{"id":"https://openalex.org/W7130539490","doi":"https://doi.org/10.1016/j.bpj.2025.11.2483","title":"BPS2026 \u2013 Modeling simultaneous binding of drugs and sex-steroid hormones to the hERG channel to predict sex-specific arrhythmia risk","display_name":"BPS2026 \u2013 Modeling simultaneous binding of drugs and sex-steroid hormones to the hERG channel to predict sex-specific arrhythmia risk","publication_year":2026,"publication_date":"2026-02-01","ids":{"openalex":"https://openalex.org/W7130539490","doi":"https://doi.org/10.1016/j.bpj.2025.11.2483"},"language":"en","primary_location":{"id":"doi:10.1016/j.bpj.2025.11.2483","doi":"https://doi.org/10.1016/j.bpj.2025.11.2483","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bpj.2025.11.2483","pdf_url":null,"source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5119756824","display_name":"Sophia Brunkow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sophia A. Brunkow","raw_affiliation_strings":["Department of Physiology and Membrane Biology, University of California, Davis, Davis, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Membrane Biology, University of California, Davis, Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126429575","display_name":"Jiaying Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiaying Yan","raw_affiliation_strings":["Department of Chemistry, University of California, Davis, Davis, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Davis, Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067766967","display_name":"Junko Kurokawa","orcid":"https://orcid.org/0000-0002-9098-0908","observed_orcids":["https://orcid.org/0000-0002-9098-0908"]},"institutions":[{"id":"https://openalex.org/I1298590031","display_name":"Shizuoka University","ror":"https://ror.org/01w6wtk13","country_code":"JP","type":"education","lineage":["https://openalex.org/I1298590031"]},{"id":"https://openalex.org/I150240954","display_name":"University of Shizuoka","ror":"https://ror.org/04rvw0k47","country_code":"JP","type":"education","lineage":["https://openalex.org/I150240954"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junko Kurokawa","raw_affiliation_strings":["Department of Bio-Informational Pharmacology, University of Shizuoka School of Pharmaceutical Sciences, Shizuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bio-Informational Pharmacology, University of Shizuoka School of Pharmaceutical Sciences, Shizuoka, Japan","institution_ids":["https://openalex.org/I1298590031","https://openalex.org/I150240954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031310158","display_name":"Igor V. Vorobyov","orcid":"https://orcid.org/0000-0002-4767-5297","observed_orcids":["https://orcid.org/0000-0002-4767-5297"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Igor V. Vorobyov","raw_affiliation_strings":["Department of Physiology and Membrane Biology, University of California, Davis, Davis, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Membrane Biology, University of California, Davis, Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026366656","display_name":"Kyle C. Rouen","orcid":"https://orcid.org/0000-0001-8684-0614","observed_orcids":["https://orcid.org/0000-0001-8684-0614"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle C. Rouen","raw_affiliation_strings":["Department of Physiology and Membrane Biology, University of California, Davis, Davis, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Membrane Biology, University of California, Davis, Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"125","issue":"4","first_page":"405a","last_page":"406a"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/herg-channel","display_name":"hERG","score":0.9700000286102295},{"id":"https://openalex.org/keywords/drug-induced-arrhythmia","display_name":"drug-induced arrhythmia","score":0.7829999923706055},{"id":"https://openalex.org/keywords/qt-interval-prolongation","display_name":"QT prolongation","score":0.8169999718666077},{"id":"https://openalex.org/keywords/sex-hormones","display_name":"sex hormones","score":0.8880000114440918},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9319999814033508},{"id":"https://openalex.org/keywords/estrone","display_name":"estrone","score":0.6610000133514404},{"id":"https://openalex.org/keywords/ethinyl-estradiol","display_name":"ethinyl estradiol","score":0.9909999966621399},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.9580000042915344},{"id":"https://openalex.org/keywords/dihydrotestosterone","display_name":"dihydrotestosterone","score":0.9739999771118164},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.9950000047683716},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.671999990940094},{"id":"https://openalex.org/keywords/cardiac-repolarization","display_name":"cardiac repolarization","score":0.8679999709129333}],"concepts":[{"id":"https://openalex.org/C2779362680","wikidata":"https://www.wikidata.org/wiki/Q905000","display_name":"hERG","level":3,"score":0.991599977016449},{"id":"https://openalex.org/C2778656385","wikidata":"https://www.wikidata.org/wiki/Q414986","display_name":"Estrone","level":3,"score":0.713699996471405},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6103000044822693},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5976999998092651},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.5857999920845032},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5056999921798706},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.4636000096797943},{"id":"https://openalex.org/C2779881493","wikidata":"https://www.wikidata.org/wiki/Q411054","display_name":"Dihydrotestosterone","level":4,"score":0.43790000677108765},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.42289999127388},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40689998865127563},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.3831999897956848},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.3553999960422516},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3450999855995178},{"id":"https://openalex.org/C79743260","wikidata":"https://www.wikidata.org/wiki/Q2882301","display_name":"Cardiac action potential","level":4,"score":0.3352999985218048},{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.33239999413490295},{"id":"https://openalex.org/C2988455589","wikidata":"https://www.wikidata.org/wiki/Q189331","display_name":"Cardiac arrhythmia","level":3,"score":0.31130000948905945},{"id":"https://openalex.org/C2780339425","wikidata":"https://www.wikidata.org/wiki/Q412496","display_name":"Quinidine","level":2,"score":0.3077000081539154},{"id":"https://openalex.org/C2779703243","wikidata":"https://www.wikidata.org/wiki/Q653924","display_name":"Long QT syndrome","level":3,"score":0.2985999882221222},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.2939999997615814},{"id":"https://openalex.org/C2778457506","wikidata":"https://www.wikidata.org/wiki/Q7234689","display_name":"Potassium channel blocker","level":3,"score":0.26489999890327454},{"id":"https://openalex.org/C30092816","wikidata":"https://www.wikidata.org/wiki/Q419613","display_name":"Sex hormone-binding globulin","level":4,"score":0.25859999656677246}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.bpj.2025.11.2483","doi":"https://doi.org/10.1016/j.bpj.2025.11.2483","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bpj.2025.11.2483","pdf_url":null,"source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2791350588","https://openalex.org/W4380795613","https://openalex.org/W3129927991","https://openalex.org/W4319928918","https://openalex.org/W2515505179","https://openalex.org/W4210984434","https://openalex.org/W4319936497","https://openalex.org/W2615431503","https://openalex.org/W4407494876","https://openalex.org/W3005330524"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-26T11:51:55.731654","created_date":"2026-02-20T00:00:00"}