{"id":"https://openalex.org/W7130656304","doi":"https://doi.org/10.1161/jaha.125.043617","title":"Translating Mechanistic Insights Into Action and Revealing New Pathways: Machine Learning Approaches in Heart Failure With Preserved Ejection Fraction","display_name":"Translating Mechanistic Insights Into Action and Revealing New Pathways: Machine Learning Approaches in Heart Failure With Preserved Ejection Fraction","publication_year":2026,"publication_date":"2026-02-20","ids":{"openalex":"https://openalex.org/W7130656304","doi":"https://doi.org/10.1161/jaha.125.043617","pmid":"https://pubmed.ncbi.nlm.nih.gov/41717938","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13055845"},"language":"en","primary_location":{"id":"doi:10.1161/jaha.125.043617","doi":"https://doi.org/10.1161/jaha.125.043617","is_oa":true,"landing_page_url":"https://doi.org/10.1161/jaha.125.043617","pdf_url":null,"source":{"id":"https://openalex.org/S2489920150","display_name":"Journal of the American Heart Association","issn_l":"2047-9980","issn":["2047-9980"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Heart Association","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1161/jaha.125.043617","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005973854","display_name":"Tasnim F. Imran","orcid":"https://orcid.org/0000-0003-2089-8244","observed_orcids":["https://orcid.org/0000-0003-2089-8244"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2802759389","display_name":"Providence VA Medical Center","ror":"https://ror.org/041m0cc93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2802759389","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I4210107413","display_name":"SouthCoast Health","ror":"https://ror.org/01mgpsx86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210107413"]},{"id":"https://openalex.org/I4210118850","display_name":"Charlton Memorial Hospital","ror":"https://ror.org/02e5pan03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210118850"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tasnim F. Imran","raw_affiliation_strings":["Charlton Memorial Hospital, Southcoast Health","Providence VA Medical Center","Warren Alpert Medical School of Brown University"],"raw_orcid":"https://orcid.org/0000-0003-2089-8244","affiliations":[{"raw_affiliation_string":"Charlton Memorial Hospital, Southcoast Health","institution_ids":["https://openalex.org/I4210107413","https://openalex.org/I4210118850"]},{"raw_affiliation_string":"Providence VA Medical Center","institution_ids":["https://openalex.org/I2802759389"]},{"raw_affiliation_string":"Warren Alpert Medical School of Brown University","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099001496","display_name":"Nikhil Kadivar","orcid":"https://orcid.org/0009-0003-2904-8681","observed_orcids":["https://orcid.org/0009-0003-2904-8681"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikhil Kadivar","raw_affiliation_strings":["Brown University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brown University","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116081919","display_name":"Julia G. Gillotti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802759389","display_name":"Providence VA Medical Center","ror":"https://ror.org/041m0cc93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2802759389","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia Gillotti","raw_affiliation_strings":["Providence VA Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Providence VA Medical Center","institution_ids":["https://openalex.org/I2802759389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108881695","display_name":"Mahnoor Khalid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802759389","display_name":"Providence VA Medical Center","ror":"https://ror.org/041m0cc93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2802759389","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahnoor Khalid","raw_affiliation_strings":["Providence VA Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Providence VA Medical Center","institution_ids":["https://openalex.org/I2802759389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039212336","display_name":"Edward Patrick Walsh","orcid":"https://orcid.org/0000-0001-6203-4415","observed_orcids":["https://orcid.org/0000-0001-6203-4415"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Walsh","raw_affiliation_strings":["Brown University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brown University","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024450291","display_name":"Emilio A. Mendiola","orcid":"https://orcid.org/0000-0002-7774-0811","observed_orcids":["https://orcid.org/0000-0002-7774-0811"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emilio Mendiola","raw_affiliation_strings":["University of Texas A & M"],"raw_orcid":"https://orcid.org/0000-0002-7774-0811","affiliations":[{"raw_affiliation_string":"University of Texas A & M","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006348854","display_name":"Reza Avazmohammadi","orcid":"https://orcid.org/0000-0001-9787-1117","observed_orcids":["https://orcid.org/0000-0001-9787-1117"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reza Avazmohammadi","raw_affiliation_strings":["University of Texas A & M"],"raw_orcid":"https://orcid.org/0000-0001-9787-1117","affiliations":[{"raw_affiliation_string":"University of Texas A & M","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090645124","display_name":"Michael K. Atalay","orcid":"https://orcid.org/0000-0003-3549-2634","observed_orcids":["https://orcid.org/0000-0003-3549-2634"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2802759389","display_name":"Providence VA Medical Center","ror":"https://ror.org/041m0cc93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2802759389","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Atalay","raw_affiliation_strings":["Providence VA Medical Center","Warren Alpert Medical School of Brown University"],"raw_orcid":"https://orcid.org/0000-0003-3549-2634","affiliations":[{"raw_affiliation_string":"Providence VA Medical Center","institution_ids":["https://openalex.org/I2802759389"]},{"raw_affiliation_string":"Warren Alpert Medical School of Brown University","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126523978","display_name":"Ali Nebipasagil","orcid":"https://orcid.org/0009-0001-1550-4565","observed_orcids":["https://orcid.org/0009-0001-1550-4565"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ali Nebipasagil","raw_affiliation_strings":["University of North Carolina"],"raw_orcid":"https://orcid.org/0009-0001-1550-4565","affiliations":[{"raw_affiliation_string":"University of North Carolina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040705509","display_name":"Faez Ahmed","orcid":"https://orcid.org/0000-0002-5227-2628","observed_orcids":["https://orcid.org/0000-0002-5227-2628"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Faez Ahmed","raw_affiliation_strings":["Massachusetts Institute of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020182946","display_name":"Christopher T Nguyen","orcid":"https://orcid.org/0000-0003-1475-2329","observed_orcids":["https://orcid.org/0000-0003-1475-2329"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Nguyen","raw_affiliation_strings":["Cleveland Clinic Foundation"],"raw_orcid":"https://orcid.org/0000-0003-1475-2329","affiliations":[{"raw_affiliation_string":"Cleveland Clinic Foundation","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010629610","display_name":"Wen\u2010Chih Wu","orcid":"https://orcid.org/0000-0002-2834-2024","observed_orcids":["https://orcid.org/0000-0002-2834-2024"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2802759389","display_name":"Providence VA Medical Center","ror":"https://ror.org/041m0cc93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2802759389","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wen\u2010Chih Wu","raw_affiliation_strings":["Providence VA Medical Center","Warren Alpert Medical School of Brown University"],"raw_orcid":"https://orcid.org/0000-0002-2834-2024","affiliations":[{"raw_affiliation_string":"Providence VA Medical Center","institution_ids":["https://openalex.org/I2802759389"]},{"raw_affiliation_string":"Warren Alpert Medical School of Brown University","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009658255","display_name":"George Em Karniadakis","orcid":"https://orcid.org/0000-0002-9713-7120","observed_orcids":["https://orcid.org/0000-0002-9713-7120"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Karniadakis","raw_affiliation_strings":["Brown University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brown University","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006335310","display_name":"Gaurav Choudhary","orcid":"https://orcid.org/0000-0001-9343-5481","observed_orcids":["https://orcid.org/0000-0001-9343-5481"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2802759389","display_name":"Providence VA Medical Center","ror":"https://ror.org/041m0cc93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2802759389","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gaurav Choudhary","raw_affiliation_strings":["Brown University Health","Providence VA Medical Center","Warren Alpert Medical School of Brown University"],"raw_orcid":"https://orcid.org/0000-0001-9343-5481","affiliations":[{"raw_affiliation_string":"Brown University Health","institution_ids":["https://openalex.org/I27804330"]},{"raw_affiliation_string":"Providence VA Medical Center","institution_ids":["https://openalex.org/I2802759389"]},{"raw_affiliation_string":"Warren Alpert Medical School of Brown University","institution_ids":["https://openalex.org/I27804330"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5006335310"],"corresponding_institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2802759389"],"apc_list":{"value":3810,"currency":"USD","value_usd":3810},"apc_paid":{"value":3810,"currency":"USD","value_usd":3810},"fwci":1.1223,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.71631016,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"15","issue":"5","first_page":"e043617","last_page":"e043617"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.5365999937057495,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.5365999937057495,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11396","display_name":"Artificial Intelligence in Healthcare","score":0.1404000073671341,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.12099999934434891,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-failure-with-preserved-ejection-fraction","display_name":"heart failure with preserved ejection fraction","score":1.0},{"id":"https://openalex.org/keywords/machine-learning","display_name":"machine learning","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cardiac-dysfunction","display_name":"cardiac dysfunction","score":0.7369999885559082},{"id":"https://openalex.org/keywords/cardiac-imaging","display_name":"cardiac imaging","score":0.8429999947547913},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5640000104904175},{"id":"https://openalex.org/keywords/myocardial-stiffness","display_name":"myocardial stiffness","score":0.8019999861717224},{"id":"https://openalex.org/keywords/myocardial-steatosis","display_name":"myocardial steatosis","score":0.8989999890327454},{"id":"https://openalex.org/keywords/myocardial-energetics","display_name":"myocardial energetics","score":0.953000009059906},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.9350000023841858},{"id":"https://openalex.org/keywords/deep-convolutional-neural-networks","display_name":"deep convolutional neural networks","score":0.8960000276565552},{"id":"https://openalex.org/keywords/physics-informed-neural-networks","display_name":"physics-informed neural networks","score":0.9049999713897705},{"id":"https://openalex.org/keywords/multimodal-imaging","display_name":"multimodal imaging","score":0.6510000228881836},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.7009999752044678},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.43299999833106995}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7549999952316284},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.7067999839782715},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6947000026702881},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.6811000108718872},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.6599000096321106},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.5482000112533569},{"id":"https://openalex.org/C2777099384","wikidata":"https://www.wikidata.org/wiki/Q3799239","display_name":"Heart failure with preserved ejection fraction","level":4,"score":0.5358999967575073},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.462799996137619},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.4564000070095062},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.40790000557899475},{"id":"https://openalex.org/C2776127602","wikidata":"https://www.wikidata.org/wiki/Q5038319","display_name":"Cardiac imaging","level":2,"score":0.3928999900817871},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.3578999936580658},{"id":"https://openalex.org/C70587473","wikidata":"https://www.wikidata.org/wiki/Q7834111","display_name":"Transformative learning","level":2,"score":0.34619998931884766},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.3292999863624573},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.30640000104904175},{"id":"https://openalex.org/C97541855","wikidata":"https://www.wikidata.org/wiki/Q830687","display_name":"Reinforcement learning","level":2,"score":0.3012000024318695},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.2996000051498413},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2849999964237213},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.27160000801086426},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.26260000467300415},{"id":"https://openalex.org/C59404180","wikidata":"https://www.wikidata.org/wiki/Q17013334","display_name":"Feature learning","level":2,"score":0.251800000667572}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000097786","descriptor_name":"Soft Computing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098412","descriptor_name":"Predictive Learning Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098415","descriptor_name":"Convolutional Neural Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098430","descriptor_name":"Clustering Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016277","descriptor_name":"Ventricular Function, Left","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1161/jaha.125.043617","doi":"https://doi.org/10.1161/jaha.125.043617","is_oa":true,"landing_page_url":"https://doi.org/10.1161/jaha.125.043617","pdf_url":null,"source":{"id":"https://openalex.org/S2489920150","display_name":"Journal of the American Heart Association","issn_l":"2047-9980","issn":["2047-9980"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Heart Association","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13055845","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41717938/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13055845/pdf/JAH3-15-e043617.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Am Heart Assoc","raw_type":"Text"},{"id":"pmid:41717938","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41717938","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Heart Association","raw_type":"Journal Article"},{"id":"pmh:cdr.lib.unc.edu:j9602h68w","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/0pe8-q834","pdf_url":"https://cdr.lib.unc.edu/downloads/bk128t64s","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of the American Heart Association, 15","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:7f4ab73ad9a64473be2b1248dd998b4d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7f4ab73ad9a64473be2b1248dd998b4d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 15, Iss 5 (2026)","raw_type":"article"},{"id":"doi:10.17615/0pe8-q834","doi":"https://doi.org/10.17615/0pe8-q834","is_oa":true,"landing_page_url":"https://doi.org/10.17615/0pe8-q834","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1161/jaha.125.043617","doi":"https://doi.org/10.1161/jaha.125.043617","is_oa":true,"landing_page_url":"https://doi.org/10.1161/jaha.125.043617","pdf_url":null,"source":{"id":"https://openalex.org/S2489920150","display_name":"Journal of the American Heart Association","issn_l":"2047-9980","issn":["2047-9980"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Heart Association","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5344049784","display_name":"Role of right ventricular passive remodeling in ventricular-arterial uncoupling in pulmonary hypertension","funder_award_id":"1r56hl172052-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6728717930","display_name":"Role of Endothelial Anoctamin-1 in Pulmonary Arterial Hypertension","funder_award_id":"R01HL148727","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G676674222","display_name":"Role of Mitochondrial c-Src in Right Ventricular Dysfunction in Pulmonary Hypertension","funder_award_id":"1r01hl169456-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000892832","display_name":"CardioPulmonary Vascular Biology COBRE","funder_award_id":"P30GM149398","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000920643","display_name":"Integrated super-resolution CMR-deep learning to deconvolute passive and active causes of impaired relaxation","funder_award_id":"1r01hl168368-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7130656304.pdf","grobid_xml":"https://content.openalex.org/works/W7130656304.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1997997206","https://openalex.org/W2005879316","https://openalex.org/W2017955864","https://openalex.org/W2028354341","https://openalex.org/W2065367378","https://openalex.org/W2087701915","https://openalex.org/W2102780353","https://openalex.org/W2112238233","https://openalex.org/W2122244728","https://openalex.org/W2134466949","https://openalex.org/W2153819921","https://openalex.org/W2255595202","https://openalex.org/W2512162748","https://openalex.org/W2597217516","https://openalex.org/W2763651817","https://openalex.org/W2769425716","https://openalex.org/W2792636466","https://openalex.org/W2899283552","https://openalex.org/W2905924623","https://openalex.org/W2919115771","https://openalex.org/W2919958648","https://openalex.org/W2933231683","https://openalex.org/W2979786244","https://openalex.org/W2991138092","https://openalex.org/W3012616651","https://openalex.org/W3022179669","https://openalex.org/W3163367444","https://openalex.org/W3163993681","https://openalex.org/W3170300845","https://openalex.org/W3179083309","https://openalex.org/W3183865922","https://openalex.org/W3187236665","https://openalex.org/W3207903643","https://openalex.org/W4205627509","https://openalex.org/W4210242902","https://openalex.org/W4214942785","https://openalex.org/W4220662102","https://openalex.org/W4220965910","https://openalex.org/W4221158607","https://openalex.org/W4310497802","https://openalex.org/W4315630510","https://openalex.org/W4319460747","https://openalex.org/W4320913369","https://openalex.org/W4321373988","https://openalex.org/W4322720015","https://openalex.org/W4366239802","https://openalex.org/W4386660232","https://openalex.org/W4389049591","https://openalex.org/W4391229338","https://openalex.org/W4400448931","https://openalex.org/W4401167703","https://openalex.org/W4403365546","https://openalex.org/W4406958987","https://openalex.org/W4411469037","https://openalex.org/W4412520555"],"related_works":["https://openalex.org/W4415655804","https://openalex.org/W4214942785","https://openalex.org/W7161625119","https://openalex.org/W2998441924","https://openalex.org/W4394578048","https://openalex.org/W7162242875","https://openalex.org/W2951459620","https://openalex.org/W4205879554","https://openalex.org/W3119322416","https://openalex.org/W4399972851"],"abstract_inverted_index":{"Heart":[0],"failure":[1,57,86,171],"with":[2,17,58,87,158,172],"preserved":[3,59,88,173],"ejection":[4,60,89,174],"fraction":[5,90],"is":[6],"a":[7,12,40],"prevalent":[8],"condition":[9],"that":[10],"carries":[11],"high":[13],"morbidity":[14],"and":[15,22,47,67,79,94,103,107,117,127,148,165],"mortality,":[16],"limited":[18],"treatment":[19,33],"options.":[20],"Obtaining":[21],"integrating":[23,91,155],"critical":[24],"mechanistic":[25],"insights":[26,142],"are":[27],"essential":[28],"to":[29,51,73,76],"development":[30],"of":[31,123],"optimal":[32],"strategies.":[34],"Machine":[35],"learning":[36,109],"(ML)":[37],"has":[38],"played":[39],"transformative":[41],"role":[42],"in":[43,55,84],"advancing":[44],"clinical":[45],"research":[46],"can":[48,70,96,120,139,161],"be":[49,71],"employed":[50],"understanding":[52],"myocardial":[53,100,124],"dysfunction":[54],"heart":[56,85,170],"fraction.":[61],"ML":[62,95,131,156],"techniques,":[63],"including":[64],"supervised,":[65],"unsupervised,":[66],"reinforcement":[68],"learning,":[69],"applied":[72],"cardiac":[74],"imaging":[75,93,160],"identify":[77],"phenotypes":[78],"extract":[80],"biomarkers.":[81],"Mechanistic":[82],"evaluation":[83],"advanced":[92,159],"provide":[97],"information":[98],"on":[99],"stiffness,":[101],"steatosis,":[102],"energetics.":[104],"Feature":[105],"extraction":[106],"feature":[108],"techniques":[110],"build":[111],"upon":[112],"deep":[113],"convolutional":[114],"neural":[115,137],"networks,":[116,138],"clustering":[118,147],"algorithms":[119],"automate":[121],"detection":[122],"fibrosis,":[125],"energetics,":[126],"other":[128],"mechanisms.":[129],"Multimodal":[130],"frameworks,":[132],"such":[133],"as":[134],"multifidelity":[135],"physics-informed":[136],"offer":[140],"deeper":[141],"into":[143],"mechanisms,":[144],"improving":[145],"phenotype":[146],"patient-specific":[149],"interventions.":[150],"This":[151],"review":[152],"addresses":[153],"how":[154],"approaches":[157],"address":[162],"traditional":[163],"challenges":[164],"advance":[166],"precision":[167],"medicine":[168],"for":[169],"fraction,":[175],"guiding":[176],"targeted":[177],"therapies.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-02-20T00:00:00"}