{"id":"https://openalex.org/W7129581069","doi":"https://doi.org/10.1016/j.btre.2026.e00951","title":"Development of anti-dengue virus D8 neutralizing monoclonal antibody production in Nicotiana benthamiana","display_name":"Development of anti-dengue virus D8 neutralizing monoclonal antibody production in Nicotiana benthamiana","publication_year":2026,"publication_date":"2026-02-17","ids":{"openalex":"https://openalex.org/W7129581069","doi":"https://doi.org/10.1016/j.btre.2026.e00951","pmid":"https://pubmed.ncbi.nlm.nih.gov/41766791"},"language":"en","primary_location":{"id":"doi:10.1016/j.btre.2026.e00951","doi":"https://doi.org/10.1016/j.btre.2026.e00951","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.btre.2026.e00951","pdf_url":null,"source":{"id":"https://openalex.org/S2764596916","display_name":"Biotechnology Reports","issn_l":"2215-017X","issn":["2215-017X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.btre.2026.e00951","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5126175134","display_name":"Gunt Niyompun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Gunt Niyompun","raw_affiliation_strings":["MSc. Program in Research for Enterprise, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MSc. Program in Research for Enterprise, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand","institution_ids":["https://openalex.org/I158708052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023102968","display_name":"Kaewta Rattanapisit","orcid":"https://orcid.org/0000-0001-6773-076X","observed_orcids":["https://orcid.org/0000-0001-6773-076X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kaewta Rattanapisit","raw_affiliation_strings":["Baiya Phytopharm Co., Ltd, Bangkok 10330, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baiya Phytopharm Co., Ltd, Bangkok 10330, Thailand","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039124100","display_name":"Janejira Jaratsittisin","orcid":"https://orcid.org/0000-0002-0651-5377","observed_orcids":["https://orcid.org/0000-0002-0651-5377"]},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Janejira Jaratsittisin","raw_affiliation_strings":["Baiya Phytopharm Co., Ltd, Bangkok 10330, Thailand","Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baiya Phytopharm Co., Ltd, Bangkok 10330, Thailand","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand","institution_ids":["https://openalex.org/I158708052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021284731","display_name":"Pipob Suwanchaikasem","orcid":"https://orcid.org/0000-0001-7991-6414","observed_orcids":["https://orcid.org/0000-0001-7991-6414"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pipob Suwanchaikasem","raw_affiliation_strings":["Baiya Phytopharm Co., Ltd, Bangkok 10330, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baiya Phytopharm Co., Ltd, Bangkok 10330, Thailand","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004892735","display_name":"Rochanawan Sootichote","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Rochanawan Sootichote","raw_affiliation_strings":["Center of Excellence for Antibody Research, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence for Antibody Research, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand","institution_ids":["https://openalex.org/I25399158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079640522","display_name":"Pichamon Sittikul","orcid":"https://orcid.org/0009-0002-2730-4349","observed_orcids":["https://orcid.org/0009-0002-2730-4349"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Pichamon Sittikul","raw_affiliation_strings":["Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand","institution_ids":["https://openalex.org/I25399158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003618996","display_name":"Pannamthip Pitaksajjakul","orcid":"https://orcid.org/0000-0002-1251-045X","observed_orcids":["https://orcid.org/0000-0002-1251-045X","https://orcid.org/0000-0003-2088-6999"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Pannamthip Pitaksajjakul","raw_affiliation_strings":["Center of Excellence for Antibody Research, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand","Department of Social and Environmental Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence for Antibody Research, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand","institution_ids":["https://openalex.org/I25399158"]},{"raw_affiliation_string":"Department of Social and Environmental Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand","institution_ids":["https://openalex.org/I25399158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025107575","display_name":"Pongrama Ramasoota","orcid":"https://orcid.org/0000-0003-3097-5733","observed_orcids":["https://orcid.org/0000-0003-3097-5733"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Pongrama Ramasoota","raw_affiliation_strings":["Center of Excellence for Antibody Research, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand","Department of Social and Environmental Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence for Antibody Research, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand","institution_ids":["https://openalex.org/I25399158"]},{"raw_affiliation_string":"Department of Social and Environmental Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand","institution_ids":["https://openalex.org/I25399158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049878186","display_name":"Waranyoo Phoolcharoen","orcid":"https://orcid.org/0000-0001-5958-7406","observed_orcids":["https://orcid.org/0000-0001-5958-7406"]},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Waranyoo Phoolcharoen","raw_affiliation_strings":["Center of Excellence in Plant-produced Pharmaceuticals, Chulalongkorn University, Bangkok 10330, Thailand","Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence in Plant-produced Pharmaceuticals, Chulalongkorn University, Bangkok 10330, Thailand","institution_ids":["https://openalex.org/I158708052"]},{"raw_affiliation_string":"Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand","institution_ids":["https://openalex.org/I158708052"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5049878186"],"corresponding_institution_ids":["https://openalex.org/I158708052"],"apc_list":{"value":3480,"currency":"USD","value_usd":3480},"apc_paid":{"value":3480,"currency":"USD","value_usd":3480},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09178848,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"49","issue":null,"first_page":"e00951","last_page":"e00951"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12856","display_name":"Transgenic Plants and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12856","display_name":"Transgenic Plants and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dengue-virus","display_name":"dengue virus","score":0.8159999847412109},{"id":"https://openalex.org/keywords/plant-made-antibodies","display_name":"plant-made antibodies","score":0.5759999752044678},{"id":"https://openalex.org/keywords/nicotiana-benthamiana","display_name":"Nicotiana benthamiana","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cross-neutralization","display_name":"cross-neutralization","score":0.6150000095367432},{"id":"https://openalex.org/keywords/antibody-glycosylation","display_name":"antibody glycosylation","score":0.8360000252723694},{"id":"https://openalex.org/keywords/glycoengineering","display_name":"glycoengineering","score":0.6489999890327454},{"id":"https://openalex.org/keywords/dengue-virus-serotypes","display_name":"dengue serotypes","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C2780562374","wikidata":"https://www.wikidata.org/wiki/Q3024956","display_name":"Nicotiana benthamiana","level":3,"score":0.9106000065803528},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.7972000241279602},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7840999960899353},{"id":"https://openalex.org/C2779635636","wikidata":"https://www.wikidata.org/wiki/Q476209","display_name":"Dengue virus","level":3,"score":0.7774999737739563},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6578999757766724},{"id":"https://openalex.org/C2777313579","wikidata":"https://www.wikidata.org/wiki/Q898365","display_name":"Glycosylation","level":2,"score":0.5911999940872192},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5791000127792358},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5364999771118164},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.5310999751091003},{"id":"https://openalex.org/C206212055","wikidata":"https://www.wikidata.org/wiki/Q2553138","display_name":"Glycan","level":3,"score":0.5238999724388123},{"id":"https://openalex.org/C533803919","wikidata":"https://www.wikidata.org/wiki/Q30953","display_name":"Dengue fever","level":2,"score":0.47589999437332153},{"id":"https://openalex.org/C196594336","wikidata":"https://www.wikidata.org/wiki/Q1662341","display_name":"Antibody-dependent enhancement","level":4,"score":0.45170000195503235},{"id":"https://openalex.org/C2779308166","wikidata":"https://www.wikidata.org/wiki/Q18388297","display_name":"Dengue vaccine","level":4,"score":0.4368000030517578},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.4327000081539154},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.41040000319480896},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.352400004863739},{"id":"https://openalex.org/C89138240","wikidata":"https://www.wikidata.org/wiki/Q3066564","display_name":"Vero cell","level":3,"score":0.3337000012397766},{"id":"https://openalex.org/C10389963","wikidata":"https://www.wikidata.org/wiki/Q848328","display_name":"Serotype","level":2,"score":0.32190001010894775},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.31690001487731934},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.30820000171661377},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.2903999984264374},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28859999775886536},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.28760001063346863},{"id":"https://openalex.org/C30324644","wikidata":"https://www.wikidata.org/wiki/Q3334151","display_name":"N-linked glycosylation","level":4,"score":0.2727999985218048},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2540999948978424},{"id":"https://openalex.org/C2776194381","wikidata":"https://www.wikidata.org/wiki/Q3965271","display_name":"Subclass","level":3,"score":0.2522999942302704}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.btre.2026.e00951","doi":"https://doi.org/10.1016/j.btre.2026.e00951","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.btre.2026.e00951","pdf_url":null,"source":{"id":"https://openalex.org/S2764596916","display_name":"Biotechnology Reports","issn_l":"2215-017X","issn":["2215-017X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Reports","raw_type":"journal-article"},{"id":"pmid:41766791","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41766791","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology reports (Amsterdam, Netherlands)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11731262","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12937009","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:58b136aadd904e8b8eea43a3a1a3b849","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/58b136aadd904e8b8eea43a3a1a3b849","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biotechnology Reports, Vol 49, Iss , Pp e00951- (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12937009","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12937009/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biotechnol Rep (Amst)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.btre.2026.e00951","doi":"https://doi.org/10.1016/j.btre.2026.e00951","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.btre.2026.e00951","pdf_url":null,"source":{"id":"https://openalex.org/S2764596916","display_name":"Biotechnology Reports","issn_l":"2215-017X","issn":["2215-017X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3867698216","display_name":null,"funder_award_id":"HEA_FF_69_182_3300_023","funder_id":"https://openalex.org/F4320321557","funder_display_name":"Chulalongkorn University"}],"funders":[{"id":"https://openalex.org/F4320321557","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1678784904","https://openalex.org/W1976308168","https://openalex.org/W1979039327","https://openalex.org/W2012551953","https://openalex.org/W2034125493","https://openalex.org/W2103735104","https://openalex.org/W2116471574","https://openalex.org/W2159856735","https://openalex.org/W2167041942","https://openalex.org/W2178559328","https://openalex.org/W2560347605","https://openalex.org/W2581165541","https://openalex.org/W2587552077","https://openalex.org/W2793441643","https://openalex.org/W3093466292","https://openalex.org/W3124630293","https://openalex.org/W3188641685","https://openalex.org/W4225130479","https://openalex.org/W4281401569","https://openalex.org/W4316468188","https://openalex.org/W4377093213","https://openalex.org/W4379375654","https://openalex.org/W4406350428","https://openalex.org/W4412433254"],"related_works":[],"abstract_inverted_index":{"\u2022":[0,15,30,42],"Plant-produced":[1],"anti-dengue":[2,75],"D8":[3,17,76,183],"mAb":[4,18],"in":[5,81,199,203],"\u0394XF":[6],"N.":[7],"benthamiana":[8,83],"neutralized":[9],"all":[10,115,157],"four":[11,116],"dengue":[12,117],"virus":[13,118],"serotypes.":[14],"The":[16,93,148],"showed":[19,45,110],"strong":[20],"NS1":[21,154,189],"binding":[22],"and":[23,36,84,89,99,139,161,191,202],"neutralization":[24],"potency":[25],"comparable":[26,143],"to":[27,66,144,153],"mammalian-derived":[28,166],"HuMAb.":[29],"Glycosylation":[31],"profiling":[32],"revealed":[33],"predominant":[34],"GnGn":[35],"GnM3":[37],"forms,":[38],"lacking":[39],"plant-specific":[40,97],"glycans.":[41],"FRNT":[43],"assay":[44],"highest":[46],"activity":[47,113,124,193],"against":[48,114,125,194],"DENV4,":[49],"with":[50,121,185],"FRNT\u2085\u2080":[51],"<":[52,128],"1":[53,129],"\u03bcg/mL.":[54],"Dengue":[55],"is":[56],"a":[57,73,104,175,181],"life-threatening":[58],"mosquito-borne":[59],"viral":[60],"disease":[61],"ranging":[62],"from":[63],"mild":[64],"symptoms":[65],"severe":[67],"hemorrhagic":[68],"fever.":[69],"In":[70],"this":[71],"study,":[72],"recombinant":[74],"monoclonal":[77],"antibody":[78,95,149,184],"was":[79],"produced":[80],"Nicotiana":[82],"characterized":[85],"for":[86],"protein":[87],"integrity":[88],"glycosylation":[90],"by":[91,132],"LC-MS.":[92],"plant-derived":[94],"lacked":[96],"\u03b21,2-xylose":[98],"core":[100],"\u03b11,3-fucose":[101],"residues,":[102],"displaying":[103],"mammalian-like":[105,186],"glycan":[106],"profile.":[107],"Functional":[108],"evaluation":[109,198],"potent":[111],"cross-neutralizing":[112,192],"serotypes":[119],"(DENV1\u2013DENV4),":[120],"the":[122,145],"strongest":[123],"DENV4":[126],"(FRNT50":[127],"\u00b5g/mL),":[130,135,138,142],"followed":[131],"DENV2":[133],"(5.82":[134],"DENV3":[136],"(9.49":[137],"DENV1":[140],"(28.68":[141],"mammalian-produced":[146],"counterpart.":[147],"also":[150],"bound":[151],"strongly":[152],"proteins":[155],"of":[156],"serotypes,":[158],"especially":[159],"DENV2,":[160],"demonstrated":[162],"higher":[163],"reactivity":[164],"than":[165],"anti-NS1":[167],"antibodies.":[168],"Collectively,":[169],"our":[170],"results":[171],"provide":[172],"proof-of-concept":[173],"that":[174],"glycoengineered":[176],"plant":[177],"platform":[178],"can":[179],"generate":[180],"functional":[182],"glycosylation,":[187],"robust":[188],"binding,":[190],"DENV1\u20134,":[195],"prompting":[196],"further":[197],"Fc-dependent":[200],"assays":[201],"vivo":[204],"models.":[205]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2026-02-18T00:00:00"}
