[222],"old":[226],"subjects":[228],"entrain":[230],"clocks":[232],"fibroblast":[234],"cell":[235],"cultures.":[236],"The":[237],"results":[238],"demonstrate":[239],"transcriptome":[243,303],"depends":[244],"upon":[245],"serum,":[250],"such":[251],"significant":[254],"number":[255],"transcripts":[257,274],"arrhythmic":[259],"differently":[262],"following":[263],"entrainment":[264],"aged":[266],"serum.":[267],"analyses":[269],"age-altered":[272],"provide":[275],"insight":[276],"into":[277],"changes,":[279],"as":[280,282,309,311],"well":[281,310],"potential":[283,306],"targets":[284],"for":[285],"anti-aging":[286],"therapy.":[287],"4":[289],"highlights":[290],"reprograming":[293],"occurs":[295],"metabolome":[300],"discusses":[305],"underlying":[307],"mechanisms":[308],"relevance":[312],"reprogramming.":[316]},"counts_by_year":[],"updated_date":"2026-07-02T06:18:51.028212","created_date":"2026-03-14T00:00:00"}