{"id":"https://openalex.org/W7130717153","doi":"https://doi.org/10.5167/uzh-291976","title":"Chemotherapy-related cognitive impairment and kidney dysfunction","display_name":"Chemotherapy-related cognitive impairment and kidney dysfunction","publication_year":2025,"publication_date":"2025-03-01","ids":{"openalex":"https://openalex.org/W7130717153","doi":"https://doi.org/10.5167/uzh-291976"},"language":"en","primary_location":{"id":"doi:10.5167/uzh-291976","doi":"https://doi.org/10.5167/uzh-291976","is_oa":true,"landing_page_url":"https://doi.org/10.5167/uzh-291976","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5167/uzh-291976","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047650157","display_name":"Mariadelina Simeoni","orcid":"https://orcid.org/0000-0001-8203-9416","observed_orcids":["https://orcid.org/0000-0001-8203-9416"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simeoni, Mariadelina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017749674","display_name":"Michele Marie Mulholland","orcid":"https://orcid.org/0000-0003-1957-0436","observed_orcids":["https://orcid.org/0000-0003-1957-0436"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mulholland, Michele M","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071390801","display_name":"Biruh Workeneh","orcid":"https://orcid.org/0000-0002-9612-3640","observed_orcids":["https://orcid.org/0000-0002-9612-3640"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Workeneh, Biruh T","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009090023","display_name":"Anna Capasso","orcid":"https://orcid.org/0000-0002-6579-7802","observed_orcids":["https://orcid.org/0000-0002-6579-7802"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Capasso, Anna","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126485682","display_name":"Gaye Hafez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hafez, Gaye","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033170314","display_name":"Sophie Liabeuf","orcid":"https://orcid.org/0000-0001-5384-9006","observed_orcids":["https://orcid.org/0000-0001-5384-9006"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liabeuf, Sophie","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5384-9006","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085600917","display_name":"Jolanta Ma\u0142yszko","orcid":"https://orcid.org/0000-0001-8701-8171","observed_orcids":["https://orcid.org/0000-0001-8701-8171"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Malyszko, Jolanta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023484768","display_name":"Laila\u2010Yasmin Mani","orcid":"https://orcid.org/0000-0002-4693-7814","observed_orcids":["https://orcid.org/0000-0002-4693-7814"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mani, Laila-Yasmin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4693-7814","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049544683","display_name":"Francesco Trevisani","orcid":"https://orcid.org/0000-0003-4205-8959","observed_orcids":["https://orcid.org/0000-0003-4205-8959"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Trevisani, Francesco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039460900","display_name":"Ananya De","orcid":"https://orcid.org/0009-0003-0288-5893","observed_orcids":["https://orcid.org/0009-0003-0288-5893"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"De, Ananya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126451209","display_name":"Carsten Alexande Wagner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wagner, Carsten A","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071660720","display_name":"Ziad A. Massy","orcid":"https://orcid.org/0000-0001-5771-5996","observed_orcids":["https://orcid.org/0000-0001-5771-5996"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Massy, Ziad A","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031062920","display_name":"Robert John Unwin","orcid":"https://orcid.org/0000-0001-7839-6031","observed_orcids":["https://orcid.org/0000-0001-7839-6031"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Unwin, Robert","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7839-6031","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034689878","display_name":"Giovambattista Capasso","orcid":"https://orcid.org/0000-0003-3469-8614","observed_orcids":["https://orcid.org/0000-0003-3469-8614"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Capasso, Giovambattista","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3469-8614","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5126455402","display_name":"CONNECT Action (Cognitive Decline in Nephro-Neurology European Cooperative Target) collaborators","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"CONNECT Action (Cognitive Decline in Nephro-Neurology European Cooperative Target) collaborators","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.57821213,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemotherapy-induced-cognitive-impairment","display_name":"chemotherapy-induced cognitive impairment","score":0.996999979019165},{"id":"https://openalex.org/keywords/kidney-disease","display_name":"kidney disease","score":0.753000020980835},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.7720000147819519},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.9409999847412109},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.6290000081062317},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7170000076293945},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.996999979019165},{"id":"https://openalex.org/keywords/vascular-disease","display_name":"vascular disease","score":0.6050000190734863},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7922000288963318},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.6358000040054321},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5652999877929688},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.4650999903678894},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4641000032424927},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4553000032901764},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.4004000127315521},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.39989998936653137},{"id":"https://openalex.org/C2909231917","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Antineoplastic Drugs","level":2,"score":0.387800008058548},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.38370001316070557},{"id":"https://openalex.org/C25274449","wikidata":"https://www.wikidata.org/wiki/Q1805481","display_name":"Long-term potentiation","level":3,"score":0.37439998984336853},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3732999861240387},{"id":"https://openalex.org/C2777601897","wikidata":"https://www.wikidata.org/wiki/Q3409113","display_name":"Presentation (obstetrics)","level":2,"score":0.36739999055862427},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.36489999294281006},{"id":"https://openalex.org/C2781068499","wikidata":"https://www.wikidata.org/wiki/Q3242950","display_name":"Kidney cancer","level":3,"score":0.36410000920295715},{"id":"https://openalex.org/C3018842126","wikidata":"https://www.wikidata.org/wiki/Q11072","display_name":"Memory impairment","level":3,"score":0.3465000092983246},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.34389999508857727},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.32899999618530273},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.325300008058548},{"id":"https://openalex.org/C2780566141","wikidata":"https://www.wikidata.org/wiki/Q3065932","display_name":"Cognitive disorder","level":4,"score":0.30799999833106995},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3009999990463257},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.29420000314712524},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.29019999504089355},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.28999999165534973},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.28780001401901245},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.27570000290870667},{"id":"https://openalex.org/C2986762682","wikidata":"https://www.wikidata.org/wiki/Q964754","display_name":"Basic research","level":2,"score":0.2752000093460083},{"id":"https://openalex.org/C172268261","wikidata":"https://www.wikidata.org/wiki/Q4764988","display_name":"Animal studies","level":2,"score":0.26759999990463257},{"id":"https://openalex.org/C2777964233","wikidata":"https://www.wikidata.org/wiki/Q1424956","display_name":"Neuroleptic malignant syndrome","level":2,"score":0.26330000162124634},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2572999894618988},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.2522999942302704},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.251800000667572}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.5167/uzh-291976","doi":"https://doi.org/10.5167/uzh-291976","is_oa":true,"landing_page_url":"https://doi.org/10.5167/uzh-291976","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.5167/uzh-291976","doi":"https://doi.org/10.5167/uzh-291976","is_oa":true,"landing_page_url":"https://doi.org/10.5167/uzh-291976","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"No poverty","score":0.4221768379211426,"id":"https://metadata.un.org/sdg/1"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Cancer":[0],"and":[1,55,64,89,94,102,141],"kidney":[2],"diseases":[3],"(KD)":[4],"intersect":[5],"in":[6,10,24,100,122,148],"many":[7,31],"ways":[8],"resulting":[9],"worse":[11],"outcomes.":[12],"Both":[13],"conditions":[14],"are":[15],"correlated":[16],"with":[17,125,151],"cognitive":[18,43,98,146],"impairment,":[19],"which":[20],"can":[21],"be":[22,111],"exacerbated":[23],"cancer":[25,149],"patients":[26,124,150],"by":[27],"known":[28,40],"effects":[29],"of":[30,69,106,138,145],"antineoplastic":[32,139],"drugs":[33,121,140],"on":[34,71,128],"cognition,":[35],"leading":[36],"to":[37,119,160],"a":[38,112,133,142],"phenomenon":[39],"as":[41,48],"chemotherapy-related":[42],"impairment":[44,99,147],"(CRCI).":[45],"This":[46,59],"manifests":[47],"poor":[49],"attention":[50],"span,":[51],"disturbed":[52],"short-term":[53],"memory,":[54],"general":[56],"mental":[57],"sluggishness.":[58],"literature":[60],"review":[61],"explores":[62],"CRCI":[63],"investigates":[65],"the":[66,77,107],"potential":[67,134],"impact":[68],"KD":[70,101],"this":[72,162],"phenomenon.":[73],"Additionally,":[74],"we":[75,131],"highlight":[76],"shared":[78],"pathogenetic":[79],"mechanisms":[80],"(including":[81],"neurotoxicity,":[82],"neuroinflammation,":[83],"oxidative":[84],"stress,":[85],"vascular":[86],"disease,":[87],"electrolyte,":[88],"acid-base":[90],"imbalances),":[91],"clinical":[92],"presentation":[93],"imaging":[95],"findings":[96],"between":[97],"CRCI.":[103],"The":[104],"disruption":[105],"blood\u2013brain":[108],"barrier":[109],"might":[110],"key":[113],"mechanism":[114],"for":[115,135],"increased":[116],"brain":[117],"permeability":[118],"anticancer":[120],"nephropathic":[123],"cancer.":[126],"Based":[127],"existing":[129],"knowledge,":[130],"found":[132],"heightened":[136],"neurotoxicity":[137],"synergistic":[143],"potentiation":[144],"KD.":[152],"However,":[153],"further":[154],"translational":[155],"research":[156],"is":[157],"urgently":[158],"required":[159],"validate":[161],"hypothesis.":[163]},"counts_by_year":[],"updated_date":"2026-10-05T09:50:58.205359","created_date":"2026-02-21T00:00:00"}