{"id":"https://openalex.org/W7135014288","doi":"https://doi.org/10.1002/cncr.70343","title":"A randomized phase II trial of gemcitabine, nab\u2010paclitaxel, cisplatin with or without a medically supervised ketogenic diet for patients with metastatic pancreatic cancer","display_name":"A randomized phase II trial of gemcitabine, nab\u2010paclitaxel, cisplatin with or without a medically supervised ketogenic diet for patients with metastatic pancreatic cancer","publication_year":2026,"publication_date":"2026-03-12","ids":{"openalex":"https://openalex.org/W7135014288","doi":"https://doi.org/10.1002/cncr.70343","pmid":"https://pubmed.ncbi.nlm.nih.gov/41817106"},"language":"en","primary_location":{"id":"doi:10.1002/cncr.70343","doi":"https://doi.org/10.1002/cncr.70343","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.70343","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1002/cncr.70343","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003323232","display_name":"Gayle Jameson","orcid":"https://orcid.org/0000-0003-0987-5965","observed_orcids":["https://orcid.org/0000-0003-0987-5965"]},"institutions":[{"id":"https://openalex.org/I4210130412","display_name":"HonorHealth","ror":"https://ror.org/03szbwj17","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210130412"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gayle S. Jameson","raw_affiliation_strings":["Oncology Division HonorHealth Research Institute  Scottsdale Arizona USA"],"raw_orcid":"https://orcid.org/0000-0003-0987-5965","affiliations":[{"raw_affiliation_string":"Oncology Division HonorHealth Research Institute  Scottsdale Arizona USA","institution_ids":["https://openalex.org/I4210130412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016715621","display_name":"Denise J. Roe","orcid":"https://orcid.org/0000-0001-6989-6579","observed_orcids":["https://orcid.org/0000-0001-6989-6579"]},"institutions":[{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denise J. Roe","raw_affiliation_strings":["The University of Arizona Cancer Center  Tucson Arizona USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Arizona Cancer Center  Tucson Arizona USA","institution_ids":["https://openalex.org/I4390039223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070523850","display_name":"Erkut Hasan Borazanci","orcid":"https://orcid.org/0000-0001-5136-5462","observed_orcids":["https://orcid.org/0000-0001-5136-5462"]},"institutions":[{"id":"https://openalex.org/I4210130412","display_name":"HonorHealth","ror":"https://ror.org/03szbwj17","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210130412"]},{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erkut Borazanci","raw_affiliation_strings":["Oncology Division HonorHealth Research Institute  Scottsdale Arizona USA","School of Medicine and Advanced Medical Engineering Arizona State University  Tempe Arizona USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Division HonorHealth Research Institute  Scottsdale Arizona USA","institution_ids":["https://openalex.org/I4210130412"]},{"raw_affiliation_string":"School of Medicine and Advanced Medical Engineering Arizona State University  Tempe Arizona USA","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102929792","display_name":"Diana L. Hanna","orcid":"https://orcid.org/0000-0003-2681-5032","observed_orcids":["https://orcid.org/0000-0003-2681-5032"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Diana L. Hanna","raw_affiliation_strings":["USC Norris Comprehensive Cancer Center Medical Oncology  Los Angeles California USA"],"raw_orcid":"https://orcid.org/0000-0003-2681-5032","affiliations":[{"raw_affiliation_string":"USC Norris Comprehensive Cancer Center Medical Oncology  Los Angeles California USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048514068","display_name":"Caroline G. P. Roberts","orcid":"https://orcid.org/0000-0002-0237-1038","observed_orcids":["https://orcid.org/0000-0002-0237-1038","https://orcid.org/0000-0001-7846-9800"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Caroline G. P. Roberts","raw_affiliation_strings":["Research Department Virta Health  Denver Colorado USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Department Virta Health  Denver Colorado USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082164882","display_name":"Meredith S. Pelster","orcid":"https://orcid.org/0009-0005-2448-3478","observed_orcids":["https://orcid.org/0009-0005-2448-3478"]},"institutions":[{"id":"https://openalex.org/I4210100810","display_name":"Sarah Cannon","ror":"https://ror.org/014t21j89","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210100810"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meredith S. Pelster","raw_affiliation_strings":["Sarah Cannon Research Institute  Nashville Tennessee USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarah Cannon Research Institute  Nashville Tennessee USA","institution_ids":["https://openalex.org/I4210100810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018212344","display_name":"Richard C. Frank","orcid":"https://orcid.org/0000-0002-5923-7171","observed_orcids":["https://orcid.org/0000-0002-5923-7171"]},"institutions":[{"id":"https://openalex.org/I4405252557","display_name":"Nuvance Health","ror":"https://ror.org/02rymmk58","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I1302444339","https://openalex.org/I4405252557"]}],"countries":[],"is_corresponding":false,"raw_author_name":"Richard C. Frank","raw_affiliation_strings":["Department of Medicine Nuvance Health  Norwalk Connecticut USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Nuvance Health  Norwalk Connecticut USA","institution_ids":["https://openalex.org/I4405252557"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023523894","display_name":"Angela Tatiana Alistar","orcid":"https://orcid.org/0009-0009-0473-7513","observed_orcids":["https://orcid.org/0009-0009-0473-7513"]},"institutions":[{"id":"https://openalex.org/I2802646204","display_name":"Morristown Medical Center","ror":"https://ror.org/03m6tev69","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802646204","https://openalex.org/I67339987"]},{"id":"https://openalex.org/I67339987","display_name":"Atlantic Health System","ror":"https://ror.org/02jz99c72","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I67339987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela T. Alistar","raw_affiliation_strings":["Atlantic Health Atlantic Medical Oncology Morristown Medical Center Morristown  Morristown New Jersey USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Atlantic Health Atlantic Medical Oncology Morristown Medical Center Morristown  Morristown New Jersey USA","institution_ids":["https://openalex.org/I2802646204","https://openalex.org/I67339987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066238218","display_name":"Alan M. Miller","orcid":"https://orcid.org/0009-0004-2357-5656","observed_orcids":["https://orcid.org/0009-0004-2357-5656"]},"institutions":[{"id":"https://openalex.org/I4405267688","display_name":"Translational Drug Development (United States)","ror":"https://ror.org/03wprby34","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267688"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan M. Miller","raw_affiliation_strings":["TD2 Oncology  Scottsdale Arizona USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TD2 Oncology  Scottsdale Arizona USA","institution_ids":["https://openalex.org/I4405267688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121823889","display_name":"Julia Erin Wiedmeier-Nutor","orcid":"https://orcid.org/0000-0001-9434-5269","observed_orcids":["https://orcid.org/0000-0001-9434-5269"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]},{"id":"https://openalex.org/I4390039332","display_name":"Mayo Clinic Comprehensive Cancer Center (Arizona)","ror":"https://ror.org/003xpy695","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4390039332"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Erin Wiedmeier\u2010Nutor","raw_affiliation_strings":["Division of Hematology/Oncology Mayo Clinic  Phoenix Arizona USA"],"raw_orcid":"https://orcid.org/0000-0001-9434-5269","affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology Mayo Clinic  Phoenix Arizona USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210127938","https://openalex.org/I4390039332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060361217","display_name":"Sandra D. Algaze","orcid":"https://orcid.org/0000-0001-7233-5019","observed_orcids":["https://orcid.org/0000-0001-7233-5019"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra D. Algaze","raw_affiliation_strings":["USC Norris Comprehensive Cancer Center Medical Oncology  Los Angeles California USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USC Norris Comprehensive Cancer Center Medical Oncology  Los Angeles California USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099133878","display_name":"Alison R. Zoller","orcid":"https://orcid.org/0009-0005-1443-5253","observed_orcids":["https://orcid.org/0009-0005-1443-5253"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alison R. Zoller","raw_affiliation_strings":["Research Department Virta Health  Denver Colorado USA"],"raw_orcid":"https://orcid.org/0009-0005-1443-5253","affiliations":[{"raw_affiliation_string":"Research Department Virta Health  Denver Colorado USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072462255","display_name":"Sarah J. Hallberg","orcid":"https://orcid.org/0000-0002-8553-8293","observed_orcids":["https://orcid.org/0000-0002-8553-8293"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarah J. Hallberg","raw_affiliation_strings":["Research Department Virta Health  Denver Colorado USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Department Virta Health  Denver Colorado USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103053147","display_name":"Betsy C. Wertheim","orcid":"https://orcid.org/0000-0003-2470-3440","observed_orcids":["https://orcid.org/0000-0003-2470-3440"]},"institutions":[{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Betsy C. Wertheim","raw_affiliation_strings":["The University of Arizona Cancer Center  Tucson Arizona USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Arizona Cancer Center  Tucson Arizona USA","institution_ids":["https://openalex.org/I4390039223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005230179","display_name":"Keehoon Lee","orcid":"https://orcid.org/0000-0002-1751-3043","observed_orcids":["https://orcid.org/0000-0002-1751-3043"]},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keehoon Lee","raw_affiliation_strings":["Translational Genomics Research Institute (TGen) Clinical Genomics and Therapeutics  Phoenix Arizona USA","Translational Genomics Research Institute (TGen) TGen Integrated Microbiomics Center  Flagstaff Arizona USA"],"raw_orcid":"https://orcid.org/0000-0002-1751-3043","affiliations":[{"raw_affiliation_string":"Translational Genomics Research Institute (TGen) Clinical Genomics and Therapeutics  Phoenix Arizona USA","institution_ids":["https://openalex.org/I1284308235"]},{"raw_affiliation_string":"Translational Genomics Research Institute (TGen) TGen Integrated Microbiomics Center  Flagstaff Arizona USA","institution_ids":["https://openalex.org/I1284308235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048652560","display_name":"Derek Cridebring","orcid":"https://orcid.org/0000-0001-5630-0350","observed_orcids":["https://orcid.org/0000-0001-5630-0350"]},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derek Cridebring","raw_affiliation_strings":["Translational Genomics Research Institute (TGen) Clinical Genomics and Therapeutics  Phoenix Arizona USA"],"raw_orcid":"https://orcid.org/0000-0001-5630-0350","affiliations":[{"raw_affiliation_string":"Translational Genomics Research Institute (TGen) Clinical Genomics and Therapeutics  Phoenix Arizona USA","institution_ids":["https://openalex.org/I1284308235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053467552","display_name":"Joshua D. Rabinowitz","orcid":"https://orcid.org/0000-0002-1247-4727","observed_orcids":["https://orcid.org/0000-0002-1247-4727"]},"institutions":[{"id":"https://openalex.org/I196064397","display_name":"Ludwig Cancer Research","ror":"https://ror.org/05923xh51","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I196064397","https://openalex.org/I4210150094"]},{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]},{"id":"https://openalex.org/I4210150094","display_name":"Ludwig Cancer Research","ror":"https://ror.org/05qdwtz81","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210150094"]}],"countries":["BE","US"],"is_corresponding":false,"raw_author_name":"Joshua D. Rabinowitz","raw_affiliation_strings":["Department of Chemistry Princeton University Lewis\u2010Sigler Institute of Integrative Genomics, and Ludwig Institute for Cancer Research  Princeton New Jersey USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry Princeton University Lewis\u2010Sigler Institute of Integrative Genomics, and Ludwig Institute for Cancer Research  Princeton New Jersey USA","institution_ids":["https://openalex.org/I196064397","https://openalex.org/I20089843","https://openalex.org/I4210150094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027828131","display_name":"Stephen Thomas Gately","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267688","display_name":"Translational Drug Development (United States)","ror":"https://ror.org/03wprby34","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267688"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Gately","raw_affiliation_strings":["TD2 Oncology  Scottsdale Arizona USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TD2 Oncology  Scottsdale Arizona USA","institution_ids":["https://openalex.org/I4405267688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055073529","display_name":"Jennifer S. Keppler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267688","display_name":"Translational Drug Development (United States)","ror":"https://ror.org/03wprby34","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267688"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Keppler","raw_affiliation_strings":["TD2 Oncology  Scottsdale Arizona USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TD2 Oncology  Scottsdale Arizona USA","institution_ids":["https://openalex.org/I4405267688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100722858","display_name":"Sunil Kumar Sharma","orcid":"https://orcid.org/0000-0001-7295-0441","observed_orcids":["https://orcid.org/0000-0001-7295-0441"]},"institutions":[{"id":"https://openalex.org/I4210130412","display_name":"HonorHealth","ror":"https://ror.org/03szbwj17","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210130412"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunil Sharma","raw_affiliation_strings":["Oncology Division HonorHealth Research Institute  Scottsdale Arizona USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Division HonorHealth Research Institute  Scottsdale Arizona USA","institution_ids":["https://openalex.org/I4210130412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080900202","display_name":"Daniel D. Von Hoff","orcid":"https://orcid.org/0000-0003-4723-7681","observed_orcids":["https://orcid.org/0000-0003-4723-7681"]},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]},{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]},{"id":"https://openalex.org/I4210130412","display_name":"HonorHealth","ror":"https://ror.org/03szbwj17","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210130412"]},{"id":"https://openalex.org/I4390039332","display_name":"Mayo Clinic Comprehensive Cancer Center (Arizona)","ror":"https://ror.org/003xpy695","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4390039332"]},{"id":"https://openalex.org/I4405267688","display_name":"Translational Drug Development (United States)","ror":"https://ror.org/03wprby34","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267688"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel D. Von Hoff","raw_affiliation_strings":["Department of Medical Oncology and Therapeutic Research City of Hope  Duarte California USA","Division of Hematology/Oncology Mayo Clinic  Phoenix Arizona USA","Oncology Division HonorHealth Research Institute  Scottsdale Arizona USA","TD2 Oncology  Scottsdale Arizona USA","Translational Genomics Research Institute (TGen) Clinical Genomics and Therapeutics  Phoenix Arizona USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology and Therapeutic Research City of Hope  Duarte California USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"raw_affiliation_string":"Division of Hematology/Oncology Mayo Clinic  Phoenix Arizona USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210127938","https://openalex.org/I4390039332"]},{"raw_affiliation_string":"Oncology Division HonorHealth Research Institute  Scottsdale Arizona USA","institution_ids":["https://openalex.org/I4210130412"]},{"raw_affiliation_string":"TD2 Oncology  Scottsdale Arizona USA","institution_ids":["https://openalex.org/I4405267688"]},{"raw_affiliation_string":"Translational Genomics Research Institute (TGen) Clinical Genomics and Therapeutics  Phoenix Arizona USA","institution_ids":["https://openalex.org/I1284308235"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073134832","display_name":"Drew Warren Rasco","orcid":"https://orcid.org/0009-0009-6619-2854","observed_orcids":["https://orcid.org/0009-0009-6619-2854"]},"institutions":[{"id":"https://openalex.org/I4210119066","display_name":"South Texas Accelerated Research Therapeutics","ror":"https://ror.org/01scs7915","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210119066"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Drew W. Rasco","raw_affiliation_strings":["START \u2013 San Antonio  San Antonio Texas USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"START \u2013 San Antonio  San Antonio Texas USA","institution_ids":["https://openalex.org/I4210119066"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":20,"corresponding_author_ids":["https://openalex.org/A5102929792"],"corresponding_institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":{"value":4790,"currency":"USD","value_usd":4790},"fwci":16.0788,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.9917129,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"132","issue":"6","first_page":"e70343","last_page":"e70343"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies","score":0.029400000348687172,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ketogenic-diet","display_name":"ketogenic diet","score":0.7910000085830688},{"id":"https://openalex.org/keywords/metastatic-pancreatic-ductal-adenocarcinoma","display_name":"metastatic pancreatic ductal adenocarcinoma","score":0.9490000009536743},{"id":"https://openalex.org/keywords/gemcitabine","display_name":"gemcitabine","score":0.9950000047683716},{"id":"https://openalex.org/keywords/nab-paclitaxel","display_name":"nab-paclitaxel","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nutritional-ketosis","display_name":"nutritional ketosis","score":0.8479999899864197},{"id":"https://openalex.org/keywords/beta-hydroxybutyrate","display_name":"beta-hydroxybutyrate","score":0.9739999771118164},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8870000243186951},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9850000143051147},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.7850000262260437},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.9150000214576721},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.5669999718666077},{"id":"https://openalex.org/keywords/treatment-naive-patients","display_name":"treatment-naive patients","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.967199981212616},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7124000191688538},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.6607000231742859},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6557999849319458},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.6474000215530396},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5374000072479248},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.44209998846054077},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.4350000023841858},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.41850000619888306},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37130001187324524},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3582000136375427},{"id":"https://openalex.org/C2776737053","wikidata":"https://www.wikidata.org/wiki/Q7130407","display_name":"Pancreatic disease","level":3,"score":0.34779998660087585},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.33570000529289246},{"id":"https://openalex.org/C2776907518","wikidata":"https://www.wikidata.org/wiki/Q1734165","display_name":"Performance status","level":3,"score":0.30219998955726624},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.2872999906539917},{"id":"https://openalex.org/C2778587478","wikidata":"https://www.wikidata.org/wiki/Q1070684","display_name":"Ketogenic diet","level":3,"score":0.2702000141143799},{"id":"https://openalex.org/C2777844706","wikidata":"https://www.wikidata.org/wiki/Q422504","display_name":"Deoxycytidine","level":4,"score":0.2685000002384186},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.2614000141620636},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2599000036716461}],"mesh":[{"descriptor_ui":"D000077982","descriptor_name":"Progression-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077982","descriptor_name":"Progression-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077982","descriptor_name":"Progression-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000093542","descriptor_name":"Gemcitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000093542","descriptor_name":"Gemcitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000093542","descriptor_name":"Gemcitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000093542","descriptor_name":"Gemcitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000093542","descriptor_name":"Gemcitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000093542","descriptor_name":"Gemcitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000093542","descriptor_name":"Gemcitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D055423","descriptor_name":"Diet, Ketogenic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055423","descriptor_name":"Diet, Ketogenic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055423","descriptor_name":"Diet, Ketogenic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055423","descriptor_name":"Diet, Ketogenic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055423","descriptor_name":"Diet, Ketogenic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055423","descriptor_name":"Diet, Ketogenic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055423","descriptor_name":"Diet, Ketogenic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/cncr.70343","doi":"https://doi.org/10.1002/cncr.70343","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.70343","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"doi:10.1101/2025.06.01.25328728","doi":"https://doi.org/10.1101/2025.06.01.25328728","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.06.01.25328728","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2025/06/09/2025.06.01.25328728.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmid:41817106","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41817106","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12980701","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12980701/pdf/CNCR-132-e70343.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/cncr.70343","doi":"https://doi.org/10.1002/cncr.70343","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.70343","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8456882834434509,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320311496","display_name":"Ludwig Institute for Cancer Research","ror":"https://ror.org/05qdwtz81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1987238295","https://openalex.org/W2005033595","https://openalex.org/W2015012139","https://openalex.org/W2019607817","https://openalex.org/W2065215232","https://openalex.org/W2097259163","https://openalex.org/W2102634879","https://openalex.org/W2149721689","https://openalex.org/W2605315883","https://openalex.org/W2609972574","https://openalex.org/W2747163024","https://openalex.org/W2887963412","https://openalex.org/W2951175507","https://openalex.org/W2965696960","https://openalex.org/W2972507666","https://openalex.org/W2977856709","https://openalex.org/W3025267759","https://openalex.org/W3039815594","https://openalex.org/W3156108334","https://openalex.org/W3201633312","https://openalex.org/W4211225142","https://openalex.org/W4214715099","https://openalex.org/W4220798004","https://openalex.org/W4290803961","https://openalex.org/W4292528167","https://openalex.org/W4310170829","https://openalex.org/W4392401568","https://openalex.org/W4399919270","https://openalex.org/W4400903469","https://openalex.org/W4402197838","https://openalex.org/W4402846489","https://openalex.org/W4403114231","https://openalex.org/W4403330393","https://openalex.org/W4403563837","https://openalex.org/W4405072044"],"related_works":[],"abstract_inverted_index":{"ABSTRACT":[0],"Background":[1],"A":[2],"randomized":[3,42],"phase":[4],"II":[5],"screening":[6],"trial":[7],"of":[8,59,81,98,109,131,140,228,290],"gemcitabine,":[9,50,267],"nab\u2010paclitaxel,":[10,51,268],"and":[11,52,57,73,107,155,179,224,262,269,286],"cisplatin":[12,53],"with":[13,28,37,78,177,248,266],"a":[14,60,68,94],"medically":[15],"supervised":[16],"ketogenic":[17],"diet":[18,22],"(MSKD)":[19],"versus":[20],"usual":[21],"(non\u2010MSKD)":[23],"was":[24,65,89,144,149,174],"conducted":[25],"in":[26,113,142,152,158,182,208,222,231,246,259,293],"patients":[27,133,154,218,247],"treatment\u2010naive":[29],"metastatic":[30,39],"pancreatic":[31,294],"ductal":[32],"adenocarcinoma":[33],"(PDAC).":[34],"Methods":[35],"Patients":[36],"untreated":[38],"PDAC":[40,249],"were":[41,115,122,200,204],"1:1":[43],"to":[44,83,276,282],"MSKD":[45,64,128,153,178,217,243,292],"or":[46,274],"non\u2010MSKD":[47,159,184],"while":[48],"receiving":[49],"on":[54],"days":[55,141],"1":[56],"8":[58],"21\u2010day":[61],"cycle.":[62],"The":[63,86,146,171,242],"guided":[66],"by":[67],"remote":[69],"health":[70],"care":[71],"team":[72],"daily":[74],"ketone":[75],"(beta\u2010hydroxybutyrate)":[76],"levels,":[77],"goal":[79],"beta\u2010hydroxybutyrate":[80],"0.5":[82],"3.0":[84],"mM.":[85],"primary":[87],"endpoint":[88],"progression\u2010free":[90],"survival":[91,104],"(PFS)":[92],"using":[93],"one\u2010sided":[95,167,192],"alpha":[96],"level":[97],"0.20.":[99],"Secondary":[100],"endpoints":[101],"included":[102],"overall":[103],"(OS),":[105],"safety,":[106],"quality":[108],"life":[110],"(QOL).":[111],"Changes":[112],"microbiome":[114,233],"an":[116],"exploratory":[117],"endpoint.":[118],"Findings":[119],"Overall,":[120],"there":[121],"32":[123],"evaluable":[124],"patients.":[125],"In":[126],"the":[127,137,183,215,232,288,291],"arm,":[129],"15":[130],"16":[132],"achieved":[134],"nutritional":[135],"ketosis;":[136],"median":[138,147,172],"proportion":[139],"ketosis":[143],"39.4%.":[145],"PFS":[148,261],"8.5":[150],"months":[151,157,176,181],"6.2":[156],"patients:":[160],"hazard":[161,186],"ratio,":[162,187],"0.53":[163],"(95%":[164,189],"CI,":[165,190],"0.21\u20131.37);":[166],"p":[168,193,235],"=":[169,194],".096.":[170],"OS":[173,263],"13.7":[175],"10.2":[180],"arm:":[185],"0.58":[188],"0.25\u20131.37);":[191],".107).":[195],"All":[196],"MSKD\u2010related":[197],"adverse":[198,212],"events":[199,213],"grade":[201,209],"1\u20102.":[202],"There":[203],"no":[205,220],"significant":[206,226],"differences":[207],"\u22653":[210],"chemotherapy\u2010related":[211],"between":[214],"arms.":[216],"had":[219,225],"decline":[221],"QOL":[223],"enrichment":[227],"beneficial":[229],"taxa":[230],"(":[234],"<":[236],".05,":[237],"log\u2010fold":[238],"change":[239],"\u22652).":[240],"Conclusions":[241],"is":[244],"feasible":[245],"and,":[250],"although":[251],"not":[252],"powered":[253],"for":[254],"definitive":[255],"outcomes,":[256],"shows":[257],"trends":[258],"improved":[260],"when":[264],"combined":[265],"cisplatin,":[270],"without":[271],"added":[272],"toxicity":[273],"detriment":[275],"QOL.":[277],"Larger":[278],"studies":[279],"are":[280],"required":[281],"confirm":[283],"these":[284],"findings":[285],"establish":[287],"value":[289],"cancer":[295],"treatment.":[296]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-03-13T00:00:00"}