{"id":"https://openalex.org/W7131908122","doi":"https://doi.org/10.3390/pathogens15111176","title":"Evidence of Natural Nervous Necrosis Virus Infection in Juvenile Greenfin Horse-Faced Filefish (Thamnaconus septentrionalis) During an Aquaculture Mortality Event","display_name":"Evidence of Natural Nervous Necrosis Virus Infection in Juvenile Greenfin Horse-Faced Filefish (Thamnaconus septentrionalis) During an Aquaculture Mortality Event","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7131908122","doi":"https://doi.org/10.3390/pathogens15111176"},"language":"en","primary_location":{"id":"doi:10.3390/pathogens15111176","doi":"https://doi.org/10.3390/pathogens15111176","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pathogens15111176","pdf_url":null,"source":{"id":"https://openalex.org/S4210239906","display_name":"Pathogens","issn_l":"2076-0817","issn":["2076-0817"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/pathogens15111176","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100445394","display_name":"Yu Wang","orcid":"https://orcid.org/0009-0004-8673-8643","observed_orcids":["https://orcid.org/0009-0004-8673-8643"]},"institutions":[{"id":"https://openalex.org/I107982497","display_name":"Dalian Ocean University","ror":"https://ror.org/0523b6g79","country_code":"CN","type":"education","lineage":["https://openalex.org/I107982497"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Wang","raw_affiliation_strings":["Dalian Ocean University"],"raw_orcid":"https://orcid.org/0009-0004-8673-8643","affiliations":[{"raw_affiliation_string":"Dalian Ocean University","institution_ids":["https://openalex.org/I107982497"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127430857","display_name":"Xiao-Ling Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao-Ling Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127127134","display_name":"Lu Bai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lu Bai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064791648","display_name":"Ruo-Heng Zhao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruo-Heng Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089950789","display_name":"Liang Qiu","orcid":"https://orcid.org/0000-0001-5671-2558","observed_orcids":["https://orcid.org/0000-0001-5671-2558"]},"institutions":[{"id":"https://openalex.org/I4405261380","display_name":"Yellow Sea Fisheries Research Institute","ror":"https://ror.org/0578w5a44","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I4405261380","https://openalex.org/I46529539"]},{"id":"https://openalex.org/I46529539","display_name":"Chinese Academy of Fishery Sciences","ror":"https://ror.org/02bwk9n38","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I46529539"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liang Qiu","raw_affiliation_strings":["Chinese Academy of Fishery Sciences - Yellow Sea Fisheries Research Institute","Chinese Academy of Fishery Sciences - Yellow Sea Fisheries Research Institute, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Fishery Sciences - Yellow Sea Fisheries Research Institute","institution_ids":["https://openalex.org/I4405261380","https://openalex.org/I46529539"]},{"raw_affiliation_string":"Chinese Academy of Fishery Sciences - Yellow Sea Fisheries Research Institute, Qingdao, China","institution_ids":["https://openalex.org/I4405261380","https://openalex.org/I46529539"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5127444481","display_name":"Jie Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405261380","display_name":"Yellow Sea Fisheries Research Institute","ror":"https://ror.org/0578w5a44","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I4405261380","https://openalex.org/I46529539"]},{"id":"https://openalex.org/I46529539","display_name":"Chinese Academy of Fishery Sciences","ror":"https://ror.org/02bwk9n38","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I46529539"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Huang","raw_affiliation_strings":["Chinese Academy of Fishery Sciences - Yellow Sea Fisheries Research Institute","Chinese Academy of Fishery Sciences - Yellow Sea Fisheries Research Institute, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Fishery Sciences - Yellow Sea Fisheries Research Institute","institution_ids":["https://openalex.org/I4405261380","https://openalex.org/I46529539"]},{"raw_affiliation_string":"Chinese Academy of Fishery Sciences - Yellow Sea Fisheries Research Institute, Qingdao, China","institution_ids":["https://openalex.org/I4405261380","https://openalex.org/I46529539"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5089950789"],"corresponding_institution_ids":["https://openalex.org/I4405261380","https://openalex.org/I46529539"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2654},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2654},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"11","first_page":"1176","last_page":"1176"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10450","display_name":"Aquaculture Nutrition and Growth","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nervous-necrosis-virus","display_name":"nervous necrosis virus","score":0.9819999933242798},{"id":"https://openalex.org/keywords/host-susceptibility","display_name":"host susceptibility","score":0.546999990940094},{"id":"https://openalex.org/keywords/juvenile-fish-mortality","display_name":"juvenile fish mortality","score":0.6840000152587891},{"id":"https://openalex.org/keywords/neurological-symptoms","display_name":"neurological symptoms","score":0.5619999766349792},{"id":"https://openalex.org/keywords/retinal-lesions","display_name":"retinal lesions","score":0.7129999995231628},{"id":"https://openalex.org/keywords/viral-ultrastructure","display_name":"virus ultrastructure","score":0.5920000076293945},{"id":"https://openalex.org/keywords/red-spotted-grouper-nervous-necrosis-virus","display_name":"red-spotted grouper nervous necrosis virus","score":0.9160000085830688},{"id":"https://openalex.org/keywords/monacanthidae","display_name":"Monacanthidae","score":0.9319999814033508},{"id":"https://openalex.org/keywords/aquaculture-disease-surveillance","display_name":"aquaculture disease surveillance","score":0.7580000162124634},{"id":"https://openalex.org/keywords/biosecurity","display_name":"biosecurity","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8883000016212463},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6603000164031982},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5916000008583069},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.5397999882698059},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.5072000026702881},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4702000021934509},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.4661000072956085},{"id":"https://openalex.org/C86909935","wikidata":"https://www.wikidata.org/wiki/Q188989","display_name":"Aquaculture","level":3,"score":0.4375},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.37950000166893005},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.37540000677108765},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.37040001153945923},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.35659998655319214},{"id":"https://openalex.org/C87555872","wikidata":"https://www.wikidata.org/wiki/Q3141316","display_name":"Ultrastructure","level":2,"score":0.3440000116825104},{"id":"https://openalex.org/C2777921445","wikidata":"https://www.wikidata.org/wiki/Q203850","display_name":"Nervous tissue","level":2,"score":0.3379000127315521},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.3084999918937683},{"id":"https://openalex.org/C2909396630","wikidata":"https://www.wikidata.org/wiki/Q18819341","display_name":"Iridovirus","level":3,"score":0.3034000098705292},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.30320000648498535},{"id":"https://openalex.org/C202878990","wikidata":"https://www.wikidata.org/wiki/Q830465","display_name":"Capsid","level":3,"score":0.30250000953674316},{"id":"https://openalex.org/C2781031778","wikidata":"https://www.wikidata.org/wiki/Q16000255","display_name":"Novel virus","level":4,"score":0.2856000065803528},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.2791999876499176}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3390/pathogens15111176","doi":"https://doi.org/10.3390/pathogens15111176","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pathogens15111176","pdf_url":null,"source":{"id":"https://openalex.org/S4210239906","display_name":"Pathogens","issn_l":"2076-0817","issn":["2076-0817"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathogens","raw_type":"journal-article"},{"id":"doi:10.2139/ssrn.6297422","doi":"https://doi.org/10.2139/ssrn.6297422","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.6297422","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.3390/pathogens15111176","doi":"https://doi.org/10.3390/pathogens15111176","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pathogens15111176","pdf_url":null,"source":{"id":"https://openalex.org/S4210239906","display_name":"Pathogens","issn_l":"2076-0817","issn":["2076-0817"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033},{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.40450000762939453}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3039102090","https://openalex.org/W7165518523","https://openalex.org/W4288056506","https://openalex.org/W3042970280","https://openalex.org/W1986816791","https://openalex.org/W184455395","https://openalex.org/W2077764676","https://openalex.org/W2378467096","https://openalex.org/W1974842134","https://openalex.org/W2969967468"],"abstract_inverted_index":{"Viral":[0],"nervous":[1,6,32,208],"necrosis":[2,7,209],"(VNN),":[3],"caused":[4],"by":[5,269],"virus":[8,27,210],"(NNV),":[9],"is":[10],"a":[11,69,215,273],"devastating":[12],"viral":[13,148,175],"disease":[14,293],"affecting":[15],"marine":[16,70],"fish":[17,67,103],"aquaculture":[18,71],"worldwide,":[19],"particularly":[20],"during":[21],"larval":[22],"and":[23,34,42,55,87,99,112,159,166,213,226,238,241,271,287,297],"juvenile":[24,66],"stages.":[25],"The":[26],"primarily":[28],"targets":[29],"the":[30,47,128,164,184,193,200,205,245,248,281,304,310,317,331],"central":[31],"system":[33],"retina,":[35],"often":[36],"resulting":[37],"in":[38,65,73,151,163,180,242,300,322],"severe":[39],"neurological":[40,106],"symptoms":[41],"high":[43,147],"mortality.":[44,132],"To":[45],"clarify":[46],"relationship":[48,218],"between":[49],"greenfin":[50],"horse-faced":[51],"filefish":[52,301],"(Thamnaconus":[53],"septentrionalis)":[54],"NNV,":[56,328],"this":[57,259],"study":[58,260],"investigated":[59],"an":[60],"outbreak":[61],"of":[62,131,187,247,285,306,316,319],"abnormal":[63],"mortality":[64],"from":[68,120,224],"farm":[72],"Rizhao,":[74],"Shandong":[75],"Province,":[76],"China.":[77],"A":[78],"comprehensive":[79],"etiological":[80],"diagnosis":[81],"was":[82],"conducted":[83],"using":[84],"bacterial":[85],"isolation":[86],"identification,":[88],"real-time":[89],"quantitative":[90],"RT-PCR":[91],"(RT-qPCR),":[92],"histopathological":[93,234],"analysis,":[94],"transmission":[95],"electron":[96],"microscopy":[97],"(TEM),":[98],"phylogenetic":[100,239],"analysis.":[101],"Diseased":[102],"exhibited":[104],"typical":[105],"signs,":[107],"including":[108],"spiral":[109],"swimming,":[110],"anorexia,":[111],"body":[113],"darkening.":[114],"Several":[115],"opportunistic":[116],"bacteria":[117],"were":[118,125,140],"isolated":[119],"affected":[121],"fish;":[122],"however,":[123],"they":[124],"not":[126],"considered":[127],"primary":[129],"cause":[130],"RT-qPCR":[133],"results":[134],"demonstrated":[135],"that":[136,199,262],"all":[137],"diseased":[138],"samples":[139],"positive":[141],"for":[142,251,255,292],"NNV":[143,201,270,286],"nucleic":[144],"acid,":[145],"with":[146,183,219,244,327],"loads":[149],"detected":[150],"neural":[152],"tissues.":[153],"Histopathological":[154],"examination":[155],"revealed":[156,198],"pronounced":[157],"vacuolation":[158],"neuronal":[160],"nuclear":[161],"pyknosis":[162],"brain":[165],"retinal":[167],"tissues,":[168],"while":[169],"TEM":[170],"identified":[171],"abundant":[172],"non-enveloped,":[173],"icosahedral":[174],"particles":[176],"approximately":[177],"25\u201326":[178],"nm":[179],"diameter,":[181],"consistent":[182],"ultrastructural":[185,236],"characteristics":[186],"NNV.":[188],"Phylogenetic":[189],"analysis":[190],"based":[191],"on":[192,229],"RNA2":[194],"capsid":[195],"protein":[196],"gene":[197],"isolate":[202],"clustered":[203],"within":[204],"red-spotted":[206],"grouper":[207],"(RGNNV)":[211],"genotype":[212],"showed":[214],"close":[216],"evolutionary":[217],"RGNNV":[220],"strains":[221],"previously":[222],"reported":[223],"groupers":[225],"barramundi.":[227],"Based":[228],"clinical":[230],"manifestations,":[231],"molecular":[232,295],"detection,":[233],"lesions,":[235],"evidence,":[237],"characterization,":[240],"accordance":[243],"criteria":[246],"World":[249],"Organisation":[250],"Animal":[252],"Health":[253],"(WOAH)":[254],"defining":[256],"susceptible":[257,276,311],"hosts,":[258],"confirms":[261],"T.":[263,307],"septentrionalis":[264,308],"can":[265],"be":[266],"naturally":[267],"infected":[268],"represents":[272],"newly":[274],"confirmed":[275],"host.":[277],"These":[278],"findings":[279],"expand":[280],"known":[282],"host":[283],"range":[284],"provide":[288],"essential":[289],"baseline":[290],"information":[291],"surveillance,":[294],"epidemiology,":[296],"biosecurity":[298],"management":[299],"aquaculture.":[302],"Moreover,":[303],"addition":[305],"to":[309,325,330],"species":[312,321],"allows":[313],"further":[314],"inference":[315],"susceptibility":[318],"109":[320],"family":[323],"Monacanthidae":[324],"infection":[326],"according":[329],"WOAH":[332],"standard.":[333]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-02-28T00:00:00"}
