{"id":"https://openalex.org/W7130402015","doi":"https://doi.org/10.1002/ajmg.b.70011","title":"Patient Perspectives on Psychiatric Polygenic Risk Scores in Reproductive Decision\u2010Making and Polygenic Embryo Screening","display_name":"Patient Perspectives on Psychiatric Polygenic Risk Scores in Reproductive Decision\u2010Making and Polygenic Embryo Screening","publication_year":2026,"publication_date":"2026-02-18","ids":{"openalex":"https://openalex.org/W7130402015","doi":"https://doi.org/10.1002/ajmg.b.70011","pmid":"https://pubmed.ncbi.nlm.nih.gov/41705312","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13118807"},"language":"en","primary_location":{"id":"doi:10.1002/ajmg.b.70011","doi":"https://doi.org/10.1002/ajmg.b.70011","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ajmg.b.70011","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajmg.b.70011","source":{"id":"https://openalex.org/S2764647521","display_name":"American Journal of Medical Genetics Part B Neuropsychiatric Genetics","issn_l":"1552-4841","issn":["1552-4841","1552-485X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Medical Genetics Part B: Neuropsychiatric Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajmg.b.70011","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100086962","display_name":"Lauren A. Ginn","orcid":"https://orcid.org/0009-0001-5548-9275","observed_orcids":["https://orcid.org/0009-0001-5548-9275"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren A. Ginn","raw_affiliation_strings":["Center for Medical Ethics and Health Policy Baylor College of Medicine  Houston Texas USA"],"raw_orcid":"https://orcid.org/0009-0001-5548-9275","affiliations":[{"raw_affiliation_string":"Center for Medical Ethics and Health Policy Baylor College of Medicine  Houston Texas USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015283486","display_name":"Amanda R. Merner","orcid":"https://orcid.org/0000-0001-6450-170X","observed_orcids":["https://orcid.org/0000-0001-6450-170X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda R. Merner","raw_affiliation_strings":["Department of Neurosurgery Massachusetts General Hospital  Boston Massachusetts USA","Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA","Harvard Medical School  Boston Massachusetts USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Massachusetts General Hospital  Boston Massachusetts USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Medical School  Boston Massachusetts USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100086961","display_name":"Page M. Trotter","orcid":"https://orcid.org/0000-0003-0307-5465","observed_orcids":["https://orcid.org/0000-0003-0307-5465"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Page M. Trotter","raw_affiliation_strings":["Center for Medical Ethics and Health Policy Baylor College of Medicine  Houston Texas USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Medical Ethics and Health Policy Baylor College of Medicine  Houston Texas USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070050058","display_name":"Kaitlynn P. Craig","orcid":"https://orcid.org/0000-0002-3723-6880","observed_orcids":["https://orcid.org/0000-0002-3723-6880"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaitlynn P. Craig","raw_affiliation_strings":["Department of Neurosurgery Massachusetts General Hospital  Boston Massachusetts USA","Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA","Harvard Medical School  Boston Massachusetts USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Massachusetts General Hospital  Boston Massachusetts USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Medical School  Boston Massachusetts USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113548907","display_name":"Abigail C. Martinez","orcid":"https://orcid.org/0009-0000-2178-7285","observed_orcids":["https://orcid.org/0009-0000-2178-7285"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abigail C. Martinez","raw_affiliation_strings":["Center for Medical Ethics and Health Policy Baylor College of Medicine  Houston Texas USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Medical Ethics and Health Policy Baylor College of Medicine  Houston Texas USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118507429","display_name":"Ana Lucia Battaglino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana Luc\u00eda Battaglino","raw_affiliation_strings":["Center for Bioethics Harvard Medical School  Boston Massachusetts USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Bioethics Harvard Medical School  Boston Massachusetts USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053967853","display_name":"Dorit Barlevy","orcid":"https://orcid.org/0000-0002-1478-0111","observed_orcids":["https://orcid.org/0000-0002-1478-0111"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dorit Barlevy","raw_affiliation_strings":["Center for Medical Ethics and Health Policy Baylor College of Medicine  Houston Texas USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Medical Ethics and Health Policy Baylor College of Medicine  Houston Texas USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071956762","display_name":"Daphne M. Ayton","orcid":"https://orcid.org/0000-0002-3822-7310","observed_orcids":["https://orcid.org/0000-0002-3822-7310"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daphne M. Ayton","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences Baylor College of Medicine  Houston Texas USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences Baylor College of Medicine  Houston Texas USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027892391","display_name":"Takahiro Soda","orcid":"https://orcid.org/0000-0001-6268-2965","observed_orcids":["https://orcid.org/0000-0001-6268-2965"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takahiro Soda","raw_affiliation_strings":["Center for Autism and Neurodevelopment University of Florida  Gainesville Florida USA","Department of Psychiatry University of Florida  Gainesville Florida USA"],"raw_orcid":"https://orcid.org/0000-0001-6268-2965","affiliations":[{"raw_affiliation_string":"Center for Autism and Neurodevelopment University of Florida  Gainesville Florida USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Psychiatry University of Florida  Gainesville Florida USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089897759","display_name":"Eric A. Storch","orcid":"https://orcid.org/0000-0002-7631-3703","observed_orcids":["https://orcid.org/0000-0002-7631-3703"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric A. Storch","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences Baylor College of Medicine  Houston Texas USA"],"raw_orcid":"https://orcid.org/0000-0002-7631-3703","affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences Baylor College of Medicine  Houston Texas USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024724548","display_name":"Gabriel L\u00e1zaro\u2010Mu\u00f1oz","orcid":"https://orcid.org/0000-0003-1933-9453","observed_orcids":["https://orcid.org/0000-0003-1933-9453"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriel L\u00e1zaro\u2010Mu\u00f1oz","raw_affiliation_strings":["Department of Neurosurgery Massachusetts General Hospital  Boston Massachusetts USA","Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA","Harvard Medical School  Boston Massachusetts USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Massachusetts General Hospital  Boston Massachusetts USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Medical School  Boston Massachusetts USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044108220","display_name":"Stacey Pereira","orcid":"https://orcid.org/0000-0001-6541-3904","observed_orcids":["https://orcid.org/0000-0001-6541-3904"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stacey Pereira","raw_affiliation_strings":["Center for Medical Ethics and Health Policy Baylor College of Medicine  Houston Texas USA"],"raw_orcid":"https://orcid.org/0000-0001-6541-3904","affiliations":[{"raw_affiliation_string":"Center for Medical Ethics and Health Policy Baylor College of Medicine  Houston Texas USA","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5044108220"],"corresponding_institution_ids":["https://openalex.org/I181547552"],"apc_list":{"value":3920,"currency":"USD","value_usd":3920},"apc_paid":{"value":3920,"currency":"USD","value_usd":3920},"fwci":20.3204,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.99202979,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"201","issue":"5","first_page":"338","last_page":"348"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.1785999983549118,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.1785999983549118,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.13609999418258667,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11953","display_name":"Neuroethics, Human Enhancement, Biomedical Innovations","score":0.09139999747276306,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reproductive-decision-making","display_name":"reproductive decision-making","score":0.8889999985694885},{"id":"https://openalex.org/keywords/embryo-selection","display_name":"embryo selection","score":0.625},{"id":"https://openalex.org/keywords/in-vitro-fertilization","display_name":"in vitro fertilization","score":0.8799999952316284},{"id":"https://openalex.org/keywords/family-planning","display_name":"family planning","score":0.9369999766349792},{"id":"https://openalex.org/keywords/patient-perspectives","display_name":"patient perspectives","score":0.8360000252723694},{"id":"https://openalex.org/keywords/stigma","display_name":"stigma","score":0.6299999952316284},{"id":"https://openalex.org/keywords/genetic-risk-disclosure","display_name":"genetic risk disclosure","score":0.4560000002384186},{"id":"https://openalex.org/keywords/mental-disorders","display_name":"mental illness","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.6611999869346619},{"id":"https://openalex.org/C2776674806","wikidata":"https://www.wikidata.org/wiki/Q12135","display_name":"Mental illness","level":3,"score":0.5260999798774719},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47749999165534973},{"id":"https://openalex.org/C507311573","wikidata":"https://www.wikidata.org/wiki/Q3510807","display_name":"Psychiatric assessment","level":2,"score":0.4311000108718872},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.362199991941452},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.3587999939918518},{"id":"https://openalex.org/C2993137441","wikidata":"https://www.wikidata.org/wiki/Q28135712","display_name":"Polygenic risk score","level":5,"score":0.3522999882698059},{"id":"https://openalex.org/C2994403141","wikidata":"https://www.wikidata.org/wiki/Q2976573","display_name":"Psychiatric diagnosis","level":3,"score":0.3434000015258789},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.33550000190734863},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.3228999972343445},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.310699999332428},{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.3018999993801117},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.30000001192092896},{"id":"https://openalex.org/C134362201","wikidata":"https://www.wikidata.org/wiki/Q317309","display_name":"Mental health","level":2,"score":0.29809999465942383},{"id":"https://openalex.org/C121752807","wikidata":"https://www.wikidata.org/wiki/Q1981388","display_name":"Reproductive health","level":3,"score":0.2888999879360199},{"id":"https://openalex.org/C20555606","wikidata":"https://www.wikidata.org/wiki/Q868575","display_name":"Empowerment","level":2,"score":0.28439998626708984},{"id":"https://openalex.org/C2910983944","wikidata":"https://www.wikidata.org/wiki/Q210999","display_name":"Psychiatric units","level":3,"score":0.2784000039100647},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.27250000834465027},{"id":"https://openalex.org/C117376503","wikidata":"https://www.wikidata.org/wiki/Q751093","display_name":"Reproductive success","level":3,"score":0.2644999921321869},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2621000111103058},{"id":"https://openalex.org/C140682164","wikidata":"https://www.wikidata.org/wiki/Q5382718","display_name":"Epidemiology of child psychiatric disorders","level":2,"score":0.26019999384880066},{"id":"https://openalex.org/C2780673598","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic testing","level":2,"score":0.25929999351501465},{"id":"https://openalex.org/C500014431","wikidata":"https://www.wikidata.org/wiki/Q25862","display_name":"Assisted reproductive technology","level":4,"score":0.2581999897956848},{"id":"https://openalex.org/C84201533","wikidata":"https://www.wikidata.org/wiki/Q7256235","display_name":"Psychiatric genetics","level":3,"score":0.25690001249313354}],"mesh":[{"descriptor_ui":"D000096442","descriptor_name":"Genetic Risk Score","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D003657","descriptor_name":"Decision Making","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012098","descriptor_name":"Reproduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020412","descriptor_name":"Multifactorial Inheritance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/ajmg.b.70011","doi":"https://doi.org/10.1002/ajmg.b.70011","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ajmg.b.70011","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajmg.b.70011","source":{"id":"https://openalex.org/S2764647521","display_name":"American Journal of Medical Genetics Part B Neuropsychiatric Genetics","issn_l":"1552-4841","issn":["1552-4841","1552-485X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Medical Genetics Part B: Neuropsychiatric Genetics","raw_type":"journal-article"},{"id":"pmid:41705312","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41705312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13118807","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41705312/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Med Genet B Neuropsychiatr Genet","raw_type":"Text"},{"id":"pmh:oai:digitalcommons.library.tmc.edu:med_ethics-1369","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/med_ethics/382","pdf_url":"https://digitalcommons.library.tmc.edu/context/med_ethics/article/1369/viewcontent/nihms_2164111.pdf","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Center for Medical Ethics and Health Policy Staff Publications","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1002/ajmg.b.70011","doi":"https://doi.org/10.1002/ajmg.b.70011","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ajmg.b.70011","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajmg.b.70011","source":{"id":"https://openalex.org/S2764647521","display_name":"American Journal of Medical Genetics Part B Neuropsychiatric Genetics","issn_l":"1552-4841","issn":["1552-4841","1552-485X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Medical Genetics Part B: Neuropsychiatric Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5375980098","display_name":"Polygenic Risk Scores in Child and Adolescent Psychiatry: Ethical, Clinical, and Legal Implications","funder_award_id":"R01MH128676","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G9000893636","display_name":"2/2 TRANS-ANCESTRY GENOMIC ANALYSIS OF OBSESSIVE COMPULSIVE DISORDER","funder_award_id":"U01MH125062","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320309371","display_name":"International OCD Foundation","ror":"https://ror.org/04f3cbh67"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7130402015.pdf","grobid_xml":"https://content.openalex.org/works/W7130402015.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1967700305","https://openalex.org/W1979290264","https://openalex.org/W1981722146","https://openalex.org/W2005245306","https://openalex.org/W2041390144","https://openalex.org/W2047107520","https://openalex.org/W2075037646","https://openalex.org/W2087216143","https://openalex.org/W2098597355","https://openalex.org/W2114999674","https://openalex.org/W2117217687","https://openalex.org/W2133674686","https://openalex.org/W2138223431","https://openalex.org/W2144247539","https://openalex.org/W2149919973","https://openalex.org/W2164769605","https://openalex.org/W2207583083","https://openalex.org/W2238387778","https://openalex.org/W2345958530","https://openalex.org/W2808275628","https://openalex.org/W2890739253","https://openalex.org/W2899876723","https://openalex.org/W2908499146","https://openalex.org/W2911487850","https://openalex.org/W2950555128","https://openalex.org/W2965054109","https://openalex.org/W2977358733","https://openalex.org/W2995148308","https://openalex.org/W3015631361","https://openalex.org/W3024240210","https://openalex.org/W3028329270","https://openalex.org/W3089846215","https://openalex.org/W3092074878","https://openalex.org/W3094024601","https://openalex.org/W3095207642","https://openalex.org/W3120914834","https://openalex.org/W3121333903","https://openalex.org/W3122905843","https://openalex.org/W3132810618","https://openalex.org/W3152237564","https://openalex.org/W3167631374","https://openalex.org/W3174033603","https://openalex.org/W3177492916","https://openalex.org/W3196246408","https://openalex.org/W3201444946","https://openalex.org/W3207198721","https://openalex.org/W3208645186","https://openalex.org/W4200623875","https://openalex.org/W4282933530","https://openalex.org/W4284668411","https://openalex.org/W4285798513","https://openalex.org/W4289525557","https://openalex.org/W4302945587","https://openalex.org/W4315621773","https://openalex.org/W4319812817","https://openalex.org/W4372342583","https://openalex.org/W4381327186","https://openalex.org/W4390666588","https://openalex.org/W4392111913","https://openalex.org/W4392714828","https://openalex.org/W4394740511","https://openalex.org/W4396629516","https://openalex.org/W4396889112","https://openalex.org/W4400402175","https://openalex.org/W4406442677","https://openalex.org/W4408718186","https://openalex.org/W4411508062"],"related_works":["https://openalex.org/W7214518631","https://openalex.org/W6889651340","https://openalex.org/W4400402175","https://openalex.org/W4407351531","https://openalex.org/W4289525557","https://openalex.org/W4410465357","https://openalex.org/W3112626030","https://openalex.org/W7167642123","https://openalex.org/W4284668411","https://openalex.org/W4247492908"],"abstract_inverted_index":{"Polygenic":[0],"risk":[1,7,156],"scores":[2],"(PRS)":[3],"estimate":[4],"individuals'":[5],"genetic":[6,155],"for":[8,69,75,127,157,178],"developing":[9],"multifactorial":[10],"conditions.":[11,32],"Recent":[12],"genome-wide":[13],"association":[14],"studies":[15],"have":[16],"enabled":[17],"development":[18],"of":[19,30,86,97,118,142,164],"psychiatric":[20,31,44,59,87,100,125,158,170,183],"PRS,":[21],"which":[22],"hold":[23],"potential":[24,112],"to":[25,57,105,138,186],"streamline":[26],"diagnosis":[27],"and":[28,114,132,144],"treatment":[29],"As":[33,182],"individuals":[34],"with":[35,99,154],"mental":[36],"illness":[37],"often":[38],"identify":[39],"concern":[40],"about":[41],"passing":[42],"on":[43,83],"conditions":[45,101],"as":[46],"a":[47],"key":[48],"factor":[49],"in":[50,61,70,89,123,172,197],"family":[51,133],"planning,":[52],"some":[53],"may":[54],"also":[55],"seek":[56,145],"use":[58],"PRS":[60,88,126,171,184],"reproductive":[62,90,128,173,198],"decisions":[63,174],"like":[64],"childbearing":[65],"or":[66],"embryo":[67,130],"selection":[68],"vitro":[71],"fertilization.":[72],"Despite":[73],"calls":[74],"increased":[76],"regulation,":[77],"there":[78],"remains":[79],"no":[80],"clinical":[81],"consensus":[82],"the":[84,110,179],"utility":[85],"contexts.":[91],"Therefore,":[92],"we":[93],"conducted":[94],"semi-structured":[95],"interviews":[96],"adults":[98],"(n":[102],"=":[103],"29)":[104],"evaluate":[106],"patient":[107,188],"perspectives":[108],"toward":[109],"tool's":[111],"benefits":[113],"risks.":[115],"Approximately":[116],"half":[117],"participants":[119],"would":[120],"be":[121,176],"interested":[122],"harnessing":[124],"purposes-including":[129],"screening":[131],"planning-driven":[134],"largely":[135],"by":[136],"desires":[137],"improve":[139],"children's":[140],"quality":[141],"life":[143],"empowerment":[146],"while":[147],"parenting.":[148],"Others":[149],"worried":[150],"selecting":[151],"against":[152],"embryos":[153],"disorders":[159],"could":[160],"exacerbate":[161],"stigma.":[162],"Regardless":[163],"personal":[165],"stance,":[166],"many":[167],"noted":[168],"using":[169],"should":[175],"permissible":[177],"general":[180],"population.":[181],"continue":[185],"mature,":[187],"views":[189],"reported":[190],"here":[191],"can":[192],"help":[193],"inform":[194],"their":[195],"future":[196],"spaces.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-02-19T00:00:00"}
