{"id":"https://openalex.org/W7135244709","doi":"https://doi.org/10.64898/2026.03.11.711076","title":"Metabolic reprogramming by caloric restriction enhances acute phase virological control and reduces chronic inflammation in SIV-infected rhesus macaques","display_name":"Metabolic reprogramming by caloric restriction enhances acute phase virological control and reduces chronic inflammation in SIV-infected rhesus macaques","publication_year":2026,"publication_date":"2026-03-12","ids":{"openalex":"https://openalex.org/W7135244709","doi":"https://doi.org/10.64898/2026.03.11.711076","pmid":"https://pubmed.ncbi.nlm.nih.gov/41959369","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13060828"},"language":"en","primary_location":{"id":"doi:10.64898/2026.03.11.711076","doi":"https://doi.org/10.64898/2026.03.11.711076","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.03.11.711076","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pubmed.ncbi.nlm.nih.gov/41959369/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115807886","display_name":"Naveen Suresh Babu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naveen Suresh Babu","raw_affiliation_strings":["Department of Microbiology & Immunology, Tulane School of Medicine, New Orleans, Louisiana, 70112, USA","Division of Immunology, Tulane National Primate Research Center, Covington, Louisiana, 70433, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology & Immunology, Tulane School of Medicine, New Orleans, Louisiana, 70112, USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Division of Immunology, Tulane National Primate Research Center, Covington, Louisiana, 70433, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043981143","display_name":"Chrysostomos Perdios","orcid":"https://orcid.org/0000-0001-6000-6373","observed_orcids":["https://orcid.org/0000-0001-6000-6373"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chrysostomos Perdios","raw_affiliation_strings":["Division of Immunology, Tulane National Primate Research Center, Covington, Louisiana, 70433, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Tulane National Primate Research Center, Covington, Louisiana, 70433, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128957613","display_name":"Maggie Hallmets","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maggie Hallmets","raw_affiliation_strings":["Department of Microbiology & Immunology, Tulane School of Medicine, New Orleans, Louisiana, 70112, USA","Division of Immunology, Tulane National Primate Research Center, Covington, Louisiana, 70433, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology & Immunology, Tulane School of Medicine, New Orleans, Louisiana, 70112, USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Division of Immunology, Tulane National Primate Research Center, Covington, Louisiana, 70433, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110499665","display_name":"Anna T. Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna T. Brown","raw_affiliation_strings":["Division of Immunology, Tulane National Primate Research Center, Covington, Louisiana, 70433, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Tulane National Primate Research Center, Covington, Louisiana, 70433, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059779564","display_name":"Celeste D. Coleman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Celeste Coleman","raw_affiliation_strings":["Division of Immunology, Tulane National Primate Research Center, Covington, Louisiana, 70433, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Tulane National Primate Research Center, Covington, Louisiana, 70433, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008829382","display_name":"Christine M. Fennessey","orcid":"https://orcid.org/0000-0002-8736-8523","observed_orcids":["https://orcid.org/0000-0002-8736-8523"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine M. Fennessey","raw_affiliation_strings":["AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, 21701, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, 21701, USA","institution_ids":["https://openalex.org/I4210130649"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056645769","display_name":"Carolina Allers","orcid":"https://orcid.org/0000-0001-8576-770X","observed_orcids":["https://orcid.org/0000-0001-8576-770X"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carolina Allers","raw_affiliation_strings":["Pathogen Detection & Quantification Core, Division of Microbiology, Tulane National Primate Research Center, Covington, 70433, Louisiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathogen Detection & Quantification Core, Division of Microbiology, Tulane National Primate Research Center, Covington, 70433, Louisiana, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044449102","display_name":"Matilda J. Mostr\u00f6m","orcid":"https://orcid.org/0000-0001-7261-6638","observed_orcids":["https://orcid.org/0000-0001-7261-6638"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matilda J. Mostr\u00f6m","raw_affiliation_strings":["Division of Immunology, Tulane National Primate Research Center, Covington, Louisiana, 70433, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Tulane National Primate Research Center, Covington, Louisiana, 70433, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030227597","display_name":"Pratik Khare","orcid":"https://orcid.org/0000-0002-1633-8765","observed_orcids":["https://orcid.org/0000-0002-1633-8765"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pratik Khare","raw_affiliation_strings":["Gigantest Inc., Baltimore, Maryland, 21202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gigantest Inc., Baltimore, Maryland, 21202, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073796467","display_name":"Cissy Zhang","orcid":"https://orcid.org/0000-0003-0469-2086","observed_orcids":["https://orcid.org/0000-0003-0469-2086"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cissy Zhang","raw_affiliation_strings":["Gigantest Inc., Baltimore, Maryland, 21202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gigantest Inc., Baltimore, Maryland, 21202, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027447440","display_name":"Brandon Smith","orcid":"https://orcid.org/0009-0008-1714-5990","observed_orcids":["https://orcid.org/0009-0008-1714-5990"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandon T. Smith","raw_affiliation_strings":["High Containment Research Performance Core, Tulane National Primate Research Center, Covington, Louisiana, 70433, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"High Containment Research Performance Core, Tulane National Primate Research Center, Covington, Louisiana, 70433, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089018347","display_name":"Nadia Golden","orcid":"https://orcid.org/0000-0003-4161-7181","observed_orcids":["https://orcid.org/0000-0003-4161-7181"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nadia A. Golden","raw_affiliation_strings":["High Containment Research Performance Core, Tulane National Primate Research Center, Covington, Louisiana, 70433, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"High Containment Research Performance Core, Tulane National Primate Research Center, Covington, Louisiana, 70433, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111514028","display_name":"Adam Myers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Myers","raw_affiliation_strings":["Division of Veterinary Medicine, Tulane National Primate Research Center, Covington, Louisiana, 70433, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Veterinary Medicine, Tulane National Primate Research Center, Covington, Louisiana, 70433, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087506594","display_name":"Lara A. Doyle\u2010Meyers","orcid":"https://orcid.org/0000-0003-0212-9548","observed_orcids":["https://orcid.org/0000-0003-0212-9548"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lara Doyle-Meyers","raw_affiliation_strings":["Division of Veterinary Medicine, Tulane National Primate Research Center, Covington, Louisiana, 70433, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Veterinary Medicine, Tulane National Primate Research Center, Covington, Louisiana, 70433, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030083999","display_name":"Alexandra Blaney","orcid":"https://orcid.org/0000-0002-2988-3535","observed_orcids":["https://orcid.org/0000-0002-2988-3535"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra Blaney","raw_affiliation_strings":["Center for Comparative Medicine, Massachusetts General Hospital, Boston, Massachusetts, 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Comparative Medicine, Massachusetts General Hospital, Boston, Massachusetts, 02114, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061331589","display_name":"Robert V. Blair","orcid":"https://orcid.org/0000-0001-9616-9414","observed_orcids":["https://orcid.org/0000-0001-9616-9414"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert V. Blair","raw_affiliation_strings":["Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, 70433, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, 70433, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039903887","display_name":"Ahmad A. Saied","orcid":"https://orcid.org/0000-0002-3944-7112","observed_orcids":["https://orcid.org/0000-0002-3944-7112"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ahmad A. Saied","raw_affiliation_strings":["Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, 70433, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, 70433, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013727506","display_name":"Ricki J. Colman","orcid":"https://orcid.org/0000-0001-9706-0525","observed_orcids":["https://orcid.org/0000-0001-9706-0525"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ricki Colman","raw_affiliation_strings":["Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, Wisconsin, 53706, USA","Wisconsin National Primate Research Center, Madison, Wisconsin, 53715, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, Wisconsin, 53706, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Wisconsin National Primate Research Center, Madison, Wisconsin, 53715, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056797877","display_name":"Brandon F. Keele","orcid":"https://orcid.org/0000-0002-2381-1151","observed_orcids":["https://orcid.org/0000-0002-2381-1151"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandon F. Keele","raw_affiliation_strings":["AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, 21701, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, 21701, USA","institution_ids":["https://openalex.org/I4210130649"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034847293","display_name":"Anne Le","orcid":"https://orcid.org/0000-0002-2958-8149","observed_orcids":["https://orcid.org/0000-0002-2958-8149"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anne Le","raw_affiliation_strings":["Gigantest Inc., Baltimore, Maryland, 21202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gigantest Inc., Baltimore, Maryland, 21202, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052865218","display_name":"Clovis Steve Palmer","orcid":"https://orcid.org/0000-0001-9822-4181","observed_orcids":["https://orcid.org/0000-0001-9822-4181","https://orcid.org/0000-0002-5031-6922"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clovis S. Palmer","raw_affiliation_strings":["Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, 70433, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, 70433, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109511513","display_name":"Joseph C. Mudd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joseph C. Mudd","raw_affiliation_strings":["Department of Microbiology & Immunology, Tulane School of Medicine, New Orleans, Louisiana, 70112, USA","Division of Immunology, Tulane National Primate Research Center, Covington, Louisiana, 70433, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology & Immunology, Tulane School of Medicine, New Orleans, Louisiana, 70112, USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Division of Immunology, Tulane National Primate Research Center, Covington, Louisiana, 70433, USA","institution_ids":["https://openalex.org/I114832834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5109511513"],"corresponding_institution_ids":["https://openalex.org/I114832834"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12745","display_name":"Dietary Effects on Health","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caloric-restriction","display_name":"caloric restriction","score":1.0},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.9409999847412109},{"id":"https://openalex.org/keywords/siv-infection","display_name":"SIV infection","score":0.9070000052452087},{"id":"https://openalex.org/keywords/rhesus-macaques","display_name":"rhesus monkeys","score":0.9399999976158142},{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.8529999852180481},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.9629999995231628},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8619999885559082},{"id":"https://openalex.org/keywords/type-i-interferon-signaling","display_name":"type I interferon signaling","score":0.8309999704360962},{"id":"https://openalex.org/keywords/tricarboxylic-acid-cycle","display_name":"TCA cycle","score":0.9350000023841858},{"id":"https://openalex.org/keywords/soluble-cd14","display_name":"soluble CD14","score":0.8769999742507935},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.875},{"id":"https://openalex.org/keywords/viral-persistence","display_name":"viral persistence","score":0.7020000219345093},{"id":"https://openalex.org/keywords/dietary-intervention","display_name":"dietary intervention","score":0.3619999885559082}],"concepts":[{"id":"https://openalex.org/C2776185481","wikidata":"https://www.wikidata.org/wiki/Q1425304","display_name":"Viremia","level":3,"score":0.8008000254631042},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6545000076293945},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6043999791145325},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5949000120162964},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.5758000016212463},{"id":"https://openalex.org/C2778513237","wikidata":"https://www.wikidata.org/wiki/Q419553","display_name":"CD14","level":3,"score":0.506600022315979},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49059998989105225},{"id":"https://openalex.org/C2777995582","wikidata":"https://www.wikidata.org/wiki/Q1890246","display_name":"Simian immunodeficiency virus","level":3,"score":0.4311999976634979},{"id":"https://openalex.org/C3019392825","wikidata":"https://www.wikidata.org/wiki/Q383126","display_name":"Chronic infection","level":3,"score":0.4034000039100647},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.3781000077724457},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3758000135421753},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.35010001063346863},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.34950000047683716},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34450000524520874},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.34200000762939453},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.3409999907016754},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.3345000147819519},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.322299987077713},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.31700000166893005},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.3091000020503998},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.2946000099182129},{"id":"https://openalex.org/C2779889181","wikidata":"https://www.wikidata.org/wiki/Q423984","display_name":"Stavudine","level":5,"score":0.2915000021457672},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.27900001406669617},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2777000069618225},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.275299996137619},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.27300000190734863},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.2696000039577484},{"id":"https://openalex.org/C2778302649","wikidata":"https://www.wikidata.org/wiki/Q16956975","display_name":"Overnutrition","level":3,"score":0.2687000036239624},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.2671000063419342},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.2653000056743622},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2635999917984009},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.25769999623298645},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.250900000333786}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.03.11.711076","doi":"https://doi.org/10.64898/2026.03.11.711076","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.03.11.711076","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:41959369","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41959369","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13060828","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41959369/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13060828","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41959369/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9958000183105469,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":94,"referenced_works":["https://openalex.org/W1891017166","https://openalex.org/W1909810986","https://openalex.org/W1924955228","https://openalex.org/W1934435884","https://openalex.org/W1945834141","https://openalex.org/W1975566288","https://openalex.org/W1976714959","https://openalex.org/W1994252478","https://openalex.org/W1998251684","https://openalex.org/W1999396723","https://openalex.org/W2002511732","https://openalex.org/W2008994596","https://openalex.org/W2010084870","https://openalex.org/W2032523448","https://openalex.org/W2043738446","https://openalex.org/W2051316659","https://openalex.org/W2062016902","https://openalex.org/W2062221236","https://openalex.org/W2073295531","https://openalex.org/W2075345074","https://openalex.org/W2079999658","https://openalex.org/W2090324498","https://openalex.org/W2098152094","https://openalex.org/W2098836196","https://openalex.org/W2103065132","https://openalex.org/W2104586170","https://openalex.org/W2107660257","https://openalex.org/W2115509057","https://openalex.org/W2130746744","https://openalex.org/W2143046247","https://openalex.org/W2145131058","https://openalex.org/W2145487507","https://openalex.org/W2146791037","https://openalex.org/W2149492547","https://openalex.org/W2150484278","https://openalex.org/W2156579478","https://openalex.org/W2160925670","https://openalex.org/W2180931407","https://openalex.org/W2256397044","https://openalex.org/W2321920454","https://openalex.org/W2343796589","https://openalex.org/W2408117442","https://openalex.org/W2523989131","https://openalex.org/W2551680789","https://openalex.org/W2559827082","https://openalex.org/W2577597748","https://openalex.org/W2611282009","https://openalex.org/W2625416742","https://openalex.org/W2744772724","https://openalex.org/W2896947777","https://openalex.org/W2900567433","https://openalex.org/W2906650498","https://openalex.org/W2921682820","https://openalex.org/W2948742834","https://openalex.org/W2951924500","https://openalex.org/W2958570257","https://openalex.org/W2959448571","https://openalex.org/W2969456171","https://openalex.org/W2969628442","https://openalex.org/W2972866614","https://openalex.org/W2978201354","https://openalex.org/W2984000721","https://openalex.org/W2984034208","https://openalex.org/W2995968083","https://openalex.org/W2997046468","https://openalex.org/W3004951004","https://openalex.org/W3009979659","https://openalex.org/W3011812382","https://openalex.org/W3041989668","https://openalex.org/W3087486964","https://openalex.org/W3111997123","https://openalex.org/W3119054953","https://openalex.org/W3134857370","https://openalex.org/W3139303129","https://openalex.org/W3174588009","https://openalex.org/W4220708448","https://openalex.org/W4221049186","https://openalex.org/W4247995135","https://openalex.org/W4283812906","https://openalex.org/W4284974371","https://openalex.org/W4306861794","https://openalex.org/W4308891624","https://openalex.org/W4383875457","https://openalex.org/W4384627195","https://openalex.org/W4384816694","https://openalex.org/W4386303546","https://openalex.org/W4386708524","https://openalex.org/W4387252323","https://openalex.org/W4387266434","https://openalex.org/W4389128355","https://openalex.org/W4390610758","https://openalex.org/W4403243577","https://openalex.org/W4415937363","https://openalex.org/W4416665575"],"related_works":["https://openalex.org/W4416451530","https://openalex.org/W4407223664","https://openalex.org/W7128926406","https://openalex.org/W7168259245","https://openalex.org/W4319309361","https://openalex.org/W1849247882","https://openalex.org/W7208756924","https://openalex.org/W4389021277","https://openalex.org/W2984034208","https://openalex.org/W2786708647"],"abstract_inverted_index":{"ABSTRACT":[0],"Nutrient":[1],"metabolism":[2,23],"influences":[3],"HIV-1":[4,30],"replication,":[5],"antiviral":[6,223],"immunity,":[7],"and":[8,50,54,62,102,159,165,185,238,258,292,316],"chronic":[9,296,320],"inflammation,":[10],"yet":[11],"is":[12,229],"difficult":[13],"to":[14,21,67,235,263,273],"leverage":[15],"for":[16,39],"therapeutic":[17],"gain.":[18],"We":[19],"sought":[20],"modulate":[22],"in":[24,52,58,84,113,133,169,203,219,248,318],"the":[25,76,85,211,249,275,312],"non-human":[26,331],"primate":[27,205,332],"model":[28],"of":[29,45,69,78,109,126,162,217,251,277,295,314],"by":[31,178],"caloric":[32],"restriction":[33,227],"(CR),":[34],"a":[35,105,123,197,204,230,328],"modality":[36,199],"canonically":[37],"known":[38,234],"its":[40,246],"antiaging":[41],"benefits.":[42],"Four":[43],"months":[44],"30%":[46],"CR":[47,74,92,147,272,288],"was":[48,120],"safe":[49,231],"resulted":[51],"broad":[53],"systemic":[55],"metabolic":[56,306],"reprogramming":[57],"healthy":[59],"adult":[60],"male":[61],"female":[63],"rhesus":[64],"macaques.":[65],"Relative":[66],"that":[68,135,181,196,287,301],"ad":[70],"libitum-":[71],"fed":[72],"animals,":[73],"lowered":[75,160],"frequencies":[77],"target":[79],"CCR5+":[80],"CD4":[81],"T":[82,111],"cells":[83,112],"gut":[86],"mucosa.":[87],"Upon":[88],"infection":[89,282,322],"with":[90,122,143,304],"SIV,":[91,326],"reduced":[93,289],"acute":[94,222],"phase":[95],"viremia,":[96],"dampened":[97],"type":[98],"I":[99],"interferon":[100],"signaling,":[101],"overall":[103],"permitted":[104],"more":[106],"vigorous":[107],"cycling":[108],"CD8+":[110],"lymphoid":[114],"tissues.":[115],"CR-induced":[116],"protection":[117],"from":[118,190],"SIV":[119,172,281],"associated":[121,303],"robust":[124,212],"up-regulation":[125],"glycolysis,":[127],"which":[128],"supported":[129],"an":[130,221],"early":[131],"reduction":[132],"viremia":[134,291],"ultimately":[136],"waned":[137],"over":[138],"time.":[139],"During":[140],"virologic":[141],"suppression":[142],"antiretroviral":[144],"therapy":[145],"(ART),":[146],"significantly":[148],"limited":[149,262],"gastrointestinal":[150],"(GI)":[151],"immune":[152],"activation,":[153],"improved":[154],"tricarboxylic":[155],"acid":[156],"cycle":[157],"flux,":[158],"concentrations":[161],"soluble":[163],"CD14":[164],"several":[166],"TNF-related":[167],"molecules":[168],"plasma.":[170],"Blood":[171],"DNA":[173],"levels":[174],"however":[175],"were":[176,302],"unchanged":[177],"CR,":[179],"suggesting":[180],"residual":[182],"GI":[183],"dysfunction":[184],"inflammation":[186,297],"can":[187,200],"be":[188],"decoupled":[189],"viral":[191,321],"persistence.":[192],"Our":[193,284],"findings":[194,285,310],"highlight":[195],"dietary":[198,232,278],"limit":[201],"pathology":[202],"lentiviral":[206],"infection.":[207],"They":[208],"also":[209],"reveal":[210],"but":[213],"temporally":[214],"constrained":[215],"nature":[216],"glycolysis":[218],"supporting":[220],"response.":[224],"SIGNIFICANCE":[225],"Caloric":[226],"(CR)":[228],"intervention":[233],"confer":[236],"anti-aging":[237],"health":[239],"benefits":[240],"across":[241],"diverse":[242],"animal":[243],"models.":[244],"However,":[245],"application":[247],"context":[250],"infectious":[252],"diseases":[253],"has":[254,259],"yielded":[255],"mixed":[256],"outcomes":[257],"largely":[260],"been":[261],"murine":[264],"systems.":[265],"In":[266],"this":[267],"study,":[268],"we":[269],"therefore":[270],"employed":[271],"examine":[274],"impact":[276],"modulation":[279],"on":[280],"outcomes.":[283],"demonstrate":[286],"acute-phase":[290],"attenuated":[293],"markers":[294],"following":[298],"ART,":[299],"effects":[300],"distinct":[305],"signatures.":[307],"Collectively,":[308],"these":[309],"underscore":[311],"importance":[313],"diet":[315],"nutrition":[317],"shaping":[319],"outcomes,":[323],"such":[324],"as":[325],"within":[327],"clinically":[329],"relevant":[330],"model.":[333]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-03-14T00:00:00"}
