{"id":"https://openalex.org/W7129723402","doi":"https://doi.org/10.1158/1557-3265.sabcs25-ps4-03-18","title":"Abstract PS4-03-18: Homologous Recombination Deficiency and DNA-Damage Response in Breast Invasive Lobular Carcinoma","display_name":"Abstract PS4-03-18: Homologous Recombination Deficiency and DNA-Damage Response in Breast Invasive Lobular Carcinoma","publication_year":2026,"publication_date":"2026-02-17","ids":{"openalex":"https://openalex.org/W7129723402","doi":"https://doi.org/10.1158/1557-3265.sabcs25-ps4-03-18"},"language":"en","primary_location":{"id":"doi:10.1158/1557-3265.sabcs25-ps4-03-18","doi":"https://doi.org/10.1158/1557-3265.sabcs25-ps4-03-18","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1557-3265.sabcs25-ps4-03-18","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5126260739","display_name":"C. J. Schwartz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. J. Schwartz","raw_affiliation_strings":["1Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060254045","display_name":"Daniel M. Muldoon","orcid":"https://orcid.org/0000-0001-7936-4365","observed_orcids":["https://orcid.org/0000-0001-7936-4365"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Muldoon","raw_affiliation_strings":["1Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080827385","display_name":"Higinio Dopeso","orcid":"https://orcid.org/0000-0003-0060-1861","observed_orcids":["https://orcid.org/0000-0003-0060-1861"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Dopeso","raw_affiliation_strings":["1Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036719753","display_name":"Andrea M. Gazzo","orcid":"https://orcid.org/0009-0009-9282-4667","observed_orcids":["https://orcid.org/0009-0009-9282-4667"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Gazzo","raw_affiliation_strings":["1Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068783266","display_name":"Panieh Terraf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Terraf","raw_affiliation_strings":["1Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126248695","display_name":"M. Repetto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Repetto","raw_affiliation_strings":["1Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040506127","display_name":"Britta Weigelt","orcid":"https://orcid.org/0000-0001-9927-1270","observed_orcids":["https://orcid.org/0000-0001-9927-1270"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Weigelt","raw_affiliation_strings":["1Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062778506","display_name":"Diana L. Mandelker","orcid":"https://orcid.org/0000-0003-4154-0567","observed_orcids":["https://orcid.org/0000-0003-4154-0567"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Mandelker","raw_affiliation_strings":["1Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L. Norton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Norton","raw_affiliation_strings":["2Medicine, Memorial Sloan Kettering Cancer Center, New York City, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Medicine, Memorial Sloan Kettering Cancer Center, New York City, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126220175","display_name":"H. Y. Wen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Y. Wen","raw_affiliation_strings":["1Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126250149","display_name":"H. Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Zhang","raw_affiliation_strings":["1Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126195066","display_name":"D. Ross","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Ross","raw_affiliation_strings":["1Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080183722","display_name":"Edi Brogi","orcid":"https://orcid.org/0000-0003-4737-8468","observed_orcids":["https://orcid.org/0000-0003-4737-8468"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Edi","raw_affiliation_strings":["1Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059070480","display_name":"Anita Mamtani","orcid":"https://orcid.org/0000-0002-5637-5667","observed_orcids":["https://orcid.org/0000-0002-5637-5667"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Mamtani","raw_affiliation_strings":["3Surgery, Memorial Sloan Kettering Cancer Center, New York City, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Surgery, Memorial Sloan Kettering Cancer Center, New York City, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020383268","display_name":"Sherry Shen","orcid":"https://orcid.org/0000-0001-9566-2864","observed_orcids":["https://orcid.org/0000-0001-9566-2864"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Shen","raw_affiliation_strings":["2Medicine, Memorial Sloan Kettering Cancer Center, New York City, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Medicine, Memorial Sloan Kettering Cancer Center, New York City, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126247754","display_name":"C. Bandlamudi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Bandlamudi","raw_affiliation_strings":["1Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003635959","display_name":"Fresia G. Pareja","orcid":"https://orcid.org/0000-0003-3748-8049","observed_orcids":["https://orcid.org/0000-0003-3748-8049"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. Pareja","raw_affiliation_strings":["1Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"4_Supplement","first_page":"PS4","last_page":"03"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.8720999956130981,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.8720999956130981,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0348999984562397,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.027300000190734863,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/homologous-recombination-deficiency","display_name":"homologous recombination deficiency","score":0.8870000243186951},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.9390000104904175},{"id":"https://openalex.org/keywords/somatic-alterations","display_name":"somatic alterations","score":0.7480000257492065},{"id":"https://openalex.org/keywords/brca2","display_name":"BRCA2","score":0.9169999957084656},{"id":"https://openalex.org/keywords/atm","display_name":"ATM","score":0.9980000257492065},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mutational-signatures","display_name":"mutational signatures","score":0.9819999933242798},{"id":"https://openalex.org/keywords/her2-positive","display_name":"HER2-positive","score":0.6129999756813049},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.5910000205039978},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.367000013589859},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.6129999756813049},{"id":"https://openalex.org/keywords/targeted-therapy-biomarkers","display_name":"targeted therapy biomarkers","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.8438000082969666},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.7348999977111816},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.7113999724388123},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6100000143051147},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5544000267982483},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.512499988079071},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.423799991607666},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4235999882221222},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.41679999232292175},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4025000035762787},{"id":"https://openalex.org/C2780862961","wikidata":"https://www.wikidata.org/wiki/Q5311598","display_name":"Ductal carcinoma","level":4,"score":0.400299996137619},{"id":"https://openalex.org/C2776372563","wikidata":"https://www.wikidata.org/wiki/Q929221","display_name":"Invasive lobular carcinoma","level":5,"score":0.3953000009059906},{"id":"https://openalex.org/C2779296616","wikidata":"https://www.wikidata.org/wiki/Q6663895","display_name":"Lobular carcinoma","level":5,"score":0.38280001282691956},{"id":"https://openalex.org/C64894306","wikidata":"https://www.wikidata.org/wiki/Q849622","display_name":"Homologous chromosome","level":3,"score":0.36820000410079956},{"id":"https://openalex.org/C113968399","wikidata":"https://www.wikidata.org/wiki/Q7559241","display_name":"Somatic evolution in cancer","level":3,"score":0.3538999855518341},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.3314000070095062},{"id":"https://openalex.org/C3018521938","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast carcinoma","level":4,"score":0.3163999915122986},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.2944999933242798},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.2935999929904938},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2865999937057495},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.2833999991416931},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27129998803138733}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1557-3265.sabcs25-ps4-03-18","doi":"https://doi.org/10.1158/1557-3265.sabcs25-ps4-03-18","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1557-3265.sabcs25-ps4-03-18","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6326561570167542,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Identification":[2],"of":[3,61,72,98,196,206,210,218,268,296,304,315,319,330,394,443,506],"genetic":[4,64,91,198],"alterations":[5,38,65,92,158,199,335,397],"in":[6,17,47,66,93,159,200,313,356,391,401,446,498],"homologous":[7],"recombination":[8],"deficiency":[9,385],"(HRD)":[10],"and":[11,25,68,105,135,151,165,189,208,230,240,274,317,341,364,408,426,495],"DNA":[12,383],"damage":[13],"response":[14],"(DDR)":[15],"genes":[16,179,355,400],"breast":[18],"cancer":[19],"(BC)":[20],"is":[21],"key":[22],"for":[23,28,88,118,251,284,380],"prognostication":[24],"potential":[26,440],"selection":[27],"targeted":[29,85],"therapies,":[30],"such":[31],"as":[32,124,308,339],"PARPi.":[33],"While":[34,415],"HRD/DDR":[35,62,95,160,178,197,387,399,444],"somatic":[36,63,90,156],"oncogenic":[37,89,157],"are":[39,403,418],"generally":[40],"associated":[41,430],"with":[42,162,278,301,332,406,431],"ductal":[43,381],"BCs,":[44],"their":[45,69],"roles":[46],"invasive":[48],"lobular":[49],"carcinoma":[50],"(ILC)":[51],"remain":[52],"unclear.":[53],"Here,":[54],"we":[55],"sought":[56],"to":[57,82,428],"investigate":[58],"the":[59,126,169,234,252,285,328,357,411,439,507],"spectrum":[60],"ILC":[67,79,255,288,402],"histologic":[70,226],"features":[71,224],"these":[73,416],"BCs.":[74],"Design:":[75],"We":[76,143],"interrogated":[77],"1,076":[78],"previously":[80],"subjected":[81],"paired":[83],"tumor-normal":[84],"sequencing":[86],"(MSK-IMPACT)":[87],"22":[94],"genes.":[96,414],"Loss":[97],"heterozygosity":[99],"(LOH)":[100],"was":[101,112,122,130,257,290],"assessed":[102],"using":[103,108,114],"FACETS,":[104],"mutational":[106,325],"signatures":[107],"SigMA.":[109],"HRD":[110,309,324],"status":[111,129],"evaluated":[113],"an":[115],"algorithm":[116,312],"optimized":[117],"MSK-IMPACT.":[119],"Histologic":[120],"assessment":[121],"performed":[123],"per":[125,132],"WHO.":[127],"ER/HER2":[128],"determined":[131],"ASCO/CAP":[133],"guidelines,":[134],"follow-up":[136,250,282],"data":[137],"retrieved":[138],"from":[139],"medical":[140],"records.":[141],"Results:":[142],"identified":[144],"53":[145],"ILC,":[146,447],"including":[147,204,386],"14":[148],"primary":[149,215,254],"ILCs":[150,154,201,216,300],"39":[152],"recurrent/metastatic":[153],"harboring":[155],"genes,":[161],"BRCA2":[163,207,305,407],"(38%)":[164],"ATM":[166,211,333,409],"(23%)":[167],"being":[168,410],"most":[170,241,351,412],"frequently":[171],"affected.":[172],"Other":[173],"recurrently":[174],"altered":[175,413],"(\u22652":[176],"cases)":[177],"were":[180,202,217,238,242,271,276,298,306,337,359],"CHEK2,":[181],"PALB2,":[182],"BRCA1,":[183],"BARD1,":[184],"RAD50,":[185],"RAD51C,":[186],"NBN,":[187],"RECQL":[188],"ABRAXAS1.":[190],"LOH":[191],"analysis":[192],"revealed":[193],"that":[194,378],"53%":[195],"bi-allelic,":[203],"75%":[205],"70%":[209],"cases.":[212],"Most":[213],"(71%)":[214],"pleomorphic":[219,223,424],"type":[220],"or":[221,346],"exhibited":[222,342],"(Pleo-ILC),":[225],"grade":[227],"2/3":[228],"(93%)":[229],"ER+/HER2-":[231,243],"(93%).":[232],"Of":[233],"metastatic":[235,287],"ILCs,":[236],"59%":[237],"pleomorphic,":[239],"(74%),":[244],"followed":[245],"by":[246,310],"HER2+":[247],"(18%).":[248],"Median":[249,281],"HRD/DDR-mutant":[253,286],"cohort":[256,289,358],"72":[258],"months":[259,292],"(range":[260,293],"21-150);":[261],"6":[262],"patients":[263,297],"(43%)":[264],"had":[265],"no":[266],"evidence":[267],"disease,":[269],"5":[270],"deceased":[272],"(36%),":[273],"3":[275],"alive":[277],"disease":[279],"(21%).":[280,366],"time":[283],"84":[291],"19-288);":[294],"62%":[295],"deceased.":[299],"biallelic":[302,334],"inactivation":[303],"classified":[307,338],"our":[311],"60%":[314],"cases,":[316],"half":[318],"them":[320],"showed":[321],"a":[322,374,392],"dominant":[323,344],"signature,":[326],"whereas":[327],"majority":[329],"those":[331],"(83%)":[336],"non-HRD":[340],"either":[343],"APOBEC":[345],"clock":[347],"signature":[348],"(60%).":[349],"The":[350],"frequent":[352],"non-HRD/DDR":[353],"affected":[354],"CDH1":[360],"(76%),":[361],"PIK3CA":[362],"(48%),":[363],"FOXA1":[365],"Conclusion:":[367],"Our":[368],"findings":[369,437],"show":[370],"that,":[371],"although":[372],"at":[373],"lower":[375],"frequency":[376],"than":[377],"reported":[379],"BC,":[382],"repair":[384],"defects":[388],"can":[389],"occur":[390],"subset":[393],"ILC.":[395],"Somatic":[396],"affecting":[398],"often":[404,422],"biallelic,":[405],"tumors":[417],"phenotypically":[419],"diverse,":[420],"they":[421],"display":[423],"histology":[425],"appear":[427],"be":[429],"more":[432],"aggressive":[433],"clinical":[434,441],"behavior.":[435],"These":[436],"highlight":[438],"relevance":[442],"profiling":[445],"which":[448],"may":[449],"help":[450],"inform":[451],"treatment":[452],"strategies.":[453],"Citation":[454],"Format:":[455],"C.":[456,488],"J.":[457],"Schwartz,":[458],"D.":[459,471,480],"Muldoon,":[460],"H.":[461,475,478],"Dopeso,":[462],"A.":[463,484],"Gazzo,":[464],"P.":[465],"Terraf,":[466],"M.":[467],"Repetto,":[468],"B.":[469,482],"Weigelt,":[470],"Mandelker,":[472],"L.":[473],"Norton,":[474],"Y.":[476],"Wen,":[477],"Zhang,":[479],"Ross,":[481],"Edi,":[483],"Mamtani,":[485],"S.":[486],"Shen,":[487],"Bandlamudi,":[489],"F.":[490],"Pareja.":[491],"Homologous":[492],"Recombination":[493],"Deficiency":[494],"DNA-Damage":[496],"Response":[497],"Breast":[499,510],"Invasive":[500],"Lobular":[501],"Carcinoma":[502],"[abstract].":[503],"In:":[504],"Proceedings":[505],"San":[508,517],"Antonio":[509],"Cancer":[511,524],"Symposium":[512],"2025;":[513],"2025":[514],"Dec":[515],"9-12;":[516],"Antonio,":[518],"TX.":[519],"Philadelphia":[520],"(PA):":[521],"AACR;":[522],"Clin":[523],"Res":[525],"2026;32(4":[526],"Suppl):Abstract":[527],"nr":[528],"PS4-03-18.":[529]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-02-18T00:00:00"}