{"id":"https://openalex.org/W7131075673","doi":"https://doi.org/10.1007/s10238-026-02093-8","title":"Safety profile of FLT3 inhibitors in acute myeloid leukemia: a systematic review and meta-analysis of adverse events","display_name":"Safety profile of FLT3 inhibitors in acute myeloid leukemia: a systematic review and meta-analysis of adverse events","publication_year":2026,"publication_date":"2026-02-23","ids":{"openalex":"https://openalex.org/W7131075673","doi":"https://doi.org/10.1007/s10238-026-02093-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/41729312"},"language":"en","primary_location":{"id":"doi:10.1007/s10238-026-02093-8","doi":"https://doi.org/10.1007/s10238-026-02093-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10238-026-02093-8","pdf_url":null,"source":{"id":"https://openalex.org/S1255940","display_name":"Clinical and Experimental Medicine","issn_l":"1591-8890","issn":["1591-8890","1591-9528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1007/s10238-026-02093-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058915028","display_name":"Mario Gaio","orcid":"https://orcid.org/0000-0003-4287-5510","observed_orcids":["https://orcid.org/0000-0003-4287-5510"]},"institutions":[{"id":"https://openalex.org/I2801384276","display_name":"Regione Campania","ror":"https://ror.org/02kg21794","country_code":"IT","type":"government","lineage":["https://openalex.org/I2801384276"]},{"id":"https://openalex.org/I42775652","display_name":"Link Campus University","ror":"https://ror.org/035mh1293","country_code":"IT","type":"education","lineage":["https://openalex.org/I42775652"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mario Gaio","raw_affiliation_strings":["Campania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, Naples, Italy","Department of Life Science, Health, and Health Professions, Link Campus University, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Campania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, Naples, Italy","institution_ids":["https://openalex.org/I2801384276"]},{"raw_affiliation_string":"Department of Life Science, Health, and Health Professions, Link Campus University, Rome, Italy","institution_ids":["https://openalex.org/I42775652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032246167","display_name":"Alessia Zinzi","orcid":"https://orcid.org/0000-0002-9425-9923","observed_orcids":["https://orcid.org/0000-0002-9425-9923"]},"institutions":[{"id":"https://openalex.org/I2801384276","display_name":"Regione Campania","ror":"https://ror.org/02kg21794","country_code":"IT","type":"government","lineage":["https://openalex.org/I2801384276"]},{"id":"https://openalex.org/I42775652","display_name":"Link Campus University","ror":"https://ror.org/035mh1293","country_code":"IT","type":"education","lineage":["https://openalex.org/I42775652"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessia Zinzi","raw_affiliation_strings":["Campania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, Naples, Italy","Department of Life Science, Health, and Health Professions, Link Campus University, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Campania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, Naples, Italy","institution_ids":["https://openalex.org/I2801384276"]},{"raw_affiliation_string":"Department of Life Science, Health, and Health Professions, Link Campus University, Rome, Italy","institution_ids":["https://openalex.org/I42775652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016680176","display_name":"Valerio Liguori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]},{"id":"https://openalex.org/I2801384276","display_name":"Regione Campania","ror":"https://ror.org/02kg21794","country_code":"IT","type":"government","lineage":["https://openalex.org/I2801384276"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valerio Liguori","raw_affiliation_strings":["Campania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, Naples, Italy","Department of Experimental Medicine, University of Campania Luigi Vanvitelli, Via Santa Maria di Costantinopoli, 104, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Campania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, Naples, Italy","institution_ids":["https://openalex.org/I2801384276"]},{"raw_affiliation_string":"Department of Experimental Medicine, University of Campania Luigi Vanvitelli, Via Santa Maria di Costantinopoli, 104, Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040328648","display_name":"Cecilia Cagnotta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]},{"id":"https://openalex.org/I2801384276","display_name":"Regione Campania","ror":"https://ror.org/02kg21794","country_code":"IT","type":"government","lineage":["https://openalex.org/I2801384276"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Cecilia Cagnotta","raw_affiliation_strings":["Campania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, Naples, Italy. cecilia.cagnotta@unicampania.it","Department of Experimental Medicine, University of Campania Luigi Vanvitelli, Via Santa Maria di Costantinopoli, 104, Naples, Italy. cecilia.cagnotta@unicampania.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Campania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, Naples, Italy. cecilia.cagnotta@unicampania.it","institution_ids":["https://openalex.org/I2801384276"]},{"raw_affiliation_string":"Department of Experimental Medicine, University of Campania Luigi Vanvitelli, Via Santa Maria di Costantinopoli, 104, Naples, Italy. cecilia.cagnotta@unicampania.it","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031961411","display_name":"Mario Frasca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]},{"id":"https://openalex.org/I2801384276","display_name":"Regione Campania","ror":"https://ror.org/02kg21794","country_code":"IT","type":"government","lineage":["https://openalex.org/I2801384276"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mario Frasca","raw_affiliation_strings":["Campania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, Naples, Italy","Department of Experimental Medicine, University of Campania Luigi Vanvitelli, Via Santa Maria di Costantinopoli, 104, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Campania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, Naples, Italy","institution_ids":["https://openalex.org/I2801384276"]},{"raw_affiliation_string":"Department of Experimental Medicine, University of Campania Luigi Vanvitelli, Via Santa Maria di Costantinopoli, 104, Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119099527","display_name":"Ludovica Vittoria Laino","orcid":"https://orcid.org/0009-0003-8975-4019","observed_orcids":["https://orcid.org/0009-0003-8975-4019"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]},{"id":"https://openalex.org/I2801384276","display_name":"Regione Campania","ror":"https://ror.org/02kg21794","country_code":"IT","type":"government","lineage":["https://openalex.org/I2801384276"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ludovica Vittoria Laino","raw_affiliation_strings":["Campania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, Naples, Italy","Department of Experimental Medicine, University of Campania Luigi Vanvitelli, Via Santa Maria di Costantinopoli, 104, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Campania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, Naples, Italy","institution_ids":["https://openalex.org/I2801384276"]},{"raw_affiliation_string":"Department of Experimental Medicine, University of Campania Luigi Vanvitelli, Via Santa Maria di Costantinopoli, 104, Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085334357","display_name":"Francesco Rossi","orcid":"https://orcid.org/0009-0003-5141-7527","observed_orcids":["https://orcid.org/0009-0003-5141-7527","https://orcid.org/0000-0002-3093-2277"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]},{"id":"https://openalex.org/I2801384276","display_name":"Regione Campania","ror":"https://ror.org/02kg21794","country_code":"IT","type":"government","lineage":["https://openalex.org/I2801384276"]},{"id":"https://openalex.org/I42775652","display_name":"Link Campus University","ror":"https://ror.org/035mh1293","country_code":"IT","type":"education","lineage":["https://openalex.org/I42775652"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Rossi","raw_affiliation_strings":["Campania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, Naples, Italy","Department of Experimental Medicine, University of Campania Luigi Vanvitelli, Via Santa Maria di Costantinopoli, 104, Naples, Italy","Department of Life Science, Health, and Health Professions, Link Campus University, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Campania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, Naples, Italy","institution_ids":["https://openalex.org/I2801384276"]},{"raw_affiliation_string":"Department of Experimental Medicine, University of Campania Luigi Vanvitelli, Via Santa Maria di Costantinopoli, 104, Naples, Italy","institution_ids":["https://openalex.org/I197809005"]},{"raw_affiliation_string":"Department of Life Science, Health, and Health Professions, Link Campus University, Rome, Italy","institution_ids":["https://openalex.org/I42775652"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105696391","display_name":"Capuano Annalisa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]},{"id":"https://openalex.org/I2801384276","display_name":"Regione Campania","ror":"https://ror.org/02kg21794","country_code":"IT","type":"government","lineage":["https://openalex.org/I2801384276"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Annalisa Capuano","raw_affiliation_strings":["Campania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, Naples, Italy","Department of Experimental Medicine, University of Campania Luigi Vanvitelli, Via Santa Maria di Costantinopoli, 104, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Campania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, Naples, Italy","institution_ids":["https://openalex.org/I2801384276"]},{"raw_affiliation_string":"Department of Experimental Medicine, University of Campania Luigi Vanvitelli, Via Santa Maria di Costantinopoli, 104, Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5040328648"],"corresponding_institution_ids":["https://openalex.org/I197809005","https://openalex.org/I2801384276"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":{"value":4790,"currency":"USD","value_usd":4790},"fwci":2.4764,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.83506944,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"26","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flt3-inhibitors","display_name":"FLT3 inhibitors","score":0.9879999756813049},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/flt3-mutation","display_name":"FLT3 mutation","score":0.8450000286102295},{"id":"https://openalex.org/keywords/midostaurin","display_name":"midostaurin","score":0.984000027179718},{"id":"https://openalex.org/keywords/gilteritinib","display_name":"gilteritinib","score":0.9980000257492065},{"id":"https://openalex.org/keywords/quizartinib","display_name":"quizartinib","score":1.0},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.9179999828338623},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.9259999990463257},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.46399998664855957},{"id":"https://openalex.org/keywords/gastrointestinal-side-effects","display_name":"gastrointestinal adverse effects","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8962000012397766},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.741599977016449},{"id":"https://openalex.org/C2776481607","wikidata":"https://www.wikidata.org/wiki/Q6842945","display_name":"Midostaurin","level":3,"score":0.6144999861717224},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6008999943733215},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5383999943733215},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.48339998722076416},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.46160000562667847},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4189000129699707},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.4043999910354614},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3578999936580658},{"id":"https://openalex.org/C3018359032","wikidata":"https://www.wikidata.org/wiki/Q1550789","display_name":"Safety profile","level":3,"score":0.33649998903274536},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.329800009727478},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.3264999985694885},{"id":"https://openalex.org/C2910954276","wikidata":"https://www.wikidata.org/wiki/Q14912399","display_name":"Fms-Like Tyrosine Kinase 3","level":4,"score":0.31299999356269836},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.30329999327659607},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.2847000062465668},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.2840999960899353},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.26969999074935913},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2660999894142151},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.26600000262260437},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.26600000262260437},{"id":"https://openalex.org/C2778570526","wikidata":"https://www.wikidata.org/wiki/Q653197","display_name":"Rash","level":2,"score":0.25600001215934753}],"mesh":[{"descriptor_ui":"D000814","descriptor_name":"Aniline Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000814","descriptor_name":"Aniline Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000814","descriptor_name":"Aniline Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000814","descriptor_name":"Aniline Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000814","descriptor_name":"Aniline Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000814","descriptor_name":"Aniline Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000814","descriptor_name":"Aniline Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000814","descriptor_name":"Aniline Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000814","descriptor_name":"Aniline Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000814","descriptor_name":"Aniline Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000814","descriptor_name":"Aniline Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000814","descriptor_name":"Aniline Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051941","descriptor_name":"fms-Like Tyrosine Kinase 3","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051941","descriptor_name":"fms-Like Tyrosine Kinase 3","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051941","descriptor_name":"fms-Like Tyrosine Kinase 3","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051941","descriptor_name":"fms-Like Tyrosine Kinase 3","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051941","descriptor_name":"fms-Like Tyrosine Kinase 3","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051941","descriptor_name":"fms-Like Tyrosine Kinase 3","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051941","descriptor_name":"fms-Like Tyrosine Kinase 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051941","descriptor_name":"fms-Like Tyrosine Kinase 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051941","descriptor_name":"fms-Like Tyrosine Kinase 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051941","descriptor_name":"fms-Like Tyrosine Kinase 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051941","descriptor_name":"fms-Like Tyrosine Kinase 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051941","descriptor_name":"fms-Like Tyrosine Kinase 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D052160","descriptor_name":"Benzothiazoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D052160","descriptor_name":"Benzothiazoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D052160","descriptor_name":"Benzothiazoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D052160","descriptor_name":"Benzothiazoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D052160","descriptor_name":"Benzothiazoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D052160","descriptor_name":"Benzothiazoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D052160","descriptor_name":"Benzothiazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D052160","descriptor_name":"Benzothiazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D052160","descriptor_name":"Benzothiazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D052160","descriptor_name":"Benzothiazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D052160","descriptor_name":"Benzothiazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D052160","descriptor_name":"Benzothiazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s10238-026-02093-8","doi":"https://doi.org/10.1007/s10238-026-02093-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10238-026-02093-8","pdf_url":null,"source":{"id":"https://openalex.org/S1255940","display_name":"Clinical and Experimental Medicine","issn_l":"1591-8890","issn":["1591-8890","1591-9528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Medicine","raw_type":"journal-article"},{"id":"pmid:41729312","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41729312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12953341","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12953341/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12953341/pdf/10238_2026_Article_2093.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clin Exp Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s10238-026-02093-8","doi":"https://doi.org/10.1007/s10238-026-02093-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10238-026-02093-8","pdf_url":null,"source":{"id":"https://openalex.org/S1255940","display_name":"Clinical and Experimental Medicine","issn_l":"1591-8890","issn":["1591-8890","1591-9528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5654487609863281,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320325777","display_name":"Universit\u00e0 degli Studi della Campania Luigi Vanvitelli","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1971028883","https://openalex.org/W1981811959","https://openalex.org/W1985877500","https://openalex.org/W1988062934","https://openalex.org/W1991687104","https://openalex.org/W2002927399","https://openalex.org/W2056465113","https://openalex.org/W2059150276","https://openalex.org/W2105434446","https://openalex.org/W2108331580","https://openalex.org/W2151222524","https://openalex.org/W2461928138","https://openalex.org/W2715749014","https://openalex.org/W2885063710","https://openalex.org/W2909346948","https://openalex.org/W2942855506","https://openalex.org/W2948900598","https://openalex.org/W2982353618","https://openalex.org/W2995587299","https://openalex.org/W3000653492","https://openalex.org/W3111594720","https://openalex.org/W3112633607","https://openalex.org/W3114932971","https://openalex.org/W3118615836","https://openalex.org/W3124535932","https://openalex.org/W3167688297","https://openalex.org/W3207885600","https://openalex.org/W4224290890","https://openalex.org/W4234907574","https://openalex.org/W4280583654","https://openalex.org/W4284884567","https://openalex.org/W4289522686","https://openalex.org/W4318542961","https://openalex.org/W4365812843","https://openalex.org/W4366977509","https://openalex.org/W4386605219","https://openalex.org/W4392877595","https://openalex.org/W4402271583","https://openalex.org/W4403384287","https://openalex.org/W4408318914"],"related_works":[],"abstract_inverted_index":{"Acute":[0],"myeloid":[1],"leukemia":[2,9],"(AML)":[3],"is":[4],"the":[5,19,51,73,80,136,180,197],"most":[6,127,157],"common":[7],"acute":[8],"in":[10,18,56,118,124,179,191,239],"adults.":[11],"Approximately":[12],"30%":[13],"of":[14,53,66,76,93,150,182,207],"patients":[15],"present":[16],"alterations":[17],"FMS-like":[20],"receptor":[21],"tyrosine":[22],"kinase":[23],"3":[24],"(FLT3)":[25],"gene,":[26],"which":[27],"are":[28,172],"associated":[29,174],"with":[30,175,210],"poor":[31],"prognosis.":[32],"FLT3":[33,48,77,154,170],"inhibitors":[34,171],"-":[35,42],"midostaurin":[36,117],"(first-generation),":[37],"gilteritinib":[38,123,211],"and":[39,64,87,116,122,142,168,226,229],"quizartinib":[40,115],"(second-generation)":[41],"have":[43],"been":[44],"developed":[45],"to":[46,71,153,185],"block":[47],"activation.":[49],"Given":[50],"need":[52],"optimizing":[54],"treatment":[55],"FLT3-mutated":[57],"AML,":[58],"we":[59,83],"conducted":[60],"a":[61,176,234],"systematic":[62],"review":[63],"meta-analysis":[65],"randomized":[67],"controlled":[68],"trials":[69,120],"(RCTs)":[70],"compare":[72],"safety":[74,222,237],"profiles":[75],"inhibitors.":[78],"Following":[79],"PRISMA":[81],"statement,":[82],"searched":[84],"Embase,":[85],"MEDLINE":[86],"Cochrane":[88,91],"Library.":[89],"The":[90,126,156,200],"Risk":[92],"Bias":[94],"Tool":[95],"for":[96,100,233],"RCTs":[97],"was":[98,203],"used":[99],"quality":[101],"assessment.":[102],"Of":[103],"2132":[104],"references,":[105],"seven":[106],"RCTs,":[107],"involving":[108],"2409":[109],"adult":[110],"patients,":[111],"met":[112],"inclusion":[113],"criteria:":[114],"two":[119],"each":[121],"three.":[125],"frequently":[128,158],"reported":[129],"adverse":[130],"events":[131],"(AEs)":[132],"were":[133,162,194],"classified":[134],"under":[135],"System":[137],"Organ":[138],"Class":[139],"(SOC)":[140],"Blood":[141],"lymphatic":[143],"system":[144],"disorders":[145],"(N":[146],"=":[147,213],"5474,":[148],"58.4%":[149],"them":[151],"related":[152],"inhibitors).":[155],"observed":[159,195],"non-hematological":[160],"AEs":[161,183],"gastrointestinal":[163],"disorders,":[164],"pyrexia,":[165],"elevated":[166],"ALT/AST":[167],"headache.":[169],"not":[173],"significant":[177],"increase":[178],"risk":[181,193,206],"compared":[184],"standard":[186],"treatments.":[187],"No":[188],"meaningful":[189],"differences":[190],"AE":[192],"among":[196],"three":[198],"drugs.":[199],"only":[201],"exception":[202],"an":[204],"higher":[205],"ALT":[208],"increased":[209],"(RR":[212],"2.40,":[214],"95%":[215],"CI:":[216],"1.16-4.95).":[217],"Future":[218],"studies":[219],"should":[220],"stratify":[221],"outcomes":[223],"by":[224],"demographic":[225],"clinical":[227,240],"characteristics":[228],"incorporate":[230],"long-term":[231],"follow-up":[232],"more":[235],"comprehensive":[236],"assessment":[238],"practice.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2026-02-24T00:00:00"}