{"id":"https://openalex.org/W7129003497","doi":"https://doi.org/10.25934/pr00012125","title":"Evaluation of Gene Expression Biomarkers to Predict Response to Immune Checkpoint Inhibitors and Angiogenesis Inhibitors in Clear Cell Renal Cell Carcinoma","display_name":"Evaluation of Gene Expression Biomarkers to Predict Response to Immune Checkpoint Inhibitors and Angiogenesis Inhibitors in Clear Cell Renal Cell Carcinoma","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7129003497","doi":"https://doi.org/10.25934/pr00012125"},"language":"en","primary_location":{"id":"doi:10.25934/pr00012125","doi":"https://doi.org/10.25934/pr00012125","is_oa":true,"landing_page_url":"https://doi.org/10.25934/pr00012125","pdf_url":null,"source":{"id":"https://openalex.org/S7407053272","display_name":"Vivli","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4387156298","host_organization_name":"Vivli","host_organization_lineage":["https://openalex.org/I4387156298"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Project"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.25934/pr00012125","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007926027","display_name":"Scott Mattox Haake","orcid":"https://orcid.org/0000-0003-3455-0791","observed_orcids":["https://orcid.org/0000-0003-3455-0791"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Scott Haake","raw_affiliation_strings":["Vanderbilt University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University Medical Center","institution_ids":["https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007926027"],"corresponding_institution_ids":["https://openalex.org/I901861585"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.020800000056624413,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clear-cell-renal-cell-carcinoma","display_name":"clear cell renal cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.8240000009536743},{"id":"https://openalex.org/keywords/angiogenesis-inhibitors","display_name":"angiogenesis inhibitors","score":0.9769999980926514},{"id":"https://openalex.org/keywords/gene-expression-biomarkers","display_name":"gene expression biomarkers","score":0.8949999809265137},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.8740000128746033},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.656000018119812},{"id":"https://openalex.org/keywords/checkmate-214","display_name":"CheckMate 214","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-immune-activity","display_name":"tumor immune activity","score":0.5879999995231628},{"id":"https://openalex.org/keywords/tumor-vasculature","display_name":"tumor vasculature","score":0.6899999976158142},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C2781068499","wikidata":"https://www.wikidata.org/wiki/Q3242950","display_name":"Kidney cancer","level":3,"score":0.7964000105857849},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7204999923706055},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6887000203132629},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.595300018787384},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5727999806404114},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5681999921798706},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.46939998865127563},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.46480000019073486},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.45910000801086426},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4472000002861023},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4212999939918518},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4025999903678894},{"id":"https://openalex.org/C2781278892","wikidata":"https://www.wikidata.org/wiki/Q18556340","display_name":"Clear cell renal cell carcinoma","level":3,"score":0.3935000002384186},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3889000117778778},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.37689998745918274},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37630000710487366},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3492000102996826},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.3181999921798706},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2946000099182129},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2897999882698059},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.28769999742507935},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.2872999906539917},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.2842000126838684},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27160000801086426},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.27090001106262207},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2660999894142151},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2581999897956848},{"id":"https://openalex.org/C2777663904","wikidata":"https://www.wikidata.org/wiki/Q988343","display_name":"Blood vessel","level":2,"score":0.2551000118255615},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.2526000142097473}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.25934/pr00012125","doi":"https://doi.org/10.25934/pr00012125","is_oa":true,"landing_page_url":"https://doi.org/10.25934/pr00012125","pdf_url":null,"source":{"id":"https://openalex.org/S7407053272","display_name":"Vivli","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4387156298","host_organization_name":"Vivli","host_organization_lineage":["https://openalex.org/I4387156298"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Project"}],"best_oa_location":{"id":"doi:10.25934/pr00012125","doi":"https://doi.org/10.25934/pr00012125","is_oa":true,"landing_page_url":"https://doi.org/10.25934/pr00012125","pdf_url":null,"source":{"id":"https://openalex.org/S7407053272","display_name":"Vivli","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4387156298","host_organization_name":"Vivli","host_organization_lineage":["https://openalex.org/I4387156298"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Project"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W7106520882","https://openalex.org/W7106537563","https://openalex.org/W7106568033"],"related_works":["https://openalex.org/W4386085401","https://openalex.org/W4409652616","https://openalex.org/W4389131654","https://openalex.org/W7133206550","https://openalex.org/W4403400566","https://openalex.org/W4306411150","https://openalex.org/W4312140520","https://openalex.org/W4324147302","https://openalex.org/W7166521993","https://openalex.org/W7081972078"],"abstract_inverted_index":{"Kidney":[0],"cancer":[1,7,53,129,143,295,419],"is":[2,96,249],"a":[3,44,115,132,152,171,186,413],"disease":[4],"in":[5,10,167,185,360,369],"which":[6,179,181,398],"cells":[8],"grow":[9],"the":[11,13,19,62,66,139,148,161,306,356,361],"kidneys,":[12],"organs":[14],"that":[15,42,60,99,123,137,146,155,237,393],"filter":[16],"waste":[17],"from":[18,114,253,273,291,341,442],"blood.":[20],"It":[21,421],"affects":[22],"hundreds":[23],"of":[24,26,134,224,320,427],"thousands":[25],"people":[27],"worldwide":[28],"each":[29,106,370],"year.":[30],"Several":[31],"effective":[32],"treatments":[33,100,239],"are":[34,183,257,279,401],"available":[35],"to":[36,48,86,105,160,209,214,233,260,268,276,352,355,373,385,404,406,417,435],"treatment":[37,154,321,447],"these":[38,80,94,190,342],"patients,":[39],"including":[40],"drugs":[41,59],"activate":[43],"patient\u2019s":[45],"immune":[46,55,140,225],"system":[47,141,226],"help":[49,424],"it":[50,382],"attack":[51,61,142],"their":[52,244],"(so-called":[54,68],"checkpoint":[56],"inhibitors)":[57],"and":[58,144,206,228,281,301,314,323,338,364,438],"blood":[63,150,158,218],"vessels":[64],"feeding":[65],"tumor":[67,168,288,308,335,399],"angiogenesis":[69],"inhibitors).":[70],"However,":[71],"not":[72,241,258,432],"all":[73],"patients":[74,125,368,428],"respond":[75,84,91,405,433],"similarly":[76],"when":[77],"treated":[78],"with":[79,126],"drugs.":[81],"Some":[82,211],"tumors":[83,192,351,430],"well":[85,434],"certain":[87],"medicines,":[88],"while":[89],"others":[90,221],"poorly.":[92],"Understanding":[93],"differences":[95],"important":[97],"so":[98],"can":[101,310],"be":[102,269,311],"better":[103],"matched":[104],"patient.":[107],"We":[108,284,326,344,376],"will":[109,285,327,345,377,411],"build":[110],"on":[111,189,217],"earlier":[112,362,388],"research":[113,248,330,444],"large":[116],"clinical":[117,339],"trial":[118],"called":[119,173,198],"IMmotion":[120],"151.":[121],"In":[122],"study,":[124],"advanced":[127],"kidney":[128,294,418],"received":[130],"either":[131],"combination":[133],"two":[135,229],"medicines\u2014one":[136],"helps":[138],"another":[145],"reduces":[147,157],"tumor\u2019s":[149],"supply\u2014or":[151],"standard":[153],"mainly":[156,216],"supply":[159],"tumor.":[162,187],"Researchers":[163],"studied":[164],"gene":[165,289,336,347],"activity":[166,348],"samples":[169],"using":[170,271,390],"method":[172],"ribonucleic":[174],"acid":[175],"sequencing":[176],"(RNA":[177],"sequencing),":[178],"measures":[180],"genes":[182],"active":[184],"Based":[188],"patterns,":[191],"were":[193,231],"grouped":[194],"into":[195,445],"seven":[196],"categories,":[197],"clusters.":[199],"Each":[200],"cluster":[201,371],"showed":[202,222],"different":[203,374],"biological":[204],"features":[205],"responded":[207,372],"differently":[208],"treatment.":[210],"clusters":[212,230,309,358],"appeared":[213],"depend":[215],"vessel":[219],"growth,":[220],"signs":[223],"activity,":[227],"linked":[232],"poorer":[234],"outcomes,":[235],"suggesting":[236],"current":[238,436],"may":[240,422,440],"effectively":[242],"address":[243],"underlying":[245],"biology.":[246],"This":[247],"necessary":[250],"because":[251,381],"results":[252],"one":[254],"study":[255,363],"alone":[256],"enough":[259],"guide":[261],"future":[262,443],"patient":[263,324],"care.":[264,420],"Scientific":[265],"findings":[266,389],"need":[267],"confirmed":[270],"data":[272,290,337,392],"other":[274],"studies":[275],"ensure":[277],"they":[278,316],"reliable":[280],"broadly":[282],"applicable.":[283],"use":[286,378],"existing":[287],"three":[292],"additional":[293],"trials\u2014CheckMate":[296],"(CM)":[297],"025,":[298],"CheckMate":[299,302],"214,":[300],"920\u2014to":[303],"test":[304],"whether":[305,315],"same":[307,357],"identified":[312,359],"again":[313],"show":[317],"similar":[318],"patterns":[319,349],"response":[322],"outcomes.":[325],"conduct":[328],"this":[329,379],"by":[331],"analyzing":[332],"previously":[333],"collected":[334],"information":[340],"trials.":[343],"compare":[346],"across":[350],"assign":[353],"them":[354],"then":[365],"examine":[366],"how":[367],"treatments.":[375],"approach":[380,416],"allows":[383],"us":[384],"carefully":[386],"validate":[387],"high-quality":[391],"already":[394],"exist.":[395],"By":[396],"confirming":[397],"types":[400],"more":[402,414],"likely":[403],"specific":[407],"treatments,":[408],"our":[409],"work":[410],"support":[412],"personalized":[415],"also":[423],"identify":[425],"groups":[426],"whose":[429],"do":[431],"therapies":[437],"who":[439],"benefit":[441],"new":[446],"strategies.":[448]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-02-17T00:00:00"}
