{"id":"https://openalex.org/W7131925665","doi":null,"title":"Clinical features associated with epidermal growth factor receptor and K-RAS gene mutations in non-small cell lung cancer","display_name":"Clinical features associated with epidermal growth factor receptor and K-RAS gene mutations in non-small cell lung cancer","publication_year":2006,"publication_date":"2006-09-02","ids":{"openalex":"https://openalex.org/W7131925665"},"language":"en","primary_location":{"id":"pmh:oai:lsmu.lt:20.500.12512/80657","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.12512/80657","pdf_url":null,"source":{"id":"https://openalex.org/S7407055191","display_name":"Lithuanian University of Health Sciences","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"conference paper"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028565439","display_name":"Marius \u017demaitis","orcid":"https://orcid.org/0000-0002-6633-5749","observed_orcids":["https://orcid.org/0000-0002-6633-5749"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u017demaitis, Marius","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040695029","display_name":"Michael A. Meister","orcid":"https://orcid.org/0000-0002-2242-1696","observed_orcids":["https://orcid.org/0000-0002-2242-1696"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meister, Michael","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052004888","display_name":"Hendrik Dienemann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dienemann, Hendrik C","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112621941","display_name":"\ufffd. Fischer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fischer, J\u00fcrgen Richard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111985189","display_name":"Christian Manegold","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manegold, Christian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061442217","display_name":"Raimundas Sakalauskas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sakalauskas, Raimundas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5045906291","display_name":"Harald Lahm","orcid":"https://orcid.org/0000-0002-4477-3406","observed_orcids":["https://orcid.org/0000-0002-4477-3406"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lahm, Harald","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.6742532,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9599999785423279},{"id":"https://openalex.org/keywords/egfr-mutation","display_name":"EGFR mutation","score":0.828000009059906},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/exon-19-deletion","display_name":"exon 19 deletion","score":0.7649999856948853},{"id":"https://openalex.org/keywords/codon-12-mutation","display_name":"codon 12 mutation","score":0.8169999718666077},{"id":"https://openalex.org/keywords/smoking-status","display_name":"smoking status","score":0.8889999985694885},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.703000009059906},{"id":"https://openalex.org/keywords/clinicopathological-features","display_name":"clinicopathological features","score":0.7570000290870667},{"id":"https://openalex.org/keywords/genetic-alterations","display_name":"genetic alterations","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.7980999946594238},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6845999956130981},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.6377000212669373},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5958999991416931},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5652999877929688},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5400999784469604},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.46619999408721924},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40139999985694885},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.39570000767707825},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.38609999418258667},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3605000078678131},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.35420000553131104},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.3458999991416931},{"id":"https://openalex.org/C17757408","wikidata":"https://www.wikidata.org/wiki/Q4135516","display_name":"genomic DNA","level":3,"score":0.3296999931335449},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.30329999327659607},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2924000024795532},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.2924000024795532},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2863999903202057},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.27549999952316284},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.27090001106262207},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.2653000056743622},{"id":"https://openalex.org/C124942203","wikidata":"https://www.wikidata.org/wiki/Q656638","display_name":"Comparative genomic hybridization","level":4,"score":0.2574999928474426}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:lsmu.lt:20.500.12512/80657","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.12512/80657","pdf_url":null,"source":{"id":"https://openalex.org/S7407055191","display_name":"Lithuanian University of Health Sciences","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"conference paper"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2386416168","https://openalex.org/W2093968233","https://openalex.org/W3030697905","https://openalex.org/W67480823","https://openalex.org/W1992277751","https://openalex.org/W2570944343","https://openalex.org/W2405569611","https://openalex.org/W4283577603","https://openalex.org/W2211671952","https://openalex.org/W2017418429"],"abstract_inverted_index":{"Purpose:":[0],"To":[1],"determine":[2],"the":[3,19,43,62,82,113,131,143],"frequency":[4],"of":[5,42,81,108,122,130,148,212],"EGFR":[6,45,83,123,149,213],"and":[7,16,24,54,93,171,188,206,231],"K-RAS":[8,70,109,125,201],"gene":[9],"mutations":[10,77,121,137],"in":[11,78,89,99,105,112,116,128,142,154,165,191,203,214,217],"24":[12],"resected":[13],"primary":[14],"NSCLCs":[15],"to":[17,40,57,68,158],"evaluate":[18],"association":[20,197],"between":[21,200],"genetic":[22],"alterations":[23],"clinicopathological":[25,208],"characteristics.":[26],"Methods:":[27],"Genomic":[28],"DNA":[29],"was":[30,66,198],"extracted":[31],"from":[32,221],"snap-frozen":[33],"NSCLC":[34,222],"tissue":[35,115,205,220],"sam-":[36],"ples.":[37],"Exons":[38],"18":[39,101],"21":[41],"human":[44],"were":[46,110,126,138,150,172],"amplified":[47],"by":[48],"PCR,":[49],"purified":[50],"over":[51],"spin":[52],"columns":[53],"subsequently":[55],"subjected":[56],"sequencing.":[58],"On":[59],"a":[60,94],"LightCycler":[61],"hybridization":[63],"probes":[64],"format":[65],"used":[67],"detect":[69],"mutations.":[71],"Results:":[72],"8.3%(2/24)":[73],"tumor":[74,114,145,177,204,234],"tissues":[75],"showed":[76],"exons":[79,215],"18-21":[80,216],"tyrosine":[84],"kinase":[85],"domain:":[86],"in-frame":[87,97],"deletion":[88,98],"exon":[90,100],"19":[91],"(E746-A750)":[92],"3":[95],"nt":[96],"(E709D":[102],"delT710).":[103],"Mutations":[104,147,211],"codon":[106],"12":[107],"detected":[111,199],"16.7%":[117],"(4/20),":[118],"whereas":[119],"no":[120],"or":[124,160],"detectable":[127],"any":[129,207],"corresponding":[132],"non-malignant":[133],"lung":[134,219],"tissues.":[135],"Both":[136],"not":[139],"found":[140,151],"together":[141],"same":[144],"sample.":[146],"more":[152],"frequently":[153],"non-smokers":[155],"(2/3,66.7%)":[156],"compared":[157],"smokers":[159],"ex-smokers":[161],"(0/21,0%)":[162],"(p<0.05),":[163],"only":[164],"adenocarcinomas":[166],"with":[167,174,227],"bronchoalveolar":[168],"component":[169],"(p<0.05)":[170],"associated":[173,226],"an":[175,232],"advanced":[176,233],"stage":[178,192],"(0/13,0%":[179],"instage":[180,183,186],"I;":[181],"0/4,0%":[182],"II,":[184],"1/6,16.7%":[185],"III":[187],"1/1,":[189],"100%":[190],"IV)":[193],"(p<0.05).":[194],"No":[195],"significant":[196],"mutation":[202],"characteristic.":[209],"Conclusion:":[210],"malignant":[218],"patients":[223],"can":[224],"be":[225],"smoking":[228],"status,":[229],"histology":[230],"stage.":[235]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2026-02-28T00:00:00"}