{"id":"https://openalex.org/W7130818878","doi":"https://doi.org/10.1002/agm2.70054","title":"Hainan Longevity Model, Senile Degeneration, Cognitive Disability and Healthy Longevity","display_name":"Hainan Longevity Model, Senile Degeneration, Cognitive Disability and Healthy Longevity","publication_year":2026,"publication_date":"2026-02-01","ids":{"openalex":"https://openalex.org/W7130818878","doi":"https://doi.org/10.1002/agm2.70054","pmid":"https://pubmed.ncbi.nlm.nih.gov/42610035"},"language":"en","primary_location":{"id":"doi:10.1002/agm2.70054","doi":"https://doi.org/10.1002/agm2.70054","is_oa":true,"landing_page_url":"https://doi.org/10.1002/agm2.70054","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/agm2.70054","source":{"id":"https://openalex.org/S4210217152","display_name":"Aging Medicine","issn_l":"2475-0360","issn":["2475-0360"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AGING MEDICINE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/agm2.70054","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5123818980","display_name":"Shihui Fu","orcid":"https://orcid.org/0000-0001-6707-9049","observed_orcids":["https://orcid.org/0000-0001-6707-9049"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shihui Fu","raw_affiliation_strings":["Department of Cardiology Hainan Hospital of Chinese PLA General Hospital, Hainan Geriatric Disease Clinical Medical Research Center, Hainan Branch of China Geriatric Disease Clinical Research Center  Sanya China","Department of Geriatric Cardiology Chinese PLA General Hospital  Beijing China","The Second School of Clinical Medicine Southern Medical University  Guangzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology Hainan Hospital of Chinese PLA General Hospital, Hainan Geriatric Disease Clinical Medical Research Center, Hainan Branch of China Geriatric Disease Clinical Research Center  Sanya China","institution_ids":["https://openalex.org/I2802939634"]},{"raw_affiliation_string":"Department of Geriatric Cardiology Chinese PLA General Hospital  Beijing China","institution_ids":["https://openalex.org/I2802939634"]},{"raw_affiliation_string":"The Second School of Clinical Medicine Southern Medical University  Guangzhou China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061277788","display_name":"Jiacai Lin","orcid":"https://orcid.org/0000-0002-2921-7954","observed_orcids":["https://orcid.org/0000-0002-2921-7954"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiacai Lin","raw_affiliation_strings":["Department of Neurology Hainan Hospital of Chinese PLA General Hospital  Sanya China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology Hainan Hospital of Chinese PLA General Hospital  Sanya China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123810754","display_name":"Qianshuo Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099028","display_name":"Fourth Affiliated Hospital of China Medical University","ror":"https://ror.org/012sz4c50","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qianshuo Liu","raw_affiliation_strings":["Department of Neurology the Fourth Affiliated Hospital of China Medical University  Shenyang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology the Fourth Affiliated Hospital of China Medical University  Shenyang China","institution_ids":["https://openalex.org/I4210099028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147383197","display_name":"Lianbo Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099028","display_name":"Fourth Affiliated Hospital of China Medical University","ror":"https://ror.org/012sz4c50","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lianbo Gao","raw_affiliation_strings":["Department of Neurology the Fourth Affiliated Hospital of China Medical University  Shenyang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology the Fourth Affiliated Hospital of China Medical University  Shenyang China","institution_ids":["https://openalex.org/I4210099028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126537953","display_name":"Zhirui Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhirui Li","raw_affiliation_strings":["Department of Orthopedics Hainan Hospital of Chinese PLA General Hospital  Sanya China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics Hainan Hospital of Chinese PLA General Hospital  Sanya China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126543574","display_name":"Feng Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Lin","raw_affiliation_strings":["Department of Orthopedics Hainan Hospital of Chinese PLA General Hospital  Sanya China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics Hainan Hospital of Chinese PLA General Hospital  Sanya China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126559429","display_name":"Leixing Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Leixing Xie","raw_affiliation_strings":["Medical Department Hainan Hospital of Chinese PLA General Hospital  Sanya China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department Hainan Hospital of Chinese PLA General Hospital  Sanya China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100379478","display_name":"Xiong Liu","orcid":"https://orcid.org/0000-0001-6536-9544","observed_orcids":["https://orcid.org/0000-0001-6536-9544"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiong Liu","raw_affiliation_strings":["Medical Care Center Hainan Hospital of Chinese PLA General Hospital  Sanya China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Care Center Hainan Hospital of Chinese PLA General Hospital  Sanya China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147416861","display_name":"Wenkai Xiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenkai Xiao","raw_affiliation_strings":["Department of Cardiology the Second Medical Center of Chinese PLA General Hospital  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology the Second Medical Center of Chinese PLA General Hospital  Beijing China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126531099","display_name":"Qiwei Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiwei Zhu","raw_affiliation_strings":["Department of Cardiology the Second Medical Center of Chinese PLA General Hospital  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology the Second Medical Center of Chinese PLA General Hospital  Beijing China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fan Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fan Wang","raw_affiliation_strings":["Department of Cardiology the Second Medical Center of Chinese PLA General Hospital  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology the Second Medical Center of Chinese PLA General Hospital  Beijing China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000212677","display_name":"Jin Zheng","orcid":"https://orcid.org/0000-0001-6136-6098","observed_orcids":["https://orcid.org/0000-0001-6136-6098"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin Zheng","raw_affiliation_strings":["Department of Cardiology the Second Medical Center of Chinese PLA General Hospital  Beijing China"],"raw_orcid":"https://orcid.org/0000-0001-6136-6098","affiliations":[{"raw_affiliation_string":"Department of Cardiology the Second Medical Center of Chinese PLA General Hospital  Beijing China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100775153","display_name":"Yali Zhao","orcid":"https://orcid.org/0000-0003-0052-6486","observed_orcids":["https://orcid.org/0000-0003-0052-6486","https://orcid.org/0009-0001-7410-5855"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yali Zhao","raw_affiliation_strings":["Central Laboratory, Hainan Hospital of Chinese PLA General Hospital  Sanya China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Laboratory, Hainan Hospital of Chinese PLA General Hospital  Sanya China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100759111","display_name":"Xiaolei Chen","orcid":"https://orcid.org/0000-0002-3407-621X","observed_orcids":["https://orcid.org/0000-0002-3407-621X","https://orcid.org/0000-0001-8573-1475"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaolei Chen","raw_affiliation_strings":["Department of Neurosurgery the First Medical Center, Chinese PLA General Hospital  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery the First Medical Center, Chinese PLA General Hospital  Beijing China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126544048","display_name":"Yao Yao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yao Yao","raw_affiliation_strings":["Center for Healthy Aging Transdisciplinary Sciences, China Center for Health Development Studies Peking University  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Healthy Aging Transdisciplinary Sciences, China Center for Health Development Studies Peking University  Beijing China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044976422","display_name":"Long Feng","orcid":"https://orcid.org/0000-0002-2134-0106","observed_orcids":["https://orcid.org/0000-0002-2134-0106"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]},{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Long Feng","raw_affiliation_strings":["Department of Anesthesiology Hainan Hospital of Chinese PLA General Hospital  Sanya China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology Hainan Hospital of Chinese PLA General Hospital  Sanya China","institution_ids":["https://openalex.org/I2802939634","https://openalex.org/I4210160531"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5044976422","https://openalex.org/A5100759111","https://openalex.org/A5100775153","https://openalex.org/A5126544048"],"corresponding_institution_ids":["https://openalex.org/I20231570","https://openalex.org/I2802939634","https://openalex.org/I4210160531"],"apc_list":{"value":2200,"currency":"USD","value_usd":2200},"apc_paid":{"value":2200,"currency":"USD","value_usd":2200},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10181711,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"1","first_page":"67","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12811","display_name":"Aging, Health, and Disability","score":0.7070000171661377,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12811","display_name":"Aging, Health, and Disability","score":0.7070000171661377,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.10400000214576721,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11265","display_name":"Aging and Gerontology Research","score":0.07859999686479568,"subfield":{"id":"https://openalex.org/subfields/3206","display_name":"Neuropsychology and Physiological Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/centenarians","display_name":"centenarians","score":0.9399999976158142},{"id":"https://openalex.org/keywords/healthy-longevity","display_name":"healthy longevity","score":0.9779999852180481},{"id":"https://openalex.org/keywords/senile-degeneration","display_name":"senile degeneration","score":0.9750000238418579},{"id":"https://openalex.org/keywords/cognitive-disability","display_name":"cognitive disability","score":0.9779999852180481},{"id":"https://openalex.org/keywords/population-aging","display_name":"population aging","score":0.8849999904632568},{"id":"https://openalex.org/keywords/healthy-lifestyle","display_name":"healthy lifestyle","score":0.5770000219345093},{"id":"https://openalex.org/keywords/comorbidity-management","display_name":"comorbidity management","score":0.6520000100135803},{"id":"https://openalex.org/keywords/lifespan-extension","display_name":"lifespan extension","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C2779403534","wikidata":"https://www.wikidata.org/wiki/Q2944360","display_name":"Centenarian","level":3,"score":0.9681000113487244},{"id":"https://openalex.org/C2776759703","wikidata":"https://www.wikidata.org/wiki/Q1066907","display_name":"Longevity","level":2,"score":0.9429000020027161},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.5903000235557556},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5730999708175659},{"id":"https://openalex.org/C3017819807","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Healthy aging","level":2,"score":0.5105999708175659},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4690000116825104},{"id":"https://openalex.org/C13774568","wikidata":"https://www.wikidata.org/wiki/Q439112","display_name":"Population ageing","level":3,"score":0.4205000102519989},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.3921000063419342},{"id":"https://openalex.org/C137176749","wikidata":"https://www.wikidata.org/wiki/Q4105337","display_name":"Psychological resilience","level":2,"score":0.3856000006198883},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36719998717308044},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.3418000042438507},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.31290000677108765},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.29179999232292175},{"id":"https://openalex.org/C2778175527","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Successful aging","level":2,"score":0.2883000075817108},{"id":"https://openalex.org/C2776893239","wikidata":"https://www.wikidata.org/wiki/Q1778765","display_name":"Social isolation","level":2,"score":0.2822999954223633},{"id":"https://openalex.org/C133925201","wikidata":"https://www.wikidata.org/wiki/Q188419","display_name":"Life expectancy","level":3,"score":0.2809000015258789},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.2711000144481659},{"id":"https://openalex.org/C3018697994","wikidata":"https://www.wikidata.org/wiki/Q191089","display_name":"Elderly people","level":2,"score":0.25679999589920044},{"id":"https://openalex.org/C110379092","wikidata":"https://www.wikidata.org/wiki/Q1571836","display_name":"Social environment","level":2,"score":0.2547999918460846}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1002/agm2.70054","doi":"https://doi.org/10.1002/agm2.70054","is_oa":true,"landing_page_url":"https://doi.org/10.1002/agm2.70054","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/agm2.70054","source":{"id":"https://openalex.org/S4210217152","display_name":"Aging Medicine","issn_l":"2475-0360","issn":["2475-0360"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AGING MEDICINE","raw_type":"journal-article"},{"id":"pmid:42610035","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42610035","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging medicine (Milton (N.S.W))","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13479968","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13479968/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Aging Med (Milton)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/agm2.70054","doi":"https://doi.org/10.1002/agm2.70054","is_oa":true,"landing_page_url":"https://doi.org/10.1002/agm2.70054","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/agm2.70054","source":{"id":"https://openalex.org/S4210217152","display_name":"Aging Medicine","issn_l":"2475-0360","issn":["2475-0360"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AGING MEDICINE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1092113687","display_name":null,"funder_award_id":"821QN389","funder_id":"https://openalex.org/F4320322866","funder_display_name":"Natural Science Foundation of Hainan Province"},{"id":"https://openalex.org/G1974352109","display_name":"\u892a\u9ed1\u7d20\u6fc0\u6d3bSIRT1\u8c03\u63a7\u7ebf\u7c92\u4f53\u878d\u5408-\u5206\u88c2\u52a8\u6001\u5e73\u8861\u5728\u8113\u6bd2\u6027\u5fc3\u808c\u75c5\u7684\u5fc3\u808c\u4fdd\u62a4\u673a\u5236\u7814\u7a76","funder_award_id":"824MS173","funder_id":"https://openalex.org/F4320322866","funder_display_name":"Natural Science Foundation of Hainan Province"},{"id":"https://openalex.org/G2840781840","display_name":"\u4ee3\u8c22\u7ec4\u5b66\u548c\u80a0\u9053\u83cc\u7fa4\u5728\u767e\u5c81\u957f\u5bff\u8001\u4eba\u8ba4\u77e5\u8001\u5316\u4e2d\u7684\u4f5c\u7528\u7814\u7a76","funder_award_id":"824MS171","funder_id":"https://openalex.org/F4320322866","funder_display_name":"Natural Science Foundation of Hainan Province"},{"id":"https://openalex.org/G564360001","display_name":null,"funder_award_id":"821MS117","funder_id":"https://openalex.org/F4320322866","funder_display_name":"Natural Science Foundation of Hainan Province"},{"id":"https://openalex.org/G5652347400","display_name":"\u57fa\u56e0\u4fee\u9970\u5de8\u566c\u7ec6\u80de\u5916\u6ccc\u4f53\u5728\u6539\u5584\u521b\u4f24\u6027\u9885\u8111\u635f\u4f24\u708e\u75c7\u73af\u5883\u4e2d\u7684\u5e94\u7528","funder_award_id":"823MS161","funder_id":"https://openalex.org/F4320322866","funder_display_name":"Natural Science Foundation of Hainan Province"},{"id":"https://openalex.org/G7301792723","display_name":null,"funder_award_id":"821MS115","funder_id":"https://openalex.org/F4320322866","funder_display_name":"Natural Science Foundation of Hainan Province"},{"id":"https://openalex.org/G7601352497","display_name":null,"funder_award_id":"822MS198,824MS171,821QN389,821MS117,824MS173,821MS115,823MS161","funder_id":"https://openalex.org/F4320322866","funder_display_name":"Natural Science Foundation of Hainan Province"},{"id":"https://openalex.org/G8326196429","display_name":"PINK1/Parkin\u7ebf\u7c92\u4f53\u81ea\u566c\u5728\u672f\u540e\u8ba4\u77e5\u529f\u80fd\u969c\u788d\u4e2d\u7684\u4f5c\u7528\u53ca\u673a\u5236\u7814\u7a76","funder_award_id":"822MS198","funder_id":"https://openalex.org/F4320322866","funder_display_name":"Natural Science Foundation of Hainan Province"}],"funders":[{"id":"https://openalex.org/F4320322866","display_name":"Natural Science Foundation of Hainan Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7130818878.pdf","grobid_xml":"https://content.openalex.org/works/W7130818878.grobid-xml"},"referenced_works_count":115,"referenced_works":["https://openalex.org/W1496582607","https://openalex.org/W1944063352","https://openalex.org/W1965428617","https://openalex.org/W1991278728","https://openalex.org/W2004460254","https://openalex.org/W2007499376","https://openalex.org/W2010001860","https://openalex.org/W2016021252","https://openalex.org/W2018819121","https://openalex.org/W2027746649","https://openalex.org/W2036971355","https://openalex.org/W2053729976","https://openalex.org/W2055989740","https://openalex.org/W2056968151","https://openalex.org/W2057299480","https://openalex.org/W2058299442","https://openalex.org/W2062222093","https://openalex.org/W2067904167","https://openalex.org/W2068441239","https://openalex.org/W2071817336","https://openalex.org/W2076816107","https://openalex.org/W2098516684","https://openalex.org/W2110496054","https://openalex.org/W2114198116","https://openalex.org/W2135625287","https://openalex.org/W2138089826","https://openalex.org/W2150619186","https://openalex.org/W2167722080","https://openalex.org/W2167887953","https://openalex.org/W2171776652","https://openalex.org/W2324096339","https://openalex.org/W2371807656","https://openalex.org/W2413472284","https://openalex.org/W2429762803","https://openalex.org/W2461795017","https://openalex.org/W2511880271","https://openalex.org/W2514338176","https://openalex.org/W2520575821","https://openalex.org/W2562582244","https://openalex.org/W2568352511","https://openalex.org/W2573624341","https://openalex.org/W2592108951","https://openalex.org/W2592612549","https://openalex.org/W2603228471","https://openalex.org/W2772388901","https://openalex.org/W2775588489","https://openalex.org/W2781928680","https://openalex.org/W2792617219","https://openalex.org/W2793027503","https://openalex.org/W2797347068","https://openalex.org/W2805558108","https://openalex.org/W2810952045","https://openalex.org/W2901760741","https://openalex.org/W2919947473","https://openalex.org/W2945275243","https://openalex.org/W2969742062","https://openalex.org/W2970686316","https://openalex.org/W2974259154","https://openalex.org/W2978813262","https://openalex.org/W2981240981","https://openalex.org/W2981736543","https://openalex.org/W2982699696","https://openalex.org/W2983425537","https://openalex.org/W2986788348","https://openalex.org/W3015869682","https://openalex.org/W3032784914","https://openalex.org/W3033362920","https://openalex.org/W3087297619","https://openalex.org/W3092055647","https://openalex.org/W3092649130","https://openalex.org/W3107869128","https://openalex.org/W3108147327","https://openalex.org/W3119215170","https://openalex.org/W3126756019","https://openalex.org/W3134160853","https://openalex.org/W3135230972","https://openalex.org/W3135508802","https://openalex.org/W3135645091","https://openalex.org/W3165851641","https://openalex.org/W4200186461","https://openalex.org/W4205687601","https://openalex.org/W4210435711","https://openalex.org/W4210896397","https://openalex.org/W4220930165","https://openalex.org/W4221067042","https://openalex.org/W4224275381","https://openalex.org/W4225258337","https://openalex.org/W4226397047","https://openalex.org/W4229363625","https://openalex.org/W4247759744","https://openalex.org/W4251404648","https://openalex.org/W4283263279","https://openalex.org/W4289987981","https://openalex.org/W4290693622","https://openalex.org/W4307261707","https://openalex.org/W4310565752","https://openalex.org/W4310972698","https://openalex.org/W4313299363","https://openalex.org/W4318464653","https://openalex.org/W4319460636","https://openalex.org/W4320037554","https://openalex.org/W4321017977","https://openalex.org/W4362466820","https://openalex.org/W4366821202","https://openalex.org/W4378188819","https://openalex.org/W4380992375","https://openalex.org/W4386496916","https://openalex.org/W4388629509","https://openalex.org/W4388774091","https://openalex.org/W4390258131","https://openalex.org/W4394958648","https://openalex.org/W4394998020","https://openalex.org/W4398180464","https://openalex.org/W4399706528","https://openalex.org/W4399854567"],"related_works":[],"abstract_inverted_index":{"The":[0,21,49],"aging":[1],"process":[2],"is":[3,114,213],"an":[4],"inevitable":[5],"and":[6,31,70,79,99,125,157,167,191,196,223,247,252],"universal":[7],"phenomenon":[8],"characterized":[9],"by":[10,24],"a":[11,46,243],"decline":[12],"in":[13,88,107,117,142,149,219,231],"function":[14,58],"that":[15,41],"all":[16],"living":[17],"organisms":[18],"must":[19],"undergo.":[20],"challenges":[22],"posed":[23],"population":[25,111,141],"aging,":[26],"along":[27],"with":[28,67,153],"senile":[29,68],"degeneration":[30,69],"cognitive":[32,71],"disability,":[33],"have":[34],"emerged":[35],"as":[36],"pressing":[37],"public":[38],"health":[39],"issues":[40],"require":[42],"urgent":[43],"attention":[44],"on":[45],"global":[47],"scale.":[48],"ability":[50],"of":[51,83,110,123,129,193,199,242],"older":[52,233],"adults":[53],"to":[54,137,205,215,239],"maintain":[55],"robust":[56],"physiological":[57],"may":[59],"confer":[60],"resistance":[61],"against":[62],"the":[63,97,101,108,115,120,126,139,150,207,232,240],"risk":[64],"factors":[65,202],"associated":[66],"disability.":[72],"Investigating":[73],"centenarians":[74,124,130,145],"who":[75],"exemplify":[76],"healthy":[77,105,169,221,229,244],"longevity":[78,106,209,222,230],"their":[80],"underlying":[81],"mechanisms":[82],"functional":[84],"resilience":[85],"can":[86],"aid":[87],"formulating":[89],"preventive":[90],"strategies":[91],"aimed":[92],"at":[93],"achieving":[94,228],"health,":[95],"extending":[96],"lifespan,":[98],"identifying":[100],"pathways":[102],"for":[103,227],"promoting":[104,220],"context":[109],"aging.":[112],"Hainan":[113,144,208],"province":[116],"China":[118],"where":[119],"largest":[121],"number":[122],"highest":[127],"density":[128],"are":[131,134],"distributed.":[132],"There":[133],"unique":[135],"advantages":[136],"studying":[138],"centenarian":[140],"Hainan.":[143],"not":[146],"only":[147],"live":[148],"natural":[151],"environment":[152],"high":[154],"oxygen":[155],"concentration":[156],"dense":[158],"greenery":[159],"coverage":[160],"but":[161],"also":[162,237],"inherit":[163],"favorable":[164],"genetic":[165],"traits":[166],"adopt":[168],"lifestyles,":[170],"including":[171],"social":[172,250],"participation,":[173],"good":[174],"education,":[175],"stable":[176],"emotion,":[177],"balanced":[178],"nutrition,":[179],"moderate":[180],"exercise,":[181],"reasonable":[182],"sleep,":[183],"optimized":[184],"senses,":[185],"coordinated":[186],"metabolism,":[187],"improved":[188],"immunity,":[189],"prevention":[190],"treatment":[192,198],"chronic":[194],"diseases,":[195],"joint":[197],"comorbidities.":[200],"These":[201],"work":[203],"together":[204],"form":[206],"model":[210],"(HLM),":[211],"which":[212],"expected":[214],"play":[216],"key":[217],"roles":[218],"provide":[224],"scientific":[225],"evidence":[226],"populations.":[234],"It":[235],"will":[236],"contribute":[238],"construction":[241],"human":[245],"society":[246],"has":[248],"important":[249],"value":[251],"practical":[253],"significance.":[254]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2026-02-21T00:00:00"}