{"id":"https://openalex.org/W7131663252","doi":"https://doi.org/10.1007/s12668-026-02428-5","title":"Development of Quality by Design Based Novel Zaltoprofen Cubosomal Gel for its improved Anti-Inflammatory Therapy by Transdermal Delivery: Formulation, Characterization, and In Vivo Evaluation","display_name":"Development of Quality by Design Based Novel Zaltoprofen Cubosomal Gel for its improved Anti-Inflammatory Therapy by Transdermal Delivery: Formulation, Characterization, and In Vivo Evaluation","publication_year":2026,"publication_date":"2026-02-26","ids":{"openalex":"https://openalex.org/W7131663252","doi":"https://doi.org/10.1007/s12668-026-02428-5"},"language":"en","primary_location":{"id":"doi:10.1007/s12668-026-02428-5","doi":"https://doi.org/10.1007/s12668-026-02428-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12668-026-02428-5","pdf_url":null,"source":{"id":"https://openalex.org/S4210168380","display_name":"BioNanoScience","issn_l":"2191-1630","issn":["2191-1630","2191-1649"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioNanoScience","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7131663252"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078279137","display_name":"Sujay Hulyalkar","orcid":"https://orcid.org/0000-0001-5874-4983","observed_orcids":["https://orcid.org/0000-0001-5874-4983","https://orcid.org/0009-0004-2258-5908"]},"institutions":[{"id":"https://openalex.org/I4210125823","display_name":"KLE Academy of Higher Education and Research","ror":"https://ror.org/03aam9155","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210125823"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Sujay Hulyalkar","raw_affiliation_strings":["Department of Pharmaceutics, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, India","Department of Pharmaceutics, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, Karnataka, 590010, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, India","institution_ids":["https://openalex.org/I4210125823"]},{"raw_affiliation_string":"Department of Pharmaceutics, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, Karnataka, 590010, India","institution_ids":["https://openalex.org/I4210125823"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030474574","display_name":"Panchaxari Mallappa Dandagi","orcid":"https://orcid.org/0000-0001-6933-2298","observed_orcids":["https://orcid.org/0000-0001-6933-2298"]},"institutions":[{"id":"https://openalex.org/I4210125823","display_name":"KLE Academy of Higher Education and Research","ror":"https://ror.org/03aam9155","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210125823"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Panchaxari M. Dandagi","raw_affiliation_strings":["Department of Pharmaceutics, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, India","Department of Pharmaceutics, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, Karnataka, 590010, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, India","institution_ids":["https://openalex.org/I4210125823"]},{"raw_affiliation_string":"Department of Pharmaceutics, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, Karnataka, 590010, India","institution_ids":["https://openalex.org/I4210125823"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058228548","display_name":"Prakash R. Biradar","orcid":"https://orcid.org/0000-0001-5573-4595","observed_orcids":["https://orcid.org/0000-0001-5573-4595"]},"institutions":[{"id":"https://openalex.org/I4210125823","display_name":"KLE Academy of Higher Education and Research","ror":"https://ror.org/03aam9155","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210125823"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Prakash Biradar","raw_affiliation_strings":["Department of Pharmacology, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, India","Department of Pharmacology, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, Karnataka, 590010, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, India","institution_ids":["https://openalex.org/I4210125823"]},{"raw_affiliation_string":"Department of Pharmacology, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, Karnataka, 590010, India","institution_ids":["https://openalex.org/I4210125823"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117087179","display_name":"Atith Muppayyanamath","orcid":"https://orcid.org/0009-0004-5481-7478","observed_orcids":["https://orcid.org/0009-0004-5481-7478"]},"institutions":[{"id":"https://openalex.org/I4210125823","display_name":"KLE Academy of Higher Education and Research","ror":"https://ror.org/03aam9155","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210125823"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Atith Muppayyanamath","raw_affiliation_strings":["Department of Pharmaceutical Quality Assurance, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, India","Department of Pharmaceutical Quality Assurance, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, Karnataka, 590010, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Quality Assurance, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, India","institution_ids":["https://openalex.org/I4210125823"]},{"raw_affiliation_string":"Department of Pharmaceutical Quality Assurance, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, Karnataka, 590010, India","institution_ids":["https://openalex.org/I4210125823"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5126926067","display_name":"Sandeep Kurani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125823","display_name":"KLE Academy of Higher Education and Research","ror":"https://ror.org/03aam9155","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210125823"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sandeep Kurani","raw_affiliation_strings":["Department of Pharmaceutics, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, India","Department of Pharmaceutics, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, Karnataka, 590010, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, India","institution_ids":["https://openalex.org/I4210125823"]},{"raw_affiliation_string":"Department of Pharmaceutics, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, Karnataka, 590010, India","institution_ids":["https://openalex.org/I4210125823"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078279137"],"corresponding_institution_ids":["https://openalex.org/I4210125823"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":null,"fwci":2.8506,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.83046723,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"16","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zaltoprofen","display_name":"zaltoprofen","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cubosomes","display_name":"cubosomes","score":0.9710000157356262},{"id":"https://openalex.org/keywords/transdermal-drug-delivery","display_name":"transdermal drug delivery","score":0.8679999709129333},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.7820000052452087},{"id":"https://openalex.org/keywords/glycerol-monooleate","display_name":"glycerol monooleate","score":0.8730000257492065},{"id":"https://openalex.org/keywords/pluronic-f127","display_name":"Pluronic F127","score":0.9940000176429749},{"id":"https://openalex.org/keywords/quality-by-design","display_name":"quality by design","score":0.6690000295639038},{"id":"https://openalex.org/keywords/box-behnken-design","display_name":"Box-Behnken design","score":0.9300000071525574},{"id":"https://openalex.org/keywords/skin-permeation","display_name":"skin permeation","score":0.652999997138977},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.843999981880188},{"id":"https://openalex.org/keywords/carrageenan-induced-paw-edema","display_name":"carrageenan-induced paw edema","score":0.9160000085830688},{"id":"https://openalex.org/keywords/carbopol-934-gel","display_name":"Carbopol 934 gel","score":0.8769999742507935},{"id":"https://openalex.org/keywords/topical-gel-formulation","display_name":"topical gel formulation","score":0.5889999866485596},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C205679159","wikidata":"https://www.wikidata.org/wiki/Q3375179","display_name":"Transdermal","level":2,"score":0.8037999868392944},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.6590999960899353},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.6255999803543091},{"id":"https://openalex.org/C50670333","wikidata":"https://www.wikidata.org/wiki/Q907651","display_name":"Permeation","level":3,"score":0.6133000254631042},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6101999878883362},{"id":"https://openalex.org/C2779826273","wikidata":"https://www.wikidata.org/wiki/Q244408","display_name":"Diclofenac","level":2,"score":0.5512999892234802},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5361999869346619},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.44780001044273376},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4415000081062317},{"id":"https://openalex.org/C104628117","wikidata":"https://www.wikidata.org/wiki/Q3964828","display_name":"Sonication","level":2,"score":0.4325000047683716},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4219000041484833},{"id":"https://openalex.org/C101335993","wikidata":"https://www.wikidata.org/wiki/Q408943","display_name":"Poloxamer","level":4,"score":0.41519999504089355},{"id":"https://openalex.org/C2776634624","wikidata":"https://www.wikidata.org/wiki/Q4914690","display_name":"Bioadhesive","level":3,"score":0.39489999413490295},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.3878999948501587},{"id":"https://openalex.org/C56918372","wikidata":"https://www.wikidata.org/wiki/Q288903","display_name":"Thixotropy","level":2,"score":0.36570000648498535},{"id":"https://openalex.org/C11432220","wikidata":"https://www.wikidata.org/wiki/Q1975334","display_name":"Dispersity","level":2,"score":0.34700000286102295},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.3418000042438507},{"id":"https://openalex.org/C3952536","wikidata":"https://www.wikidata.org/wiki/Q571327","display_name":"Syneresis","level":2,"score":0.3375000059604645},{"id":"https://openalex.org/C2780744026","wikidata":"https://www.wikidata.org/wiki/Q409192","display_name":"Ketoprofen","level":2,"score":0.3269999921321869},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.30160000920295715},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.29100000858306885},{"id":"https://openalex.org/C169222746","wikidata":"https://www.wikidata.org/wiki/Q4116558","display_name":"Factorial experiment","level":2,"score":0.28949999809265137},{"id":"https://openalex.org/C2780306666","wikidata":"https://www.wikidata.org/wiki/Q7225971","display_name":"Poloxamer 407","level":5,"score":0.2867000102996826},{"id":"https://openalex.org/C2781131970","wikidata":"https://www.wikidata.org/wiki/Q28134859","display_name":"Spreadability","level":2,"score":0.2849999964237213},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.28369998931884766},{"id":"https://openalex.org/C86178769","wikidata":"https://www.wikidata.org/wiki/Q1130789","display_name":"Micronization","level":3,"score":0.28060001134872437},{"id":"https://openalex.org/C2780976021","wikidata":"https://www.wikidata.org/wiki/Q481757","display_name":"Aceclofenac","level":2,"score":0.27970001101493835},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.2777000069618225},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.2750000059604645},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2644999921321869},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.25839999318122864}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s12668-026-02428-5","doi":"https://doi.org/10.1007/s12668-026-02428-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12668-026-02428-5","pdf_url":null,"source":{"id":"https://openalex.org/S4210168380","display_name":"BioNanoScience","issn_l":"2191-1630","issn":["2191-1630","2191-1649"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioNanoScience","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1995676656","https://openalex.org/W2003775201","https://openalex.org/W2014451654","https://openalex.org/W2031095463","https://openalex.org/W2073455617","https://openalex.org/W2227100533","https://openalex.org/W2297123046","https://openalex.org/W2345032351","https://openalex.org/W2564419925","https://openalex.org/W2782701314","https://openalex.org/W2890333289","https://openalex.org/W2988404588","https://openalex.org/W3006259938","https://openalex.org/W3087809905","https://openalex.org/W3124563177","https://openalex.org/W3131091053","https://openalex.org/W3158275130","https://openalex.org/W3194489202","https://openalex.org/W4214819075","https://openalex.org/W4289203915","https://openalex.org/W4307585038","https://openalex.org/W4315927966","https://openalex.org/W4362698656","https://openalex.org/W4386157742","https://openalex.org/W4387640101","https://openalex.org/W4395089806","https://openalex.org/W4403401464","https://openalex.org/W4405697498","https://openalex.org/W4408933141","https://openalex.org/W4411533851"],"related_works":["https://openalex.org/W3131091053","https://openalex.org/W4414794412","https://openalex.org/W7212227334","https://openalex.org/W7203574169","https://openalex.org/W4399536490","https://openalex.org/W4393132341","https://openalex.org/W2297123046","https://openalex.org/W4233548412","https://openalex.org/W4413987205","https://openalex.org/W7127111390"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-02-27T00:00:00"}
