{"id":"https://openalex.org/W7131080098","doi":"https://doi.org/10.1097/js9.0000000000003971","title":"Global, regional, and national burden of non-rheumatic calcific aortic valve disease, 1990\u20132021: a systematic analysis for the Global Burden of Disease Study 2021","display_name":"Global, regional, and national burden of non-rheumatic calcific aortic valve disease, 1990\u20132021: a systematic analysis for the Global Burden of Disease Study 2021","publication_year":2025,"publication_date":"2025-11-14","ids":{"openalex":"https://openalex.org/W7131080098","doi":"https://doi.org/10.1097/js9.0000000000003971","pmid":"https://pubmed.ncbi.nlm.nih.gov/41731863"},"language":"en","primary_location":{"id":"doi:10.1097/js9.0000000000003971","doi":"https://doi.org/10.1097/js9.0000000000003971","is_oa":true,"landing_page_url":"https://doi.org/10.1097/js9.0000000000003971","pdf_url":null,"source":{"id":"https://openalex.org/S67965910","display_name":"International Journal of Surgery","issn_l":"1743-9159","issn":["1743-9159","1743-9191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-3","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1097/js9.0000000000003971","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000426993","display_name":"Minghui Xie","orcid":"https://orcid.org/0000-0003-3118-233X","observed_orcids":["https://orcid.org/0000-0003-3118-233X"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210117763","display_name":"Xinqiao Hospital","ror":"https://ror.org/02d217z27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minghui Xie","raw_affiliation_strings":["Department of Cardiovascular Surgery, Xinqiao Hospital, Army Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Xinqiao Hospital, Army Medical University, Chongqing, China","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210117763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013559167","display_name":"Xingyu Qian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingyu Qian","raw_affiliation_strings":["Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126621625","display_name":"Ge Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ge Yan","raw_affiliation_strings":["Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I4210129459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126640288","display_name":"Lixue Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I50632499","display_name":"Chongqing University of Technology","ror":"https://ror.org/04vgbd477","country_code":"CN","type":"education","lineage":["https://openalex.org/I50632499"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lixue Chen","raw_affiliation_strings":["School of Economics and Finance, Chongqing University of Technology, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Economics and Finance, Chongqing University of Technology, Chongqing, China","institution_ids":["https://openalex.org/I50632499"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101100436","display_name":"Ruiyan Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210117763","display_name":"Xinqiao Hospital","ror":"https://ror.org/02d217z27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117763"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ruiyan Ma","raw_affiliation_strings":["Department of Cardiovascular Surgery, Xinqiao Hospital, Army Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Xinqiao Hospital, Army Medical University, Chongqing, China","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210117763"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078474551","display_name":"Yingbin Xiao","orcid":"https://orcid.org/0000-0003-1854-8982","observed_orcids":["https://orcid.org/0000-0003-1854-8982"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210117763","display_name":"Xinqiao Hospital","ror":"https://ror.org/02d217z27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117763"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yingbin Xiao","raw_affiliation_strings":["Department of Cardiovascular Surgery, Xinqiao Hospital, Army Medical University, Chongqing, China"],"raw_orcid":"https://orcid.org/0000-0003-1854-8982","affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Xinqiao Hospital, Army Medical University, Chongqing, China","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210117763"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5078474551","https://openalex.org/A5101100436"],"corresponding_institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210117763"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":{"value":3450,"currency":"USD","value_usd":3450},"fwci":0.6486,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.78362232,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"112","issue":"2","first_page":"3238","last_page":"3251"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10618","display_name":"Aortic Disease and Treatment Approaches","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12935","display_name":"Healthcare Systems and Public Health","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aortic-stenosis","display_name":"aortic stenosis","score":0.796999990940094},{"id":"https://openalex.org/keywords/disease-burden","display_name":"disease burden","score":0.9459999799728394},{"id":"https://openalex.org/keywords/mortality-trends","display_name":"mortality trends","score":0.5950000286102295},{"id":"https://openalex.org/keywords/incidence","display_name":"incidence","score":0.6159999966621399},{"id":"https://openalex.org/keywords/disability-adjusted-life-years","display_name":"disability-adjusted life years","score":0.9769999980926514},{"id":"https://openalex.org/keywords/health-disparities","display_name":"health disparities","score":0.7329999804496765},{"id":"https://openalex.org/keywords/sociodemographic-index","display_name":"socio-demographic index","score":0.8930000066757202},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6159999966621399},{"id":"https://openalex.org/keywords/transcatheter-aortic-valve-replacement","display_name":"transcatheter aortic valve implantation","score":0.9570000171661377},{"id":"https://openalex.org/keywords/population-aging","display_name":"population aging","score":0.6579999923706055},{"id":"https://openalex.org/keywords/health-equity","display_name":"health equity","score":0.5009999871253967},{"id":"https://openalex.org/keywords/future-projections","display_name":"future projections","score":0.3179999887943268}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9307000041007996},{"id":"https://openalex.org/C2780664029","wikidata":"https://www.wikidata.org/wiki/Q5282120","display_name":"Disease burden","level":3,"score":0.6065999865531921},{"id":"https://openalex.org/C3020448403","wikidata":"https://www.wikidata.org/wiki/Q5282120","display_name":"Burden of disease","level":3,"score":0.6015999913215637},{"id":"https://openalex.org/C158016649","wikidata":"https://www.wikidata.org/wiki/Q161726","display_name":"Multinational corporation","level":2,"score":0.5212000012397766},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4677000045776367},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4668999910354614},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.4603999853134155},{"id":"https://openalex.org/C46578552","wikidata":"https://www.wikidata.org/wiki/Q2725393","display_name":"Global health","level":3,"score":0.4602000117301941},{"id":"https://openalex.org/C199728807","wikidata":"https://www.wikidata.org/wiki/Q2578557","display_name":"Equity (law)","level":2,"score":0.4366999864578247},{"id":"https://openalex.org/C2988170871","wikidata":"https://www.wikidata.org/wiki/Q11000047","display_name":"Healthcare system","level":3,"score":0.3982999920845032},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3853999972343445},{"id":"https://openalex.org/C2982889124","wikidata":"https://www.wikidata.org/wiki/Q107439039","display_name":"Disease management","level":4,"score":0.36419999599456787},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.30720001459121704},{"id":"https://openalex.org/C45555294","wikidata":"https://www.wikidata.org/wiki/Q28113351","display_name":"Inequality","level":2,"score":0.29350000619888306},{"id":"https://openalex.org/C2250968","wikidata":"https://www.wikidata.org/wiki/Q1512929","display_name":"Health equity","level":3,"score":0.2865999937057495},{"id":"https://openalex.org/C184356942","wikidata":"https://www.wikidata.org/wiki/Q830382","display_name":"Best practice","level":2,"score":0.27090001106262207}],"mesh":[{"descriptor_ui":"D000071219","descriptor_name":"Global Burden of Disease","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D000071219","descriptor_name":"Global Burden of Disease","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D000071219","descriptor_name":"Global Burden of Disease","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D000071219","descriptor_name":"Global Burden of Disease","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D000087509","descriptor_name":"Disability-Adjusted Life Years","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000087509","descriptor_name":"Disability-Adjusted Life Years","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000087509","descriptor_name":"Disability-Adjusted Life Years","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000087509","descriptor_name":"Disability-Adjusted Life Years","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014943","descriptor_name":"Global Health","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D014943","descriptor_name":"Global Health","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D014943","descriptor_name":"Global Health","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D014943","descriptor_name":"Global Health","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/js9.0000000000003971","doi":"https://doi.org/10.1097/js9.0000000000003971","is_oa":true,"landing_page_url":"https://doi.org/10.1097/js9.0000000000003971","pdf_url":null,"source":{"id":"https://openalex.org/S67965910","display_name":"International Journal of Surgery","issn_l":"1743-9159","issn":["1743-9159","1743-9191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-3","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Surgery","raw_type":"journal-article"},{"id":"pmid:41731863","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41731863","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of surgery (London, England)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1097/js9.0000000000003971","doi":"https://doi.org/10.1097/js9.0000000000003971","is_oa":true,"landing_page_url":"https://doi.org/10.1097/js9.0000000000003971","pdf_url":null,"source":{"id":"https://openalex.org/S67965910","display_name":"International Journal of Surgery","issn_l":"1743-9159","issn":["1743-9159","1743-9191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-3","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Surgery","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"},{"score":0.7578999996185303,"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W3003299879","https://openalex.org/W3003612395","https://openalex.org/W3013380890","https://openalex.org/W3120946165","https://openalex.org/W3162681156","https://openalex.org/W3173196666","https://openalex.org/W3195842247","https://openalex.org/W4213091955","https://openalex.org/W4367031360","https://openalex.org/W4379117789","https://openalex.org/W4385856126","https://openalex.org/W4387844498","https://openalex.org/W4387996403","https://openalex.org/W4388662450","https://openalex.org/W4389574595","https://openalex.org/W4390722338","https://openalex.org/W4391959015","https://openalex.org/W4399391600","https://openalex.org/W4401028671","https://openalex.org/W4401802182","https://openalex.org/W4402467094","https://openalex.org/W4403142327","https://openalex.org/W4403812729","https://openalex.org/W4409150820","https://openalex.org/W4414380490"],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"Non-rheumatic":[1],"calcific":[2],"aortic":[3],"valve":[4],"disease":[5,29,152],"(NRCAVD)":[6],"has":[7],"emerged":[8],"as":[9],"a":[10,176],"critical":[11],"global":[12,132],"health":[13,33,57,256,278],"challenge,":[14],"intensified":[15],"by":[16,213],"aging":[17,165,246,282],"populations":[18,140],"and":[19,31,44,59,90,109,130,139,166,195,254,267],"persistent":[20],"sociodemographic":[21,91],"disparities.":[22],"Existing":[23],"studies":[24],"inadequately":[25],"address":[26],"its":[27],"specific":[28],"burden":[30,46,78,97,134,226],"associated":[32,174],"inequities.":[34],"This":[35],"study":[36],"aims":[37],"to":[38,51,53,125,164,221,250,263,276],"comprehensively":[39],"evaluate":[40],"the":[41,67],"global,":[42],"regional,":[43],"national":[45],"of":[47,70,96,171,180],"NRCAVD":[48,77,133,225,265],"from":[49],"1990":[50,129],"2021":[52,73],"inform":[54],"equitable":[55],"public":[56],"policies":[58],"resource":[60],"allocation":[61],"strategies.":[62],"MATERIALS":[63],"AND":[64],"METHODS:":[65],"Utilizing":[66],"Global":[68,224],"Burden":[69],"Disease":[71],"(GBD)":[72],"dataset,":[74],"we":[75],"quantified":[76],"through":[79,114],"age-standardized":[80,205],"incidence":[81],"rates":[82,206,235],"(ASIR),":[83],"mortality":[84,157,194,234],"(ASDR),":[85],"disability-adjusted":[86],"life":[87],"years":[88],"(DALYs),":[89],"index":[92],"(SDI).":[93],"Key":[94],"drivers":[95],"trends":[98],"were":[99,112,197],"identified":[100],"via":[101],"age-sex":[102],"decomposition,":[103],"age-period-cohort":[104,119],"(APC)":[105],"modeling.":[106],"Health":[107,159],"inequalities":[108,241],"TAVR":[110,172],"penetration":[111,170],"assessed":[113],"disparity":[115],"metrics,":[116],"while":[117],"Bayesian":[118],"(BAPC)":[120],"models":[121],"projected":[122],"future":[123],"trajectories":[124],"2041.":[126],"RESULTS:":[127],"Between":[128],"2021,":[131],"increased":[135],"significantly,":[136],"with":[137,175],"males":[138,219],"in":[141,178,185,218,230,258,271,280],"high-SDI":[142,231],"regions":[143,232],"experiencing":[144],"disproportionately":[145,237],"higher":[146,156],"burdens.":[147],"While":[148],"women":[149],"showed":[150],"lower":[151],"incidence,":[153],"they":[154],"faced":[155],"rates.":[158],"disparities":[160],"worsened":[161],"primarily":[162],"due":[163],"population":[167],"growth.":[168],"Higher":[169],"is":[173,274],"decrease":[177],"ASDR":[179],"NRCAVD,":[181],"which":[182],"was":[183],"observed":[184],"multinational":[186],"registries.":[187],"Incidence":[188],"peaked":[189],"at":[190,199],"ages":[191],"75-79,":[192],"whereas":[193],"DALYs":[196],"highest":[198],"85-89":[200],"years.":[201],"Projections":[202],"indicate":[203],"declining":[204],"(ASIR:":[207],"-2.88%,":[208],"ASDR:":[209],"-0.69%,":[210],"DALYs:":[211],"-7.54%":[212],"2041),":[214],"though":[215],"reductions":[216],"lagged":[217],"compared":[220],"females.":[222],"CONCLUSION:":[223],"remains":[227],"unequal,":[228],"particularly":[229],"where":[233],"are":[236],"high.":[238],"Addressing":[239],"widening":[240],"requires":[242],"sex-specific":[243],"interventions":[244],"for":[245],"populations,":[247],"expanded":[248],"access":[249],"cost-effective":[251],"valvular":[252],"therapies,":[253],"strengthened":[255],"systems":[257],"underserved":[259],"regions.":[260],"Multinational":[261],"collaboration":[262],"standardize":[264],"surveillance":[266],"share":[268],"best":[269],"practices":[270],"lifecycle":[272],"management":[273],"imperative":[275],"achieve":[277],"equity":[279],"an":[281],"world.":[283]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-07T09:51:55.459714","created_date":"2026-02-24T00:00:00"}