{"id":"https://openalex.org/W7130875243","doi":"https://doi.org/10.1038/s41393-026-01177-2","title":"Nanoformulated fingolimod attenuates NLRP3 inflammasome activation and promotes functional recovery in a rat model of spinal cord injury","display_name":"Nanoformulated fingolimod attenuates NLRP3 inflammasome activation and promotes functional recovery in a rat model of spinal cord injury","publication_year":2026,"publication_date":"2026-02-21","ids":{"openalex":"https://openalex.org/W7130875243","doi":"https://doi.org/10.1038/s41393-026-01177-2","pmid":"https://pubmed.ncbi.nlm.nih.gov/41723253"},"language":"en","primary_location":{"id":"doi:10.1038/s41393-026-01177-2","doi":"https://doi.org/10.1038/s41393-026-01177-2","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41393-026-01177-2","pdf_url":null,"source":{"id":"https://openalex.org/S95854419","display_name":"Spinal Cord","issn_l":"1362-4393","issn":["1362-4393","1476-5624"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Spinal Cord","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103191580","display_name":"Mohammed Hussein M. Alsharbaty","orcid":"https://orcid.org/0000-0003-4977-8713","observed_orcids":["https://orcid.org/0000-0003-4977-8713"]},"institutions":[{"id":"https://openalex.org/I4405264678","display_name":"University of Al-Ameed","ror":"https://ror.org/02mpwke65","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4405264678"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Mohammed Hussein M. Alsharbaty","raw_affiliation_strings":["Branch of Prosthodontics, College of Dentistry, University of Al-Ameed, Karbala, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Branch of Prosthodontics, College of Dentistry, University of Al-Ameed, Karbala, Iraq","institution_ids":["https://openalex.org/I4405264678"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074804408","display_name":"Reem S. Alazragi","orcid":"https://orcid.org/0000-0003-1472-8337","observed_orcids":["https://orcid.org/0000-0003-1472-8337"]},"institutions":[{"id":"https://openalex.org/I4210099699","display_name":"University of Jeddah","ror":"https://ror.org/015ya8798","country_code":"SA","type":"education","lineage":["https://openalex.org/I4210099699"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Reem S. Alazragi","raw_affiliation_strings":["Department of Biological Sciences, College of Science, University of Jeddah, Jeddah, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, College of Science, University of Jeddah, Jeddah, Saudi Arabia","institution_ids":["https://openalex.org/I4210099699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126551998","display_name":"Siba Mekaael yaseen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153874","display_name":"Al-Zahraa University for Women","ror":"https://ror.org/05c2btq38","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4387153874"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Siba Mekaael yaseen","raw_affiliation_strings":["College of Medical and Health Technologies, Al-Zahraa University for Women, Karbala, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medical and Health Technologies, Al-Zahraa University for Women, Karbala, Iraq","institution_ids":["https://openalex.org/I4387153874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123636246","display_name":"Uday Abdul-Reda Hussein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405264678","display_name":"University of Al-Ameed","ror":"https://ror.org/02mpwke65","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4405264678"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Uday Abdul-Reda Hussein","raw_affiliation_strings":["College of Pharmacy, University of Al-Ameed, Karbala, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, University of Al-Ameed, Karbala, Iraq","institution_ids":["https://openalex.org/I4405264678"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051035618","display_name":"Mustafa Mudhafar","orcid":"https://orcid.org/0000-0002-3785-7396","observed_orcids":["https://orcid.org/0000-0002-3785-7396"]},"institutions":[{"id":"https://openalex.org/I4210142005","display_name":"University of Kerbala","ror":"https://ror.org/0449bkp65","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4210142005"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Mustafa Mudhafar","raw_affiliation_strings":["Centre for Research on Environment and Renewable Energy, University of Karbala, 56001, Karbala, Iraq","Department of Anesthesia Techniques and Intensive Care, Al-Taff university college, 56001, Kerbala, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Research on Environment and Renewable Energy, University of Karbala, 56001, Karbala, Iraq","institution_ids":["https://openalex.org/I4210142005"]},{"raw_affiliation_string":"Department of Anesthesia Techniques and Intensive Care, Al-Taff university college, 56001, Kerbala, Iraq","institution_ids":["https://openalex.org/I4210142005"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047807846","display_name":"Hasan Ali Alsailawi","orcid":"https://orcid.org/0009-0008-9431-3994","observed_orcids":["https://orcid.org/0009-0008-9431-3994","https://orcid.org/0009-0000-9193-3831"]},"institutions":[{"id":"https://openalex.org/I4210142005","display_name":"University of Kerbala","ror":"https://ror.org/0449bkp65","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4210142005"]}],"countries":["IQ"],"is_corresponding":true,"raw_author_name":"Hasan Ali Alsailawi","raw_affiliation_strings":["Faculty of Dentistry, University of Kerbala, Karbala, 56001, Iraq. hasanali.alsailawi@gmail.com"],"raw_orcid":"https://orcid.org/0009-0000-9193-3831","affiliations":[{"raw_affiliation_string":"Faculty of Dentistry, University of Kerbala, Karbala, 56001, Iraq. hasanali.alsailawi@gmail.com","institution_ids":["https://openalex.org/I4210142005"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5047807846"],"corresponding_institution_ids":["https://openalex.org/I4210142005"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":10.1077,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.97915255,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"64","issue":"8","first_page":"669","last_page":"677"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fingolimod","display_name":"fingolimod","score":0.9800000190734863},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9490000009536743},{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"spinal cord injury","score":0.9990000128746033},{"id":"https://openalex.org/keywords/plga-nanoparticles","display_name":"PLGA nanoparticles","score":0.9409999847412109},{"id":"https://openalex.org/keywords/nanodelivery","display_name":"nanodelivery","score":0.7379999756813049},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9760000109672546},{"id":"https://openalex.org/keywords/glial-activation","display_name":"glial activation","score":0.972000002861023},{"id":"https://openalex.org/keywords/functional-recovery","display_name":"functional recovery","score":0.7139999866485596},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.8019999861717224},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9430000185966492},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8220000267028809},{"id":"https://openalex.org/keywords/contusions","display_name":"bruising","score":0.8299999833106995},{"id":"https://openalex.org/keywords/bbb-locomotor-score","display_name":"BBB locomotor score","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9247999787330627},{"id":"https://openalex.org/C3019114686","wikidata":"https://www.wikidata.org/wiki/Q3089676","display_name":"Rat model","level":2,"score":0.7960000038146973},{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.6897000074386597},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.597100019454956},{"id":"https://openalex.org/C2776036978","wikidata":"https://www.wikidata.org/wiki/Q425137","display_name":"Fingolimod","level":3,"score":0.5701000094413757},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.4993000030517578},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.4893999993801117},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.4203999936580658},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.3968000113964081},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3813999891281128},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.3328000009059906},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3183000087738037},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3046000003814697},{"id":"https://openalex.org/C2777597760","wikidata":"https://www.wikidata.org/wiki/Q1049655","display_name":"Paraplegia","level":3,"score":0.2624000012874603},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.25999999046325684}],"mesh":[{"descriptor_ui":"D000068876","descriptor_name":"Fingolimod Hydrochloride","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000068876","descriptor_name":"Fingolimod Hydrochloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000077182","descriptor_name":"Polylactic Acid-Polyglycolic Acid Copolymer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020127","descriptor_name":"Recovery of Function","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020127","descriptor_name":"Recovery of Function","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D058847","descriptor_name":"Inflammasomes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D058847","descriptor_name":"Inflammasomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1038/s41393-026-01177-2","doi":"https://doi.org/10.1038/s41393-026-01177-2","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41393-026-01177-2","pdf_url":null,"source":{"id":"https://openalex.org/S95854419","display_name":"Spinal Cord","issn_l":"1362-4393","issn":["1362-4393","1476-5624"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Spinal Cord","raw_type":"journal-article"},{"id":"pmid:41723253","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41723253","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Spinal cord","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W1739546152","https://openalex.org/W2028031986","https://openalex.org/W2028457710","https://openalex.org/W2042637953","https://openalex.org/W2054810085","https://openalex.org/W2065844354","https://openalex.org/W2083044674","https://openalex.org/W2130166533","https://openalex.org/W2170645579","https://openalex.org/W2395300225","https://openalex.org/W2409180530","https://openalex.org/W2462773201","https://openalex.org/W2516203892","https://openalex.org/W2559673433","https://openalex.org/W2567458296","https://openalex.org/W2606236501","https://openalex.org/W2767111854","https://openalex.org/W2769599719","https://openalex.org/W2770789883","https://openalex.org/W2789272046","https://openalex.org/W2916155651","https://openalex.org/W2948910679","https://openalex.org/W2961112538","https://openalex.org/W2994604520","https://openalex.org/W3043986515","https://openalex.org/W3045327856","https://openalex.org/W3080758841","https://openalex.org/W3092160979","https://openalex.org/W3180405207","https://openalex.org/W3200394304","https://openalex.org/W3216523241","https://openalex.org/W3216795707","https://openalex.org/W4225935984","https://openalex.org/W4229076241","https://openalex.org/W4283330967","https://openalex.org/W4283689652","https://openalex.org/W4292307386","https://openalex.org/W4304957531","https://openalex.org/W4317788223","https://openalex.org/W4322718537","https://openalex.org/W4323348539","https://openalex.org/W4324132504","https://openalex.org/W4360991660","https://openalex.org/W4376279887","https://openalex.org/W4383558588","https://openalex.org/W4390456179","https://openalex.org/W4390716262","https://openalex.org/W4399761816","https://openalex.org/W4401694819","https://openalex.org/W4404641568","https://openalex.org/W4406882321","https://openalex.org/W4407529684","https://openalex.org/W4408245685","https://openalex.org/W4408922320","https://openalex.org/W4410070517","https://openalex.org/W4412731507","https://openalex.org/W4412862913","https://openalex.org/W4412946988","https://openalex.org/W4414084143","https://openalex.org/W4415106072","https://openalex.org/W4415353907","https://openalex.org/W7117313785"],"related_works":["https://openalex.org/W7168131662","https://openalex.org/W7168172161","https://openalex.org/W2767111854","https://openalex.org/W4416136637","https://openalex.org/W3180405207","https://openalex.org/W4404516098","https://openalex.org/W4292307386","https://openalex.org/W3214551656","https://openalex.org/W3007367681","https://openalex.org/W7214579741"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-02-22T00:00:00"}