{"id":"https://openalex.org/W7130683406","doi":"https://doi.org/10.1158/1557-3265.sabcs25-ps2-09-08","title":"Abstract PS2-09-08: Tertiary lymphoid structure (TLS)-related gene expression and outcomes in HER2-Positive (HER2+) breast cancer (BC) in the Real-World Database","display_name":"Abstract PS2-09-08: Tertiary lymphoid structure (TLS)-related gene expression and outcomes in HER2-Positive (HER2+) breast cancer (BC) in the Real-World Database","publication_year":2026,"publication_date":"2026-02-17","ids":{"openalex":"https://openalex.org/W7130683406","doi":"https://doi.org/10.1158/1557-3265.sabcs25-ps2-09-08"},"language":"en","primary_location":{"id":"doi:10.1158/1557-3265.sabcs25-ps2-09-08","doi":"https://doi.org/10.1158/1557-3265.sabcs25-ps2-09-08","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1557-3265.sabcs25-ps2-09-08","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5126208033","display_name":"S. Chumsri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Chumsri","raw_affiliation_strings":["1Hematology Oncology, Mayo Clinic, Jacksonville, FL,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Hematology Oncology, Mayo Clinic, Jacksonville, FL,","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126465729","display_name":"S. Kumar Deshmukh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140103","display_name":"Caris Life Sciences (United States)","ror":"https://ror.org/04wh5hg83","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Deshmukh","raw_affiliation_strings":["2N/A, Caris Life Sciences, Phoenix, AZ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2N/A, Caris Life Sciences, Phoenix, AZ,","institution_ids":["https://openalex.org/I4210140103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126489936","display_name":"Y. Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Liu","raw_affiliation_strings":["3Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL,","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126460844","display_name":"S. Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140103","display_name":"Caris Life Sciences (United States)","ror":"https://ror.org/04wh5hg83","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Wu","raw_affiliation_strings":["4Caris Life Sciences, Caris Life Sciences, Phoenix, AZ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Caris Life Sciences, Caris Life Sciences, Phoenix, AZ,","institution_ids":["https://openalex.org/I4210140103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087103669","display_name":"Joanne Xiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140103","display_name":"Caris Life Sciences (United States)","ror":"https://ror.org/04wh5hg83","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Xiu","raw_affiliation_strings":["4Caris Life Sciences, Caris Life Sciences, Phoenix, AZ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Caris Life Sciences, Caris Life Sciences, Phoenix, AZ,","institution_ids":["https://openalex.org/I4210140103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085662522","display_name":"N. Norton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Norton","raw_affiliation_strings":["5Cancer Biology, Mayo Clinic, Jacksonville, FL,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Cancer Biology, Mayo Clinic, Jacksonville, FL,","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126490572","display_name":"S. Shipra Gandhi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Shipra Gandhi","raw_affiliation_strings":["6Hematology Oncology, Emory, Atlanta, GA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Hematology Oncology, Emory, Atlanta, GA,","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126472374","display_name":"E. Torres","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Torres","raw_affiliation_strings":["7Hematology Oncology, University of Southern California, Los Angeles, FL,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Hematology Oncology, University of Southern California, Los Angeles, FL,","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126246688","display_name":"M. Lustberg","orcid":"https://orcid.org/0000-0001-8559-5645","observed_orcids":["https://orcid.org/0000-0001-8559-5645"]},"institutions":[{"id":"https://openalex.org/I2802730090","display_name":"Yale Cancer Center","ror":"https://ror.org/03j7sze86","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802730090","https://openalex.org/I4210117499","https://openalex.org/I4210165192"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Lustberg","raw_affiliation_strings":["8Hematology Oncology, Yale Cancer Center, New Haven, CT,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Hematology Oncology, Yale Cancer Center, New Haven, CT,","institution_ids":["https://openalex.org/I2802730090","https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065306642","display_name":"Edith A. Perez","orcid":"https://orcid.org/0000-0002-5037-6677","observed_orcids":["https://orcid.org/0000-0002-5037-6677","https://orcid.org/0000-0001-7009-7467"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Perez","raw_affiliation_strings":["1Hematology Oncology, Mayo Clinic, Jacksonville, FL,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Hematology Oncology, Mayo Clinic, Jacksonville, FL,","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126248963","display_name":"A. Nassar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Nassar","raw_affiliation_strings":["9Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"9Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL,","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066769011","display_name":"George W. Sledge","orcid":"https://orcid.org/0000-0003-0297-0775","observed_orcids":["https://orcid.org/0000-0003-0297-0775"]},"institutions":[{"id":"https://openalex.org/I4210140103","display_name":"Caris Life Sciences (United States)","ror":"https://ror.org/04wh5hg83","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Sledge","raw_affiliation_strings":["4Caris Life Sciences, Caris Life Sciences, Phoenix, AZ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Caris Life Sciences, Caris Life Sciences, Phoenix, AZ,","institution_ids":["https://openalex.org/I4210140103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026692399","display_name":"E. Aubrey Thompson","orcid":"https://orcid.org/0000-0002-9001-4240","observed_orcids":["https://orcid.org/0000-0002-9001-4240"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Thompson","raw_affiliation_strings":["5Cancer Biology, Mayo Clinic, Jacksonville, FL,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Cancer Biology, Mayo Clinic, Jacksonville, FL,","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031005364","display_name":"Keith L. Knutson","orcid":"https://orcid.org/0000-0001-9932-4467","observed_orcids":["https://orcid.org/0000-0001-9932-4467"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Knutson","raw_affiliation_strings":["10Cancer Immunology, Mayo Clinic, Jacksonville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"10Cancer Immunology, Mayo Clinic, Jacksonville, FL","institution_ids":["https://openalex.org/I4210146710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"4_Supplement","first_page":"PS2","last_page":"09"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.5468999743461609,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.5468999743461609,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.2328999936580658,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.15639999508857727,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tertiary-lymphoid-structures","display_name":"tertiary lymphoid structures","score":0.9950000047683716},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/interleukin-21-receptor","display_name":"interleukin-21 receptor","score":0.7990000247955322},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.515999972820282},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9369999766349792},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8579999804496765},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.9129999876022339},{"id":"https://openalex.org/keywords/b-cell-infiltration","display_name":"B cell infiltration","score":0.4950000047683716},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.7950000166893005},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.5889999866485596},{"id":"https://openalex.org/keywords/real-world-outcomes","display_name":"real-world outcomes","score":0.6940000057220459},{"id":"https://openalex.org/keywords/hr-her2-breast-cancer","display_name":"hormone receptor-positive HER2-negative breast cancer","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cxcl9","display_name":"CXCL9","score":0.5509999990463257},{"id":"https://openalex.org/keywords/cxcl10","display_name":"CXCL10","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cxcr3","display_name":"CXCR3","score":0.8889999985694885}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6983000040054321},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5462999939918518},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5013999938964844},{"id":"https://openalex.org/C2777537477","wikidata":"https://www.wikidata.org/wiki/Q17847411","display_name":"BCL6","level":5,"score":0.5012999773025513},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.49300000071525574},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.48840001225471497},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4320000112056732},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.4293999969959259},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4077000021934509},{"id":"https://openalex.org/C68443243","wikidata":"https://www.wikidata.org/wiki/Q2786686","display_name":"Quartile","level":3,"score":0.4027999937534332},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.4018999934196472},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39419999718666077},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3659000098705292},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.33629998564720154},{"id":"https://openalex.org/C122048520","wikidata":"https://www.wikidata.org/wiki/Q2913954","display_name":"Percentile","level":2,"score":0.3287000060081482},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.31299999356269836},{"id":"https://openalex.org/C65409693","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Statistical significance","level":2,"score":0.29679998755455017},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.29649999737739563},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.29089999198913574},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2849999964237213},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.28299999237060547},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.2728999853134155},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.26159998774528503},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.2551000118255615},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.25429999828338623}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1557-3265.sabcs25-ps2-09-08","doi":"https://doi.org/10.1158/1557-3265.sabcs25-ps2-09-08","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1557-3265.sabcs25-ps2-09-08","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Tertiary":[2,479],"lymphoid":[3,10,14,57,480],"structures":[4],"(TLS),":[5],"which":[6],"are":[7],"organized":[8],"ectopic":[9],"aggregates":[11,58],"resembling":[12],"secondary":[13],"organs,":[15],"have":[16],"been":[17],"associated":[18,195,217,365,397,411],"with":[19,41,59,67,173,183,196,204,218,356,366,398,412],"improved":[20,68,197,219,367],"outcomes":[21,69,83,368,400,486],"across":[22,401],"various":[23],"cancer":[24,491],"types.":[25],"However,":[26],"limited":[27],"data":[28],"exist":[29],"on":[30],"the":[31,50,71,85,114,143,376,393,427,431,494,501],"prognostic":[32,377],"relevance":[33],"of":[34,52,62,119,157,188,209,232,325,361,379,430,500],"TLS":[35],"in":[36,70,84,369,372,434,487,493],"HER2+":[37,90,370,435],"BC":[38,95,371,436],"pts":[39,182,203],"treated":[40],"trastuzumab.":[42],"In":[43,75,200,221],"our":[44,357],"prior":[45,358],"work,":[46],"we":[47,78],"demonstrated":[48],"that":[49],"presence":[51],"functional":[53],"TLS,":[54],"defined":[55],"by":[56,137,383],"elevated":[60],"expression":[61,117,139,187,208,323,409,484],"BCL6":[63],"or":[64,111,141],"IL21R,":[65,189,215],"correlated":[66],"NCCTG":[72],"N9831":[73],"trial.":[74],"this":[76],"study,":[77],"evaluated":[79],"TLS-related":[80,120,362,380],"gene":[81,395,483],"and":[82,131,153,170,192,214,224,404,421,437,445,485],"real-world":[86,373],"database.":[87],"Methods:":[88],"1344":[89],"(HR-HER2+:":[91,235,245,255,265,276,285,301,311],"560;":[92],"HR+HER2+:":[93,239,249,259,269,280,289,305,315],"784)":[94],"samples":[96],"were":[97,122,135,194,216],"analyzed":[98],"via":[99],"NGS":[100],"(592-gene":[101],"panel,":[102],"NextSeq;":[103],"WES/WTS,":[104],"NovaSeq;":[105],"Caris":[106],"Life":[107],"Sciences).":[108],"Above":[109],"(high)":[110],"below":[112,142],"(low)":[113],"50th":[115,144],"percentile":[116],"levels":[118,324],"genes":[121,329,341,363,381],"used":[123],"to":[124,159,351,441],"calculate":[125],"overall":[126],"survival":[127],"(OS).":[128],"IL21R-high":[129],"(H)":[130],"-low":[132],"(L)":[133],"tumors":[134],"classified":[136],"RNA":[138],"above":[140],"percentile.":[145],"Real-world":[146],"OS":[147,198],"was":[148,166,364],"derived":[149],"from":[150,155],"insurance":[151],"claims":[152],"calculated":[154],"date":[156],"biopsy":[158],"last":[160],"contact":[161],"using":[162,168],"Kaplan-Meier.":[163],"Statistical":[164],"significance":[165],"assessed":[167],"chi-square":[169],"Mann-Whitney":[171],"U":[172],"multiple":[174],"comparison":[175],"adjustments":[176],"(q":[177],"<":[178],"0.05).":[179],"Results:":[180],"Among":[181,388],"HR-HER2+":[184,223],"BC,":[185,206],"high":[186,207],"CXCL9,":[190],"CD38,":[191],"CXCL10":[193],"(Table).":[199],"contrast,":[201],"among":[202],"HR+HER2+":[205],"CXCR3,":[210],"PDCD1,":[211],"TBX21,":[212],"CD200":[213],"OS.":[220],"both":[222,402],"HR+HER2+,":[225],"IL21R-H":[226],"groups":[227],"had":[228],"1)":[229],"higher":[230,296,322],"infiltration":[231],"B":[233,414],"cells":[234,264],"4.4%":[236],"vs":[237,241,247,251,257,261,267,271,278,282,287,291,303,307,313,317],"2.9%;":[238],"5.6%":[240],"4.2%),":[242],"M1":[243,416],"M\u03a6":[244,254],"3.9%":[246],"2.6%;":[248],"3%":[250],"2.1%),":[252],"M2":[253],"4%":[256],"3.2%;":[258],"5.7%":[260],"4.4%),":[262],"NK":[263,422],"2.8%":[266,290],"2.5%;":[268],"2.7%":[270],"2.4%),":[272],"CD8+":[273],"T":[274,297,419],"cell":[275,298,420],"0.9%":[277],"0%;":[279],"0.7%":[281],"0%),":[283],"Tregs":[284],"2.9%":[286],"1.4%;":[288],"1.5%),":[292],"all":[293,319,336,348],"q<.05;":[294,320],"2)":[295],"inflamed":[299],"score":[300,310],"87.5":[302],"-95;":[304],"71":[306],"-86),":[308],"IFNy":[309],"-0.19":[312],"-0.48;":[314],"-0.27":[316],"-0.49),":[318],"3)":[321],"MHC":[326,338],"class":[327,339],"I":[328],"(HLA-A,":[330],"HLA-B,":[331],"HLA-C,":[332],"HLA-E,":[333],"FC:":[334,346],"1.6-2.3;":[335],"q<.05),":[337],"II":[340],"(HLA-DQA1,":[342],"HLA-DOA,":[343],"HLA-DPA1,":[344],"HLA-DMA,":[345],"2.2-3.2;":[347],"q<.05)":[349],"compared":[350],"IL21R-L":[352],"group.":[353],"Conclusion:":[354],"Consistent":[355],"findings,":[359],"overexpression":[360],"data.":[374],"Notably,":[375],"impact":[378],"differed":[382],"hormone":[384],"receptor":[385],"(HR)":[386],"status.":[387],"these,":[389],"IL21R":[390,408],"emerged":[391],"as":[392],"only":[394],"significantly":[396],"clinical":[399],"datasets":[403],"HR":[405],"subgroups.":[406],"Higher":[407],"is":[410],"more":[413],"cell,":[415],"M\u03a6,":[417],"CD8":[418],"cells.":[423],"These":[424],"findings":[425],"underscore":[426],"potential":[428],"importance":[429],"IL21/IL21R":[432],"axis":[433],"warrant":[438],"further":[439],"investigation":[440],"validate":[442],"its":[443],"role":[444],"therapeutic":[446],"relevance.":[447],"Citation":[448],"Format:":[449],"S.":[450,452,456,462],"Chumsri,":[451],"Deshmukh,":[453],"Y.":[454],"Liu,":[455],"Wu,":[457],"J.":[458],"Xiu,":[459],"N.":[460],"Norton,":[461],"Shipra":[463],"Gandhi,":[464],"E.":[465,469,475],"Torres,":[466],"M.":[467],"Lustberg,":[468],"Perez,":[470],"A.":[471],"Nassar,":[472],"G.":[473],"Sledge,":[474],"Thompson,":[476],"K.":[477],"Knutson.":[478],"structure":[481],"(TLS)-related":[482],"HER2-Positive":[488],"(HER2+)":[489],"breast":[490],"(BC)":[492],"Real-World":[495],"Database":[496],"[abstract].":[497],"In:":[498],"Proceedings":[499],"San":[502,511],"Antonio":[503],"Breast":[504],"Cancer":[505,518],"Symposium":[506],"2025;":[507],"2025":[508],"Dec":[509],"9-12;":[510],"Antonio,":[512],"TX.":[513],"Philadelphia":[514],"(PA):":[515],"AACR;":[516],"Clin":[517],"Res":[519],"2026;32(4":[520],"Suppl):Abstract":[521],"nr":[522],"PS2-09-08.":[523]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2026-02-21T00:00:00"}
