{"id":"https://openalex.org/W7135073711","doi":"https://doi.org/10.1016/j.phytochem.2026.114871","title":"Quantitative analysis of 7-hydroxymitragynine in commercial kratom products and its stability under chemical and physiological conditions","display_name":"Quantitative analysis of 7-hydroxymitragynine in commercial kratom products and its stability under chemical and physiological conditions","publication_year":2026,"publication_date":"2026-03-11","ids":{"openalex":"https://openalex.org/W7135073711","doi":"https://doi.org/10.1016/j.phytochem.2026.114871","pmid":"https://pubmed.ncbi.nlm.nih.gov/41825819"},"language":"en","primary_location":{"id":"doi:10.1016/j.phytochem.2026.114871","doi":"https://doi.org/10.1016/j.phytochem.2026.114871","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phytochem.2026.114871","pdf_url":null,"source":{"id":"https://openalex.org/S88226677","display_name":"Phytochemistry","issn_l":"0031-9422","issn":["0031-9422","1873-3700"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.phytochem.2026.114871","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039173092","display_name":"Bharathi Avula","orcid":"https://orcid.org/0000-0002-8656-9526","observed_orcids":["https://orcid.org/0000-0002-8656-9526"]},"institutions":[{"id":"https://openalex.org/I368840534","display_name":"University of Mississippi","ror":"https://ror.org/02teq1165","country_code":"US","type":"education","lineage":["https://openalex.org/I368840534","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bharathi Avula","raw_affiliation_strings":["National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States","institution_ids":["https://openalex.org/I368840534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079995719","display_name":"Syed Azmal Ali","orcid":"https://orcid.org/0000-0003-3024-9379","observed_orcids":["https://orcid.org/0000-0003-3024-9379"]},"institutions":[{"id":"https://openalex.org/I368840534","display_name":"University of Mississippi","ror":"https://ror.org/02teq1165","country_code":"US","type":"education","lineage":["https://openalex.org/I368840534","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Syed Kashif Ali","raw_affiliation_strings":["National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States","institution_ids":["https://openalex.org/I368840534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115619863","display_name":"Kiran Kumar Tatapudi","orcid":"https://orcid.org/0000-0003-2279-7236","observed_orcids":["https://orcid.org/0000-0003-2279-7236"]},"institutions":[{"id":"https://openalex.org/I368840534","display_name":"University of Mississippi","ror":"https://ror.org/02teq1165","country_code":"US","type":"education","lineage":["https://openalex.org/I368840534","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kiran K. Tatapudi","raw_affiliation_strings":["National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States","institution_ids":["https://openalex.org/I368840534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055071589","display_name":"Pankaj Pandey","orcid":"https://orcid.org/0000-0001-9128-8254","observed_orcids":["https://orcid.org/0000-0001-9128-8254"]},"institutions":[{"id":"https://openalex.org/I368840534","display_name":"University of Mississippi","ror":"https://ror.org/02teq1165","country_code":"US","type":"education","lineage":["https://openalex.org/I368840534","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pankaj Pandey","raw_affiliation_strings":["National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States","institution_ids":["https://openalex.org/I368840534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128821682","display_name":"Lochana Cheepilla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I368840534","display_name":"University of Mississippi","ror":"https://ror.org/02teq1165","country_code":"US","type":"education","lineage":["https://openalex.org/I368840534","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lochana Cheepilla","raw_affiliation_strings":["Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States","institution_ids":["https://openalex.org/I368840534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033686523","display_name":"Islam Husain","orcid":"https://orcid.org/0000-0002-6150-5788","observed_orcids":["https://orcid.org/0000-0002-6150-5788"]},"institutions":[{"id":"https://openalex.org/I368840534","display_name":"University of Mississippi","ror":"https://ror.org/02teq1165","country_code":"US","type":"education","lineage":["https://openalex.org/I368840534","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Islam Husain","raw_affiliation_strings":["National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States","institution_ids":["https://openalex.org/I368840534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101388218","display_name":"Shabana I Khan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I368840534","display_name":"University of Mississippi","ror":"https://ror.org/02teq1165","country_code":"US","type":"education","lineage":["https://openalex.org/I368840534","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shabana I. Khan","raw_affiliation_strings":["National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States; Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States; Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States","institution_ids":["https://openalex.org/I368840534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013500556","display_name":"Kumar Katragunta","orcid":"https://orcid.org/0000-0002-8787-4602","observed_orcids":["https://orcid.org/0000-0002-8787-4602"]},"institutions":[{"id":"https://openalex.org/I368840534","display_name":"University of Mississippi","ror":"https://ror.org/02teq1165","country_code":"US","type":"education","lineage":["https://openalex.org/I368840534","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kumar Katragunta","raw_affiliation_strings":["National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States","institution_ids":["https://openalex.org/I368840534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038420905","display_name":"Zulf\u0131qar Ali","orcid":"https://orcid.org/0000-0003-3902-5152","observed_orcids":["https://orcid.org/0000-0003-3902-5152","https://orcid.org/0000-0002-3111-003X"]},"institutions":[{"id":"https://openalex.org/I368840534","display_name":"University of Mississippi","ror":"https://ror.org/02teq1165","country_code":"US","type":"education","lineage":["https://openalex.org/I368840534","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zulfiqar Ali","raw_affiliation_strings":["National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States","institution_ids":["https://openalex.org/I368840534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049082763","display_name":"Ikhlas Ahmed Khan","orcid":"https://orcid.org/0000-0001-5464-4643","observed_orcids":["https://orcid.org/0000-0001-5464-4643"]},"institutions":[{"id":"https://openalex.org/I368840534","display_name":"University of Mississippi","ror":"https://ror.org/02teq1165","country_code":"US","type":"education","lineage":["https://openalex.org/I368840534","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ikhlas A. Khan","raw_affiliation_strings":["National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States; Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States. Electronic address: ikhan@olemiss.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States; Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States. Electronic address: ikhan@olemiss.edu","institution_ids":["https://openalex.org/I368840534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026678057","display_name":"Amar Gopal Chittiboyina","orcid":"https://orcid.org/0000-0002-7047-5373","observed_orcids":["https://orcid.org/0000-0002-7047-5373"]},"institutions":[{"id":"https://openalex.org/I368840534","display_name":"University of Mississippi","ror":"https://ror.org/02teq1165","country_code":"US","type":"education","lineage":["https://openalex.org/I368840534","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amar G. Chittiboyina","raw_affiliation_strings":["National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States; Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States. Electronic address: amar@olemiss.edu"],"raw_orcid":"https://orcid.org/0000-0002-7047-5373","affiliations":[{"raw_affiliation_string":"National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States; Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States. Electronic address: amar@olemiss.edu","institution_ids":["https://openalex.org/I368840534"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026678057","https://openalex.org/A5049082763"],"corresponding_institution_ids":["https://openalex.org/I368840534"],"apc_list":{"value":4350,"currency":"USD","value_usd":4350},"apc_paid":{"value":4350,"currency":"USD","value_usd":4350},"fwci":30.7344,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.99766861,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"247","issue":null,"first_page":"114871","last_page":"114871"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12649","display_name":"Alkaloids: synthesis and pharmacology","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12649","display_name":"Alkaloids: synthesis and pharmacology","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/7-hydroxymitragynine","display_name":"7-hydroxymitragynine","score":1.0},{"id":"https://openalex.org/keywords/kratom","display_name":"Mitragyna speciosa","score":0.9909999966621399},{"id":"https://openalex.org/keywords/label-accuracy","display_name":"label accuracy","score":0.6050000190734863},{"id":"https://openalex.org/keywords/opioid-receptor-agonism","display_name":"opioid receptor agonism","score":0.7210000157356262},{"id":"https://openalex.org/keywords/schedule-i-controlled-substances","display_name":"Schedule I controlled substances","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6078000068664551},{"id":"https://openalex.org/C2777667214","wikidata":"https://www.wikidata.org/wiki/Q70702","display_name":"Alkaloid","level":2,"score":0.4456999897956848},{"id":"https://openalex.org/C95986675","wikidata":"https://www.wikidata.org/wiki/Q185168","display_name":"Quantitative analysis (chemistry)","level":2,"score":0.44269999861717224},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.42160001397132874},{"id":"https://openalex.org/C2991878520","wikidata":"https://www.wikidata.org/wiki/Q664183","display_name":"Consumer safety","level":2,"score":0.3513999879360199},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3345000147819519},{"id":"https://openalex.org/C2987857752","wikidata":"https://www.wikidata.org/wiki/Q12147","display_name":"Human health","level":2,"score":0.33070001006126404},{"id":"https://openalex.org/C2994400308","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolite profiling","level":3,"score":0.3208000063896179},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.28369998931884766},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.2791000008583069},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2712000012397766},{"id":"https://openalex.org/C2987718291","wikidata":"https://www.wikidata.org/wiki/Q2095","display_name":"Food products","level":2,"score":0.2605000138282776},{"id":"https://openalex.org/C2983668108","wikidata":"https://www.wikidata.org/wiki/Q280453","display_name":"Spectral analysis","level":3,"score":0.2590000033378601},{"id":"https://openalex.org/C3018122547","wikidata":"https://www.wikidata.org/wiki/Q5690813","display_name":"Health benefits","level":2,"score":0.25270000100135803}],"mesh":[{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018515","descriptor_name":"Plant Leaves","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018515","descriptor_name":"Plant Leaves","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018515","descriptor_name":"Plant Leaves","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D032065","descriptor_name":"Mitragyna","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D032065","descriptor_name":"Mitragyna","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D032065","descriptor_name":"Mitragyna","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D046948","descriptor_name":"Secologanin Tryptamine Alkaloids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D046948","descriptor_name":"Secologanin Tryptamine Alkaloids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D046948","descriptor_name":"Secologanin Tryptamine Alkaloids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D046948","descriptor_name":"Secologanin Tryptamine Alkaloids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D046948","descriptor_name":"Secologanin Tryptamine Alkaloids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D046948","descriptor_name":"Secologanin Tryptamine Alkaloids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.phytochem.2026.114871","doi":"https://doi.org/10.1016/j.phytochem.2026.114871","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phytochem.2026.114871","pdf_url":null,"source":{"id":"https://openalex.org/S88226677","display_name":"Phytochemistry","issn_l":"0031-9422","issn":["0031-9422","1873-3700"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytochemistry","raw_type":"journal-article"},{"id":"pmid:41825819","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41825819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytochemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.phytochem.2026.114871","doi":"https://doi.org/10.1016/j.phytochem.2026.114871","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phytochem.2026.114871","pdf_url":null,"source":{"id":"https://openalex.org/S88226677","display_name":"Phytochemistry","issn_l":"0031-9422","issn":["0031-9422","1873-3700"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytochemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7599030137062073,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G827202040","display_name":null,"funder_award_id":"5U01FD004246","funder_id":"https://openalex.org/F4320332163","funder_display_name":"U.S. Food and Drug Administration"}],"funders":[{"id":"https://openalex.org/F4320332163","display_name":"U.S. Food and Drug Administration","ror":"https://ror.org/034xvzb47"},{"id":"https://openalex.org/F5930650767","display_name":"Center for Food Safety and Applied Nutrition","ror":"https://ror.org/05hzdft06"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1903546897","https://openalex.org/W1982986317","https://openalex.org/W2015836372","https://openalex.org/W2027077208","https://openalex.org/W2112497272","https://openalex.org/W2398657959","https://openalex.org/W2536844334","https://openalex.org/W2561647549","https://openalex.org/W2899422827","https://openalex.org/W2903849597","https://openalex.org/W2938364703","https://openalex.org/W2947253157","https://openalex.org/W2980879937","https://openalex.org/W3008285728","https://openalex.org/W3046270595","https://openalex.org/W3129682253","https://openalex.org/W3211699436","https://openalex.org/W4213442031","https://openalex.org/W4243115694","https://openalex.org/W4307635384","https://openalex.org/W4381122222","https://openalex.org/W4387472347","https://openalex.org/W4399382219","https://openalex.org/W4401815524","https://openalex.org/W4403281003","https://openalex.org/W4405885879","https://openalex.org/W4408070305","https://openalex.org/W4408765543","https://openalex.org/W4410200625","https://openalex.org/W4410444112","https://openalex.org/W4414402871","https://openalex.org/W4414986078","https://openalex.org/W4416557644"],"related_works":[],"abstract_inverted_index":{"7-Hydroxymitragynine":[0],"(7-OH),":[1],"a":[2,20,50,84,100,245],"minor":[3],"alkaloid":[4],"in":[5,44,47,129,217],"kratom":[6,48,106],"(":[7],"Mitragyna":[8],"speciosa":[9],"(Korth.)":[10],"Havil.)":[11],"(Rubiaceae)":[12],"and":[13,33,61,70,95,123,135,198,207,237],"an":[14],"active":[15],"metabolite":[16],"of":[17,55,68,72,103,151,153,224,229],"mitragynine,":[18],"is":[19,235],"critical":[21],"transient":[22],"precursor":[23],"to":[24,38,79,165,203],"mitragynine":[25,62,136],"pseudoindoxyl,":[26,137],"which":[27],"exhibits":[28],">2-fold":[29],"\u03bc-opioid":[30],"receptor\u2013biased":[31],"agonism":[32],"improved":[34],"isoform":[35],"selectivity":[36],"relative":[37],"its":[39],"precursors.":[40],"Although":[41],"present":[42],"only":[43],"trace":[45],"amounts":[46],"leaves,":[49],"recent":[51],"survey":[52],"identified":[53],"hundreds":[54],"consumer":[56,208],"products":[57,107,155,197,213,226],"with":[58,133,159,172],"semisynthetic":[59,157],"7-OH":[60,82,126,134,176,196,212,219,225,233,250],"pseudoindoxyl.":[63],"Their":[64],"high":[65],"potency,":[66],"ease":[67],"access,":[69],"risk":[71],"addiction":[73],"have":[74],"prompted":[75],"the":[76,96,116,120,124,173,179],"US":[77],"FDA":[78],"recommend":[80],"scheduling":[81],"as":[83],"Schedule":[85],"I":[86],"controlled":[87],"substance.":[88],"To":[89],"address":[90],"this":[91],"public":[92],"health":[93],"crisis":[94],"associated":[97],"analytical":[98,201],"challenges,":[99],"comprehensive":[101],"analysis":[102],"commercially":[104],"available":[105],"was":[108],"performed.":[109],"The":[110],"results":[111],"revealed":[112],"substantial":[113],"inconsistencies":[114],"between":[115],"quantities":[117],"claimed":[118],"on":[119],"products\u2019":[121],"labels":[122],"actual":[125],"amount":[127],"detected":[128],"several":[130,138],"products.":[131],"Along":[132],"(over)oxidized":[139],"byproducts":[140],"were":[141],"detected,":[142],"providing":[143],"crucial":[144],"insights":[145],"into":[146,178],"their":[147],"synthetic":[148],"origins.":[149],"Analysis":[150],">98%":[152],"7-OH-labeled":[154],"indicated":[156],"origin,":[158],"labeled":[160,218],"doses":[161],"ranging":[162],"from":[163,249],"0.001":[164],"33.6":[166],"mg":[167],"per":[168],"serving.":[169],"Furthermore,":[170],"consistent":[171],"prior":[174],"report,":[175],"degrades":[177],"potentially":[180,246],"toxic":[181,247],"byproduct":[182],"3-dehydromitragynine":[183],"under":[184,251],"simulated":[185,252],"gastric":[186,253],"conditions.":[187,254],"These":[188],"findings":[189],"underscore":[190],"significant":[191,215],"safety":[192],"concerns":[193],"over":[194],"oral":[195],"necessitate":[199],"validated":[200],"monitoring":[202],"guide":[204],"regulatory":[205],"oversight":[206],"protection.":[209],"\u2022":[210,221,232,243],"Commercial":[211],"exhibit":[214],"inaccuracies":[216],"concentrations.":[220],"UHPLC-PDA-MS":[222],"profiling":[223],"reveals":[227],"artifacts":[228],"semi-synthetic":[230],"origin.":[231],"stability":[234],"solvent-":[236],"pH-dependent,":[238],"yielding":[239],"distinct":[240],"isobaric":[241],"artifacts.":[242],"3-Dehydromitragynine,":[244],"artifact":[248]},"counts_by_year":[{"year":2026,"cited_by_count":5}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2026-03-13T00:00:00"}