{"id":"https://openalex.org/W7130663296","doi":"https://doi.org/10.3390/pharmaceutics18020263","title":"Mechanistic Insights into AAV Capsid\u2013Stationary Phase Interactions Governing Native Stability and Chromatographic Separation Using AAV8 as a Model System","display_name":"Mechanistic Insights into AAV Capsid\u2013Stationary Phase Interactions Governing Native Stability and Chromatographic Separation Using AAV8 as a Model System","publication_year":2026,"publication_date":"2026-02-20","ids":{"openalex":"https://openalex.org/W7130663296","doi":"https://doi.org/10.3390/pharmaceutics18020263","pmid":"https://pubmed.ncbi.nlm.nih.gov/41755004","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12943882"},"language":"en","primary_location":{"id":"doi:10.3390/pharmaceutics18020263","doi":"https://doi.org/10.3390/pharmaceutics18020263","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics18020263","pdf_url":"https://www.mdpi.com/1999-4923/18/2/263/pdf?version=1771583732","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1999-4923/18/2/263/pdf?version=1771583732","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002957523","display_name":"Timotej \u017dvanut","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192455894","display_name":"University of Nova Gorica","ror":"https://ror.org/00mw0tw28","country_code":"SI","type":"education","lineage":["https://openalex.org/I192455894"]},{"id":"https://openalex.org/I2957750942","display_name":"BIA Separations (Slovenia)","ror":"https://ror.org/03f2kwz12","country_code":"SI","type":"company","lineage":["https://openalex.org/I2957750942"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Timotej \u017dvanut","raw_affiliation_strings":["Graduate School, University of Nova Gorica, 5000 Nova Gorica, Slovenia","Sartorius BIA Separations, 5270 Ajdov\u0161\u010dina, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School, University of Nova Gorica, 5000 Nova Gorica, Slovenia","institution_ids":["https://openalex.org/I192455894"]},{"raw_affiliation_string":"Sartorius BIA Separations, 5270 Ajdov\u0161\u010dina, Slovenia","institution_ids":["https://openalex.org/I2957750942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004534065","display_name":"Mitja Martelanc","orcid":"https://orcid.org/0000-0002-2914-3289","observed_orcids":["https://orcid.org/0000-0002-2914-3289"]},"institutions":[{"id":"https://openalex.org/I192455894","display_name":"University of Nova Gorica","ror":"https://ror.org/00mw0tw28","country_code":"SI","type":"education","lineage":["https://openalex.org/I192455894"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Mitja Martelanc","raw_affiliation_strings":["Wine Research Centre, University of Nova Gorica, 5271 Vipava, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wine Research Centre, University of Nova Gorica, 5271 Vipava, Slovenia","institution_ids":["https://openalex.org/I192455894"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017096531","display_name":"Ale\u0161 \u0160trancar","orcid":"https://orcid.org/0000-0003-1550-6453","observed_orcids":["https://orcid.org/0000-0003-1550-6453"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ale\u0161 \u0160trancar","raw_affiliation_strings":["BIA Separations Inc., Wilmington, DE 19801, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIA Separations Inc., Wilmington, DE 19801, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5093269298","display_name":"Andreja Gramc Livk","orcid":"https://orcid.org/0009-0006-8909-8439","observed_orcids":["https://orcid.org/0009-0006-8909-8439"]},"institutions":[{"id":"https://openalex.org/I2957750942","display_name":"BIA Separations (Slovenia)","ror":"https://ror.org/03f2kwz12","country_code":"SI","type":"company","lineage":["https://openalex.org/I2957750942"]}],"countries":["SI"],"is_corresponding":true,"raw_author_name":"Andreja Gramc Livk","raw_affiliation_strings":["Sartorius BIA Separations, 5270 Ajdov\u0161\u010dina, Slovenia"],"raw_orcid":"https://orcid.org/0009-0006-8909-8439","affiliations":[{"raw_affiliation_string":"Sartorius BIA Separations, 5270 Ajdov\u0161\u010dina, Slovenia","institution_ids":["https://openalex.org/I2957750942"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5093269298"],"corresponding_institution_ids":["https://openalex.org/I2957750942"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":1.3024,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.71682836,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"18","issue":"2","first_page":"263","last_page":"263"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.49219998717308044,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.49219998717308044,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.4871000051498413,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adeno-associated-virus","display_name":"adeno-associated virus","score":0.8270000219345093},{"id":"https://openalex.org/keywords/aav8","display_name":"AAV8","score":0.8349999785423279},{"id":"https://openalex.org/keywords/capsid-stability","display_name":"capsid stability","score":0.7850000262260437},{"id":"https://openalex.org/keywords/anion-exchange-chromatography","display_name":"anion exchange chromatography","score":0.9049999713897705},{"id":"https://openalex.org/keywords/chromatographic-separation","display_name":"chromatographic separation","score":0.5490000247955322},{"id":"https://openalex.org/keywords/buffer-exchange","display_name":"buffer exchange","score":0.6029999852180481},{"id":"https://openalex.org/keywords/buffer-ph","display_name":"buffer pH","score":0.6639999747276306},{"id":"https://openalex.org/keywords/ionic-strength","display_name":"ionic strength","score":0.9959999918937683},{"id":"https://openalex.org/keywords/gene-therapy-vectors","display_name":"gene therapy vectors","score":0.7369999885559082},{"id":"https://openalex.org/keywords/two-dimensional-chromatography","display_name":"two-dimensional chromatography","score":0.5770000219345093},{"id":"https://openalex.org/keywords/desalination","display_name":"desalination","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C202878990","wikidata":"https://www.wikidata.org/wiki/Q830465","display_name":"Capsid","level":3,"score":0.8715000152587891},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7559000253677368},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5461999773979187},{"id":"https://openalex.org/C44280652","wikidata":"https://www.wikidata.org/wiki/Q104837","display_name":"Phase (matter)","level":2,"score":0.4733000099658966},{"id":"https://openalex.org/C3018256011","wikidata":"https://www.wikidata.org/wiki/Q898987","display_name":"Separation method","level":2,"score":0.44929999113082886},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.4465000033378601},{"id":"https://openalex.org/C2780232233","wikidata":"https://www.wikidata.org/wiki/Q898987","display_name":"Separation process","level":2,"score":0.4284999966621399},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.36890000104904175},{"id":"https://openalex.org/C117760992","wikidata":"https://www.wikidata.org/wiki/Q389137","display_name":"Ion exchange","level":3,"score":0.3652999997138977},{"id":"https://openalex.org/C187428577","wikidata":"https://www.wikidata.org/wiki/Q898396","display_name":"Ionic strength","level":3,"score":0.36079999804496765},{"id":"https://openalex.org/C2988540567","wikidata":"https://www.wikidata.org/wiki/Q12070446","display_name":"Model system","level":2,"score":0.3402000069618225},{"id":"https://openalex.org/C2992520659","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatographic separation","level":3,"score":0.3402000069618225},{"id":"https://openalex.org/C2983406500","wikidata":"https://www.wikidata.org/wiki/Q7604347","display_name":"Stationary phase","level":2,"score":0.33640000224113464},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.32249999046325684},{"id":"https://openalex.org/C2776061190","wikidata":"https://www.wikidata.org/wiki/Q7451805","display_name":"Separation (statistics)","level":2,"score":0.32089999318122864},{"id":"https://openalex.org/C2182769","wikidata":"https://www.wikidata.org/wiki/Q62500","display_name":"Ionic bonding","level":3,"score":0.31470000743865967},{"id":"https://openalex.org/C67568554","wikidata":"https://www.wikidata.org/wiki/Q385442","display_name":"Downstream processing","level":2,"score":0.31360000371932983},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.30720001459121704},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.29820001125335693},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.28130000829696655},{"id":"https://openalex.org/C6881719","wikidata":"https://www.wikidata.org/wiki/Q5611048","display_name":"Group-specific antigen","level":3,"score":0.2685000002384186},{"id":"https://openalex.org/C145018004","wikidata":"https://www.wikidata.org/wiki/Q4985944","display_name":"Buffer (optical fiber)","level":2,"score":0.2632000148296356},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2513999938964844}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/pharmaceutics18020263","doi":"https://doi.org/10.3390/pharmaceutics18020263","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics18020263","pdf_url":"https://www.mdpi.com/1999-4923/18/2/263/pdf?version=1771583732","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:41755004","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41755004","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12943882","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12943882/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Text"},{"id":"pmh:oai:repozitorij.ung.si:IzpisGradiva.php?id=11301","doi":null,"is_oa":true,"landing_page_url":"https://repozitorij.ung.si/Dokument.php?id=36288&dn=","pdf_url":"https://www.mdpi.com/1999-4923/18/2/263/pdf?version=1772075162","source":{"id":"https://openalex.org/S7407055115","display_name":"RUNG","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1999-4923","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:2800d225f5cf4a72bbc2a6cc91e032aa","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/2800d225f5cf4a72bbc2a6cc91e032aa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutics, Vol 18, Iss 2, p 263 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/pharmaceutics18020263","doi":"https://doi.org/10.3390/pharmaceutics18020263","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics18020263","pdf_url":"https://www.mdpi.com/1999-4923/18/2/263/pdf?version=1771583732","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324592","display_name":"Univerza v Ljubljani","ror":"https://ror.org/05njb9z20"},{"id":"https://openalex.org/F4320325843","display_name":"Univerza v Mariboru","ror":"https://ror.org/01d5jce07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7130663296.pdf","grobid_xml":"https://content.openalex.org/works/W7130663296.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1516027947","https://openalex.org/W1593241002","https://openalex.org/W1967200408","https://openalex.org/W1983411625","https://openalex.org/W1991865965","https://openalex.org/W2001599454","https://openalex.org/W2003123390","https://openalex.org/W2004925055","https://openalex.org/W2011646966","https://openalex.org/W2020193938","https://openalex.org/W2069948193","https://openalex.org/W2075785803","https://openalex.org/W2155752698","https://openalex.org/W2167777181","https://openalex.org/W2320653595","https://openalex.org/W2739319013","https://openalex.org/W2790584152","https://openalex.org/W2888257090","https://openalex.org/W2963001938","https://openalex.org/W2975867742","https://openalex.org/W3036737182","https://openalex.org/W3087913089","https://openalex.org/W3090678520","https://openalex.org/W3102472390","https://openalex.org/W3123929977","https://openalex.org/W3130024205","https://openalex.org/W3139242858","https://openalex.org/W3154377315","https://openalex.org/W3168865376","https://openalex.org/W3212168392","https://openalex.org/W4286498627","https://openalex.org/W4289936804","https://openalex.org/W4293678328","https://openalex.org/W4306385424","https://openalex.org/W4313367497","https://openalex.org/W4378838857","https://openalex.org/W4383533085","https://openalex.org/W4386010093","https://openalex.org/W4386019235","https://openalex.org/W4386860291","https://openalex.org/W4386865709","https://openalex.org/W4388976738","https://openalex.org/W4389328412","https://openalex.org/W4399126967","https://openalex.org/W4399780277","https://openalex.org/W4399957091","https://openalex.org/W4400452235","https://openalex.org/W4401155390","https://openalex.org/W4401220495","https://openalex.org/W4401687711","https://openalex.org/W4403046097","https://openalex.org/W4404283134","https://openalex.org/W4405046078","https://openalex.org/W4406486687","https://openalex.org/W4411356894","https://openalex.org/W4413804585","https://openalex.org/W4414976330","https://openalex.org/W4416893138","https://openalex.org/W7128401656","https://openalex.org/W7129535962"],"related_works":["https://openalex.org/W4413804585","https://openalex.org/W4386865709","https://openalex.org/W7117504012","https://openalex.org/W4387757150","https://openalex.org/W7203609778","https://openalex.org/W4401687711","https://openalex.org/W4399126967","https://openalex.org/W4408107745","https://openalex.org/W4389328412","https://openalex.org/W4387682869"],"abstract_inverted_index":{"Background/Objectives:":[0],"Adeno-associated":[1],"viruses":[2],"(AAVs)":[3],"are":[4,17,25],"widely":[5],"used":[6],"gene":[7],"therapy":[8],"vectors;":[9],"yet":[10],"their":[11],"physicochemical":[12,195],"stability":[13,151],"and":[14,34,53,73,98,123,141,197,218],"chromatographic":[15,153],"behavior":[16],"highly":[18],"sensitive":[19],"to":[20],"the":[21,78,188],"solution":[22],"conditions":[23],"they":[24],"in.":[26],"Effective":[27],"separation":[28,99,127,154,177],"of":[29,80,178,190],"full":[30],"(F),":[31],"empty":[32],"(E),":[33],"partially":[35],"filled":[36],"(P)":[37],"capsids\u2014most":[38],"commonly":[39],"achieved":[40],"by":[41],"anion":[42],"exchange":[43,166],"(AEX)":[44],"chromatography\u2014is":[45],"essential":[46],"for":[47,207,214],"standard":[48],"analytical":[49,217],"characterization,":[50],"process":[51],"development,":[52],"product":[54],"safety.":[55],"However,":[56],"conventional":[57],"AEX":[58,96,132,170],"methods":[59],"rely":[60],"on":[61,116,129],"low-conductivity":[62],"alkaline":[63],"mobile":[64],"phases":[65],"with":[66,120,152],"low":[67],"salt,":[68],"which":[69],"promote":[70],"capsid":[71,91,118,150,191],"binding":[72],"therefore":[74],"higher":[75],"resolution,":[76],"at":[77],"expense":[79],"structural":[81],"stability.":[82],"Conversely,":[83],"formulations":[84],"such":[85],"as":[86,111],"near-neutral":[87],"buffers":[88],"might":[89],"preserve":[90],"integrity":[92],"but":[93],"often":[94],"impair":[95],"retention":[97],"resolution.":[100],"Methods:":[101],"Here,":[102],"we":[103,144,158],"extend":[104],"a":[105,112,130,212],"mechanistic":[106],"investigation":[107],"using":[108],"AAV8":[109,126],"capsids":[110],"model":[113],"system,":[114],"focusing":[115],"detailed":[117],"interactions":[119],"strong":[121],"AEX,":[122],"present":[124],"novel":[125],"strategies":[128],"weak":[131],"stationary":[133],"phase.":[134],"Results:":[135],"By":[136,186],"systematically":[137],"varying":[138],"buffer":[139,165],"pH":[140],"ionic":[142],"strength,":[143],"identify":[145],"operational":[146],"regimes":[147],"that":[148,168],"balance":[149],"efficiency.":[155],"In":[156],"parallel,":[157],"introduce":[159],"an":[160],"integrated":[161],"two-dimensional":[162],"(2D)":[163],"in-line":[164],"configuration":[167],"decouples":[169],"performance":[171],"from":[172],"sample":[173],"formulation,":[174],"enabling":[175],"robust":[176],"stability-optimized,":[179],"high-salt":[180],"matrices":[181],"without":[182],"off-line":[183],"desalting.":[184],"Conclusions:":[185],"elucidating":[187],"roles":[189],"charge":[192],"modulation,":[193],"ligand":[194],"properties,":[196],"local":[198],"microenvironmental":[199],"buffering,":[200],"this":[201],"study":[202],"establishes":[203],"practical":[204],"design":[205],"principles":[206],"stability-preserving":[208],"chromatography.":[209],"It":[210],"lays":[211],"foundation":[213],"more":[215],"reliable":[216],"future":[219],"preparative":[220],"AAV":[221],"workflows.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-02-20T00:00:00"}
