{"id":"https://openalex.org/W7133341925","doi":"https://doi.org/10.1111/nyas.70224","title":"The TRIB1\u2013PPAR\u03b3 Axis Regulates Cholesterol Metabolism in Pancreatic Ductal Adenocarcinoma","display_name":"The TRIB1\u2013PPAR\u03b3 Axis Regulates Cholesterol Metabolism in Pancreatic Ductal Adenocarcinoma","publication_year":2026,"publication_date":"2026-03-01","ids":{"openalex":"https://openalex.org/W7133341925","doi":"https://doi.org/10.1111/nyas.70224","pmid":"https://pubmed.ncbi.nlm.nih.gov/41774091"},"language":"en","primary_location":{"id":"doi:10.1111/nyas.70224","doi":"https://doi.org/10.1111/nyas.70224","is_oa":false,"landing_page_url":"https://doi.org/10.1111/nyas.70224","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5127888168","display_name":"Rui Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Sun","raw_affiliation_strings":["The First Affiliated Hospital of Dalian Medical University  Dalian China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Dalian Medical University  Dalian China","institution_ids":["https://openalex.org/I4210140813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001341362","display_name":"Henan Qin","orcid":"https://orcid.org/0000-0003-2989-7424","observed_orcids":["https://orcid.org/0000-0003-2989-7424"]},"institutions":[{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Henan Qin","raw_affiliation_strings":["The First Affiliated Hospital of Dalian Medical University  Dalian China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Dalian Medical University  Dalian China","institution_ids":["https://openalex.org/I4210140813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111128890","display_name":"Wenhe Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenhe Zhang","raw_affiliation_strings":["The First Affiliated Hospital of Dalian Medical University  Dalian China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Dalian Medical University  Dalian China","institution_ids":["https://openalex.org/I4210140813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127948478","display_name":"Xin Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Guo","raw_affiliation_strings":["The First Affiliated Hospital of Dalian Medical University  Dalian China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Dalian Medical University  Dalian China","institution_ids":["https://openalex.org/I4210140813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082268047","display_name":"Yibin Teng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yibin Teng","raw_affiliation_strings":["The First Affiliated Hospital of Dalian Medical University  Dalian China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Dalian Medical University  Dalian China","institution_ids":["https://openalex.org/I4210140813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101712943","display_name":"Mengyuan Xu","orcid":"https://orcid.org/0000-0002-1788-8267","observed_orcids":["https://orcid.org/0000-0002-1788-8267"]},"institutions":[{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengyuan Xu","raw_affiliation_strings":["The First Affiliated Hospital of Dalian Medical University  Dalian China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Dalian Medical University  Dalian China","institution_ids":["https://openalex.org/I4210140813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104251306","display_name":"Jiwei Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiwei Liu","raw_affiliation_strings":["The First Affiliated Hospital of Dalian Medical University  Dalian China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Dalian Medical University  Dalian China","institution_ids":["https://openalex.org/I4210140813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100532370","display_name":"Zhen Ning","orcid":"https://orcid.org/0000-0002-2901-2991","observed_orcids":["https://orcid.org/0000-0002-2901-2991"]},"institutions":[{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhen Ning","raw_affiliation_strings":["Liaoning Key Laboratory of Molecular Targeted Drugs in Hepatobiliary and Pancreatic Cancer  Dalian China","The First Affiliated Hospital of Dalian Medical University  Dalian China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liaoning Key Laboratory of Molecular Targeted Drugs in Hepatobiliary and Pancreatic Cancer  Dalian China","institution_ids":[]},{"raw_affiliation_string":"The First Affiliated Hospital of Dalian Medical University  Dalian China","institution_ids":["https://openalex.org/I4210140813"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057564586","display_name":"A M Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Aman Wang","raw_affiliation_strings":["Liaoning Key Laboratory of Molecular Targeted Drugs in Hepatobiliary and Pancreatic Cancer  Dalian China","The First Affiliated Hospital of Dalian Medical University  Dalian China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liaoning Key Laboratory of Molecular Targeted Drugs in Hepatobiliary and Pancreatic Cancer  Dalian China","institution_ids":[]},{"raw_affiliation_string":"The First Affiliated Hospital of Dalian Medical University  Dalian China","institution_ids":["https://openalex.org/I4210140813"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5057564586","https://openalex.org/A5100532370","https://openalex.org/A5104251306"],"corresponding_institution_ids":["https://openalex.org/I4210140813"],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":4.3307,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.93134564,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"1557","issue":"1","first_page":"e70224","last_page":"e70224"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trib1","display_name":"TRIB1","score":0.9769999980926514},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9139999747276306},{"id":"https://openalex.org/keywords/cholesterol-metabolism","display_name":"cholesterol metabolism","score":0.9810000061988831},{"id":"https://openalex.org/keywords/hmgcr","display_name":"HMGCR","score":0.8519999980926514},{"id":"https://openalex.org/keywords/mevalonate-pathway","display_name":"mevalonate pathway","score":0.9929999709129333},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.8320000171661377},{"id":"https://openalex.org/keywords/atorvastatin","display_name":"atorvastatin","score":0.8109999895095825},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.7749999761581421},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8259999752044678},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.7519999742507935},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.583899974822998},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5619999766349792},{"id":"https://openalex.org/C2992026798","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic ductal adenocarcinoma","level":4,"score":0.5037000179290771},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.49729999899864197},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47540000081062317},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4490000009536743},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.4325000047683716},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4318999946117401},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.42149999737739563},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4032999873161316},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.3944999873638153},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39320001006126404},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38920000195503235},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.3788999915122986},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.3560999929904938},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3555999994277954},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.35269999504089355},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.34439998865127563},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.32420000433921814},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3230000138282776},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.31189998984336853},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.29269999265670776},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.28679999709129333},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2856999933719635},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.2799000144004822},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.27869999408721924},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2766999900341034},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.2741999924182892},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.2703999876976013},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2628999948501587},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.26080000400543213}],"mesh":[{"descriptor_ui":"D000069059","descriptor_name":"Atorvastatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000097784","descriptor_name":"Metabolic Reprogramming","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006903","descriptor_name":"Hydroxymethylglutaryl CoA Reductases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/nyas.70224","doi":"https://doi.org/10.1111/nyas.70224","is_oa":false,"landing_page_url":"https://doi.org/10.1111/nyas.70224","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:41774091","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41774091","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5858991707","display_name":null,"funder_award_id":"81802272","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G975321988","display_name":"USP22\u901a\u8fc7\u53bb\u6cdb\u7d20\u5316SND1\u4ecb\u5bfc\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\u6781\u5316\u5e76\u4fc3\u8fdb\u80f0\u817a\u764c\u751f\u957f\u548c\u8f6c\u79fb\u7684\u673a\u5236\u7814\u7a76","funder_award_id":"81502024","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1826323605","https://openalex.org/W1867988442","https://openalex.org/W1926163647","https://openalex.org/W1968659767","https://openalex.org/W1977773843","https://openalex.org/W1986256219","https://openalex.org/W1988068290","https://openalex.org/W2023839452","https://openalex.org/W2040932190","https://openalex.org/W2048880738","https://openalex.org/W2055091294","https://openalex.org/W2074340664","https://openalex.org/W2095236486","https://openalex.org/W2115837052","https://openalex.org/W2140079333","https://openalex.org/W2552432519","https://openalex.org/W2568414132","https://openalex.org/W2593410994","https://openalex.org/W2619486396","https://openalex.org/W2727069564","https://openalex.org/W2802173235","https://openalex.org/W2809279418","https://openalex.org/W2899008892","https://openalex.org/W2911157836","https://openalex.org/W2912394453","https://openalex.org/W2996185966","https://openalex.org/W3004642442","https://openalex.org/W3010534550","https://openalex.org/W3039970473","https://openalex.org/W3088352622","https://openalex.org/W3160721338","https://openalex.org/W3167001356","https://openalex.org/W3176310708","https://openalex.org/W3198244112","https://openalex.org/W3213010179","https://openalex.org/W4220657987","https://openalex.org/W4284966733","https://openalex.org/W4292079532","https://openalex.org/W4295846684","https://openalex.org/W4379095614","https://openalex.org/W4399872438","https://openalex.org/W4402170224","https://openalex.org/W4409191632","https://openalex.org/W4414886263"],"related_works":["https://openalex.org/W7164527017","https://openalex.org/W3088352622","https://openalex.org/W1977773843","https://openalex.org/W2995239327","https://openalex.org/W4402170224","https://openalex.org/W4401116413","https://openalex.org/W4388190218","https://openalex.org/W2943934860","https://openalex.org/W4415961246","https://openalex.org/W3039970473"],"abstract_inverted_index":{"Metabolic":[0],"reprogramming,":[1],"particularly":[2],"the":[3,17,67,80,85,89,114,122,126,130],"dysregulation":[4],"of":[5,11,70,83,125,133],"cholesterol":[6,96],"metabolism,":[7],"is":[8,34,40],"a":[9,142],"hallmark":[10],"pancreatic":[12],"ductal":[13],"adenocarcinoma":[14],"(PDAC).":[15],"However,":[16],"underlying":[18],"molecular":[19],"drivers":[20],"remain":[21],"largely":[22],"elusive.":[23],"In":[24],"this":[25],"study,":[26],"we":[27],"demonstrate":[28],"that":[29,103,137],"Tribbles":[30],"homolog":[31],"1":[32],"(TRIB1)":[33],"elevated":[35],"in":[36,88,99,129],"PDAC":[37,51,104,134],"tissues":[38],"and":[39,54,72,135],"significantly":[41],"associated":[42],"with":[43,106],"poor":[44],"prognosis.":[45],"Functionally,":[46],"TRIB1":[47,63,108,138],"mRNA":[48],"knockdown":[49],"suppresses":[50],"cell":[52],"growth":[53],"tumor":[55],"formation,":[56],"while":[57],"its":[58,74],"overexpression":[59],"promotes":[60],"both.":[61],"Mechanistically,":[62],"protein":[64],"binds":[65],"to":[66,113],"DNA-binding":[68],"domain":[69],"PPAR\u03b3":[71],"inhibits":[73],"transcriptional":[75],"activity.":[76],"This":[77],"interaction":[78],"relieves":[79],"PPAR\u03b3-mediated":[81],"repression":[82],"HMGCR,":[84],"rate-limiting":[86],"enzyme":[87],"mevalonate":[90],"pathway,":[91],"thereby":[92],"fueling":[93],"de":[94],"novo":[95],"biosynthesis.":[97],"Furthermore,":[98],"vivo":[100],"experiments":[101],"indicate":[102],"tumors":[105],"high":[107],"expression":[109],"were":[110],"more":[111],"sensitive":[112],"HMGCR":[115],"inhibitor":[116],"atorvastatin.":[117],"Collectively,":[118],"our":[119],"findings":[120],"highlight":[121],"critical":[123],"role":[124],"TRIB1-PPAR\u03b3-HMGCR":[127],"axis":[128],"metabolic":[131,148],"rewiring":[132],"suggest":[136],"may":[139],"serve":[140],"as":[141],"predictive":[143],"biomarker":[144],"for":[145],"optimizing":[146],"statin-based":[147],"therapies.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-03-04T00:00:00"}