{"id":"https://openalex.org/W7133556830","doi":"https://doi.org/10.1158/1078-0432.ccr-25-4600","title":"Allogeneic B7-H3\u2013Targeted CAR V\u03b41T-cell Therapy in Advanced Solid Tumors: A Phase I Study","display_name":"Allogeneic B7-H3\u2013Targeted CAR V\u03b41T-cell Therapy in Advanced Solid Tumors: A Phase I Study","publication_year":2026,"publication_date":"2026-03-04","ids":{"openalex":"https://openalex.org/W7133556830","doi":"https://doi.org/10.1158/1078-0432.ccr-25-4600","pmid":"https://pubmed.ncbi.nlm.nih.gov/41779003"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-25-4600","doi":"https://doi.org/10.1158/1078-0432.ccr-25-4600","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-25-4600","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100353139","display_name":"Chang Liu","orcid":"https://orcid.org/0000-0001-9388-4180","observed_orcids":["https://orcid.org/0000-0001-9388-4180","https://orcid.org/0000-0001-5271-9867"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chang Liu","raw_affiliation_strings":["1Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Early Drug Development Center, Peking University Cancer Hospital and Institute, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0001-9388-4180","affiliations":[{"raw_affiliation_string":"1Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Early Drug Development Center, Peking University Cancer Hospital and Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100414543","display_name":"Jiarui Li","orcid":"https://orcid.org/0000-0002-9340-3962","observed_orcids":["https://orcid.org/0000-0002-9340-3962"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiarui Li","raw_affiliation_strings":["2Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China","3Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0002-9340-3962","affiliations":[{"raw_affiliation_string":"2Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]},{"raw_affiliation_string":"3Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128115202","display_name":"Dan Liu","orcid":"https://orcid.org/0000-0002-5055-5958","observed_orcids":["https://orcid.org/0000-0002-5055-5958"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dan Liu","raw_affiliation_strings":["1Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Early Drug Development Center, Peking University Cancer Hospital and Institute, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0002-5055-5958","affiliations":[{"raw_affiliation_string":"1Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Early Drug Development Center, Peking University Cancer Hospital and Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137180999","display_name":"Panpan Zhang","orcid":"https://orcid.org/0000-0002-9633-6208","observed_orcids":["https://orcid.org/0000-0002-9633-6208"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Panpan Zhang","raw_affiliation_strings":["1Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Early Drug Development Center, Peking University Cancer Hospital and Institute, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0002-9633-6208","affiliations":[{"raw_affiliation_string":"1Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Early Drug Development Center, Peking University Cancer Hospital and Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138772942","display_name":"Miao Zhang","orcid":"https://orcid.org/0009-0002-4760-8438","observed_orcids":["https://orcid.org/0009-0002-4760-8438"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Miao Zhang","raw_affiliation_strings":["1Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Early Drug Development Center, Peking University Cancer Hospital and Institute, Beijing, China"],"raw_orcid":"https://orcid.org/0009-0002-4760-8438","affiliations":[{"raw_affiliation_string":"1Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Early Drug Development Center, Peking University Cancer Hospital and Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128067454","display_name":"Ran Xue","orcid":"https://orcid.org/0000-0003-3978-6066","observed_orcids":["https://orcid.org/0000-0003-3978-6066"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ran Xue","raw_affiliation_strings":["1Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Early Drug Development Center, Peking University Cancer Hospital and Institute, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0003-3978-6066","affiliations":[{"raw_affiliation_string":"1Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Early Drug Development Center, Peking University Cancer Hospital and Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112461557","display_name":"Jifang Gong","orcid":"https://orcid.org/0000-0003-3798-7024","observed_orcids":["https://orcid.org/0000-0003-3798-7024"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jifang Gong","raw_affiliation_strings":["3Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0003-3798-7024","affiliations":[{"raw_affiliation_string":"3Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138800117","display_name":"Lian Liu","orcid":"https://orcid.org/0009-0000-6023-6232","observed_orcids":["https://orcid.org/0009-0000-6023-6232"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lian Liu","raw_affiliation_strings":["2Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China"],"raw_orcid":"https://orcid.org/0009-0000-6023-6232","affiliations":[{"raw_affiliation_string":"2Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138762897","display_name":"Min Tao","orcid":"https://orcid.org/0009-0008-3492-1103","observed_orcids":["https://orcid.org/0009-0008-3492-1103"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Tao","raw_affiliation_strings":["2Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China"],"raw_orcid":"https://orcid.org/0009-0008-3492-1103","affiliations":[{"raw_affiliation_string":"2Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112619054","display_name":"Siyuan Cheng","orcid":"https://orcid.org/0000-0001-8601-2165","observed_orcids":["https://orcid.org/0000-0001-8601-2165"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siyuan Cheng","raw_affiliation_strings":["2Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0001-8601-2165","affiliations":[{"raw_affiliation_string":"2Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128105951","display_name":"Ting Xu","orcid":"https://orcid.org/0000-0002-1381-1609","observed_orcids":["https://orcid.org/0000-0002-1381-1609"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Xu","raw_affiliation_strings":["2Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0002-1381-1609","affiliations":[{"raw_affiliation_string":"2Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041213358","display_name":"Jiajia Yuan","orcid":"https://orcid.org/0000-0002-9614-6279","observed_orcids":["https://orcid.org/0000-0002-9614-6279"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiajia Yuan","raw_affiliation_strings":["2Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0002-9614-6279","affiliations":[{"raw_affiliation_string":"2Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074564259","display_name":"Yanshuo Cao","orcid":"https://orcid.org/0000-0003-4030-8600","observed_orcids":["https://orcid.org/0000-0003-4030-8600"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanshuo Cao","raw_affiliation_strings":["2Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0003-4030-8600","affiliations":[{"raw_affiliation_string":"2Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065755796","display_name":"Zhenghang Wang","orcid":"https://orcid.org/0000-0001-8307-693X","observed_orcids":["https://orcid.org/0000-0001-8307-693X","https://orcid.org/0009-0004-4166-576X"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenghang Wang","raw_affiliation_strings":["2Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0001-8307-693X","affiliations":[{"raw_affiliation_string":"2Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100628205","display_name":"Yakun Wang","orcid":"https://orcid.org/0000-0001-5579-2998","observed_orcids":["https://orcid.org/0000-0001-5579-2998"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yakun Wang","raw_affiliation_strings":["3Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0001-5579-2998","affiliations":[{"raw_affiliation_string":"3Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138828142","display_name":"Jun Zhou","orcid":"https://orcid.org/0009-0000-3919-7996","observed_orcids":["https://orcid.org/0009-0000-3919-7996"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Zhou","raw_affiliation_strings":["2Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China"],"raw_orcid":"https://orcid.org/0009-0000-3919-7996","affiliations":[{"raw_affiliation_string":"2Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138797211","display_name":"Ming Lu","orcid":"https://orcid.org/0009-0000-9665-9851","observed_orcids":["https://orcid.org/0009-0000-9665-9851"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Lu","raw_affiliation_strings":["3Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China"],"raw_orcid":"https://orcid.org/0009-0000-9665-9851","affiliations":[{"raw_affiliation_string":"3Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102950518","display_name":"Zhi Peng","orcid":"https://orcid.org/0000-0003-4063-9813","observed_orcids":["https://orcid.org/0000-0003-4063-9813"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi Peng","raw_affiliation_strings":["3Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0003-4063-9813","affiliations":[{"raw_affiliation_string":"3Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128093828","display_name":"Zhihao Lu","orcid":"https://orcid.org/0000-0001-9091-4946","observed_orcids":["https://orcid.org/0000-0001-9091-4946"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhihao Lu","raw_affiliation_strings":["2Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0001-9091-4946","affiliations":[{"raw_affiliation_string":"2Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137149576","display_name":"Jian Li","orcid":"https://orcid.org/0000-0002-9333-3255","observed_orcids":["https://orcid.org/0000-0002-9333-3255"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Li","raw_affiliation_strings":["2Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China","3Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0002-9333-3255","affiliations":[{"raw_affiliation_string":"2Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]},{"raw_affiliation_string":"3Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011702431","display_name":"Xiaotian Zhang","orcid":"https://orcid.org/0000-0001-6936-2622","observed_orcids":["https://orcid.org/0000-0001-6936-2622"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaotian Zhang","raw_affiliation_strings":["3Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0001-6936-2622","affiliations":[{"raw_affiliation_string":"3Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138792066","display_name":"Tian Wang","orcid":"https://orcid.org/0009-0005-3120-9282","observed_orcids":["https://orcid.org/0009-0005-3120-9282"]},"institutions":[{"id":"https://openalex.org/I4210129654","display_name":"PersonGen (China)","ror":"https://ror.org/03a5tyh47","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210129654"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tian Wang","raw_affiliation_strings":["4PersonGen BioTherapeutics (Suzhou) Co., Ltd, Suzhou, China"],"raw_orcid":"https://orcid.org/0009-0005-3120-9282","affiliations":[{"raw_affiliation_string":"4PersonGen BioTherapeutics (Suzhou) Co., Ltd, Suzhou, China","institution_ids":["https://openalex.org/I4210129654"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101331876","display_name":"Min Wang","orcid":"https://orcid.org/0009-0002-0113-3422","observed_orcids":["https://orcid.org/0009-0002-0113-3422"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Min Wang","raw_affiliation_strings":["5PersonGen-Anke Cellular Therapeutics Co., Ltd, Hefei, China"],"raw_orcid":"https://orcid.org/0009-0002-0113-3422","affiliations":[{"raw_affiliation_string":"5PersonGen-Anke Cellular Therapeutics Co., Ltd, Hefei, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071935361","display_name":"Licui Jiang","orcid":"https://orcid.org/0009-0004-5996-7117","observed_orcids":["https://orcid.org/0009-0004-5996-7117"]},"institutions":[{"id":"https://openalex.org/I4210129654","display_name":"PersonGen (China)","ror":"https://ror.org/03a5tyh47","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210129654"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Licui Jiang","raw_affiliation_strings":["4PersonGen BioTherapeutics (Suzhou) Co., Ltd, Suzhou, China"],"raw_orcid":"https://orcid.org/0009-0004-5996-7117","affiliations":[{"raw_affiliation_string":"4PersonGen BioTherapeutics (Suzhou) Co., Ltd, Suzhou, China","institution_ids":["https://openalex.org/I4210129654"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100532055","display_name":"Huimin Meng","orcid":"https://orcid.org/0009-0009-9138-5383","observed_orcids":["https://orcid.org/0009-0009-9138-5383"]},"institutions":[{"id":"https://openalex.org/I4210129654","display_name":"PersonGen (China)","ror":"https://ror.org/03a5tyh47","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210129654"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huimin Meng","raw_affiliation_strings":["4PersonGen BioTherapeutics (Suzhou) Co., Ltd, Suzhou, China"],"raw_orcid":"https://orcid.org/0009-0009-9138-5383","affiliations":[{"raw_affiliation_string":"4PersonGen BioTherapeutics (Suzhou) Co., Ltd, Suzhou, China","institution_ids":["https://openalex.org/I4210129654"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055644693","display_name":"Lin Yang","orcid":"https://orcid.org/0000-0002-4028-9801","observed_orcids":["https://orcid.org/0000-0002-4028-9801"]},"institutions":[{"id":"https://openalex.org/I4210129654","display_name":"PersonGen (China)","ror":"https://ror.org/03a5tyh47","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210129654"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Yang","raw_affiliation_strings":["4PersonGen BioTherapeutics (Suzhou) Co., Ltd, Suzhou, China","5PersonGen-Anke Cellular Therapeutics Co., Ltd, Hefei, China"],"raw_orcid":"https://orcid.org/0000-0002-4028-9801","affiliations":[{"raw_affiliation_string":"4PersonGen BioTherapeutics (Suzhou) Co., Ltd, Suzhou, China","institution_ids":["https://openalex.org/I4210129654"]},{"raw_affiliation_string":"5PersonGen-Anke Cellular Therapeutics Co., Ltd, Hefei, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043941211","display_name":"Changsong Qi","orcid":"https://orcid.org/0000-0001-9157-3768","observed_orcids":["https://orcid.org/0000-0001-9157-3768"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Changsong Qi","raw_affiliation_strings":["6Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Early Drug Development Center, Peking University Cancer Hospital and Institute, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0001-9157-3768","affiliations":[{"raw_affiliation_string":"6Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Early Drug Development Center, Peking University Cancer Hospital and Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5121078028","display_name":"Lin Shen","orcid":"https://orcid.org/0000-0003-1134-2922","observed_orcids":["https://orcid.org/0000-0003-1134-2922"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Shen","raw_affiliation_strings":["3Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0003-1134-2922","affiliations":[{"raw_affiliation_string":"3Beijing Key Laboratory of Cell and Gene Therapy for Solid Tumor, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5043941211"],"corresponding_institution_ids":["https://openalex.org/I4210093964"],"apc_list":null,"apc_paid":null,"fwci":14.4098,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.98853932,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"32","issue":"10","first_page":"2026","last_page":"2035"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b7-h3","display_name":"B7-H3","score":0.953000009059906},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor","display_name":"chimeric antigen receptor","score":0.7839999794960022},{"id":"https://openalex.org/keywords/vdelta1-t-cells","display_name":"V\u03b41 T cells","score":0.9340000152587891},{"id":"https://openalex.org/keywords/allogeneic-car-t-cell-therapy","display_name":"allogeneic CAR T-cell therapy","score":0.9190000295639038},{"id":"https://openalex.org/keywords/off-the-shelf-t-cell-therapy","display_name":"off-the-shelf T cell therapy","score":0.7009999752044678},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.8330000042915344},{"id":"https://openalex.org/keywords/car-t-cell-persistence","display_name":"CAR T cell persistence","score":0.9210000038146973},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cytokine-release-syndrome","display_name":"cytokine release syndrome","score":0.9829999804496765},{"id":"https://openalex.org/keywords/pneumonitis","display_name":"pneumonitis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.6740000247955322},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.6050000190734863},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9599999785423279},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9520000219345093},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/neuroendocrine-cancer","display_name":"neuroendocrine cancer","score":0.9470000267028809}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7788000106811523},{"id":"https://openalex.org/C2780850621","wikidata":"https://www.wikidata.org/wiki/Q3961647","display_name":"Cytokine release syndrome","level":5,"score":0.7210999727249146},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.5354999899864197},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5141000151634216},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5059999823570251},{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.48489999771118164},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.46380001306533813},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.4494999945163727},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4277999997138977},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4198000133037567},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4068000018596649},{"id":"https://openalex.org/C2993640289","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Solid tumor","level":3,"score":0.3986999988555908},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.3822999894618988},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.3813999891281128},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.37869998812675476},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37209999561309814},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36899998784065247},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3368000090122223},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3321000039577484},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32519999146461487},{"id":"https://openalex.org/C2778822529","wikidata":"https://www.wikidata.org/wiki/Q1951525","display_name":"Progressive disease","level":3,"score":0.31150001287460327},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3093999922275543},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30379998683929443},{"id":"https://openalex.org/C2777371436","wikidata":"https://www.wikidata.org/wiki/Q3237071","display_name":"Leukapheresis","level":4,"score":0.2987000048160553},{"id":"https://openalex.org/C2779972918","wikidata":"https://www.wikidata.org/wiki/Q1194520","display_name":"Graft-versus-host disease","level":3,"score":0.2944999933242798},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2921000123023987},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.2888999879360199},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.28780001401901245},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.2849000096321106},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.2775000035762787},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.27489998936653137},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2718999981880188},{"id":"https://openalex.org/C2908856526","wikidata":"https://www.wikidata.org/wiki/Q16252627","display_name":"Antibody therapy","level":4,"score":0.27129998803138733},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.26829999685287476},{"id":"https://openalex.org/C2779984678","wikidata":"https://www.wikidata.org/wiki/Q2145898","display_name":"Response Evaluation Criteria in Solid Tumors","level":4,"score":0.266400009393692},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2515000104904175}],"mesh":[{"descriptor_ui":"D000076962","descriptor_name":"Receptors, Chimeric Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060887","descriptor_name":"B7 Antigens","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D060887","descriptor_name":"B7 Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.ccr-25-4600","doi":"https://doi.org/10.1158/1078-0432.ccr-25-4600","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-25-4600","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:41779003","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41779003","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G3576736080","display_name":null,"funder_award_id":"2025YFC3409804","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G4854679285","display_name":null,"funder_award_id":"92459302/U22A20327","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8235337428","display_name":null,"funder_award_id":"Z231100007223002","funder_id":"https://openalex.org/F4320325902","funder_display_name":"Beijing Municipal Science and Technology Commission"},{"id":"https://openalex.org/G8566122234","display_name":null,"funder_award_id":"82522068","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320325902","display_name":"Beijing Municipal Science and Technology Commission","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W35202944","https://openalex.org/W1969767421","https://openalex.org/W1972245883","https://openalex.org/W1995930566","https://openalex.org/W2019607817","https://openalex.org/W2130011407","https://openalex.org/W2775369717","https://openalex.org/W2787621143","https://openalex.org/W2905654445","https://openalex.org/W2969892179","https://openalex.org/W2971477701","https://openalex.org/W2998345757","https://openalex.org/W3087753250","https://openalex.org/W3133229959","https://openalex.org/W3201749743","https://openalex.org/W4210450192","https://openalex.org/W4225247905","https://openalex.org/W4283768141","https://openalex.org/W4297519419","https://openalex.org/W4304112200","https://openalex.org/W4306795470","https://openalex.org/W4307208617","https://openalex.org/W4310107594","https://openalex.org/W4313888795","https://openalex.org/W4321003785","https://openalex.org/W4324136933","https://openalex.org/W4362636088","https://openalex.org/W4380480712","https://openalex.org/W4380563796","https://openalex.org/W4388035659","https://openalex.org/W4392560879","https://openalex.org/W4395081799","https://openalex.org/W4399283558","https://openalex.org/W4399324543","https://openalex.org/W4399738039","https://openalex.org/W4402305943","https://openalex.org/W4402400825","https://openalex.org/W4402638519","https://openalex.org/W4403092122","https://openalex.org/W4404306023","https://openalex.org/W4404395078","https://openalex.org/W4404486969","https://openalex.org/W4404754574","https://openalex.org/W4406150643","https://openalex.org/W4408413512","https://openalex.org/W4408599590","https://openalex.org/W4410315986","https://openalex.org/W4410914881","https://openalex.org/W4411855979","https://openalex.org/W4412520538","https://openalex.org/W4414756714"],"related_works":["https://openalex.org/W4415941493","https://openalex.org/W4393096103","https://openalex.org/W4402400825","https://openalex.org/W4402305943","https://openalex.org/W4297020650","https://openalex.org/W4281949775","https://openalex.org/W4286210221","https://openalex.org/W4282047255","https://openalex.org/W2039766705","https://openalex.org/W4414531192"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1,88],"aim":[2],"of":[3,16,147,159,192,206,240],"the":[4,9,136,174,235],"study":[5,45,188],"was":[6,91,109,115,130,168,179,218],"to":[7,117,233],"evaluate":[8],"safety,":[10],"pharmacokinetics,":[11],"and":[12,58,67,97,111,208,237],"preliminary":[13],"clinical":[14,190,216],"activity":[15,211],"UTAA06,":[17],"an":[18],"\"off-the-shelf\"":[19],"allogeneic":[20,195,242],"B7-H3-targeted":[21,196],"chimeric":[22],"antigen":[23],"receptor":[24],"(CAR)":[25],"V\u03b41T-cell":[26],"therapy,":[27],"in":[28,132,153,157,212],"patients":[29,48,69],"with":[30,49,203],"pretreated,":[31],"advanced":[32,50],"B7-H3-positive":[33],"solid":[34,51,213],"tumors.":[35,214],"PATIENTS":[36],"AND":[37],"METHODS:":[38],"In":[39],"this":[40,241],"first-in-human,":[41],"phase":[42],"I,":[43],"dose-escalation":[44],"(NCT06372236),":[46],"10":[47],"tumors":[52],"(including":[53],"gastric,":[54],"colorectal,":[55],"hepatocellular,":[56],"ovarian,":[57],"neuroendocrine":[59],"cancers)":[60],"were":[61],"enrolled.":[62],"Following":[63],"lymphodepletion":[64],"chemotherapy":[65],"(cyclophosphamide":[66],"fludarabine),":[68],"received":[70],"UTAA06":[71,101,144],"infusion":[72],"across":[73],"three":[74],"dose":[75,141],"levels":[76],"(5":[77],"\u00d7":[78,81,85,138],"108,":[79,82],"8":[80],"or":[83],"1":[84,121],"109":[86],"cells).":[87],"primary":[89],"endpoint":[90],"safety.":[92],"Secondary":[93],"endpoints":[94],"included":[95],"pharmacokinetics":[96],"antitumor":[98],"efficacy.":[99],"RESULTS:":[100],"demonstrated":[102,145],"a":[103,200],"manageable":[104],"safety":[105],"profile;":[106],"no":[107,161],"GVHD":[108,207],"observed,":[110],"cytokine":[112],"release":[113],"syndrome":[114],"limited":[116,175,221],"two":[118],"transient":[119,151],"grade":[120],"events.":[122],"A":[123],"single":[124],"dose-limiting":[125],"toxicity":[126],"(grade":[127],"3":[128],"pneumonitis)":[129],"reported":[131],"one":[133],"patient":[134],"at":[135],"5":[137],"108":[139],"cell":[140],"level.":[142],"Although":[143],"signals":[146],"biological":[148,210],"activity,":[149],"including":[150],"reductions":[152],"serum":[154],"tumor":[155],"markers":[156],"50%":[158],"patients,":[160],"objective":[162],"response":[163],"by":[164,182,220,225],"RECIST":[165],"v1.1":[166],"criteria":[167],"observed.":[169],"Further":[170],"analysis":[171],"identified":[172],"that":[173],"CAR":[176],"T-cell":[177],"persistence":[178,223],"likely":[180],"driven":[181],"subclinical":[183],"host-versus-graft":[184],"rejection.":[185,228],"CONCLUSIONS:":[186],"This":[187],"provides":[189],"proof":[191],"concept":[193],"for":[194],"CAR-V\u03b41T":[197],"cells":[198],"as":[199],"safe":[201],"platform":[202],"low":[204],"risk":[205],"demonstrable":[209],"However,":[215],"efficacy":[217],"constrained":[219],"cellular":[222],"caused":[224],"host":[226],"immune":[227],"Future":[229],"strategies":[230],"are":[231],"required":[232],"enhance":[234],"durability":[236],"therapeutic":[238],"potential":[239],"approach.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":6}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-03-05T00:00:00"}
