{"id":"https://openalex.org/W7130516277","doi":"https://doi.org/10.25259/ajc_743_2025","title":"Synergistic impact of silver on anticancer potential of doxorubicin-loaded chitosan-coated amino-functionalized silica nanoparticles","display_name":"Synergistic impact of silver on anticancer potential of doxorubicin-loaded chitosan-coated amino-functionalized silica nanoparticles","publication_year":2026,"publication_date":"2026-02-17","ids":{"openalex":"https://openalex.org/W7130516277","doi":"https://doi.org/10.25259/ajc_743_2025"},"language":"en","primary_location":{"id":"doi:10.25259/ajc_743_2025","doi":"https://doi.org/10.25259/ajc_743_2025","is_oa":true,"landing_page_url":"https://doi.org/10.25259/ajc_743_2025","pdf_url":"https://arabjchem.org/content/184/2026/0/1/pdf/AJC_743_2025.pdf","source":{"id":"https://openalex.org/S2357026","display_name":"Arabian Journal of Chemistry","issn_l":"1878-5352","issn":["1878-5352","1878-5379"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arabian Journal of Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://arabjchem.org/content/184/2026/0/1/pdf/AJC_743_2025.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047762566","display_name":"Noha Said Bedowr","orcid":"https://orcid.org/0000-0002-5440-6319","observed_orcids":["https://orcid.org/0000-0002-5440-6319"]},"institutions":[{"id":"https://openalex.org/I23075662","display_name":"Taibah University","ror":"https://ror.org/01xv1nn60","country_code":"SA","type":"education","lineage":["https://openalex.org/I23075662"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Noha Said Bedowr","raw_affiliation_strings":["Department of Chemistry, College of Science, Taibah University, Yanbu Governorate, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, College of Science, Taibah University, Yanbu Governorate, Saudi Arabia","institution_ids":["https://openalex.org/I23075662"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5047762566"],"corresponding_institution_ids":["https://openalex.org/I23075662"],"apc_list":{"value":1490,"currency":"USD","value_usd":1490},"apc_paid":{"value":1490,"currency":"USD","value_usd":1490},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06494868,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":null,"first_page":"7432025","last_page":"7432025"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9599999785423279},{"id":"https://openalex.org/keywords/silver-nanoparticles","display_name":"silver nanoparticles","score":0.8960000276565552},{"id":"https://openalex.org/keywords/chitosan-coating","display_name":"chitosan coating","score":0.9350000023841858},{"id":"https://openalex.org/keywords/synergistic-drug-delivery","display_name":"synergistic drug delivery","score":0.6809999942779541},{"id":"https://openalex.org/keywords/ph-responsive-drug-release","display_name":"pH-responsive drug release","score":0.8420000076293945},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.7049999833106995},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8650000095367432},{"id":"https://openalex.org/keywords/drug-encapsulation","display_name":"drug encapsulation","score":0.6370000243186951},{"id":"https://openalex.org/keywords/hybrid-nanocarriers","display_name":"hybrid nanocarriers","score":0.7760000228881836},{"id":"https://openalex.org/keywords/co-condensation-synthesis","display_name":"co-condensation synthesis","score":0.6169999837875366},{"id":"https://openalex.org/keywords/ctab-template","display_name":"CTAB template","score":0.5120000243186951}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9031999707221985},{"id":"https://openalex.org/C60100273","wikidata":"https://www.wikidata.org/wiki/Q902806","display_name":"Thermogravimetric analysis","level":2,"score":0.892300009727478},{"id":"https://openalex.org/C2777432599","wikidata":"https://www.wikidata.org/wiki/Q421458","display_name":"Tetraethyl orthosilicate","level":2,"score":0.7652000188827515},{"id":"https://openalex.org/C59061564","wikidata":"https://www.wikidata.org/wiki/Q7783071","display_name":"Thermal stability","level":2,"score":0.6309000253677368},{"id":"https://openalex.org/C39519442","wikidata":"https://www.wikidata.org/wiki/Q904893","display_name":"Differential scanning calorimetry","level":2,"score":0.6261000037193298},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.6097000241279602},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.6025999784469604},{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.5702999830245972},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5695000290870667},{"id":"https://openalex.org/C160892712","wikidata":"https://www.wikidata.org/wiki/Q901559","display_name":"Fourier transform infrared spectroscopy","level":2,"score":0.47940000891685486},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.45410001277923584},{"id":"https://openalex.org/C31499863","wikidata":"https://www.wikidata.org/wiki/Q905762","display_name":"Silver nanoparticle","level":3,"score":0.40880000591278076},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.39959999918937683},{"id":"https://openalex.org/C26771246","wikidata":"https://www.wikidata.org/wiki/Q321095","display_name":"Scanning electron microscope","level":2,"score":0.39660000801086426},{"id":"https://openalex.org/C2780472540","wikidata":"https://www.wikidata.org/wiki/Q207442","display_name":"Silver nitrate","level":2,"score":0.3749000132083893},{"id":"https://openalex.org/C2779801337","wikidata":"https://www.wikidata.org/wiki/Q21206420","display_name":"Orthosilicate","level":3,"score":0.3361000120639801},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3158000111579895},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.31060001254081726},{"id":"https://openalex.org/C129446986","wikidata":"https://www.wikidata.org/wiki/Q542419","display_name":"Thermal analysis","level":3,"score":0.29739999771118164},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.2727000117301941},{"id":"https://openalex.org/C3018146709","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Anticancer drug","level":3,"score":0.26600000262260437},{"id":"https://openalex.org/C138631740","wikidata":"https://www.wikidata.org/wiki/Q967847","display_name":"Nanomaterials","level":2,"score":0.26260000467300415},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2565999925136566}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.25259/ajc_743_2025","doi":"https://doi.org/10.25259/ajc_743_2025","is_oa":true,"landing_page_url":"https://doi.org/10.25259/ajc_743_2025","pdf_url":"https://arabjchem.org/content/184/2026/0/1/pdf/AJC_743_2025.pdf","source":{"id":"https://openalex.org/S2357026","display_name":"Arabian Journal of Chemistry","issn_l":"1878-5352","issn":["1878-5352","1878-5379"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arabian Journal of Chemistry","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.25259/ajc_743_2025","doi":"https://doi.org/10.25259/ajc_743_2025","is_oa":true,"landing_page_url":"https://doi.org/10.25259/ajc_743_2025","pdf_url":"https://arabjchem.org/content/184/2026/0/1/pdf/AJC_743_2025.pdf","source":{"id":"https://openalex.org/S2357026","display_name":"Arabian Journal of Chemistry","issn_l":"1878-5352","issn":["1878-5352","1878-5379"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arabian Journal of Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.5332285761833191,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321161","display_name":"Taibah University","ror":"https://ror.org/01xv1nn60"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7130516277.pdf","grobid_xml":"https://content.openalex.org/works/W7130516277.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1997003659","https://openalex.org/W2042956841","https://openalex.org/W2063634486","https://openalex.org/W2089890124","https://openalex.org/W2098343793","https://openalex.org/W2113379255","https://openalex.org/W2590677577","https://openalex.org/W2886255010","https://openalex.org/W2999765484","https://openalex.org/W3023473415","https://openalex.org/W3037723202","https://openalex.org/W3048065236","https://openalex.org/W3082128547","https://openalex.org/W3136238114","https://openalex.org/W3154788611","https://openalex.org/W3182799000","https://openalex.org/W4391579420","https://openalex.org/W4394869488","https://openalex.org/W4399155691","https://openalex.org/W4399653159","https://openalex.org/W4400231044","https://openalex.org/W4404436738","https://openalex.org/W4404818586","https://openalex.org/W4405284819","https://openalex.org/W4405515087","https://openalex.org/W4406199392","https://openalex.org/W4407001957","https://openalex.org/W4407018220","https://openalex.org/W4408225551","https://openalex.org/W4411847116","https://openalex.org/W4412640965","https://openalex.org/W4413526920"],"related_works":[],"abstract_inverted_index":{"This":[0],"study":[1],"investigates":[2],"the":[3,9,110,121,175],"synergistic":[4],"effect":[5],"of":[6,12,113,134,141,148,177],"silver":[7,49,52],"on":[8],"anticancer":[10,124,162],"activity":[11,163],"doxorubicin":[13],"(DOX)":[14],"encapsulated":[15],"in":[16,58,152],"silver-integrated":[17],"amino-functionalized":[18],"silica":[19],"nanoparticles":[20,81],"(AFS-NPs)":[21],"coated":[22],"with":[23,40],"chitosan":[24,68],"(DOX@AFS-NPs-Ag-CS).":[25],"AFS-NPs":[26],"were":[27],"synthesized":[28],"by":[29,48,67,73],"a":[30,45,129],"co-condensation":[31],"approach":[32],"using":[33],"tetraethyl":[34],"orthosilicate":[35],"(TEOS)":[36],"and":[37,65,96,104,115,136,183],"3-aminopropyltriethoxysilane":[38],"(APTES)":[39],"cetyltrimethylammonium":[41],"chloride":[42],"(CTAC)":[43],"as":[44],"template,":[46],"followed":[47],"incorporation":[50],"through":[51],"nitrate":[53],"(AgNO":[54],"3":[55],")":[56],"treatment":[57],"dark":[59],"conditions.":[60,157],"Doxorubicin":[61],"was":[62],"subsequently":[63],"loaded":[64],"stabilized":[66],"(CS)":[69],"coating.":[70],"Morphological":[71],"analysis":[72,94],"scanning":[74,98],"electron":[75],"microscopy":[76],"(SEM)":[77],"confirmed":[78],"spherical,":[79],"uniform":[80],"(\u223c900nm),":[82],"while":[83],"X-ray":[84],"diffraction":[85],"(XRD),":[86],"Fourier":[87],"transform":[88],"infrared":[89],"(FTIR),":[90],"UV-Visible":[91],"spectrophotometry,":[92],"thermogravimetric":[93],"(TGA),":[95],"differential":[97],"calorimetry":[99],"(DSC)":[100],"verified":[101],"successful":[102],"synthesis":[103],"drug":[105,130],"encapsulation.":[106],"Thermal":[107],"stability":[108,119],"enabled":[109],"physical":[111],"encapsulation":[112],"DOX":[114],"conferred":[116],"suitable":[117],"thermal":[118],"to":[120],"formulation":[122,127],"for":[123,181],"studies.":[125],"The":[126],"showed":[128],"loading":[131],"content":[132],"(LC)":[133],"17%":[135],"an":[137],"entrapment":[138],"efficiency":[139],"(EE)":[140],"84%.":[142],"Release":[143],"studies":[144],"revealed":[145],"pH-responsive":[146],"release":[147],"DOX,":[149],"achieving":[150],"\u223c94.2%":[151],"24":[153],"h":[154],"under":[155],"acidic":[156],"Importantly,":[158],"DOX@AFS-NPs-Ag-CS":[159],"demonstrated":[160],"significant":[161],"(60.18%":[164],"inhibition)":[165],"against":[166],"Hep":[167],"G2":[168],"cancer":[169,185],"cell":[170],"lines.":[171],"These":[172],"results":[173],"highlight":[174],"potential":[176],"this":[178],"hybrid":[179],"nanocarrier":[180],"effective":[182],"targeted":[184],"therapy.":[186]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-02-19T00:00:00"}