{"id":"https://openalex.org/W7130946459","doi":"https://doi.org/10.1016/j.molcel.2026.10.006","title":"How the TREX-2 complex associates with the nuclear pore","display_name":"How the TREX-2 complex associates with the nuclear pore","publication_year":2026,"publication_date":"2026-10-26","ids":{"openalex":"https://openalex.org/W7130946459","doi":"https://doi.org/10.1016/j.molcel.2026.10.006","pmid":"https://pubmed.ncbi.nlm.nih.gov/42933404"},"language":"en","primary_location":{"id":"doi:10.1016/j.molcel.2026.10.006","doi":"https://doi.org/10.1016/j.molcel.2026.10.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molcel.2026.10.006","pdf_url":null,"source":{"id":"https://openalex.org/S156208185","display_name":"Molecular Cell","issn_l":"1097-2765","issn":["1097-2765","1097-4164"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cell","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.molcel.2026.10.006","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064916429","display_name":"Agnieszka Obarska-Kosi\u0144ska","orcid":"https://orcid.org/0000-0001-7686-695X","observed_orcids":["https://orcid.org/0000-0001-7686-695X"]},"institutions":[{"id":"https://openalex.org/I4210124035","display_name":"Max Planck Institute of Biophysics","ror":"https://ror.org/02panr271","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210124035"]},{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Agnieszka Obarska-Kosinska","raw_affiliation_strings":["Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue-Stra\u00dfe 3, 60438 Frankfurt am Main, Germany; European Molecular Biology Laboratory Hamburg, Notkestra\u00dfe 85, 22607 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue-Stra\u00dfe 3, 60438 Frankfurt am Main, Germany; European Molecular Biology Laboratory Hamburg, Notkestra\u00dfe 85, 22607 Hamburg, Germany","institution_ids":["https://openalex.org/I4210124035","https://openalex.org/I4210153543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101458224","display_name":"Ying Zhu","orcid":"https://orcid.org/0000-0003-4158-8093","observed_orcids":["https://orcid.org/0000-0003-4158-8093"]},"institutions":[{"id":"https://openalex.org/I4210099563","display_name":"Leibniz-Forschungsinstitut f\u00fcr Molekulare Pharmakologie","ror":"https://ror.org/010s54n03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210099563"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ying Zhu","raw_affiliation_strings":["Department of Structural Biology, Leibniz - Forschungsinstitut f\u00fcr Molekulare Pharmakologie (FMP), Robert-Roessle-Str. 10, 13125 Berlin, Germany; Absea Biotechnology GmbH, Robert-Roessle-Str. 10, 13125 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Structural Biology, Leibniz - Forschungsinstitut f\u00fcr Molekulare Pharmakologie (FMP), Robert-Roessle-Str. 10, 13125 Berlin, Germany; Absea Biotechnology GmbH, Robert-Roessle-Str. 10, 13125 Berlin, Germany","institution_ids":["https://openalex.org/I4210099563"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097633253","display_name":"Katharina Gei\u00dfler","orcid":"https://orcid.org/0009-0000-7875-7052","observed_orcids":["https://orcid.org/0009-0000-7875-7052"]},"institutions":[{"id":"https://openalex.org/I4210124035","display_name":"Max Planck Institute of Biophysics","ror":"https://ror.org/02panr271","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210124035"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katharina Gei\u00dfler","raw_affiliation_strings":["Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue-Stra\u00dfe 3, 60438 Frankfurt am Main, Germany; IMPRS on Cellular Biophysics, Max-von-Laue-Stra\u00dfe 3, 60438 Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue-Stra\u00dfe 3, 60438 Frankfurt am Main, Germany; IMPRS on Cellular Biophysics, Max-von-Laue-Stra\u00dfe 3, 60438 Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I4210124035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029153380","display_name":"Remus R. E. Rosenkranz","orcid":"https://orcid.org/0000-0001-5457-4542","observed_orcids":["https://orcid.org/0000-0001-5457-4542"]},"institutions":[{"id":"https://openalex.org/I4210124035","display_name":"Max Planck Institute of Biophysics","ror":"https://ror.org/02panr271","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210124035"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Remus R.E. Rosenkranz","raw_affiliation_strings":["Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue-Stra\u00dfe 3, 60438 Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue-Stra\u00dfe 3, 60438 Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I4210124035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065344089","display_name":"Nanako Yokoyama","orcid":"https://orcid.org/0009-0005-9968-8187","observed_orcids":["https://orcid.org/0009-0005-9968-8187"]},"institutions":[{"id":"https://openalex.org/I4210099563","display_name":"Leibniz-Forschungsinstitut f\u00fcr Molekulare Pharmakologie","ror":"https://ror.org/010s54n03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210099563"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nanako Yokoyama","raw_affiliation_strings":["Department of Structural Biology, Leibniz - Forschungsinstitut f\u00fcr Molekulare Pharmakologie (FMP), Robert-Roessle-Str. 10, 13125 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Structural Biology, Leibniz - Forschungsinstitut f\u00fcr Molekulare Pharmakologie (FMP), Robert-Roessle-Str. 10, 13125 Berlin, Germany","institution_ids":["https://openalex.org/I4210099563"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044235897","display_name":"Jan Philipp Kreysing","orcid":"https://orcid.org/0000-0002-4770-6313","observed_orcids":["https://orcid.org/0000-0002-4770-6313"]},"institutions":[{"id":"https://openalex.org/I4210124035","display_name":"Max Planck Institute of Biophysics","ror":"https://ror.org/02panr271","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210124035"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan Philipp Kreysing","raw_affiliation_strings":["Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue-Stra\u00dfe 3, 60438 Frankfurt am Main, Germany; IMPRS on Cellular Biophysics, Max-von-Laue-Stra\u00dfe 3, 60438 Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue-Stra\u00dfe 3, 60438 Frankfurt am Main, Germany; IMPRS on Cellular Biophysics, Max-von-Laue-Stra\u00dfe 3, 60438 Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I4210124035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003381801","display_name":"Huaipeng Xing","orcid":"https://orcid.org/0000-0002-8622-0252","observed_orcids":["https://orcid.org/0000-0002-8622-0252"]},"institutions":[{"id":"https://openalex.org/I4210124035","display_name":"Max Planck Institute of Biophysics","ror":"https://ror.org/02panr271","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210124035"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Huaipeng Xing","raw_affiliation_strings":["Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue-Stra\u00dfe 3, 60438 Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue-Stra\u00dfe 3, 60438 Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I4210124035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048236195","display_name":"Desislava Glushkova","orcid":"https://orcid.org/0000-0001-6077-7338","observed_orcids":["https://orcid.org/0000-0001-6077-7338"]},"institutions":[{"id":"https://openalex.org/I4210124035","display_name":"Max Planck Institute of Biophysics","ror":"https://ror.org/02panr271","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210124035"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Desislava Glushkova","raw_affiliation_strings":["Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue-Stra\u00dfe 3, 60438 Frankfurt am Main, Germany; IMPRS on Cellular Biophysics, Max-von-Laue-Stra\u00dfe 3, 60438 Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue-Stra\u00dfe 3, 60438 Frankfurt am Main, Germany; IMPRS on Cellular Biophysics, Max-von-Laue-Stra\u00dfe 3, 60438 Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I4210124035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008833507","display_name":"Marta Anna Kuba\u0144ska","orcid":"https://orcid.org/0000-0003-3835-8238","observed_orcids":["https://orcid.org/0000-0003-3835-8238"]},"institutions":[{"id":"https://openalex.org/I4210124035","display_name":"Max Planck Institute of Biophysics","ror":"https://ror.org/02panr271","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210124035"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marta Anna Kuba\u0144ska","raw_affiliation_strings":["Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue-Stra\u00dfe 3, 60438 Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue-Stra\u00dfe 3, 60438 Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I4210124035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061896814","display_name":"Stefanie B\u00f6hm","orcid":"https://orcid.org/0009-0005-1690-9125","observed_orcids":["https://orcid.org/0009-0005-1690-9125"]},"institutions":[{"id":"https://openalex.org/I4210124035","display_name":"Max Planck Institute of Biophysics","ror":"https://ror.org/02panr271","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210124035"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefanie B\u00f6hm","raw_affiliation_strings":["Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue-Stra\u00dfe 3, 60438 Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue-Stra\u00dfe 3, 60438 Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I4210124035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036005209","display_name":"Hans\u2010Georg Kr\u00e4usslich","orcid":"https://orcid.org/0000-0002-8756-329X","observed_orcids":["https://orcid.org/0000-0002-8756-329X"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans-Georg Kr\u00e4usslich","raw_affiliation_strings":["Department of Infectious Diseases, Virology, University of Heidelberg, 69120 Heidelberg, Germany; German Center for Infection Research, partner site Heidelberg, 69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Virology, University of Heidelberg, 69120 Heidelberg, Germany; German Center for Infection Research, partner site Heidelberg, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210115305"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028180523","display_name":"Beata Turo\u0148ov\u00e1","orcid":"https://orcid.org/0000-0002-5457-4478","observed_orcids":["https://orcid.org/0000-0002-5457-4478"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210124035","display_name":"Max Planck Institute of Biophysics","ror":"https://ror.org/02panr271","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210124035"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Beata Turo\u0148ov\u00e1","raw_affiliation_strings":["Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue-Stra\u00dfe 3, 60438 Frankfurt am Main, Germany; Cluster of Excellence SubCellular Architecture of Life (SCALE), Goethe University, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue-Stra\u00dfe 3, 60438 Frankfurt am Main, Germany; Cluster of Excellence SubCellular Architecture of Life (SCALE), Goethe University, Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210124035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100371030","display_name":"Fan Liu","orcid":"https://orcid.org/0000-0002-2358-549X","observed_orcids":["https://orcid.org/0000-0002-2358-549X"]},"institutions":[{"id":"https://openalex.org/I4210099563","display_name":"Leibniz-Forschungsinstitut f\u00fcr Molekulare Pharmakologie","ror":"https://ror.org/010s54n03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210099563"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Fan Liu","raw_affiliation_strings":["Department of Structural Biology, Leibniz - Forschungsinstitut f\u00fcr Molekulare Pharmakologie (FMP), Robert-Roessle-Str. 10, 13125 Berlin, Germany; Absea Biotechnology GmbH, Robert-Roessle-Str. 10, 13125 Berlin, Germany; Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Charit\u00e9pl. 1, 10117 Berlin, Germany. Electronic address: fliu@fmp-berlin.de"],"raw_orcid":"https://orcid.org/0000-0002-2358-549X","affiliations":[{"raw_affiliation_string":"Department of Structural Biology, Leibniz - Forschungsinstitut f\u00fcr Molekulare Pharmakologie (FMP), Robert-Roessle-Str. 10, 13125 Berlin, Germany; Absea Biotechnology GmbH, Robert-Roessle-Str. 10, 13125 Berlin, Germany; Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Charit\u00e9pl. 1, 10117 Berlin, Germany. Electronic address: fliu@fmp-berlin.de","institution_ids":["https://openalex.org/I4210099563","https://openalex.org/I7877124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028999855","display_name":"Martin Beck","orcid":"https://orcid.org/0000-0002-7397-1321","observed_orcids":["https://orcid.org/0000-0002-7397-1321","https://orcid.org/0000-0003-3691-9257"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210124035","display_name":"Max Planck Institute of Biophysics","ror":"https://ror.org/02panr271","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210124035"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Martin Beck","raw_affiliation_strings":["Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue-Stra\u00dfe 3, 60438 Frankfurt am Main, Germany; Cluster of Excellence SubCellular Architecture of Life (SCALE), Goethe University, Frankfurt, Germany; Institute of Biochemistry, Goethe University Frankfurt, 60438 Frankfurt am Main, Germany. Electronic address: martin.beck@biophys.mpg.de"],"raw_orcid":"https://orcid.org/0000-0002-7397-1321","affiliations":[{"raw_affiliation_string":"Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue-Stra\u00dfe 3, 60438 Frankfurt am Main, Germany; Cluster of Excellence SubCellular Architecture of Life (SCALE), Goethe University, Frankfurt, Germany; Institute of Biochemistry, Goethe University Frankfurt, 60438 Frankfurt am Main, Germany. Electronic address: martin.beck@biophys.mpg.de","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210124035"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5028999855","https://openalex.org/A5100371030"],"corresponding_institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210099563","https://openalex.org/I4210124035","https://openalex.org/I7877124"],"apc_list":{"value":10400,"currency":"USD","value_usd":10400},"apc_paid":{"value":10400,"currency":"USD","value_usd":10400},"fwci":10.7613,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.98606087,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"86","issue":"21","first_page":"4432","last_page":"4448.e6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nuclear-pore-complex","display_name":"nuclear pore complex","score":0.9190000295639038},{"id":"https://openalex.org/keywords/mrna-export","display_name":"mRNA export","score":0.9279999732971191},{"id":"https://openalex.org/keywords/nuclear-rings","display_name":"nuclear rings","score":0.6700000166893005},{"id":"https://openalex.org/keywords/nuclear-basket","display_name":"nuclear basket","score":0.9100000262260437},{"id":"https://openalex.org/keywords/nup153","display_name":"Nup153","score":0.7799999713897705},{"id":"https://openalex.org/keywords/nup50","display_name":"Nup50","score":0.9670000076293945},{"id":"https://openalex.org/keywords/ganp","display_name":"GANP","score":0.8119999766349792},{"id":"https://openalex.org/keywords/centrin-2","display_name":"centrin 2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/nup214","display_name":"Nup214","score":0.8489999771118164},{"id":"https://openalex.org/keywords/nuclear-transport","display_name":"nuclear transport","score":0.9409999847412109},{"id":"https://openalex.org/keywords/cryo-electron-tomography","display_name":"cryo-electron tomography","score":0.734000027179718},{"id":"https://openalex.org/keywords/cross-linking-mass-spectrometry","display_name":"cross-linking mass spectrometry","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C126725582","wikidata":"https://www.wikidata.org/wiki/Q30679","display_name":"Nuclear pore","level":3,"score":0.921999990940094},{"id":"https://openalex.org/C68556195","wikidata":"https://www.wikidata.org/wiki/Q3571630","display_name":"Nucleoporin","level":5,"score":0.847000002861023},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.6197999715805054},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5697000026702881},{"id":"https://openalex.org/C54757728","wikidata":"https://www.wikidata.org/wiki/Q3511067","display_name":"Nuclear export signal","level":4,"score":0.550599992275238},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.534500002861023},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5241000056266785},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4528000056743622},{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.4309999942779541},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.42500001192092896},{"id":"https://openalex.org/C59157529","wikidata":"https://www.wikidata.org/wiki/Q994741","display_name":"Nuclear transport","level":4,"score":0.4146000146865845},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.3935999870300293},{"id":"https://openalex.org/C65871279","wikidata":"https://www.wikidata.org/wiki/Q42884945","display_name":"Inner membrane","level":3,"score":0.37790000438690186},{"id":"https://openalex.org/C2164484","wikidata":"https://www.wikidata.org/wiki/Q5170150","display_name":"Core (optical fiber)","level":2,"score":0.35830000042915344},{"id":"https://openalex.org/C49805395","wikidata":"https://www.wikidata.org/wiki/Q910966","display_name":"Nuclear localization sequence","level":3,"score":0.3411000072956085},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.3330000042915344},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.3163999915122986},{"id":"https://openalex.org/C75934600","wikidata":"https://www.wikidata.org/wiki/Q419245","display_name":"Ribonucleoprotein","level":4,"score":0.29660001397132874},{"id":"https://openalex.org/C186435350","wikidata":"https://www.wikidata.org/wiki/Q1050365","display_name":"NLS","level":4,"score":0.29649999737739563},{"id":"https://openalex.org/C3018069271","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Structural protein","level":3,"score":0.2865000069141388},{"id":"https://openalex.org/C94912109","wikidata":"https://www.wikidata.org/wiki/Q687194","display_name":"Nuclear lamina","level":5,"score":0.2809999883174896},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.28049999475479126},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2750999927520752},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.2689000070095062},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25850000977516174},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2549000084400177},{"id":"https://openalex.org/C57581600","wikidata":"https://www.wikidata.org/wiki/Q2449730","display_name":"Transport protein","level":2,"score":0.2533999979496002}],"mesh":[{"descriptor_ui":"D005090","descriptor_name":"Exodeoxyribonucleases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012261","descriptor_name":"Ribonucleoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012261","descriptor_name":"Ribonucleoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022022","descriptor_name":"Nuclear Pore","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D022022","descriptor_name":"Nuclear Pore","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D022022","descriptor_name":"Nuclear Pore","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D028861","descriptor_name":"Nuclear Pore Complex Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D028861","descriptor_name":"Nuclear Pore Complex Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.molcel.2026.10.006","doi":"https://doi.org/10.1016/j.molcel.2026.10.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molcel.2026.10.006","pdf_url":null,"source":{"id":"https://openalex.org/S156208185","display_name":"Molecular Cell","issn_l":"1097-2765","issn":["1097-2765","1097-4164"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cell","raw_type":"journal-article"},{"id":"doi:10.64898/2026.02.20.707084","doi":"https://doi.org/10.64898/2026.02.20.707084","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.02.20.707084","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42933404","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42933404","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cell","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.molcel.2026.10.006","doi":"https://doi.org/10.1016/j.molcel.2026.10.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molcel.2026.10.006","pdf_url":null,"source":{"id":"https://openalex.org/S156208185","display_name":"Molecular Cell","issn_l":"1097-2765","issn":["1097-2765","1097-4164"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cell","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2575772051","display_name":"SFB 1129: Integrative Analyse der Replikation und Ausbreitung pathogener Erreger","funder_award_id":"240245660","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2962312559","display_name":null,"funder_award_id":"LI 3260/6-1/","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G702571282","display_name":"SFB 1507: Proteinverb\u00fcnde und Maschinerien in Zellmembranen","funder_award_id":"450648163","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321961","display_name":"Hessisches Ministerium f\u00fcr Wissenschaft und Kunst","ror":"https://ror.org/00zd5gr55"},{"id":"https://openalex.org/F4320322434","display_name":"Max-Planck-Gesellschaft","ror":"https://ror.org/01hhn8329"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":123,"referenced_works":["https://openalex.org/W1540853973","https://openalex.org/W1838945435","https://openalex.org/W1899765255","https://openalex.org/W1970564598","https://openalex.org/W1974292824","https://openalex.org/W1980374511","https://openalex.org/W1983135362","https://openalex.org/W1984758353","https://openalex.org/W1989644696","https://openalex.org/W2004995654","https://openalex.org/W2009018280","https://openalex.org/W2009314568","https://openalex.org/W2009746447","https://openalex.org/W2011052397","https://openalex.org/W2016275804","https://openalex.org/W2021074239","https://openalex.org/W2022861419","https://openalex.org/W2029098002","https://openalex.org/W2029101220","https://openalex.org/W2030677655","https://openalex.org/W2036262978","https://openalex.org/W2036947100","https://openalex.org/W2045704444","https://openalex.org/W2051555473","https://openalex.org/W2053706533","https://openalex.org/W2065283382","https://openalex.org/W2070686658","https://openalex.org/W2078906823","https://openalex.org/W2079815614","https://openalex.org/W2081023618","https://openalex.org/W2094089096","https://openalex.org/W2099905512","https://openalex.org/W2104908223","https://openalex.org/W2106403358","https://openalex.org/W2109845157","https://openalex.org/W2110065044","https://openalex.org/W2110428381","https://openalex.org/W2111802043","https://openalex.org/W2113582597","https://openalex.org/W2114561313","https://openalex.org/W2118404419","https://openalex.org/W2120148489","https://openalex.org/W2127413138","https://openalex.org/W2132629607","https://openalex.org/W2133201628","https://openalex.org/W2141339789","https://openalex.org/W2142161929","https://openalex.org/W2144660247","https://openalex.org/W2150605329","https://openalex.org/W2158133155","https://openalex.org/W2158348177","https://openalex.org/W2163392073","https://openalex.org/W2164565059","https://openalex.org/W2166796674","https://openalex.org/W2168700705","https://openalex.org/W2171135008","https://openalex.org/W2171537806","https://openalex.org/W2220896177","https://openalex.org/W2293847040","https://openalex.org/W2335825911","https://openalex.org/W2337967254","https://openalex.org/W2580035316","https://openalex.org/W2656748229","https://openalex.org/W2734356283","https://openalex.org/W2738961268","https://openalex.org/W2768290498","https://openalex.org/W2790485917","https://openalex.org/W2801376357","https://openalex.org/W2897492435","https://openalex.org/W2899714098","https://openalex.org/W2921042206","https://openalex.org/W2935467328","https://openalex.org/W2952891171","https://openalex.org/W2967473692","https://openalex.org/W2971362908","https://openalex.org/W3086401169","https://openalex.org/W3126674454","https://openalex.org/W3157456279","https://openalex.org/W3187798705","https://openalex.org/W3207915361","https://openalex.org/W3216930177","https://openalex.org/W4212973632","https://openalex.org/W4213026325","https://openalex.org/W4220883106","https://openalex.org/W4220942300","https://openalex.org/W4251253181","https://openalex.org/W4280519641","https://openalex.org/W4281677038","https://openalex.org/W4281726159","https://openalex.org/W4281790889","https://openalex.org/W4282918855","https://openalex.org/W4282925643","https://openalex.org/W4282936228","https://openalex.org/W4282945834","https://openalex.org/W4293475204","https://openalex.org/W4295513181","https://openalex.org/W4304143157","https://openalex.org/W4316687615","https://openalex.org/W4319059263","https://openalex.org/W4322720096","https://openalex.org/W4367049503","https://openalex.org/W4383313834","https://openalex.org/W4387826005","https://openalex.org/W4389042041","https://openalex.org/W4390767906","https://openalex.org/W4394890686","https://openalex.org/W4396721167","https://openalex.org/W4396944371","https://openalex.org/W4401459440","https://openalex.org/W4402839899","https://openalex.org/W4403948742","https://openalex.org/W4404944610","https://openalex.org/W4406510165","https://openalex.org/W4406538560","https://openalex.org/W4406798728","https://openalex.org/W4409325723","https://openalex.org/W4411891364","https://openalex.org/W4412488794","https://openalex.org/W4413116854","https://openalex.org/W4415965052","https://openalex.org/W6912624719","https://openalex.org/W7125649536","https://openalex.org/W7212851669"],"related_works":["https://openalex.org/W1974292824","https://openalex.org/W4225390126","https://openalex.org/W2113656016","https://openalex.org/W2016275804","https://openalex.org/W1989644696","https://openalex.org/W2464080227","https://openalex.org/W143698314","https://openalex.org/W3086401169","https://openalex.org/W1936611779","https://openalex.org/W9041567"],"abstract_inverted_index":{"Nuclear":[0],"pore":[1],"complexes":[2],"(NPCs)":[3],"control":[4],"nucleocytoplasmic":[5],"transport":[6],"in":[7],"eukaryotes,":[8],"yet":[9],"their":[10],"architecture":[11],"remains":[12],"incompletely":[13],"understood.":[14],"Here,":[15],"we":[16],"report":[17],"a":[18,92,130],"substantially":[19],"extended":[20],"structure":[21],"of":[22,43,74,105,119],"the":[23,40,65,75,83,106,116,120],"human":[24],"NPC,":[25],"obtained":[26],"by":[27],"combining":[28],"cryo-electron":[29],"tomography,":[30],"crosslinking":[31],"mass":[32],"spectrometry,":[33],"and":[34,50,52,61,70,125],"AI-assisted":[35],"integrative":[36],"modeling.":[37],"We":[38],"resolve":[39],"molecular":[41,117],"arrangement":[42],"translocated":[44],"promoter":[45],"region":[46],"(TPR),":[47],"NUP153,":[48],"NUP50,":[49],"ZC3HC1":[51],"reveal":[53],"that":[54,134],"five":[55],"additional":[56],"proteins-TMEM209,":[57],"SMPD4,":[58],"GANP,":[59,68],"Centrin-2,":[60,69],"ENY2-are":[62],"incorporated":[63],"into":[64,82],"NPC.":[66],"Unexpectedly,":[67],"ENY2,":[71],"core":[72],"members":[73],"TREX-2":[76,89],"mRNA":[77,109],"export":[78,110],"complex,":[79],"are":[80],"built":[81],"nuclear":[84,123,126],"ring.":[85],"This":[86],"finding":[87],"establishes":[88],"not":[90],"as":[91,97],"transiently":[93],"associated":[94],"factor,":[95],"but":[96],"an":[98],"integral":[99],"NPC":[100],"module,":[101],"positioning":[102],"it":[103],"opposite":[104],"cytoplasmic":[107],"NUP214":[108],"platform.":[111],"Together,":[112],"our":[113],"results":[114],"redefine":[115],"composition":[118],"inner":[121],"ring,":[122,124],"basket.":[127],"They":[128],"suggest":[129],"direct":[131],"structural":[132],"basis":[133],"couples":[135],"TREX-2-mediated":[136],"messenger":[137],"ribonucleoprotein":[138],"particle":[139],"(mRNP)":[140],"remodeling":[141],"to":[142],"NPC-facilitated":[143],"transport.":[144]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-02-23T00:00:00"}