{"id":"https://openalex.org/W7130833276","doi":"https://doi.org/10.1186/s12967-026-07890-z","title":"Micheliolide suppresses epithelial-mesenchymal transition of lens epithelial cells via downregulating matrix metalloproteinase 8 to ameliorate posterior capsular opacification","display_name":"Micheliolide suppresses epithelial-mesenchymal transition of lens epithelial cells via downregulating matrix metalloproteinase 8 to ameliorate posterior capsular opacification","publication_year":2026,"publication_date":"2026-02-21","ids":{"openalex":"https://openalex.org/W7130833276","doi":"https://doi.org/10.1186/s12967-026-07890-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/41723479"},"language":"en","primary_location":{"id":"doi:10.1186/s12967-026-07890-z","doi":"https://doi.org/10.1186/s12967-026-07890-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12967-026-07890-z","pdf_url":null,"source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12967-026-07890-z","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074717613","display_name":"Cong Fan","orcid":"https://orcid.org/0000-0003-1930-7574","observed_orcids":["https://orcid.org/0000-0003-1930-7574"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cong Fan","raw_affiliation_strings":["Eye Center of Xiangya Hospital, Central South University, No. 87 Xiangya Road, Kaifu District, Changsha, Hunan, 410008, China","Hunan Key Laboratory of Ophthalmology, Xiangya Hospital, Central South University, Changsha, China","National Clinical Key Specialty of Ophthalmology, Changsha, China","National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eye Center of Xiangya Hospital, Central South University, No. 87 Xiangya Road, Kaifu District, Changsha, Hunan, 410008, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Hunan Key Laboratory of Ophthalmology, Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"National Clinical Key Specialty of Ophthalmology, Changsha, China","institution_ids":[]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tianyi Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianyi Kang","raw_affiliation_strings":["Eye Center of Xiangya Hospital, Central South University, No. 87 Xiangya Road, Kaifu District, Changsha, Hunan, 410008, China","Hunan Key Laboratory of Ophthalmology, Xiangya Hospital, Central South University, Changsha, China","National Clinical Key Specialty of Ophthalmology, Changsha, China","National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eye Center of Xiangya Hospital, Central South University, No. 87 Xiangya Road, Kaifu District, Changsha, Hunan, 410008, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Hunan Key Laboratory of Ophthalmology, Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"National Clinical Key Specialty of Ophthalmology, Changsha, China","institution_ids":[]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084581391","display_name":"Lexi Ding","orcid":"https://orcid.org/0000-0002-7501-4883","observed_orcids":["https://orcid.org/0000-0002-7501-4883"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lexi Ding","raw_affiliation_strings":["Eye Center of Xiangya Hospital, Central South University, No. 87 Xiangya Road, Kaifu District, Changsha, Hunan, 410008, China. lexiding@csu.edu.cn","Hunan Key Laboratory of Ophthalmology, Xiangya Hospital, Central South University, Changsha, China. lexiding@csu.edu.cn","National Clinical Key Specialty of Ophthalmology, Changsha, China. lexiding@csu.edu.cn","National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. lexiding@csu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eye Center of Xiangya Hospital, Central South University, No. 87 Xiangya Road, Kaifu District, Changsha, Hunan, 410008, China. lexiding@csu.edu.cn","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Hunan Key Laboratory of Ophthalmology, Xiangya Hospital, Central South University, Changsha, China. lexiding@csu.edu.cn","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"National Clinical Key Specialty of Ophthalmology, Changsha, China. lexiding@csu.edu.cn","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. lexiding@csu.edu.cn","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103501133","display_name":"Jian Jiang","orcid":"https://orcid.org/0009-0006-7151-6161","observed_orcids":["https://orcid.org/0009-0006-7151-6161"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jian Jiang","raw_affiliation_strings":["Eye Center of Xiangya Hospital, Central South University, No. 87 Xiangya Road, Kaifu District, Changsha, Hunan, 410008, China. jiang_jian@csu.edu.cn","Hunan Key Laboratory of Ophthalmology, Xiangya Hospital, Central South University, Changsha, China. jiang_jian@csu.edu.cn","National Clinical Key Specialty of Ophthalmology, Changsha, China. jiang_jian@csu.edu.cn","National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. jiang_jian@csu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eye Center of Xiangya Hospital, Central South University, No. 87 Xiangya Road, Kaifu District, Changsha, Hunan, 410008, China. jiang_jian@csu.edu.cn","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Hunan Key Laboratory of Ophthalmology, Xiangya Hospital, Central South University, Changsha, China. jiang_jian@csu.edu.cn","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"National Clinical Key Specialty of Ophthalmology, Changsha, China. jiang_jian@csu.edu.cn","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. jiang_jian@csu.edu.cn","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5084581391","https://openalex.org/A5103501133"],"corresponding_institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":{"value":3890,"currency":"USD","value_usd":3890},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08113885,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11291","display_name":"Intraocular Surgery and Lenses","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11291","display_name":"Intraocular Surgery and Lenses","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/micheliolide","display_name":"micheliolide","score":0.9869999885559082},{"id":"https://openalex.org/keywords/posterior-capsule-opacification","display_name":"posterior capsule opacification","score":0.9919999837875366},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9919999837875366},{"id":"https://openalex.org/keywords/lens-epithelial-cells","display_name":"lens epithelial cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/matrix-metalloproteinase-8","display_name":"matrix metalloproteinase-8","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cataract","display_name":"cataract","score":0.7680000066757202},{"id":"https://openalex.org/keywords/tgf-beta2","display_name":"TGF-beta2","score":0.8029999732971191},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.777999997138977},{"id":"https://openalex.org/keywords/extracapsular-cataract-extraction","display_name":"extracapsular cataract extraction","score":0.8460000157356262},{"id":"https://openalex.org/keywords/antifibrotic-effect","display_name":"antifibrotic effect","score":0.7559999823570251},{"id":"https://openalex.org/keywords/cell-proliferation-and-migration","display_name":"cell proliferation and migration","score":0.8339999914169312}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.8152999877929688},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6523000001907349},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.6514999866485596},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5946999788284302},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5533999800682068},{"id":"https://openalex.org/C2779295440","wikidata":"https://www.wikidata.org/wiki/Q21114943","display_name":"MMP3","level":4,"score":0.5404999852180481},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4496999979019165},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.44940000772476196},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.4242999851703644},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.39809998869895935},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.3937000036239624},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.38999998569488525},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3896999955177307},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37619999051094055},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3718000054359436},{"id":"https://openalex.org/C15336307","wikidata":"https://www.wikidata.org/wiki/Q1766051","display_name":"Lens (geology)","level":2,"score":0.37130001187324524},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35989999771118164},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3564999997615814},{"id":"https://openalex.org/C112190416","wikidata":"https://www.wikidata.org/wiki/Q2124450","display_name":"RNA extraction","level":4,"score":0.3433000147342682},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.31839999556541443},{"id":"https://openalex.org/C194232998","wikidata":"https://www.wikidata.org/wiki/Q1606712","display_name":"Transition (genetics)","level":3,"score":0.3052999973297119},{"id":"https://openalex.org/C11957725","wikidata":"https://www.wikidata.org/wiki/Q5533590","display_name":"Gentamicin protection assay","level":4,"score":0.2863999903202057},{"id":"https://openalex.org/C3020196126","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammatory response","level":3,"score":0.2840000092983246},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.27619999647140503},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.27309998869895935},{"id":"https://openalex.org/C2775958869","wikidata":"https://www.wikidata.org/wiki/Q16966320","display_name":"Matrix metalloproteinase inhibitor","level":3,"score":0.26989999413490295},{"id":"https://openalex.org/C161997846","wikidata":"https://www.wikidata.org/wiki/Q4915066","display_name":"Bioluminescence imaging","level":5,"score":0.265500009059906},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.2630999982357025},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.26109999418258667},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2547999918460846}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D045789","descriptor_name":"Sesquiterpenes, Guaiane","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D045789","descriptor_name":"Sesquiterpenes, Guaiane","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D045789","descriptor_name":"Sesquiterpenes, Guaiane","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D045789","descriptor_name":"Sesquiterpenes, Guaiane","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D045789","descriptor_name":"Sesquiterpenes, Guaiane","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D045789","descriptor_name":"Sesquiterpenes, Guaiane","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D058442","descriptor_name":"Capsule Opacification","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D058442","descriptor_name":"Capsule Opacification","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D058442","descriptor_name":"Capsule Opacification","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D058442","descriptor_name":"Capsule Opacification","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D058442","descriptor_name":"Capsule Opacification","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D058442","descriptor_name":"Capsule Opacification","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D058442","descriptor_name":"Capsule Opacification","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D058442","descriptor_name":"Capsule Opacification","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D058442","descriptor_name":"Capsule Opacification","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D058442","descriptor_name":"Capsule Opacification","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D058442","descriptor_name":"Capsule Opacification","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D058442","descriptor_name":"Capsule Opacification","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12967-026-07890-z","doi":"https://doi.org/10.1186/s12967-026-07890-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12967-026-07890-z","pdf_url":null,"source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},{"id":"pmid:41723479","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41723479","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of translational medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5bb8293c6a47460e8c4aaea0f9006ca1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5bb8293c6a47460e8c4aaea0f9006ca1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Translational Medicine, Vol 24, Iss 1 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13032300","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41723479/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Transl Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12967-026-07890-z","doi":"https://doi.org/10.1186/s12967-026-07890-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12967-026-07890-z","pdf_url":null,"source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5103198289871216,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1551669799","https://openalex.org/W1937305016","https://openalex.org/W1966877910","https://openalex.org/W1991018221","https://openalex.org/W1995667528","https://openalex.org/W1999564765","https://openalex.org/W2036409505","https://openalex.org/W2064336967","https://openalex.org/W2066879621","https://openalex.org/W2083446942","https://openalex.org/W2104598267","https://openalex.org/W2110516700","https://openalex.org/W2123179922","https://openalex.org/W2141884548","https://openalex.org/W2270451700","https://openalex.org/W2299393419","https://openalex.org/W2403366498","https://openalex.org/W2606215117","https://openalex.org/W2621934018","https://openalex.org/W2791388746","https://openalex.org/W2808247355","https://openalex.org/W2896236936","https://openalex.org/W2897246352","https://openalex.org/W2920994691","https://openalex.org/W2981882444","https://openalex.org/W2997794409","https://openalex.org/W3049601976","https://openalex.org/W3081207800","https://openalex.org/W3088759915","https://openalex.org/W3134749997","https://openalex.org/W3162148082","https://openalex.org/W4200566316","https://openalex.org/W4205806221","https://openalex.org/W4280492804","https://openalex.org/W4281785167","https://openalex.org/W4282972692","https://openalex.org/W4289518070","https://openalex.org/W4293105824","https://openalex.org/W4307566811","https://openalex.org/W4307921307","https://openalex.org/W4381849203","https://openalex.org/W4386424485","https://openalex.org/W4386844779","https://openalex.org/W4388333003","https://openalex.org/W4389454032","https://openalex.org/W4390985863","https://openalex.org/W4392234165","https://openalex.org/W4399037844","https://openalex.org/W4403330009","https://openalex.org/W4403883525","https://openalex.org/W4405186478","https://openalex.org/W4405314970","https://openalex.org/W4409149457","https://openalex.org/W4411932960","https://openalex.org/W4412200455","https://openalex.org/W4412724791","https://openalex.org/W4413297736"],"related_works":[],"abstract_inverted_index":{"OBJECTIVE:":[0],"Posterior":[1],"capsular":[2,166],"opacification":[3],"(PCO)":[4],"is":[5],"a":[6],"significant":[7],"complication":[8],"that":[9,180,209],"causes":[10],"decreased":[11],"vision":[12],"in":[13,26,38,63,69,130,133,205,224,234],"cataract":[14],"patients":[15],"after":[16,190],"surgery.":[17],"Epithelial-mesenchymal":[18],"transition":[19],"(EMT)":[20],"and":[21,41,83,92,104,111,122,132,147,150,174,192,239,242],"inflammation":[22],"are":[23],"key":[24],"factors":[25],"PCO":[27,40,236],"development.":[28],"This":[29],"study":[30],"examined":[31],"the":[32,120,140,148,158,219,230],"protective":[33],"effect":[34],"of":[35,90,125,144,153,221,232,247],"Micheliolide":[36],"(MCL)":[37],"preventing":[39],"its":[42,245],"related":[43],"mechanisms.":[44],"METHODS:":[45],"In":[46,74,128],"vivo":[47,75,131],"studies":[48,207],"were":[49,78,95,116],"conducted":[50],"using":[51],"an":[52,213],"extracapsular":[53],"lens":[54,70],"extraction":[55],"(ECLE)":[56],"model":[57],"combined":[58],"with":[59,202,212],"intracameral":[60],"injection,":[61],"while":[62],"vitro":[64,134,206],"experiments":[65],"utilized":[66],"TGF-\u03b22-induced":[67],"EMT":[68,91,145,249],"epithelial":[71],"cells":[72],"(LECs).":[73],"biological":[76],"effects":[77],"assessed":[79],"by":[80,97,198],"TUNEL":[81],"staining":[82],"alizarin":[84],"red":[85],"staining.":[86],"The":[87],"expression":[88,143,220],"levels":[89],"inflammatory":[93,141],"markers":[94],"analyzed":[96],"Western":[98],"blotting,":[99],"quantitative":[100],"real-time":[101],"PCR":[102],"(qRT-PCR),":[103],"immunofluorescence.":[105],"Hematoxylin-eosin":[106],"(HE)":[107],"staining,":[108],"Transwell":[109],"assays,":[110],"scratch":[112],"wound":[113],"healing":[114],"assays":[115],"employed":[117],"to":[118],"evaluate":[119],"migratory":[121,151],"proliferative":[123,149],"capacities":[124,152],"LECs.":[126,154,225],"RESULTS:":[127],"both":[129],"experiments,":[135],"MCL":[136,199,211,233],"treatment":[137],"significantly":[138],"suppressed":[139,218],"response,":[142],"markers,":[146],"To":[155],"further":[156],"elucidate":[157],"underlying":[159],"mechanism,":[160],"RNA":[161],"sequencing":[162],"was":[163,185,195],"performed":[164],"on":[165],"bags":[167],"collected":[168],"at":[169,187],"0":[170],"h,":[171,173],"24":[172,188],"5d":[175],"post-ECLE.":[176],"Transcriptomic":[177],"analysis":[178],"revealed":[179],"matrix":[181],"metalloproteinase":[182],"8":[183],"(MMP8)":[184],"upregulated":[186],"hours":[189],"surgery,":[191],"this":[193],"induction":[194],"markedly":[196],"attenuated":[197],"administration.":[200],"Consistent":[201],"these":[203],"findings,":[204],"demonstrated":[208],"combining":[210],"MMP8":[214],"inhibitor":[215],"(M8I)":[216],"synergistically":[217],"EMT-related":[222],"proteins":[223],"CONCLUSION:":[226],"Our":[227],"research":[228],"confirms":[229],"effectiveness":[231],"inhibiting":[235,248],"through":[237,250],"anti-inflammatory":[238],"anti-fibrotic":[240],"effects,":[241],"it":[243],"exerts":[244],"mechanism":[246],"MMP8.":[251]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-02-22T00:00:00"}