{"id":"https://openalex.org/W7130645280","doi":"https://doi.org/10.1016/j.jbc.2026.111304","title":"Single-cell insights into cisplatin resistance mechanisms in bladder cancer tumor microenvironment","display_name":"Single-cell insights into cisplatin resistance mechanisms in bladder cancer tumor microenvironment","publication_year":2026,"publication_date":"2026-02-20","ids":{"openalex":"https://openalex.org/W7130645280","doi":"https://doi.org/10.1016/j.jbc.2026.111304","pmid":"https://pubmed.ncbi.nlm.nih.gov/41724379","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13092012"},"language":"en","primary_location":{"id":"doi:10.1016/j.jbc.2026.111304","doi":"https://doi.org/10.1016/j.jbc.2026.111304","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jbc.2026.111304","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.jbc.2026.111304","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000772598","display_name":"Linfei Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104616","display_name":"Taizhou Municipal Hospital","ror":"https://ror.org/027gw7s27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210104616"]},{"id":"https://openalex.org/I4210149412","display_name":"Second Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/047aw1y82","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149412"]},{"id":"https://openalex.org/I4405281598","display_name":"Taizhou University","ror":"https://ror.org/04m19xd94","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405281598"]},{"id":"https://openalex.org/I82760581","display_name":"Taizhou University","ror":"https://ror.org/04fzhyx73","country_code":"CN","type":"education","lineage":["https://openalex.org/I82760581"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linfei Xu","raw_affiliation_strings":["Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China; Department of Urology, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China; Department of Urology, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang, China","institution_ids":["https://openalex.org/I4210104616","https://openalex.org/I4210149412","https://openalex.org/I4405281598","https://openalex.org/I82760581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126450732","display_name":"Yongfeng Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104616","display_name":"Taizhou Municipal Hospital","ror":"https://ror.org/027gw7s27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210104616"]},{"id":"https://openalex.org/I4405281598","display_name":"Taizhou University","ror":"https://ror.org/04m19xd94","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405281598"]},{"id":"https://openalex.org/I82760581","display_name":"Taizhou University","ror":"https://ror.org/04fzhyx73","country_code":"CN","type":"education","lineage":["https://openalex.org/I82760581"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongfeng Lin","raw_affiliation_strings":["Department of Urology, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang, China","institution_ids":["https://openalex.org/I4210104616","https://openalex.org/I4405281598","https://openalex.org/I82760581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110982781","display_name":"Guanyun Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104616","display_name":"Taizhou Municipal Hospital","ror":"https://ror.org/027gw7s27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210104616"]},{"id":"https://openalex.org/I4405281598","display_name":"Taizhou University","ror":"https://ror.org/04m19xd94","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405281598"]},{"id":"https://openalex.org/I82760581","display_name":"Taizhou University","ror":"https://ror.org/04fzhyx73","country_code":"CN","type":"education","lineage":["https://openalex.org/I82760581"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guanyun Shi","raw_affiliation_strings":["Department of Urology, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang, China","institution_ids":["https://openalex.org/I4210104616","https://openalex.org/I4405281598","https://openalex.org/I82760581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126514243","display_name":"Liming Zhang","orcid":"https://orcid.org/0009-0008-6206-257X","observed_orcids":["https://orcid.org/0009-0008-6206-257X"]},"institutions":[{"id":"https://openalex.org/I4210104616","display_name":"Taizhou Municipal Hospital","ror":"https://ror.org/027gw7s27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210104616"]},{"id":"https://openalex.org/I4405281598","display_name":"Taizhou University","ror":"https://ror.org/04m19xd94","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405281598"]},{"id":"https://openalex.org/I82760581","display_name":"Taizhou University","ror":"https://ror.org/04fzhyx73","country_code":"CN","type":"education","lineage":["https://openalex.org/I82760581"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liming Zhang","raw_affiliation_strings":["Department of Urology, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang, China"],"raw_orcid":"https://orcid.org/0009-0008-6206-257X","affiliations":[{"raw_affiliation_string":"Department of Urology, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang, China","institution_ids":["https://openalex.org/I4210104616","https://openalex.org/I4405281598","https://openalex.org/I82760581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110982782","display_name":"Xingzhang Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104616","display_name":"Taizhou Municipal Hospital","ror":"https://ror.org/027gw7s27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210104616"]},{"id":"https://openalex.org/I4405281598","display_name":"Taizhou University","ror":"https://ror.org/04m19xd94","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405281598"]},{"id":"https://openalex.org/I82760581","display_name":"Taizhou University","ror":"https://ror.org/04fzhyx73","country_code":"CN","type":"education","lineage":["https://openalex.org/I82760581"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingzhang Lin","raw_affiliation_strings":["Department of Urology, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang, China","institution_ids":["https://openalex.org/I4210104616","https://openalex.org/I4405281598","https://openalex.org/I82760581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5126477347","display_name":"Tao Zhang","orcid":"https://orcid.org/0009-0009-9021-5163","observed_orcids":["https://orcid.org/0009-0009-9021-5163"]},"institutions":[{"id":"https://openalex.org/I4210149412","display_name":"Second Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/047aw1y82","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149412"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tao Zhang","raw_affiliation_strings":["Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China. Electronic address: zhangtao@ahmu.edu.cn"],"raw_orcid":"https://orcid.org/0009-0009-9021-5163","affiliations":[{"raw_affiliation_string":"Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China. Electronic address: zhangtao@ahmu.edu.cn","institution_ids":["https://openalex.org/I4210149412"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5126477347"],"corresponding_institution_ids":["https://openalex.org/I4210149412"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":10.1376,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.97096992,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"302","issue":"5","first_page":"111304","last_page":"111304"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cisplatin-resistance","display_name":"cisplatin resistance","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":1.0},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.7599999904632568},{"id":"https://openalex.org/keywords/fibroblast-heterogeneity","display_name":"fibroblast heterogeneity","score":0.6340000033378601},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.9559999704360962},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.9169999957084656},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.9819999933242798},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.6790000200271606},{"id":"https://openalex.org/keywords/mif-signaling","display_name":"MIF signaling","score":0.8389999866485596},{"id":"https://openalex.org/keywords/spink1","display_name":"SPINK1","score":0.9679999947547913},{"id":"https://openalex.org/keywords/prognostic-genes","display_name":"prognostic genes","score":0.7850000262260437},{"id":"https://openalex.org/keywords/drug-resistance-mechanisms","display_name":"drug resistance mechanisms","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.7265999913215637},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.6976000070571899},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.6822999715805054},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6585999727249146},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5473999977111816},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5407000184059143},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49410000443458557},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4602999985218048},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.4449000060558319},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.421099990606308},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.39899998903274536},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.398499995470047},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.37689998745918274},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.352400004863739},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3409000039100647},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.33489999175071716},{"id":"https://openalex.org/C104177226","wikidata":"https://www.wikidata.org/wiki/Q15311903","display_name":"Macrophage migration inhibitory factor","level":3,"score":0.32589998841285706},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.32409998774528503},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.32350000739097595},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.31839999556541443},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31779998540878296},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.31619998812675476},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.3138999938964844},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.2935999929904938},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.29109999537467957},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.2858999967575073},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.2711000144481659},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.2687999904155731},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.26489999890327454},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.26190000772476196},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.260699987411499}],"mesh":[{"descriptor_ui":"D000097784","descriptor_name":"Metabolic Reprogramming","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jbc.2026.111304","doi":"https://doi.org/10.1016/j.jbc.2026.111304","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jbc.2026.111304","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:41724379","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41724379","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13092012","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41724379/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.jbc.2026.111304","doi":"https://doi.org/10.1016/j.jbc.2026.111304","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jbc.2026.111304","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7659830115","display_name":null,"funder_award_id":"20ywa33","funder_id":"https://openalex.org/F4320327078","funder_display_name":"Taizhou Municipal Science and Technology Bureau"},{"id":"https://openalex.org/G8243262197","display_name":null,"funder_award_id":"23ywa40","funder_id":"https://openalex.org/F4320327078","funder_display_name":"Taizhou Municipal Science and Technology Bureau"}],"funders":[{"id":"https://openalex.org/F4320327078","display_name":"Taizhou Municipal Science and Technology Bureau","ror":"https://ror.org/041fzeq08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W1991942986","https://openalex.org/W2011810742","https://openalex.org/W2028382049","https://openalex.org/W2155104522","https://openalex.org/W2328671688","https://openalex.org/W2566679774","https://openalex.org/W2607368673","https://openalex.org/W2792106006","https://openalex.org/W2794127400","https://openalex.org/W2800755480","https://openalex.org/W2884568086","https://openalex.org/W2900499839","https://openalex.org/W2915514153","https://openalex.org/W2953204393","https://openalex.org/W2967597008","https://openalex.org/W2969356959","https://openalex.org/W3000620951","https://openalex.org/W3025152065","https://openalex.org/W3029931347","https://openalex.org/W3030131298","https://openalex.org/W3048549881","https://openalex.org/W3087505378","https://openalex.org/W3112082337","https://openalex.org/W3134746059","https://openalex.org/W3164591849","https://openalex.org/W3176769346","https://openalex.org/W3184423296","https://openalex.org/W3196616315","https://openalex.org/W3208584923","https://openalex.org/W3209852568","https://openalex.org/W3216238012","https://openalex.org/W4210287286","https://openalex.org/W4210472745","https://openalex.org/W4214728644","https://openalex.org/W4220962758","https://openalex.org/W4223454008","https://openalex.org/W4283652726","https://openalex.org/W4285085581","https://openalex.org/W4285152828","https://openalex.org/W4286213464","https://openalex.org/W4289861103","https://openalex.org/W4292427809","https://openalex.org/W4309940896","https://openalex.org/W4311503274","https://openalex.org/W4313551956","https://openalex.org/W4318478217","https://openalex.org/W4319298089","https://openalex.org/W4321502881","https://openalex.org/W4383341285","https://openalex.org/W4383753030","https://openalex.org/W4385563827","https://openalex.org/W4386139118","https://openalex.org/W4386591878","https://openalex.org/W4387733101","https://openalex.org/W4387959713","https://openalex.org/W4389266107","https://openalex.org/W4389892866","https://openalex.org/W4390837922","https://openalex.org/W4391022958","https://openalex.org/W4391151161","https://openalex.org/W4391926249","https://openalex.org/W4391979406","https://openalex.org/W4392058728","https://openalex.org/W4392348302","https://openalex.org/W4392660182","https://openalex.org/W4394875907","https://openalex.org/W4394925465","https://openalex.org/W4396574532","https://openalex.org/W4396979311","https://openalex.org/W4400464193","https://openalex.org/W4400819824","https://openalex.org/W4401892241","https://openalex.org/W4401951636","https://openalex.org/W4402231070","https://openalex.org/W4403132941","https://openalex.org/W4403304911","https://openalex.org/W4403778416","https://openalex.org/W4404127744","https://openalex.org/W4404321869","https://openalex.org/W4412521399"],"related_works":["https://openalex.org/W7169919811","https://openalex.org/W4391022958","https://openalex.org/W7155555671","https://openalex.org/W7204772266","https://openalex.org/W7155899698","https://openalex.org/W4414258734","https://openalex.org/W4409632033","https://openalex.org/W6945699267","https://openalex.org/W4406277936","https://openalex.org/W7123770488"],"abstract_inverted_index":{"This":[0],"study":[1,198],"integrates":[2],"single-cell":[3,195],"RNA":[4],"sequencing":[5],"(scRNA-seq)":[6],"with":[7,97],"in":[8,20,214],"vitro":[9],"experimental":[10,197],"validation":[11,142],"to":[12,25,120,177],"elucidate":[13],"the":[14,30,95,113,130,162,180],"molecular":[15,218],"mechanisms":[16],"underlying":[17],"cisplatin":[18,163,178,212],"resistance":[19,156,213],"bladder":[21,146],"cancer":[22,127,147],"(BC)":[23],"and":[24,40,50,63,75,89,104,139,166,196,207,223],"characterize":[26],"cellular":[27],"heterogeneity":[28,56],"within":[29,94],"tumor":[31,172],"microenvironment":[32],"(TME).":[33],"By":[34],"analyzing":[35],"scRNA-seq":[36],"datasets":[37],"from":[38,118],"cisplatin-sensitive":[39,119],"cisplatin-resistant":[41,145],"BC":[42],"samples,":[43],"we":[44],"identified":[45],"key":[46],"resistant":[47,60,86,121,171,201],"cell":[48,87,148,202],"subpopulations":[49],"resistance-associated":[51,134],"signaling":[52,106],"pathways.":[53,78,107],"Notably,":[54],"pronounced":[55],"was":[57,186],"observed":[58],"among":[59],"epithelial":[61],"cells":[62,91,173],"fibroblasts,":[64],"accompanied":[65],"by":[66,188],"extensive":[67],"metabolic":[68,204],"reprogramming":[69,205],"involving":[70],"glycolysis,":[71],"DNA":[72],"damage":[73],"repair,":[74],"drug":[76,224],"metabolism":[77],"Cell\u2013cell":[79],"communication":[80,209],"analysis":[81,110],"revealed":[82],"intensified":[83],"interactions":[84],"between":[85],"subsets":[88],"immune":[90],"or":[92],"fibroblasts":[93,117],"TME,":[96],"significant":[98],"activation":[99],"of":[100,116,133,153],"MIF,":[101],"THBS,":[102],"MHC-II,":[103],"FN1":[105],"Developmental":[108],"trajectory":[109],"further":[111],"demonstrated":[112],"dynamic":[114],"transition":[115],"states.":[122],"Survival":[123],"analyses":[124],"across":[125],"multiple":[126],"types":[128],"confirmed":[129],"prognostic":[131],"relevance":[132],"genes,":[135],"including":[136],"SPINK1,":[137],"PHGR1,":[138],"APOD.":[140],"Functional":[141],"using":[143],"a":[144],"line":[149],"showed":[150],"marked":[151],"upregulation":[152],"SPINK1":[154,158],"following":[155],"induction.":[157],"knockdown":[159],"significantly":[160],"reduced":[161],"IC":[164],"50":[165],"suppressed":[167],"MIF":[168,181,190],"signaling.":[169],"Moreover,":[170],"enhanced":[174],"macrophage":[175],"tolerance":[176],"via":[179],"axis,":[182],"an":[183],"effect":[184],"that":[185],"reversed":[187],"pharmacological":[189],"inhibition.":[191],"Collectively,":[192],"this":[193],"integrated":[194],"reveals":[199],"critical":[200],"subpopulations,":[203],"features,":[206],"intercellular":[208],"networks":[210],"driving":[211],"BC,":[215],"highlighting":[216],"potential":[217],"targets":[219],"for":[220],"therapeutic":[221],"intervention":[222],"development.":[225]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-02-20T00:00:00"}
