{"id":"https://openalex.org/W7130649459","doi":"https://doi.org/10.1158/2767-9764.31378294","title":"Figure 3 from MicroRNA-146a Protects against Hepatocellular Carcinoma through Suppression of CCL5","display_name":"Figure 3 from MicroRNA-146a Protects against Hepatocellular Carcinoma through Suppression of CCL5","publication_year":2026,"publication_date":"2026-02-20","ids":{"openalex":"https://openalex.org/W7130649459","doi":"https://doi.org/10.1158/2767-9764.31378294"},"language":"en","primary_location":{"id":"doi:10.1158/2767-9764.31378294","doi":"https://doi.org/10.1158/2767-9764.31378294","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.31378294","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2767-9764.31378294","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015684556","display_name":"Morgan C. Nelson","orcid":"https://orcid.org/0000-0001-9812-499X","observed_orcids":["https://orcid.org/0000-0001-9812-499X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Morgan C. Nelson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9812-499X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126499622","display_name":"Liam C. O\u2019Malley","orcid":"https://orcid.org/0000-0002-6097-6430","observed_orcids":["https://orcid.org/0000-0002-6097-6430"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liam C. O\u2019Malley","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6097-6430","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054912677","display_name":"Soh-Hyun Lee","orcid":"https://orcid.org/0000-0001-6620-8961","observed_orcids":["https://orcid.org/0000-0001-6620-8961"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Soh-Hyun Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6620-8961","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050309027","display_name":"Kaylyn M. Bauer","orcid":"https://orcid.org/0000-0002-5498-9083","observed_orcids":["https://orcid.org/0000-0002-5498-9083"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kaylyn M. Bauer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5498-9083","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001363655","display_name":"Arevik Ghazaryan","orcid":"https://orcid.org/0000-0002-4718-4164","observed_orcids":["https://orcid.org/0000-0002-4718-4164"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arevik Ghazaryan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4718-4164","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076077312","display_name":"William Weihao Tang","orcid":"https://orcid.org/0000-0001-7036-6460","observed_orcids":["https://orcid.org/0000-0001-7036-6460"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William W. Tang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7036-6460","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050556235","display_name":"Chad Hilton Vansant-Webb","orcid":"https://orcid.org/0000-0001-8478-9317","observed_orcids":["https://orcid.org/0000-0001-8478-9317"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chad VanSant-Webb","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8478-9317","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043633789","display_name":"Van B. Tran","orcid":"https://orcid.org/0009-0008-2327-2152","observed_orcids":["https://orcid.org/0009-0008-2327-2152"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Van B. Tran","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-2327-2152","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042070551","display_name":"Colton J. Hernandez","orcid":"https://orcid.org/0009-0001-9641-953X","observed_orcids":["https://orcid.org/0009-0001-9641-953X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Colton Hernandez","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-9641-953X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116240892","display_name":"Ben Battistone","orcid":"https://orcid.org/0000-0001-7039-3346","observed_orcids":["https://orcid.org/0000-0001-7039-3346"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ben Battistone","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7039-3346","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116240891","display_name":"Amber Thibeaux","orcid":"https://orcid.org/0009-0000-5698-5468","observed_orcids":["https://orcid.org/0009-0000-5698-5468"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amber Thibeaux","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-5698-5468","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064730632","display_name":"June L. Round","orcid":"https://orcid.org/0000-0002-7158-9874","observed_orcids":["https://orcid.org/0000-0002-7158-9874"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"June L. Round","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7158-9874","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078476145","display_name":"Micah John Drummond","orcid":"https://orcid.org/0000-0001-5961-8890","observed_orcids":["https://orcid.org/0000-0001-5961-8890"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Micah J. Drummond","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5961-8890","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083982458","display_name":"H. Atakan Ekiz","orcid":"https://orcid.org/0000-0001-7718-6841","observed_orcids":["https://orcid.org/0000-0001-7718-6841"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Atakan Ekiz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7718-6841","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016759423","display_name":"Kimberley Jane Evason","orcid":"https://orcid.org/0000-0002-0471-2473","observed_orcids":["https://orcid.org/0000-0002-0471-2473"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kimberley J. Evason","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0471-2473","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072138736","display_name":"Warren P. Voth","orcid":"https://orcid.org/0000-0003-0632-6979","observed_orcids":["https://orcid.org/0000-0003-0632-6979"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Warren P. Voth","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0632-6979","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5035059671","display_name":"Ryan M. O\u2019Connell","orcid":"https://orcid.org/0000-0003-0860-1401","observed_orcids":["https://orcid.org/0000-0003-0860-1401"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryan M. O\u2019Connell","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0860-1401","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna-146a","display_name":"microRNA-146a","score":0.921999990940094},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8479999899864197},{"id":"https://openalex.org/keywords/ccl5","display_name":"RANTES","score":0.9179999828338623},{"id":"https://openalex.org/keywords/steatohepatitis","display_name":"steatohepatitis","score":0.8659999966621399},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.871999979019165},{"id":"https://openalex.org/keywords/diethylnitrosamine","display_name":"diethylnitrosamine","score":0.7839999794960022},{"id":"https://openalex.org/keywords/hepatocellular-hypertrophy","display_name":"hepatocyte hypertrophy","score":0.8119999766349792},{"id":"https://openalex.org/keywords/steatosis","display_name":"steatosis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/liver-inflammation","display_name":"liver inflammation","score":0.8949999809265137}],"concepts":[{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.8532999753952026},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.6248999834060669},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.5716000199317932},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.570900022983551},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.5410000085830688},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5164999961853027},{"id":"https://openalex.org/C2908578062","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Liver steatosis","level":4,"score":0.49230000376701355},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.48820000886917114},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46560001373291016},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43860000371932983},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.41119998693466187},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4047999978065491},{"id":"https://openalex.org/C4144372","wikidata":"https://www.wikidata.org/wiki/Q675287","display_name":"Magnification","level":2,"score":0.3953000009059906},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36410000920295715},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.3619000017642975},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3440999984741211},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.3327000141143799},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3165999948978424},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.3149999976158142},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.305400013923645},{"id":"https://openalex.org/C2779033008","wikidata":"https://www.wikidata.org/wiki/Q464543","display_name":"Portal vein","level":2,"score":0.2793000042438507},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.25870001316070557},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.2563999891281128}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2767-9764.31378294","doi":"https://doi.org/10.1158/2767-9764.31378294","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.31378294","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2767-9764.31378294","doi":"https://doi.org/10.1158/2767-9764.31378294","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.31378294","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7130641989","https://openalex.org/W7130663935","https://openalex.org/W7130661745","https://openalex.org/W7130653436","https://openalex.org/W7130651008","https://openalex.org/W7130651862","https://openalex.org/W7130643415","https://openalex.org/W7130650229","https://openalex.org/W2397243787","https://openalex.org/W7125601015"],"abstract_inverted_index":{"Steatohepatitis":[0],"in":[1,83],"nontumor":[2],"regions":[3],"of":[4,31,38,58,128],"DEN-treated":[5],"WT":[6,13,42],"and":[7,29,34,62,76,95,100,134,151,181,196],"miR-146a\u2212/\u2212":[8],"female":[9],"mouse":[10,14,43],"livers.":[11],"A,":[12],"liver,":[15,24,44],"showing":[16,25,45,55],"no":[17],"significant":[18],"steatosis,":[19],"hypertrophy,":[20,132],"or":[21],"inflammation.":[22],"B,miR-146a\u2212/\u2212":[23],"macrovesicular":[26],"steatosis":[27,33,69,135],"(arrows)":[28],"zones":[30],"microvesicular":[32,68],"hypertrophy":[35],"(lower":[36],"right":[37],"dashed":[39],"line).":[40],"C,":[41],"a":[46,116,126],"central":[47],"vein":[48],"with":[49,119],"surrounding":[50],"unremarkable":[51],"hepatocytes.":[52],"D,miR-146a\u2212/\u2212":[53],"genotype,":[54],"two":[56],"clusters":[57],"inflammatory":[59],"cells":[60],"(circled)":[61],"hypertrophy.":[63],"Some":[64],"hypertrophied":[65],"hepatocytes":[66,82],"contain":[67],"(arrowheads),":[70],"whereas":[71],"others":[72],"have":[73],"rarified":[74],"cytoplasm":[75],"Mallory\u2013Denk":[77],"bodies":[78],"similar":[79],"to":[80],"ballooned":[81],"human":[84],"patients":[85],"(arrow).":[86],"H&E":[87],"stains.":[88],"Scale":[89],"bars":[90,198],"are":[91],"40":[92],"\u03bcm.":[93],"A":[94],"B,":[96],"Magnification":[97,102],"20\u00d7.":[98],"C":[99],"D,":[101],"40\u00d7.":[103],"E,":[104],"Non-alcoholic":[105],"fatty":[106],"liver":[107],"disease":[108],"activity":[109],"scores":[110],"(NAS).":[111],"Scores":[112],"were":[113],"calculated":[114],"on":[115],"nine-point":[117],"scale":[118],"the":[120],"nine":[121],"points":[122,192],"being":[123],"derived":[124],"from":[125],"sum":[127],"these":[129],"measurements:":[130],"hepatocyte":[131],"inflammation,":[133],"using":[136],"an":[137],"established":[138],"scoring":[139],"system":[140],"(52).":[141],"F,":[142],"Inflammation":[143],"score":[144,174],"(Fisher\u2019s":[145,175],"exact":[146,176],"test,":[147,177],"separated":[148,178],"between":[149,179],"0\u20132":[150,180],"3).":[152,182],"G,":[153],"Fat":[154],"cores:":[155],"0":[156],"\u2264":[157],"5%":[158],"fat;":[159,163,167],"1":[160],"=":[161,165],"5%\u201333%":[162],"2":[164],"33%\u201366%":[166],"3":[168],"\u2265":[169],"66%":[170],"fat.":[171],"H,":[172],"Hypertrophy":[173],"The":[183],"data":[184],"represent":[185],"three":[186],"experiments.":[187],"Bar":[188],"chart":[189],"(E)":[190],"displays":[191],"representing":[193,199],"individual":[194],"mice":[195],"error":[197],"mean":[200],"\u00b1":[201],"SEM.":[202],"*,":[203],"P":[204,208],"<":[205,209],"0.05;":[206],"**,":[207],"0.01.":[210]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-02-20T00:00:00"}
