{"id":"https://openalex.org/W7130577189","doi":"https://doi.org/10.1016/j.bpj.2025.11.2180","title":"BPS2026 \u2013 Reconsidering native proton channel composition and function: Amyloid precursor protein (APP) is an accessory subunit in Hv1 channels in microglia","display_name":"BPS2026 \u2013 Reconsidering native proton channel composition and function: Amyloid precursor protein (APP) is an accessory subunit in Hv1 channels in microglia","publication_year":2026,"publication_date":"2026-02-01","ids":{"openalex":"https://openalex.org/W7130577189","doi":"https://doi.org/10.1016/j.bpj.2025.11.2180"},"language":"en","primary_location":{"id":"doi:10.1016/j.bpj.2025.11.2180","doi":"https://doi.org/10.1016/j.bpj.2025.11.2180","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bpj.2025.11.2180","pdf_url":null,"source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5126397107","display_name":"Yiwen Ding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yiwen Ding","raw_affiliation_strings":["University of California, Irvine, Irvine, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, Irvine, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043677711","display_name":"Ruiming Zhao","orcid":"https://orcid.org/0000-0002-1329-2773","observed_orcids":["https://orcid.org/0000-0002-1329-2773"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruiming Zhao","raw_affiliation_strings":["Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013504423","display_name":"Mahasweta Nayak","orcid":"https://orcid.org/0000-0001-7404-6309","observed_orcids":["https://orcid.org/0000-0001-7404-6309"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahasweta Nayak","raw_affiliation_strings":["Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":null,"display_name":"Steve A. Goldstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve A. Goldstein","raw_affiliation_strings":["Department of Pediatrics, University of California, Irvine, Irvine, CA, USA","Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, Irvine, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"125","issue":"4","first_page":"348a","last_page":"349a"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.5121999979019165,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.5121999979019165,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.40059998631477356,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.9340000152587891},{"id":"https://openalex.org/keywords/hv1-channel","display_name":"Hv1 channel","score":0.7570000290870667},{"id":"https://openalex.org/keywords/voltage-gated-proton-channel","display_name":"voltage-gated proton channel","score":0.9300000071525574},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9440000057220459},{"id":"https://openalex.org/keywords/auxiliary-subunits","display_name":"auxiliary subunits","score":0.8379999995231628},{"id":"https://openalex.org/keywords/channel-composition","display_name":"channel composition","score":0.5360000133514404},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.7480000257492065},{"id":"https://openalex.org/keywords/ph-homeostasis","display_name":"pH homeostasis","score":0.8349999785423279},{"id":"https://openalex.org/keywords/membrane-potential","display_name":"membrane potential","score":0.7269999980926514},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.6959999799728394},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.6449999809265137},{"id":"https://openalex.org/keywords/c99","display_name":"C99","score":0.652999997138977},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8222000002861023},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.7348999977111816},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.7192999720573425},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5498999953269958},{"id":"https://openalex.org/C3019447875","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid \u03b2","level":3,"score":0.4772999882698059},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.4708000123500824},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45730000734329224},{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.453000009059906},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42899999022483826},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.4239000082015991},{"id":"https://openalex.org/C40231798","wikidata":"https://www.wikidata.org/wiki/Q1333743","display_name":"Composition (language)","level":2,"score":0.39719998836517334},{"id":"https://openalex.org/C54516573","wikidata":"https://www.wikidata.org/wiki/Q2294","display_name":"Proton","level":2,"score":0.36959999799728394},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.26429998874664307},{"id":"https://openalex.org/C3019804061","wikidata":"https://www.wikidata.org/wiki/Q14881255","display_name":"Prion protein","level":3,"score":0.2615000009536743}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.bpj.2025.11.2180","doi":"https://doi.org/10.1016/j.bpj.2025.11.2180","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bpj.2025.11.2180","pdf_url":null,"source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4415479115","https://openalex.org/W7133339266","https://openalex.org/W2049029579","https://openalex.org/W4414925128","https://openalex.org/W4412898264","https://openalex.org/W3192634946","https://openalex.org/W4417410865","https://openalex.org/W3156204327","https://openalex.org/W2487210382","https://openalex.org/W2897363187"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-02-20T00:00:00"}