{"id":"https://openalex.org/W7129018598","doi":"https://doi.org/10.1016/j.bioorg.2026.109652","title":"Stereoselective AChE/BChE/BACE1 inhibition by enantiomeric norsesquiterpenoids with an unprecedented oxatricyclo[7.2.1.01,9]dodecane scaffold from the soft coral Sclerophytum humesi","display_name":"Stereoselective AChE/BChE/BACE1 inhibition by enantiomeric norsesquiterpenoids with an unprecedented oxatricyclo[7.2.1.01,9]dodecane scaffold from the soft coral Sclerophytum humesi","publication_year":2026,"publication_date":"2026-02-16","ids":{"openalex":"https://openalex.org/W7129018598","doi":"https://doi.org/10.1016/j.bioorg.2026.109652","pmid":"https://pubmed.ncbi.nlm.nih.gov/41740353"},"language":"en","primary_location":{"id":"doi:10.1016/j.bioorg.2026.109652","doi":"https://doi.org/10.1016/j.bioorg.2026.109652","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bioorg.2026.109652","pdf_url":null,"source":{"id":"https://openalex.org/S165482960","display_name":"Bioorganic Chemistry","issn_l":"0045-2068","issn":["0045-2068","1090-2120"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5119011779","display_name":"Phuong Vu Luu","orcid":"https://orcid.org/0009-0009-0383-1815","observed_orcids":["https://orcid.org/0009-0009-0383-1815"]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Phuong Vu Luu","raw_affiliation_strings":["Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 110301, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 110301, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126121963","display_name":"Cuong-Quoc Nguyen","orcid":"https://orcid.org/0000-0002-5641-5040","observed_orcids":["https://orcid.org/0000-0002-5641-5040"]},"institutions":[{"id":"https://openalex.org/I177733328","display_name":"Can Tho University","ror":"https://ror.org/0071qz696","country_code":"VN","type":"education","lineage":["https://openalex.org/I177733328"]}],"countries":["VN"],"is_corresponding":false,"raw_author_name":"Cuong-Quoc Nguyen","raw_affiliation_strings":["Department of Health Sciences, College of Natural Sciences, Can Tho University, Can Tho 94000, Vietnam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences, College of Natural Sciences, Can Tho University, Can Tho 94000, Vietnam","institution_ids":["https://openalex.org/I177733328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5095372754","display_name":"Huong Lien Ton-Nu","orcid":"https://orcid.org/0000-0002-9156-8202","observed_orcids":["https://orcid.org/0000-0002-9156-8202"]},"institutions":[{"id":"https://openalex.org/I177733328","display_name":"Can Tho University","ror":"https://ror.org/0071qz696","country_code":"VN","type":"education","lineage":["https://openalex.org/I177733328"]}],"countries":["VN"],"is_corresponding":false,"raw_author_name":"Huong Lien Ton-Nu","raw_affiliation_strings":["Department of Chemistry, College of Natural Sciences, Can Tho University, Can Tho 94000, Vietnam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, College of Natural Sciences, Can Tho University, Can Tho 94000, Vietnam","institution_ids":["https://openalex.org/I177733328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102591698","display_name":"Thuy-Tien Thi Phan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Thuy-Tien Thi Phan","raw_affiliation_strings":["Institute of Pharmaceutical Education and Research, Binh Duong University, Thu Dau Mot, Binh Duong 820000, Vietnam; Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 110301, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Education and Research, Binh Duong University, Thu Dau Mot, Binh Duong 820000, Vietnam; Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 110301, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103103147","display_name":"Quoc-Dung Tran Huynh","orcid":"https://orcid.org/0009-0005-0908-3433","observed_orcids":["https://orcid.org/0009-0005-0908-3433"]},"institutions":[{"id":"https://openalex.org/I4210092384","display_name":"Institute of Biological Chemistry, Academia Sinica","ror":"https://ror.org/00jt3dw39","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210092384","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Quoc-Dung Tran Huynh","raw_affiliation_strings":["Institute of Pharmaceutical Education and Research, Binh Duong University, Thu Dau Mot, Binh Duong 820000, Vietnam; Institute of Biological Chemistry, Academia Sinica, Taipei 115024, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Education and Research, Binh Duong University, Thu Dau Mot, Binh Duong 820000, Vietnam; Institute of Biological Chemistry, Academia Sinica, Taipei 115024, Taiwan","institution_ids":["https://openalex.org/I4210092384","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121241344","display_name":"Ngoc-Thac Pham","orcid":"https://orcid.org/0009-0006-7602-3964","observed_orcids":["https://orcid.org/0009-0006-7602-3964"]},"institutions":[{"id":"https://openalex.org/I2802508454","display_name":"University of Medicine and Pharmacy at Ho Chi Minh City","ror":"https://ror.org/025kb2624","country_code":"VN","type":"education","lineage":["https://openalex.org/I2802508454"]},{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW","VN"],"is_corresponding":false,"raw_author_name":"Ngoc-Thac Pham","raw_affiliation_strings":["School of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City 700000, Vietnam; PhD Program in Clinical Drug Development of Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 110301, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City 700000, Vietnam; PhD Program in Clinical Drug Development of Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 110301, Taiwan","institution_ids":["https://openalex.org/I2802508454","https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102666689","display_name":"Huong-Giang Le","orcid":"https://orcid.org/0000-0003-1962-2371","observed_orcids":["https://orcid.org/0000-0003-1962-2371"]},"institutions":[{"id":"https://openalex.org/I2802508454","display_name":"University of Medicine and Pharmacy at Ho Chi Minh City","ror":"https://ror.org/025kb2624","country_code":"VN","type":"education","lineage":["https://openalex.org/I2802508454"]}],"countries":["VN"],"is_corresponding":false,"raw_author_name":"Huong-Giang Le","raw_affiliation_strings":["School of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City 700000, Vietnam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City 700000, Vietnam","institution_ids":["https://openalex.org/I2802508454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041409762","display_name":"Lo-Yun Chen","orcid":"https://orcid.org/0000-0003-3228-3933","observed_orcids":["https://orcid.org/0000-0003-3228-3933"]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Lo-Yun Chen","raw_affiliation_strings":["PhD Program in Clinical Drug Development of Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 110301, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhD Program in Clinical Drug Development of Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 110301, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121795260","display_name":"Yu-Chia Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141243467","display_name":"Chang Gung University of Science and Technology","ror":"https://ror.org/009knm296","country_code":"TW","type":"education","lineage":["https://openalex.org/I141243467"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Chia Chang","raw_affiliation_strings":["Center for Drug Research and Development, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333324, Taiwan; Department of Cosmetic Science, Chang Gung University of Science and Technology, Taoyuan City 33303, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Drug Research and Development, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333324, Taiwan; Department of Cosmetic Science, Chang Gung University of Science and Technology, Taoyuan City 33303, Taiwan","institution_ids":["https://openalex.org/I141243467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126101926","display_name":"Jui-Hsin Su","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125866","display_name":"National Museum of Marine Biology and Aquarium","ror":"https://ror.org/02apq7b82","country_code":"TW","type":"archive","lineage":["https://openalex.org/I4210125866","https://openalex.org/I4210141165","https://openalex.org/I4405257903"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jui-Hsin Su","raw_affiliation_strings":["National Museum of Marine Biology and Aquarium, Pingtung 944401, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Museum of Marine Biology and Aquarium, Pingtung 944401, Taiwan","institution_ids":["https://openalex.org/I4210125866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103415290","display_name":"Bo\u2010Rong Peng","orcid":"https://orcid.org/0000-0002-4537-1353","observed_orcids":["https://orcid.org/0000-0002-4537-1353"]},"institutions":[{"id":"https://openalex.org/I141243467","display_name":"Chang Gung University of Science and Technology","ror":"https://ror.org/009knm296","country_code":"TW","type":"education","lineage":["https://openalex.org/I141243467"]},{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Bo-Rong Peng","raw_affiliation_strings":["Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 110301, Taiwan; PhD Program in Clinical Drug Development of Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 110301, Taiwan; Center for Drug Research and Development, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333324, Taiwan. Electronic address: brpeng@mail.cgust.edu.tw"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 110301, Taiwan; PhD Program in Clinical Drug Development of Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 110301, Taiwan; Center for Drug Research and Development, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333324, Taiwan. Electronic address: brpeng@mail.cgust.edu.tw","institution_ids":["https://openalex.org/I141243467","https://openalex.org/I47519274"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113964973","display_name":"Kuei-Hung Lai","orcid":"https://orcid.org/0000-0001-7220-6356","observed_orcids":["https://orcid.org/0000-0001-7220-6356"]},"institutions":[{"id":"https://openalex.org/I2802331550","display_name":"Taipei Medical University Hospital","ror":"https://ror.org/03k0md330","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802331550"]},{"id":"https://openalex.org/I4210125866","display_name":"National Museum of Marine Biology and Aquarium","ror":"https://ror.org/02apq7b82","country_code":"TW","type":"archive","lineage":["https://openalex.org/I4210125866","https://openalex.org/I4210141165","https://openalex.org/I4405257903"]},{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Kuei-Hung Lai","raw_affiliation_strings":["Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 110301, Taiwan; PhD Program in Clinical Drug Development of Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 110301, Taiwan; National Museum of Marine Biology and Aquarium, Pingtung 944401, Taiwan; Traditional Herbal Medicine Research Center, Taipei Medical University Hospital, Taipei 110301, Taiwan; PhD Program in Drug Discovery and Development Industry, College of Pharmacy, Taipei Medical University, Taipei 110301, Taiwan. Electronic address: kueihunglai@tmu.edu.tw"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 110301, Taiwan; PhD Program in Clinical Drug Development of Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 110301, Taiwan; National Museum of Marine Biology and Aquarium, Pingtung 944401, Taiwan; Traditional Herbal Medicine Research Center, Taipei Medical University Hospital, Taipei 110301, Taiwan; PhD Program in Drug Discovery and Development Industry, College of Pharmacy, Taipei Medical University, Taipei 110301, Taiwan. Electronic address: kueihunglai@tmu.edu.tw","institution_ids":["https://openalex.org/I2802331550","https://openalex.org/I4210125866","https://openalex.org/I47519274"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5113964973"],"corresponding_institution_ids":["https://openalex.org/I2802331550","https://openalex.org/I4210125866","https://openalex.org/I47519274"],"apc_list":{"value":4240,"currency":"USD","value_usd":4240},"apc_paid":null,"fwci":8.2208,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.97570937,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"173","issue":null,"first_page":"109652","last_page":"109652"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":0.6826000213623047,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":0.6826000213623047,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.12449999898672104,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.03709999844431877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/norsesquiterpenoids","display_name":"norsesquiterpenoids","score":0.8650000095367432},{"id":"https://openalex.org/keywords/soft-coral-natural-products","display_name":"soft coral natural products","score":0.8809999823570251},{"id":"https://openalex.org/keywords/acetylcholinesterase-inhibition","display_name":"acetylcholinesterase inhibition","score":0.9490000009536743},{"id":"https://openalex.org/keywords/butyrylcholinesterase-inhibition","display_name":"butyrylcholinesterase inhibition","score":0.9660000205039978},{"id":"https://openalex.org/keywords/absolute-configuration","display_name":"absolute configuration","score":0.781000018119812},{"id":"https://openalex.org/keywords/biosynthetic-pathway","display_name":"biosynthetic pathway","score":0.8569999933242798},{"id":"https://openalex.org/keywords/drug-likeness-prediction","display_name":"drug-likeness prediction","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9517999887466431},{"id":"https://openalex.org/C181647583","wikidata":"https://www.wikidata.org/wiki/Q903429","display_name":"Stereoselectivity","level":3,"score":0.7644000053405762},{"id":"https://openalex.org/C486523","wikidata":"https://www.wikidata.org/wiki/Q494483","display_name":"Enantiomer","level":2,"score":0.7580999732017517},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6851999759674072},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.6082000136375427},{"id":"https://openalex.org/C75079739","wikidata":"https://www.wikidata.org/wiki/Q1571801","display_name":"Intramolecular force","level":2,"score":0.5724999904632568},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.5302000045776367},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5232999920845032},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.5108000040054321},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.49000000953674316},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.40720000863075256},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4068000018596649},{"id":"https://openalex.org/C129694887","wikidata":"https://www.wikidata.org/wiki/Q47455153","display_name":"Stereoisomerism","level":3,"score":0.4025000035762787},{"id":"https://openalex.org/C178910836","wikidata":"https://www.wikidata.org/wiki/Q2196961","display_name":"Molecular model","level":2,"score":0.3776000142097473},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.3603000044822693},{"id":"https://openalex.org/C25170562","wikidata":"https://www.wikidata.org/wiki/Q2052053","display_name":"Absolute configuration","level":2,"score":0.357699990272522},{"id":"https://openalex.org/C69118441","wikidata":"https://www.wikidata.org/wiki/Q2941663","display_name":"Enzyme catalysis","level":3,"score":0.33820000290870667},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.32019999623298645},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3111000061035156},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.3109999895095825},{"id":"https://openalex.org/C2776980637","wikidata":"https://www.wikidata.org/wiki/Q427492","display_name":"Enzyme inhibitor","level":3,"score":0.3052999973297119},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.30239999294281006},{"id":"https://openalex.org/C3141732","wikidata":"https://www.wikidata.org/wiki/Q568761","display_name":"Enantiomeric excess","level":4,"score":0.29840001463890076},{"id":"https://openalex.org/C118792377","wikidata":"https://www.wikidata.org/wiki/Q108584245","display_name":"Selectivity","level":3,"score":0.2838999927043915},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.28110000491142273},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27730000019073486},{"id":"https://openalex.org/C56856141","wikidata":"https://www.wikidata.org/wiki/Q883112","display_name":"Enzyme kinetics","level":4,"score":0.26649999618530273},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.25929999351501465},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.25290000438690186}],"mesh":[{"descriptor_ui":"D000110","descriptor_name":"Acetylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000110","descriptor_name":"Acetylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000110","descriptor_name":"Acetylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000110","descriptor_name":"Acetylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000110","descriptor_name":"Acetylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002091","descriptor_name":"Butyrylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002091","descriptor_name":"Butyrylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002091","descriptor_name":"Butyrylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002091","descriptor_name":"Butyrylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002091","descriptor_name":"Butyrylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037421","descriptor_name":"Anthozoa","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D037421","descriptor_name":"Anthozoa","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D037421","descriptor_name":"Anthozoa","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D037421","descriptor_name":"Anthozoa","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D037421","descriptor_name":"Anthozoa","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bioorg.2026.109652","doi":"https://doi.org/10.1016/j.bioorg.2026.109652","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bioorg.2026.109652","pdf_url":null,"source":{"id":"https://openalex.org/S165482960","display_name":"Bioorganic Chemistry","issn_l":"0045-2068","issn":["0045-2068","1090-2120"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic Chemistry","raw_type":"journal-article"},{"id":"pmid:41740353","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41740353","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.428600013256073,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Life below water","score":0.8630338311195374,"id":"https://metadata.un.org/sdg/14"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1860052689","display_name":null,"funder_award_id":"DP2-TMU-114-C-06","funder_id":"https://openalex.org/F4320311687","funder_display_name":"Ministry of Education"},{"id":"https://openalex.org/G3138810535","display_name":"Development of Taiwan\u2019S Orchids as Functional Foods for Inflammatory Metabolic Disorders( III )","funder_award_id":"NSTC113-2321-B255-001","funder_id":"https://openalex.org/F2461203286","funder_display_name":"National Science and Technology Council"},{"id":"https://openalex.org/G7569843079","display_name":"Unveiling Marine Medicinal Resources through Chemical Molecular Networking: Establishing a Bioactive Metabolomic Database for Marine Sponges in Taiwanese Waters","funder_award_id":"NSTC113-2628-B038-009-MY3","funder_id":"https://openalex.org/F2461203286","funder_display_name":"National Science and Technology Council"},{"id":"https://openalex.org/G8268499335","display_name":"Construction of an Integrative Metabolomic Repository for Traditional Chinese Medicines through Advanced Chemical Molecular Networking: a Paradigm for Addressing Circulatory Pathologies","funder_award_id":"NSTC114-2326-B038-002-MY3","funder_id":"https://openalex.org/F2461203286","funder_display_name":"National Science and Technology Council"}],"funders":[{"id":"https://openalex.org/F2461203286","display_name":"National Science and Technology Council","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320311687","display_name":"Ministry of Education","ror":"https://ror.org/03m01yf64"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1977742774","https://openalex.org/W1987051648","https://openalex.org/W1994525974","https://openalex.org/W2004629831","https://openalex.org/W2028856433","https://openalex.org/W2032049376","https://openalex.org/W2069457036","https://openalex.org/W2071036665","https://openalex.org/W2103226619","https://openalex.org/W2112727163","https://openalex.org/W2131768857","https://openalex.org/W2150332371","https://openalex.org/W2593436234","https://openalex.org/W2936717658","https://openalex.org/W2949084793","https://openalex.org/W2952915471","https://openalex.org/W2982526810","https://openalex.org/W3036089986","https://openalex.org/W3044000953","https://openalex.org/W3080905188","https://openalex.org/W3174730194","https://openalex.org/W4210495866","https://openalex.org/W4211090408","https://openalex.org/W4295560299","https://openalex.org/W4323046938","https://openalex.org/W4323056218","https://openalex.org/W4384133222","https://openalex.org/W4385933203","https://openalex.org/W4389725263","https://openalex.org/W4393163094","https://openalex.org/W4394725190","https://openalex.org/W4406683066","https://openalex.org/W4407275043","https://openalex.org/W4407955027","https://openalex.org/W4408746330","https://openalex.org/W4409795824","https://openalex.org/W4411154443","https://openalex.org/W4411989624","https://openalex.org/W4412392682","https://openalex.org/W4412465327","https://openalex.org/W4412673028","https://openalex.org/W4412713560","https://openalex.org/W4413109078","https://openalex.org/W4413270454","https://openalex.org/W4413344673","https://openalex.org/W4413641084","https://openalex.org/W4413854196","https://openalex.org/W4413990346","https://openalex.org/W4414320445","https://openalex.org/W4414501050","https://openalex.org/W4414573182","https://openalex.org/W4414573768","https://openalex.org/W4416407155","https://openalex.org/W4417436674","https://openalex.org/W7124467449","https://openalex.org/W7124535412"],"related_works":[],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2026-02-17T00:00:00"}
