{"id":"https://openalex.org/W7134040722","doi":"https://doi.org/10.3390/ijms27052440","title":"Neurotrophin and Adipokine Signatures Associated with Visceral Adiposity-Driven Cardiometabolic and Endocrine Risk in Polycystic Ovary Syndrome","display_name":"Neurotrophin and Adipokine Signatures Associated with Visceral Adiposity-Driven Cardiometabolic and Endocrine Risk in Polycystic Ovary Syndrome","publication_year":2026,"publication_date":"2026-03-06","ids":{"openalex":"https://openalex.org/W7134040722","doi":"https://doi.org/10.3390/ijms27052440","pmid":"https://pubmed.ncbi.nlm.nih.gov/41828655","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12986381"},"language":"en","primary_location":{"id":"doi:10.3390/ijms27052440","doi":"https://doi.org/10.3390/ijms27052440","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27052440","pdf_url":"https://www.mdpi.com/1422-0067/27/5/2440/pdf?version=1772801068","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7134040722"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/27/5/2440/pdf?version=1772801068","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092814443","display_name":"Daniela Ivanova Koleva-Tyutyundzhieva","orcid":"https://orcid.org/0000-0002-5973-3503","observed_orcids":["https://orcid.org/0000-0002-5973-3503"]},"institutions":[{"id":"https://openalex.org/I2801117330","display_name":"Medical University Plovdiv","ror":"https://ror.org/02kzxd152","country_code":"BG","type":"education","lineage":["https://openalex.org/I2801117330"]}],"countries":["BG"],"is_corresponding":true,"raw_author_name":"Daniela Koleva-Tyutyundzhieva","raw_affiliation_strings":["Department of Endocrinology and Metabolic Diseases , Faculty of Medicine , Medical University of Plovdiv , 15A Blvd Vasil Aprilov , 4002 Plovdiv , Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolic Diseases , Faculty of Medicine , Medical University of Plovdiv , 15A Blvd Vasil Aprilov , 4002 Plovdiv , Bulgaria","institution_ids":["https://openalex.org/I2801117330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002216792","display_name":"Maria Ilieva-Gerova","orcid":"https://orcid.org/0000-0001-9293-3016","observed_orcids":["https://orcid.org/0000-0001-9293-3016"]},"institutions":[{"id":"https://openalex.org/I2801117330","display_name":"Medical University Plovdiv","ror":"https://ror.org/02kzxd152","country_code":"BG","type":"education","lineage":["https://openalex.org/I2801117330"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Maria Ilieva-Gerova","raw_affiliation_strings":["Department of Endocrinology and Metabolic Diseases , Faculty of Medicine , Medical University of Plovdiv , 15A Blvd Vasil Aprilov , 4002 Plovdiv , Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolic Diseases , Faculty of Medicine , Medical University of Plovdiv , 15A Blvd Vasil Aprilov , 4002 Plovdiv , Bulgaria","institution_ids":["https://openalex.org/I2801117330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040951496","display_name":"Elena A. Becheva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801117330","display_name":"Medical University Plovdiv","ror":"https://ror.org/02kzxd152","country_code":"BG","type":"education","lineage":["https://openalex.org/I2801117330"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Elena Becheva","raw_affiliation_strings":["Department of Endocrinology and Metabolic Diseases , Faculty of Medicine , Medical University of Plovdiv , 15A Blvd Vasil Aprilov , 4002 Plovdiv , Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolic Diseases , Faculty of Medicine , Medical University of Plovdiv , 15A Blvd Vasil Aprilov , 4002 Plovdiv , Bulgaria","institution_ids":["https://openalex.org/I2801117330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065233896","display_name":"Tanya Deneva","orcid":"https://orcid.org/0000-0002-0089-4230","observed_orcids":["https://orcid.org/0000-0002-0089-4230"]},"institutions":[{"id":"https://openalex.org/I2801117330","display_name":"Medical University Plovdiv","ror":"https://ror.org/02kzxd152","country_code":"BG","type":"education","lineage":["https://openalex.org/I2801117330"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Tanya Deneva","raw_affiliation_strings":["Department of Clinical Laboratory , Faculty of Medicine , Medical University of Plovdiv , 4002 Plovdiv , Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory , Faculty of Medicine , Medical University of Plovdiv , 4002 Plovdiv , Bulgaria","institution_ids":["https://openalex.org/I2801117330"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034359504","display_name":"Maria Mitkova Orbetzova","orcid":"https://orcid.org/0000-0001-9918-0707","observed_orcids":["https://orcid.org/0000-0001-9918-0707"]},"institutions":[{"id":"https://openalex.org/I2801117330","display_name":"Medical University Plovdiv","ror":"https://ror.org/02kzxd152","country_code":"BG","type":"education","lineage":["https://openalex.org/I2801117330"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Maria Orbetzova","raw_affiliation_strings":["Department of Endocrinology and Metabolic Diseases , Faculty of Medicine , Medical University of Plovdiv , 15A Blvd Vasil Aprilov , 4002 Plovdiv , Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolic Diseases , Faculty of Medicine , Medical University of Plovdiv , 15A Blvd Vasil Aprilov , 4002 Plovdiv , Bulgaria","institution_ids":["https://openalex.org/I2801117330"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5092814443"],"corresponding_institution_ids":["https://openalex.org/I2801117330"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":6.5375,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.94419134,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"27","issue":"5","first_page":"2440","last_page":"2440"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycystic-ovary-syndrome","display_name":"polycystic ovary syndrome","score":1.0},{"id":"https://openalex.org/keywords/visceral-fat","display_name":"visceral fat","score":0.9039999842643738},{"id":"https://openalex.org/keywords/neurotrophins","display_name":"neurotrophins","score":0.9549999833106995},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.9340000152587891},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.9940000176429749},{"id":"https://openalex.org/keywords/beta-nerve-growth-factor","display_name":"beta-nerve growth factor","score":0.7979999780654907},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.9639999866485596},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":1.0},{"id":"https://openalex.org/keywords/resistin","display_name":"resistin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9710000157356262},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.8769999742507935},{"id":"https://openalex.org/keywords/cardiometabolic-risk","display_name":"cardiometabolic risk","score":0.9480000138282776},{"id":"https://openalex.org/keywords/visceral-adiposity-index","display_name":"visceral adiposity index","score":0.8759999871253967},{"id":"https://openalex.org/keywords/leptin-to-adiponectin-ratio","display_name":"leptin/adiponectin ratio","score":0.875},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.7739999890327454},{"id":"https://openalex.org/keywords/non-hdl-cholesterol","display_name":"non-HDL cholesterol","score":0.7279999852180481},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C194832188","wikidata":"https://www.wikidata.org/wiki/Q2638593","display_name":"Adipokine","level":4,"score":0.9412000179290771},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7980999946594238},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7501999735832214},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6481000185012817},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.6324999928474426},{"id":"https://openalex.org/C2779760629","wikidata":"https://www.wikidata.org/wiki/Q419499","display_name":"Resistin","level":5,"score":0.6304000020027161},{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.6147000193595886},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.5965999960899353},{"id":"https://openalex.org/C2779357093","wikidata":"https://www.wikidata.org/wiki/Q422269","display_name":"Ghrelin","level":3,"score":0.5544999837875366},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.487199991941452},{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.4097000062465668},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.385699987411499},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.36480000615119934},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.33809998631477356},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.33399999141693115},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.3330000042915344},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.3303999900817871},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.3093999922275543},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.26660001277923584},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.2574000060558319},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.25540000200271606},{"id":"https://openalex.org/C68710172","wikidata":"https://www.wikidata.org/wiki/Q14906191","display_name":"Ciliary neurotrophic factor","level":4,"score":0.2547999918460846}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009414","descriptor_name":"Nerve Growth Factors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020932","descriptor_name":"Nerve Growth Factor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D050152","descriptor_name":"Intra-Abdominal Fat","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050154","descriptor_name":"Adiposity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D052243","descriptor_name":"Resistin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D054392","descriptor_name":"Adipokines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D054392","descriptor_name":"Adipokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056128","descriptor_name":"Obesity, Abdominal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms27052440","doi":"https://doi.org/10.3390/ijms27052440","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27052440","pdf_url":"https://www.mdpi.com/1422-0067/27/5/2440/pdf?version=1772801068","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"doi:10.20944/preprints202601.2399.v1","doi":"https://doi.org/10.20944/preprints202601.2399.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202601.2399.v1","pdf_url":"https://www.preprints.org/frontend/manuscript/4e891ee72f0048d043daa0365113ba77/download_pub","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmid:41828655","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41828655","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12986381","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12986381/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/ijms27052440","doi":"https://doi.org/10.3390/ijms27052440","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27052440","pdf_url":"https://www.mdpi.com/1422-0067/27/5/2440/pdf?version=1772801068","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7134040722.pdf","grobid_xml":"https://content.openalex.org/works/W7134040722.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W35160924","https://openalex.org/W131170316","https://openalex.org/W1156362633","https://openalex.org/W1538464857","https://openalex.org/W1890452043","https://openalex.org/W1994593372","https://openalex.org/W2000020150","https://openalex.org/W2021262492","https://openalex.org/W2032092887","https://openalex.org/W2056184901","https://openalex.org/W2065767769","https://openalex.org/W2089059131","https://openalex.org/W2096887626","https://openalex.org/W2100211815","https://openalex.org/W2101316067","https://openalex.org/W2104295145","https://openalex.org/W2118268869","https://openalex.org/W2121926694","https://openalex.org/W2124509857","https://openalex.org/W2125944762","https://openalex.org/W2127187614","https://openalex.org/W2132575272","https://openalex.org/W2133009672","https://openalex.org/W2162655989","https://openalex.org/W2171871916","https://openalex.org/W2299929805","https://openalex.org/W2398526138","https://openalex.org/W2523733243","https://openalex.org/W2612079343","https://openalex.org/W2767601386","https://openalex.org/W2885247948","https://openalex.org/W2908506786","https://openalex.org/W2945219586","https://openalex.org/W3044817976","https://openalex.org/W3118630608","https://openalex.org/W3120157680","https://openalex.org/W3131117140","https://openalex.org/W3205044456","https://openalex.org/W4205329307","https://openalex.org/W4285731679","https://openalex.org/W4286470647","https://openalex.org/W4301943016","https://openalex.org/W4312763327","https://openalex.org/W4317423645","https://openalex.org/W4378672789","https://openalex.org/W4393987901","https://openalex.org/W4396742769","https://openalex.org/W4401411513","https://openalex.org/W4403300469","https://openalex.org/W4405609274","https://openalex.org/W4409891584","https://openalex.org/W4410760361","https://openalex.org/W4411612521","https://openalex.org/W4414206619","https://openalex.org/W4415809686","https://openalex.org/W4417349568"],"related_works":["https://openalex.org/W7212017532","https://openalex.org/W2134913181","https://openalex.org/W2945219586","https://openalex.org/W4402725565","https://openalex.org/W1823276895","https://openalex.org/W4412357001","https://openalex.org/W4414862473","https://openalex.org/W4280580671","https://openalex.org/W3200466949","https://openalex.org/W3047720742"],"abstract_inverted_index":{"Polycystic":[0],"ovary":[1],"syndrome":[2],"(PCOS)":[3],"is":[4,25,178],"a":[5,26,163,172],"heterogeneous":[6],"endocrine-metabolic":[7],"disorder":[8],"associated":[9,113,179],"with":[10,37,53,114,132,157,180],"insulin":[11,76],"resistance":[12],"(IR),":[13],"visceral":[14,21,149,188],"adiposity,":[15,150],"and":[16,40,62,75,80,94,101,116,127,134,142,155,191],"increased":[17],"cardiometabolic":[18,176,190],"risk.":[19,193],"The":[20],"adiposity":[22],"index":[23],"(VAI)":[24],"validated":[27],"surrogate":[28],"marker":[29],"of":[30,83],"adipose":[31],"tissue":[32],"dysfunction,":[33],"but":[34],"its":[35],"relationship":[36],"circulating":[38],"neurotrophins":[39],"adipokine":[41,99,153],"balance":[42],"in":[43],"PCOS":[44,54,173],"remains":[45],"incompletely":[46],"understood.":[47],"In":[48],"this":[49],"study,":[50],"100":[51],"women":[52],"were":[55,96,104],"stratified":[56],"into":[57],"lower-":[58],"(n":[59,64],"=":[60,65],"50)":[61,66],"higher-risk":[63],"groups":[67],"according":[68],"to":[69,124],"VAI.":[70],"Anthropometric":[71],"measures,":[72],"fasting":[73],"glucose":[74],"concentrations,":[77],"lipid":[78],"profile,":[79],"serum":[81],"levels":[82],"brain-derived":[84],"neurotrophic":[85],"factor":[86],"(BDNF),":[87],"nerve":[88],"growth":[89],"factor-\u03b2":[90],"(NGF\u03b2),":[91],"leptin,":[92],"adiponectin,":[93],"resistin":[95],"assessed.":[97],"HOMA-IR,":[98],"ratios":[100],"atherogenic":[102],"indices":[103],"calculated.":[105],"Multivariate":[106],"regression":[107],"showed":[108],"that":[109,170],"BDNF":[110],"was":[111,121],"independently":[112,122],"VAI":[115],"non-HDL":[117],"cholesterol,":[118],"whereas":[119],"NGF\u03b2":[120],"linked":[123],"HDL":[125],"cholesterol":[126],"estradiol,":[128],"highlighting":[129,184],"neurotrophin":[130],"relationships":[131],"metabolic":[133],"endocrine":[135,192],"parameters":[136],"beyond":[137],"general":[138],"adiposity.":[139],"Correlation":[140],"heatmap":[141],"network":[143],"analyses":[144],"demonstrated":[145],"interconnected":[146],"clusters":[147],"linking":[148],"IR,":[151],"dyslipidemia,":[152],"imbalance,":[154],"neurotrophins,":[156],"the":[158],"leptin/adiponectin":[159],"ratio":[160],"emerging":[161],"as":[162],"central":[164],"integrative":[165],"marker.":[166],"These":[167],"findings":[168],"suggest":[169],"within":[171],"population,":[174],"VAI-defined":[175],"risk":[177],"distinct":[181],"neurotrophin-adipokine":[182,185],"signatures,":[183],"networks":[186],"underlying":[187],"adiposity-driven":[189]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-03-07T00:00:00"}