{"id":"https://openalex.org/W7130717874","doi":"https://doi.org/10.1055/s-0046-1818449","title":"Analysis of Primary CNS Lymphoma and Its Overall Survival, Assessment of Response Rate, and Its Toxicity Profile (Grade III/IV Toxicity) with High-Dose Methotrexate-Based Chemotherapy in Tertiary Care Hospital","display_name":"Analysis of Primary CNS Lymphoma and Its Overall Survival, Assessment of Response Rate, and Its Toxicity Profile (Grade III/IV Toxicity) with High-Dose Methotrexate-Based Chemotherapy in Tertiary Care Hospital","publication_year":2026,"publication_date":"2026-02-01","ids":{"openalex":"https://openalex.org/W7130717874","doi":"https://doi.org/10.1055/s-0046-1818449"},"language":"en","primary_location":{"id":"doi:10.1055/s-0046-1818449","doi":"https://doi.org/10.1055/s-0046-1818449","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0046-1818449","pdf_url":null,"source":{"id":"https://openalex.org/S112025928","display_name":"Indian Journal of Medical and Paediatric Oncology","issn_l":"0971-5851","issn":["0971-5851","0975-2129"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Medical and Paediatric Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1055/s-0046-1818449","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5117597448","display_name":"Punam Rabha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108369","display_name":"Fortis Memorial Research Institute","ror":"https://ror.org/01h7phh70","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210108369"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Punam Rabha","raw_affiliation_strings":["Fortis Memorial Research Institute, Gurgaon, Haryana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fortis Memorial Research Institute, Gurgaon, Haryana, India","institution_ids":["https://openalex.org/I4210108369"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5117597448"],"corresponding_institution_ids":["https://openalex.org/I4210108369"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09098446,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"47","issue":"01","first_page":"A01","last_page":"A58"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12212","display_name":"CNS Lymphoma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12212","display_name":"CNS Lymphoma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-central-nervous-system-lymphoma","display_name":"primary central nervous system lymphoma","score":0.9589999914169312},{"id":"https://openalex.org/keywords/high-dose-methotrexate","display_name":"high-dose methotrexate","score":0.9769999980926514},{"id":"https://openalex.org/keywords/methotrexate-chemotherapy","display_name":"methotrexate chemotherapy","score":0.8270000219345093},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8889999985694885},{"id":"https://openalex.org/keywords/treatment-response-rate","display_name":"treatment response rate","score":0.7919999957084656},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.8650000095367432},{"id":"https://openalex.org/keywords/neutropenic-sepsis","display_name":"neutropenic sepsis","score":0.9039999842643738},{"id":"https://openalex.org/keywords/pancytopenia","display_name":"pancytopenia","score":0.9559999704360962},{"id":"https://openalex.org/keywords/syndrome-of-inappropriate-antidiuretic-hormone-secretion","display_name":"syndrome of inappropriate antidiuretic hormone secretion","score":0.953000009059906},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.8259999752044678},{"id":"https://openalex.org/keywords/intracranial-lesions","display_name":"intracranial lesions","score":0.7390000224113464},{"id":"https://openalex.org/keywords/immunocompetent-patient","display_name":"immunocompetent patient","score":0.8579999804496765},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.33399999141693115},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.41600000858306885},{"id":"https://openalex.org/keywords/relapsed-multiple-myeloma","display_name":"relapsed multiple myeloma","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9804999828338623},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6383000016212463},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6381999850273132},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6258999705314636},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5892000198364258},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.46380001306533813},{"id":"https://openalex.org/C2991842025","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Tertiary care","level":2,"score":0.42080000042915344},{"id":"https://openalex.org/C2984752397","wikidata":"https://www.wikidata.org/wiki/Q3259956","display_name":"Primary care","level":2,"score":0.39079999923706055},{"id":"https://openalex.org/C2993769353","wikidata":"https://www.wikidata.org/wiki/Q7598360","display_name":"Standard of care","level":2,"score":0.3779999911785126},{"id":"https://openalex.org/C2781173314","wikidata":"https://www.wikidata.org/wiki/Q3246818","display_name":"Primary central nervous system lymphoma","level":3,"score":0.2944999933242798},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.2671999931335449},{"id":"https://openalex.org/C2993624421","wikidata":"https://www.wikidata.org/wiki/Q16917","display_name":"Hospital care","level":3,"score":0.25609999895095825},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2556000053882599}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0046-1818449","doi":"https://doi.org/10.1055/s-0046-1818449","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0046-1818449","pdf_url":null,"source":{"id":"https://openalex.org/S112025928","display_name":"Indian Journal of Medical and Paediatric Oncology","issn_l":"0971-5851","issn":["0971-5851","0975-2129"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Medical and Paediatric Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1055/s-0046-1818449","doi":"https://doi.org/10.1055/s-0046-1818449","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0046-1818449","pdf_url":null,"source":{"id":"https://openalex.org/S112025928","display_name":"Indian Journal of Medical and Paediatric Oncology","issn_l":"0971-5851","issn":["0971-5851","0975-2129"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Medical and Paediatric Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2170487277","https://openalex.org/W3178735616","https://openalex.org/W2041746801","https://openalex.org/W3111431175","https://openalex.org/W2039791161","https://openalex.org/W3096580218","https://openalex.org/W1985027375","https://openalex.org/W2074242271","https://openalex.org/W2241942439","https://openalex.org/W2597584494"],"abstract_inverted_index":{"Aims":[0],"and":[1,10,14,41,80,109,130,199,219,241,283,297],"Objectives:":[2],"Primary":[3],"Objective:":[4,24],"Analysis":[5],"of":[6,16,26,32,47,51,58,133,146,227,273],"primary":[7,52],"CNS":[8,53],"lymphoma":[9,54],"its":[11],"clinical":[12],"feature":[13],"outcome":[15],"treatment":[17,39],"at":[18,106],"FMRI":[19],"since":[20,97],"January":[21,69,98,101],"2014.":[22],"Secondary":[23],"Assessment":[25],"response":[27,171],"rate":[28,176],"Overall":[29,179],"survival":[30,180],"Pattern":[31],"failure":[33],"Grade":[34],"V":[35],"toxicity":[36],"due":[37],"to":[38,71,100,135],"Materials":[40],"Methods:":[42],"Single":[43],"center":[44],"ambispective":[45],"analysis":[46,245],"histopathologically":[48],"proven":[49],"patients":[50,63,95,207,216,228],"attending":[55],"the":[56,131,238,271,274,288],"Department":[57],"Medical":[59,296],"oncology,":[60],"FMRI.":[61],"These":[62],"were":[64,78,104,119,142,187,217],"treated":[65],"with":[66,115,220,229],"chemotherapy":[67,77,114,234],"from":[68],"2013":[70,99],"November":[72],"2025.":[73],"Adverse":[74],"events":[75],"during":[76,237],"documented":[79],"graded":[81],"using":[82],"CTCAE":[83],"v.5":[84],"(Common":[85],"terminology":[86],"criteria":[87],"for":[88],"adverse":[89],"events).":[90],"Results:":[91],"Till":[92],"now":[93],"40":[94],"enrolled":[96],"2023":[102],"who":[103],"registered":[105],"our":[107,215],"institute":[108],"received":[110],"high-dose":[111],"methotrexate":[112,232],"(HDMTX)-based":[113],"sufficient":[116],"medical":[117],"records":[118],"analyzed.":[120],"The":[121,148,164,225,259],"median":[122],"age":[123],"was":[124,137,150,154,158,173],"58":[125],"years":[126],"(range,":[127],"22\u201382":[128],"years),":[129],"ratio":[132],"male":[134],"female":[136],"3:1.":[138],"Multiple":[139],"intracranial":[140],"lesions":[141],"present":[143],"in":[144,203],"47.5%":[145],"patients.":[147],"CR":[149,167],"20":[151,254],"(50%),":[152],"PR":[153,169],"4":[155],"(10%),":[156],"PD":[157],"2":[159,195],"(5%),":[160,196],"expired":[161],"14":[162,177],"(35%).":[163,178],"ORR":[165],"=":[166],"+":[168],"(overall":[170],"rate)":[172],"60%.":[174],"Mortality":[175],"26":[181],"(65%).":[182],"Significant":[183],"grade":[184,192,200],"IV":[185,193],"toxicities":[186],"neutropenic":[188],"sepsis":[189],"9":[190],"(22.5%),":[191],"pancytopenia":[194],"SIADH":[197],"2.5%":[198],"III":[201],"anemia":[202],"1":[204],"(2.5%).":[205],"67.5%":[206],"did":[208],"not":[209],"show":[210],"any":[211],"toxicity.":[212],"Conclusion:":[213],"All":[214],"immunocompetent":[218],"good":[221],"performance":[222],"status":[223],"(ECOG).":[224],"prognosis":[226],"high":[230],"dose":[231],"based":[233],"has":[235],"improved":[236],"last":[239],"decades":[240],"appears":[242],"safe.":[243],"This":[244,261],"is":[246,262,291],"still":[247],"ongoing.":[248],"Publication":[249],"History":[250],"Article":[251],"published":[252,267],"online:":[253],"February":[255],"2026":[256],"\u00a9":[257],"2026.":[258],"Author(s).":[260],"an":[263],"open":[264],"access":[265],"article":[266],"by":[268],"Thieme":[269,295],"under":[270],"terms":[272],"Creative":[275],"Commons":[276],"Attribution":[277],"License,":[278],"permitting":[279],"unrestricted":[280],"use,":[281],"distribution,":[282],"reproduction":[284],"so":[285],"long":[286],"as":[287],"original":[289],"work":[290],"properly":[292],"cited.":[293],"(https://creativecommons.org/licenses/by/4.0/)":[294],"Scientific":[298],"Publishers":[299],"Pvt.":[300],"Ltd.":[301],"A-12,":[302],"2nd":[303],"Floor,":[304],"Sector":[305],"2,":[306],"Noida-201301":[307],"UP,":[308],"India":[309]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-02-21T00:00:00"}
